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Topic: Scopolamine

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	Reference.com/Encyclopedia/Scopolamine
		Scopolamine, also known as hyoscine, is a tropane alkaloid drug obtained from plants of the family Solanaceae (nightshades), such as henbane or jimson weed (Datura species).
		Scopolamine was one of the active ingredients in Asthmador, an over the counter smoking preparation marketed in the 1950's and 60's claiming to combat asthma and bronchitis.
		Scopolamine, in common with the large percentage of anticholinergics which cross the blood-brain barrier such as diphenhydramine, dicyclomine, trihexyphenidyl and related drugs, is said to produce euphoria at and around therapeutic doses as well as to potentiate this and other effects of morphine, methadone, hydromorphone, oxycodone and other opioids.
	www.reference.com /browse/wiki/Scopolamine (1667 words)

	scopolamine. The Columbia Encyclopedia, Sixth Edition. 2001-05
		Structurally similar to the nerve substance acetylcholine, scopolamine acts by interfering with the transmission of nerve impulses by acetylcholine in the parasympathetic nervous system and produces symptoms typical of parasympathetic system depression: dilated pupils, rapid heartbeat, and dry skin, mouth, and respiratory passages.
		Because scopolamine depresses the central nervous system, it is used as a sedative prior to anesthesia and as an antispasmodic in certain disorders characterized by restlessness and agitation, e.g., delirium tremens, psychosis, mania, and Parkinsonism.
		Overdosage of scopolamine causes delirium, delusions, paralysis, and stupor.
	www.bartleby.com /65/sc/scopolam.html (197 words)

	Scopolamine (hyoscine) for preventing and treating motion sickness
		However, scopolamine was not shown to be superior to antihistamines and combinations of scopolamine and ephedrine.
		Scopolamine was less likely to cause drowsiness, blurred vision or dizziness when compared to these other agents.
		Scopolamine was compared against placebo, calcium channel antagonists, antihistamine, methscopolamine or a combination of scopolamine and ephedrine.
	www.cochrane.org /reviews/en/ab002851.html (660 words)

	Drug Turns Crime Victims Into Zombies
		Since scopolamine completely blocks the formation of memories, unlike most date-rape drugs used in the United States and elsewhere, it is usually impossible for victims to ever identify their aggressors.
		The tree which naturally produces scopolamine grows wild around the capital and is so famous in the countryside that mothers warn their children not to fall asleep below its yellow and white flowers.
		The use of scopolamine by criminals appears to be confined to Colombia, at least for now, and it's not clear why the drug is such a rampant problem in Colombia.
	www.rense.com /general38/frug.htm (792 words)

	scopolamine - Digestion and Digestive-Related Information on MedicineNet.com
		Transderm-Scop is scopolamine administered topically (through the skin or transdermal) via a special delivery system that gradually releases scopolamine onto the skin over a period of three days.
		Scientists believe that scopolamine prevents communication between the nerves of the vestibule and the vomiting center in the brain by blocking the action of acetylcholine.
		Scopolamine may worsen narrow angle glaucoma, cause difficulty urinating and lead to dry, itchy eyes.
	www.medicinenet.com /scopolamine/article.htm (532 words)

	MedlinePlus Drug Information: Scopolamine Patch
		Scopolamine is used to prevent nausea and vomiting caused by motion sickness.
		Scopolamine comes as a patch to be placed on the skin behind your ear.
		At the end of 3 days, or when the scopolamine patch is no longer needed, remove the patch and throw it away.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a682509.html (757 words)

	NTP: Abstract for TR-445 - Scopolamine Hydrobromide Trihydrate (Site not responding. Last check: )
		Scopolamine hydrobromide trihydrate is used in ophthalmic preparations and as a preanesthetic sedative.
		Scopolamine hydrobromide trihydrate was selected for study because of considerable human exposure resulting from its use in prescription and over-the-counter preparations.
		The serum scopolamine concentrations were 6 ng scopolamine/mL serum for the 5 mg/kg female sample and 12 and 28 ng/mL for the 25 mg/kg male and female samples, respectively.
	ntp-server.niehs.nih.gov /index.cfm?objectid=070A21C8-C79D-97F0-D4A8B848B096F890 (2003 words)

	Scopolamine Summary
		Scopolamine (d-hyoscine) and attopine (dl-hyosycamine) is a tropane alkaloid found in the leaves and seeds of several plant species of the family Solanaceae, including deadly nightshade (Atropa bella-donna) and henbane (Hyoscyamus niger).
		Scopolamine, also known as hyoscine, is a tropane alkaloid drug obtained from plants of the family Solanaceae (nightshades), such as henbane or jimson weed (Datura species).
		Scopolamine is used criminally as a date rape drug and as an aid to robbery, the most common act being the clandestine drugging of a victim's drink.
	www.bookrags.com /Scopolamine (976 words)

	Scopolamine: Encyclopedia of Cancer
		Scopolamine, also called hyoscine hydrobromide, is used in cancer treatment to prevent nausea and vomiting that results from movement of the head.
		Scopolamine is used to treat nausea and vomiting that result from movement of the head.
		Scopolamine is a natural product and is familiar to many people as a motion sickness medicine.
	health.enotes.com /cancer-encyclopedia/scopolamine (109 words)

	Scopolamine Patch Information on Healthline
		Scopolamine patches are prescribed to reduce postoperative nausea and vomiting (PONV) associated with anesthesia and surgery.
		For women who are prescribed a scopolamine patch to reduce nausea and vomiting related to a cesarean section, the patch should be applied just one hour before the procedure to minimize the baby's exposure to the drug.
		Scopolamine does cross the placental barrier, but as of early 2003, clinical studies have not shown any negative affects on newborn babies of mothers who used the drug in a caesarean delivery.
	www.healthline.com /galecontent/scopolamine-patch (793 words)

	scopolamine - HighBeam Encyclopedia
		Structurally similar to the nerve substance acetylcholine, scopolamine acts by interfering with the transmission of nerve impulses by acetylcholine in the parasympathetic nervous system and produces symptoms typical of parasympathetic system depression: dilated pupils, rapid heartbeat, and dry skin, mouth, and respiratory passages.
		Because scopolamine depresses the central nervous system, it is used as a sedative prior to anesthesia and as an antispasmodic in certain disorders characterized by restlessness and agitation, e.g., delirium tremens, psychosis, mania, and Parkinsonism.
		Scopolamine poisoning among heroin users - New York City, Newark, Philadelphia, and Baltimore, 1995 and 1996.
	www.encyclopedia.com /doc/1E1-scopolam.html (544 words)

	It:Scopolamine - ChemWiki
		The reason behind the lack of frequency of the presence of scopolamine throughout the Solonaceae family of plants, is the lack of a particular gene.
		Scopolamine was one of the drugs investigated in the 1950's for its 'truth drug' or mind control properties by the CIA and the British government.
		Scopolamine was abandoned as a possible truth drug because its hallucinogenic side effects meant that the answers obtained from subjects under the influence of the drug were were prone to distortion.
	www.ch.ic.ac.uk /wiki/index.php/It:Scopolamine (891 words)

	scopolamine topical - Drug Finder - MSN Health & Fitness (Site not responding. Last check: )
		Scopolamine topical is used to relieve nausea, vomiting, and dizziness associated with motion sickness.
		Scopolamine topical is in the FDA pregnancy category C. This means that it is not known whether scopolamine topical will harm an unborn baby.
		Scopolamine topical may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, sedatives (used to treat insomnia), pain relievers, anxiety medicines, and muscle relaxants.
	health.msn.com /drugfinder/articlepage.aspx?cp-documentid=100060649 (1139 words)

	Howstuffworks "Scopolamine: A Profile of an Antiemetic and Antivertigo Drug"
		Scopolamine is used to prevent nausea and vomiting associated with motion sickness.
		Scopolamine can cause additive drowsiness when combined with alcohol or other central nervous system depressants (such as antihistamines, barbiturates, benzodiazepine tranquilizers, muscle relaxants, narcotics, and pain medications) or with tricyclic antidepressants.
		Scopolamine can cause additive anticholinergic effects (such as dryness of the mouth, nose, and throat or difficulty in urinating) when combined with drugs such as belladonna alkaloids, antidepressants, and antihistamines.
	health.howstuffworks.com /define-scopolamine-transdermal.htm (833 words)

	ACS :: Cancer Drug Guide: scopolamine
		Scopolamine belongs to a general class of drugs called anticholinergics (antimuscarinics) used to treat nausea and vomiting.
		Scopolamine appears to prevent nausea and vomiting related to motion sickness by blocking messages that stimulate the part of the brain responsible for nausea and vomiting.
		Scopolamine is usually given as a transdermal patch placed behind the ear.
	www.cancer.org /docroot/CDG/content/CDG_scopolamine.asp (371 words)

	A General Review of the Chemistry and Utility of Scopolamine
		In humans, scopolamine is therapeutically employed in opthamallogical procedures to cause mydriosis, prolonged dialation of the iris, and is used to prevent and treat motion sickness.
		In addition, scopolamine was used as an anaesthetic during surgery, until physicians were accused of sorcery upon the disclosure of their patients' odd dreams.
		Scopolamine's relative toxicity, resulting in death with the use of as little as 0.6g (4), was reportedly exploited for a brief period around the beginning of the Second World War by Germany as a part of its T-4 program for the euthanasia of the terminally ill (5).
	www.ucalgary.ca /~bali/chem353/project/00final/00final.htm (2169 words)

	scopolamine - Drug Finder - MSN Health & Fitness (Site not responding. Last check: )
		Scopolamine is used to relieve nausea, vomiting, and dizziness associated with motion sickness and recovery from anesthesia and surgery.
		Scopolamine may also be used in the treatment of parkinsonism, spastic muscle states, irritable bowel syndrome, diverticulitis, and other conditions.
		Scopolamine is in the FDA pregnancy category C. This means that it is not known whether scopolamine will harm an unborn baby.
	health.msn.com /drugfinder/articlepage.aspx?cp-documentid=100060143 (1094 words)

	Scopolamine for preventing and treating motion sickness (Site not responding. Last check: )
		Scopolamine was compared against placebo, calcium channel antagonists, antihistamine, meth-scopolamine or a combination of scopolamine and ephedrine.
		Comparisons between scopolamine and other agents were few and suggested that scopolamine was superior (versus meth-scopolamine) or equivalent (versus antihistamines) as a preventative agent.
		Evidence comparing scopolamine to cinnarizine or combinations of scopolamine and ephedrine is equivocal or minimal.
	www.cochrane-ent.org /motion_sickness.htm (495 words)

	Prescribing Transderm Scop purchase information, buy scopolamine motion sickness cures
		Since scopolamine can cause temporary dilation of the pupils and blurred vision if it comes in contact with the eyes, patients should be strongly advised to wash their hands thoroughly with soap and water immediately after handling the patch.
		Scopolamine should be used with care in patients taking other drugs that are capable of causing CNS effects such as sedatives, tranquilizers, or alcohol.
		Scopolamine hydrobromide has been shown to have a marginal embryotoxic effect in rabbits when administered by daily intravenous injection at doses producing plasma levels approximately 100 times the level achieved in humans using a transdermal system.
	www.transdermscop.com /infomed_prescribing.htm (2539 words)

	Consumer Reports Medical Guide - Scopolamine Patch
		Scopolamine is used to prevent nausea and vomiting caused by motion sickness.
		Scopolamine comes as a patch to be placed on the skin behind your ear.
		At the end of 3 days, or when the scopolamine patch is no longer needed, remove the patch and throw it away.
	www.consumerreports.org /mg/drug-reports/scopolamine-patch.htm (853 words)

	Carilion - Scopolamine (Transderm-Scop) for vertigo - [Medication]
		Scopolamine (Transderm-Scop) is a patch placed on the skin behind the ear.
		It is believed that scopolamine reduces the activity of the vestibular nerve, which connects the inner ear and the brain.
		Some people who use scopolamine for 3 or more days in a row may experience dizziness, nausea, vomiting, or headache when they stop using the medication.
	www.carilion.com /kbase/htm/aa59/590/aa59590.htm (180 words)

	The Corpus Callosum
		scopolamine is old; presumably, it is not very expensive.
		One interesting aspect of this study is that scopolamine is an ingredient in nightshade, jimson weed, mandrake, and henbane.
		Subsequently, individuals were randomized to receive either placebo (3 sessions) followed by scopolamine (3 sessions) or scopolamine (3 sessions) followed by placebo (3 sessions) in a double-blind, placebo-controlled, crossover design.
	scienceblogs.com /corpuscallosum/2006/10/scopolamine_for_depression.php (1119 words)

	Scopolamine
		Scopolamine, at usual recommended cardiovascular doses, causes blockade of muscarinic receptors at the cardiac SA-node and is parasympatholytic (ie, blocks vagal activity increasing heart rate).
		In administering scopolamine, it is important to recognize that lower doses (0.1 mg) may have vagal mimetic effects (ie, increase vagal tone causing paradoxical bradycardia).
		It is likely that the vagal tonic effects of scopolamine are mediated by blockade of muscarinic receptors at the level of the brain.
	metagenics.com /resources/imc/OneMedicineProf/ProfDrugs/Scopolaminepd.html (977 words)

	Clinical Trial: Scopolamine to Treat Depression
		Scopolamine is commonly used to treat motion sickness and diarrhea, and is sometimes given before anesthesia or during eye examinations.
		Half of the time the medications contain scopolamine and half of the time they contain an "active" placebo called glycopyrrolate, a drug that produces side effects similar to those that may be experienced with scopolamine, but that does not go into the brain.
		The goal of this research project is to perform a clinical trial to evaluate the efficacy of the muscarinic cholinergic receptor antagonist scopolamine administered via transdermal patch on clinical symptoms of depression.
	clinicaltrials.gov /show/NCT00369915 (1236 words)

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