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Topic: Secobarbital

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	Secobarbital - Wikipedia, the free encyclopedia
		The salt is a white hygroscopic powder that is soluble in water and ethanol.
		Secobarbital began to be widely abused in the 1960s and 1970s, although with the advent of benzodiazepines, they have become less commonly used.
		Secobarbital overdose was the most common method of implementing physician-assisted suicide (PAS) in Oregon until Eli Lilly and Company discontinued manufacturing it in May 2001, leading to a shortage of the drug.
	en.wikipedia.org /wiki/Secobarbital (366 words)

	Secobarbital
		Secobarbital is available as either a free acid or a sodium salt.
		Secobarbital is a barbiturate derivative that is short acting.
		As little as 2 g of secobarbital was ingested in documented fatal cases.
	www.sdrl.com /druglist/secobarbital.html (309 words)

	on MediResource TM - Health Simplified
		Secobarbital is a barbiturate medication that is used or the treatment of insomnia (difficulty sleeping) and as a sedative to relieve the symptoms of anxiety or tension.
		Secobarbital should not be taken by elderly people who get confused at night or who get restless after taking barbiturate drugs.
		Barbiturates such as secobarbital should be used with caution in people with impaired liver function or in those with a history of drug dependence or abuse.
	www.mediresource.com /e/health/drug_detail.asp?brand_name_id=101944&dowhat=accept_disclaimer (490 words)

	Anxiolytics, Sedatives quiz with answers (Site not responding. Last check: 2007-11-04)
		Secobarbital is a short-acting oral and parenteral barbiturate.
		Secobarbital was approved by the FDA in 1950.
		Secobarbital should be used cautiously in patients with mental status changes, such as major depression or suicidal ideation, because the CNS-depressant effects of the drug can exacerbate the condition.
	www.rockford.uic.edu /jc/anxiqua.htm (2638 words)

	Secobarbital
		SECOBARBITAL (SeconalÂ®) is a barbiturate that slows down activity of the brain and nervous system.
		Secobarbital has sedative and hypnotic properties, which will help make you feel relaxed and sleepy when used before surgery.
		In general secobarbital should not be taken for longer than 1 or 2 weeks as a sleep aid.
	www.stjohn.org /HealthInfoLib/swArticle.aspx?26,559 (618 words)

	Secobarbital - Talk Medical
		Secobarbital is habit forming, which means that you can become addicted to it.
		Secobarbital should not be used for longer than 2 weeks to treat insomnia.
		Continue to take Secobarbital and talk to your doctor if you experience ·drowsiness or dizziness; ·confusion; ·agitation, irritability, or excitability; ·nightmares, nervousness, or anxiety; ·headache; or ·"hangover" effect (drowsiness the day after a dose).
	www.talkmedical.com /medications/5550/Secobarbital (1029 words)

	Drug Shortage Bulletin: Secobarbital Capsules
		Secobarbital is a barbiturate sedative–hypnotic agent labeled for the short-term treatment of insomnia and as a preanesthetic agent.
		Although not an FDA-labeled indication, secobarbital has been used to treat insomnia in the peripartum period, including the period before delivery, the early stages of labor, and the early postpartum period.
		Secobarbital may be used after the onset of contractions because it has no significant effect on uterine tone or contractility.
	www.ashp.org /shortage/drug.cfm?cfid=3993746&CFToken=85697112&id=1064 (536 words)

	Publication Details - Rona Giffard - Stanford University School of Medicine
		We examined the effects of secobarbital and other sedative-hypnotic barbiturates on the neuronal death induced by exposure to excitatory amino acids or deprivation of oxygen or glucose in mouse cortical cell cultures.
		Antagonism of NMDA toxicity was not overcome by increasing NMDA concentration and not mimicked by gamma-aminobutyrate.
		Despite these antiexcitotoxic actions, secobarbital exacerbated the neuronal death induced by deprivation of either glucose alone or oxygen and glucose together; death induced by oxygen deprivation alone was little affected.
	www-med.stanford.edu /profiles/frdActionServlet?choiceId=showPublication&pubid=35142&fid=4657 (203 words)

	Welcome to Zellers Pharmacy Online
		It is used for the treatment of insomnia (difficulty sleeping) and as a sedative to relieve the symptoms of anxiety or tension.
		Secobarbital should not be taken by seniors who get confused at night or who get restless after taking other barbiturate medications.
		Occupational hazards: Barbiturates such as secobarbital may reduce the mental or physical abilities needed for tasks such as driving a car or operating machinery.
	www.mediresource.com /zellers/health/DrugInfo.asp?BrandNameID=447&dowhat=accept_disclaimer (870 words)

	Tuinal - Wikipedia, the free encyclopedia
		Tuinal (often misspelt as Tuinol) is the brand name of a drug composed of two barbiturates — secobarbital and amobarbital — in equal proportions.
		Although both secobarbital and amobarbital are classified as short-acting barbiturates, combining the two drugs results in a longer duration of action, thus making the combination medically useful in situations requiring both a long and intense period of sedation.
		As a result, most legitimate medical use of the combination takes place in a hospital setting.
	en.wikipedia.org /wiki/Tuinal (183 words)

	MedlinePlus Drug Information: Secobarbital
		Secobarbital, a barbiturate, is used in the short-term treatment of insomnia to help you fall asleep and stay asleep through the night.
		Secobarbital comes as a capsule to take by mouth.
		If you become pregnant while taking secobarbital, call your doctor immediately.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a682386.html (587 words)

	Medical Dictionary: Secobarbital - WrongDiagnosis.com
		Secobarbital: barbiturate that is a white odorless slightly bitter powder (trade name Seconal) used as a sodium salt for sedation and to treat convulsions
		Secobarbital: A barbiturate that is used as a sedative.
		Secobarbital is reported to have no anti-anxiety activity.
	www.wrongdiagnosis.com /medical/secobarbital.htm (184 words)

	SOFT/TIAFT 98 - Application of the Cassette COBAS INTEGRA Serum Barbiturates ... (Site not responding. Last check: 2007-11-04)
		Secobarbital was spiked into the saliva at 0.854 µg/mL and 2.333 µg/mL and analyzed using a standard curve prepared in serum; mean recovery in saliva was 96.1% and 96.2% respectively.
		Interference was evaluated by spiking secobarbital into water and urine containing either 7.5 g/L hemoglobin, 1.5% ascorbic acid, 2 mg/mL oxalic acid, 5% liquid hand soap, 2% glucose, 220 mg/L calcium hypochlorite, 0.5N sodium chloride, 1% ethanol, 5 mg/mL creatinine, 0.5% human albumin, 1% acetone, 0.25 mg/mL bilirubin, or 6% urea.
		Recovery of secobarbital was > 90% for all the interfering substances evaluated.
	www.tiaft.org /tiaft98/wed/p/w_p_34.html (370 words)

	SCOTUSblog: Cert. Petition in Lethal Injection Case
		Secobarbital (the strongest) and pentobarbital (second strongest) would be infinitely more apt to being used as a drug to cause death.
		The only reason why the states don't use an injection of secobarbital is because deep down death penalty advocates do not want to cause a painless death, they want to make sure that the procedure is painful and horrifying because they believe that makes it a deterrent.
		If the states really wanted to ensure a quick and painless death, a lethal injection of a strong schedule II opioid would be more than enough, by itself, to accomplish that.
	www.scotusblog.com /movabletype/archives/2006/02/cert_petition_i.html (3581 words)

	SOFT/TIAFT 98 - Determination of Butalbital, Secobarbital and Phenobarbital in A ... (Site not responding. Last check: 2007-11-04)
		Limits of detection were determined as 75 ng/ml for butalbital, 50 ng/mL for secobarbital and 25 ng/mL for phenobarbital.
		Cutoff precision was established with a CV of 1.42% for butalbital, 1.58% for secobarbital and 1.32% for phenobarbital.
		Linearity was determined over the range of lower limit of quantitation of 75 ng/mL to an upper limit of quantitation of 3000, 1000 and 4000 for butalbital, secobarbital and phenobarbital respectively.
	www.tiaft.org /tiaft98/fri/p/f_p_24.html (428 words)

	Pro-life Infonet - 11/14/2001 (Site not responding. Last check: 2007-11-04)
		Secobarbital, the short-acting sedative and drug of choice for assisted suicide, is in short supply, and the future availability of the drug is unclear.
		And an alternative, a drinkable form of pentobarbital, lacks the track record of secobarbital, prescribed to 66 of the 70 patients reported by health officials to have been killed under Oregon's law.
		That Oregon advocates can't exactly lobby the manufacturer to make more secobarbital so dying patients can commit suicide is emblematic of life in a maverick state with its one-of-a-kind law.
	www.priestsforlife.org /news/infonet/infonet01-11-14.htm (3909 words)

	Secobarbital - Patient UK
		If you suspect that you or someone else has taken an overdose of Secobarbital contact your doctor or go to the accident and emergency department of your local hospital at once.
		Secobarbital can cause drowsiness and dizziness which can continue to the following day.
		Make sure you know how you react to this medicine before driving, operating machinery or doing any other jobs which could be dangerous if you were not fully alert.
	www.patient.co.uk /showdoc/30002977 (588 words)

	warfarinfo
		When secobarbital was added to their medications, the warfarin dose had to be increased in order to maintain the same level of anticoagulation.
		No data was available on what happened when secobarbital was stopped and a person continued to take warfarin.
		There are other, safer medications that serve the same purpose as secobarbital and do not have the serious interaction potential.
	www.warfarinfo.com /secobarbital.htm (211 words)

	Barbiturate Drug Tests - $5.95.. Sedative Hypnotics, Pentobarbital, Secobarbital, Prescription Sleep Medications.
		A drug-free urine pool was spiked with Secobarbital at the following concentrations: 0 ng/mL, 150 ng/mL, 225 ng/mL, 300 ng/mL, 375 ng/mL and 450 ng/mL.
		Fifteen (15) urine samples with specific gravity ranges from 1.000 to 1.037 were spiked with 150 ng/mL and 450 ng/mL of Secobarbital respectively.
		The pH of an aliquoted negative urine pool was adjusted to a pH range of 5 to 9 in 1 pH unit increments and spiked with Secobarbital to 150 ng/mL and 450 ng/mL.
	www.drugtestsuccess.com /instantdrugtest-1p-bar2.htm (337 words)

	Antinausea Drugs: Encyclopedia of Surgery (Site not responding. Last check: 2007-11-04)
		When this happens, the effects of one or both of the drugs may change or the risk of side effects may be greater.
		Among the drugs that may interact with prochlorperazine are antiseizure drugs such as phenytoin (Dilantin) and carbamazepine (Tegretol), anticoagulants such as warfarin (Coumadin), and drugs that slow the central nervous system such as alprazolam (Xanax), diazepam (Valium), and secobarbital (Seconal).
		Not every drug that interacts with prochlorperazine is listed here, and all patients should consult with a physician or pharmacist before taking any other prescription or nonprescription (over-the-counter) drug with prochlorperazine.
	health.enotes.com /surgery-encyclopedia/antinausea-drugs (786 words)

	Amobarbital and Secobarbital Drug Information Medicine Online
		The combination of amobarbital and secobarbital comes as a capsule to take by mouth.
		tell your doctor and pharmacist if you are allergic to amobarbital, secobarbital, or any other drugs.
		These medications may add to the drowsiness caused by amobarbital and secobarbital.
	www.medicineonline.com /druginfo/info1/Amobarbital_and_Secobarbital (609 words)

	Seconal - Drugs & Vitamins - Drug Library - DrugDigest
		Use another method of birth control while you are taking phenobarbital.
		If you are going to have surgery, tell your prescriber or health care professional that you are taking secobarbital.
		Keep out of the reach of children in a container that small children cannot open.
	www.drugdigest.org /DD/DVH/Uses/0,3915,603\|Seconal,00.html (738 words)

	Barbiturates Induce Mitochondrial Depolarization and Potentiate Excitotoxic Neuronal Death -- Anderson et al. 22 (21): ... (Site not responding. Last check: 2007-11-04)
		A, Secobarbital induced an increase in total cell rhodamine-123 fluorescence, indicative of mitochondrial depolarization.
		C, Secobarbital and the complex 1 inhibitor rotenone increased peak mitochondrial depolarization to a plateau at approximately
		The effects of secobarbital on NMDA-induced mitochondrial depolarization were paralleled by its effects on intracellular free
	www.jneurosci.org /cgi/content/full/22/21/9203 (4130 words)

	UNODC - Strengthening of the control of international trade in s
		Recalling that the International Narcotics Control Board in its report for 198416/ recommended--and that the Commission on Narcotic Drugs supported the recommendation--that additional voluntary action should be undertaken by Governments to strengthen the impact of the controls which the 1971 Convention on Psychotropic Substances17/ imposes upon substances listed in Schedules III and IV,
		Recognizing that the present controls over the import and export of secobarbital ought to be made stronger to further prevent its diversion,
		Invites Governments of exporting countries to consult the International Narcotics Control Board before authorizing shipments of secobarbital and other Schedule III substances whenever questions arise as to the authenticity of import requests or when the amounts in question appear excessive with respect to the legitimate medical requirements of the countries concerned;
	www.unodc.org /unodc/de/resolution_1986-05-21_1.html (383 words)

	Barbiturates - Drug Testing for Barbiturates. Side Effects, Barbiturates Abuse, and Barbiturates Addiction.
		Barbiturates are commonly divided into groups based on the onset and duration of their action.
		The intermediate and short-acting barbiturates are the categories most commonly abused, most notably Seconal (secobarbital) and Tuinal (secobarbital with amobarbital).
		Examples of short-acting barbiturates are secobarbital and pentobarbital.
	www.drugtestsuccess.com /barbiturates.htm (376 words)

	36-2/Bartlett.../Rapid Simultaneous Capillary Electrophoresis Determination of... (Site not responding. Last check: 2007-11-04)
		Secobarbital is a hypnotic sedative that is used in the treatment of preoperative anxiety and to manage elevated intracranial pressures and cerebral ischemia due to neurosurgical procedures.
		Separation is accomplished as predicted using 40mM HPGCD in 50mM phosphate buffer (pH 9.0), resulting in a rapid, sensitive method for the determination of (S)- and (R)- enantiomers of secobarbital from serum using solid-phase extraction, capillary electrophoresis (CE), and ultraviolet detection.
		The method involves extraction of both enantiomers and the internal standard, aprobarbital, from serum using C
	www.j-chrom-sci.com /abstracts/1998/february/362bara.htm (247 words)

	Erowid Experience Vaults: Red Pills : Ethchlorvynol? Secobarbital? - Insanity in a Red Capsule - 25825 (Site not responding. Last check: 2007-11-04)
		The only barbiturate/sedative hypnotic, or 'downer' drugs for that matter produced in an entirely red capsule is Secobarbital (Seconal Sodium) and Ethchlorvynol (Placidyl, 500 mg).
		Given that the author was not specific as to characteristics of the capsule (i.e.
		Consuming two 100 mg capsules of Seconal would certainly bring on effects like that, as would consuming two 500 mg capsules of Placidyl (had the subjects had a tolerance to either substance, such effects would not be as pronounced).
	www.erowid.org /experiences/exp.php?ID=25825 (1000 words)

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