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	Selegiline (MAO inhibitor) (Site not responding. Last check: 2007-11-04)
		Selegiline's duration of action depends on the time required to regenerate MAO type B. At higher selegiline doses (e.g., 20÷40 mg/day), brain MAO is blocked nonselectively, predisposing patients to the risks of traditional MAOIs that block MOA type A (e.g., hypertension).
		: Selegiline is administered orally and is readily absorbed from the GI tract and crosses the blood/brain barrier.
		Selegiline is eliminated slowly by the kidneys; about 45% of a single 10 mg dose is eliminated in the urine as the three active metabolites in 48 hours.
	www.rockford.uic.edu /jc/selegil.htm (349 words)

	Selegiline
		Selegiline, because it protects the section of the brain that produces dopamine, may have a protective effect on the decay of the brain brought on by dopamine deficiency.
		Selegiline is therefore free of restricting "cheese effects," yet is able to increase brain dopamine by preventing its normal breakdown within nerve cells and in the gaps between nerve fibers.
		Increase in depression in the elderly, age-dependent decline in male sexual vigor and the frequent appearance of Parkinsonian symptoms in the latter decades of life may be due to a decrease of dopamine and trace amines in the brain.
	www.medical-library.net /sites/_selegiline.html (1337 words)

	Treatment Options - Selegiline (Site not responding. Last check: 2007-11-04)
		Selegiline hydrochloride selectively and irreversibly inhibits cerebral monoamine oxidase type B (MAO B), the enzyme responsible for the breakdown of dopamine [1].
		Selegiline increases the levels of dopamine in the striatum (a brain area dependent on the dopamine signal) of rats [2].
		Selegiline can be used as monotherapy and as a levodopa adjunct in patients with PD and increases the levels of dopamine in their striatum [4].
	www.parkinsonsdisease.com /pcp/PCP7B.HTM (597 words)

	Selegiline for Parkinson's disease - [Medication]
		Selegiline prolongs the effects of dopamine in the brain by preventing its breakdown.
		Selegiline may be used in the early stages of Parkinson's disease to treat very mild symptoms (such as resting tremor) and delay the need for levodopa.
		In people with advanced Parkinson's disease who are taking levodopa, selegiline may be added to levodopa treatment to reduce motor fluctuations, increase the time of effect of the levodopa, and decrease the amount of levodopa needed to control symptoms.
	www.bchealthguide.org /kbase/topic/detail/drug/hw91653/detail.htm (577 words)

	Research Page: Effects of Selegiline on craving for nicotine
		Selegiline is a medication which helps to increase the amount of this chemical in the brain.
		We will determine whether selegiline is useful by measuring the extent to which the medication reduces nicotine craving after study participants stop smoking and the extent to which participants are able to remain off cigarettes for the duration of the study..
		Selegiline is of interest because this medication may be able to reduce cravings that increase the likelihood that smokers will relapse after quitting.
	www.trdrp.org /research/PageGrant.asp?grant_id=509 (932 words)

	Selegiline :: S : Gourt
		Selegiline is also used (at extremely high dosages relative to humans) in veterinary medicine to treat the symptoms of Cushing's disease and so-called "cognitive dysfunction" in dogs.
		Selegiline can indirectly raise norepinephrine because dopamine can be catabolized within the brain to norepinephrine, although the extent of this is variable.
		Selegiline is partly metabolized to an inactive stereoisomer of methamphetamine in vivo in levels that, even if active, most likely are far too low to have any significant effect.
	www.gourt.com /Health/Pharmacy/Drugs-and-Medications/S/Selegiline.html (333 words)

	Selegiline for Parkinson's disease - Clinical Pharmacology, part 204 American Family Physician - Find Articles
		Selegiline (Eldepryl), a selective monoamine oxidase (MAO) inhibitor, has recently been approved by the Food and Drug Administration as an adjunct to carbidopa/levodopa (Sinemet) therapy in the management of Parkinson's disease.
		Furthermore, selegiline is transformed to amphetamine and methamphetamine, an action that also interferes with neuronal reuptake and causes release of biogenic amines such as dopamine.
		The exact role of selegiline in the therapy of Parkinson's disease remain,, to be determined.
	www.findarticles.com /p/articles/mi_m3225/is_n2_v41/ai_8563177 (830 words)

	Erowid Selegiline (Deprenyl) Vault : Manufacturer's Insert (Site not responding. Last check: 2007-11-04)
		Uses and Administration Selegiline hydrochloride is a selective inhibitor of monoamine oxidase type B, an enzyme involved in the metabolic degradation of dopamine in the brain.
		Addition of selegiline to levodopa therapy may enable the dosage of levodopa to be reduced by an average of 30%.
		Although some critics have suggested that selegiline is simply providing symptomatic relief in disease which continues to progress (9-11) the promising preliminary results have been suggested by others to justify the prescription of selegiline 10 mg daily to patients, especially younger ones, in the early stages of Parkinson's disease, in the hope of impeding progression.
	www.erowid.org /smarts/selegiline/selegiline_info1.shtml (958 words)

	Howstuffworks "Selegiline: A Profile of an Antiparkinson Agent"
		Selegiline is used either alone or in combination with levodopa or levodopa/carbidopa to treat the symptoms of Parkinson's disease.
		Recent studies suggest that selegiline may help to slow the progression of Parkinson's disease when taken early in the course of the disease.
		Selegiline has not caused adverse effects to the fetuses in animal studies, and problems in humans have not been reported.
	health.howstuffworks.com /define-selegiline.htm (840 words)

	Selegiline hydrochloride
		Selegiline is usually used in combination with a medicine called levodopa to treat Parkinson's disease.
		Selegiline can be used to prolong the effect of levodopa, because it stops the dopamine that is formed from the levodopa from being broken down in the brain.
		Selegiline should not be started until at least two weeks after stopping these antidepressants and until at least five weeks after stopping fluoxetine.
	www2.netdoctor.co.uk /medicines/100002358.html (1047 words)

	Abstract from Selegiline for Smoking Cessation pilot project -News - CENTURY
		Background: Since dopaminergic mechanisms appear to be involved in nicotine dependence, we studied the safety and efficacy of the monoamine oxidase B inhibitor selegiline hydrochloride compared with placebo for smoking cessation in nicotine-dependent cigarette smokers.
		As part of a Yale University study, 20 smokers were given selegiline hydrochloride (L-Deprenyl or Eldepryl) and 20 were given a placebo; both groups attended weekly counseling.
		Selegiline inhibits the enzyme monoamine oxidase B (MAO-B), that normally breaks down dopamine, keeping dopamine levels from falling.
	info.med.yale.edu /century/news/tony_george_selegiline.html (944 words)

	Selegiline in Parkinson's Disease
		Selegiline does delay the need for levodopa therapy, however, the onset of disability or levodopa-induced motor fluctuations is not postponed by early selegiline treatment.
		While most observers now accept that selegiline does not have a neuroprotective effect, there is still a body of animal studies supporting this possibility, and some clinicians have continued to argue that selegiline may retard the progression of Parkinson’s disease.
		Selegiline may be of use for patients with motor fluctuations although it is not necessarily better than alternative strategies such as slow-release levodopa, dopamine agonists or COMT inhibition.
	www.medsafe.govt.nz /Profs/PUarticles/selegiline.htm (1400 words)

	Selepryl Cryprenyl L-Deprenyl selegiline citrate (Site not responding. Last check: 2007-11-04)
		Selepryl (Selegiline), is a drug used as an adjunct therapy of Parkinson's disease due to it's anti-neurodegenerative properties it is biochemical defined as a selective monoamine oxidase type B (MAO B) inhibitor, Selegiline was originally developed as an antidepressant agent.
		Selegiline turned out to be an efficient inhibitor of the uptake of dopamine in the striatum and this effect was found to play an important role in the facilitation of the activity of the nigrostriatal dopaminergic neurons in animals treated continuously with (-)Selegiline.
		Selegiline in striking contrast with the MAO inhibitors used previously inhibits the noradrenaline releasing effect of indirectly-acting amine in vascular smooth muscle.
	www.selepryl.com (2386 words)

	selegiline - Fort Lauderdale, Florida
		Selegiline is usually added to a treatment regimen after levodopa/carbidopa therapy begins to deteriorate.
		Selegiline is used to treat the stiffness, tremors, spasms, and poor muscle control of Parkinson's disease.
		Selegiline is in the FDA pregnancy category C. This means that it is not known whether selegiline will harm an unborn baby.
	www.browardhealth.org /19912.cfm (957 words)

	Selegiline side effects
		Since selegiline is primarily used for Parkinson's disease, I thought you might know how to control the side effects, or what drugs would have similar mechanisms of action.
		Selegiline belongs to a class of drugs called MAOI inhibitors that were initially developed for the treatment of depression.
		The major indication for the use of selegiline is to partially retard the rate of progression of Parkinson's disease.
	www.medhelp.org /forums/neuro/archive/846.html (529 words)

	Selegiline (Site not responding. Last check: 2007-11-04)
		In 1987, the hallmark NIH-sponsored DATATOP (Deprenyl and Tocopherol Antioxidative Therapy of Parkinsonism) study was begun “to examine the benefits of Deprenyl (selegiline) and alpha-tocopherol (vitamin E) in slowing the progression of Parkinson's disease.” (1) Patients with untreated Parkinson’s were randomized to selegiline or placebo.
		A continuation of the study, in which140 patients received selegiline or placebo in combination with individually tailored levodopa therapy, found that selegiline, compared with placebo, significantly slowed the progression of disease disability as measured by the Unified Parkinson Disease Rating Scale (UPDRS) total score or by motor and Activities of Daily Living subscores.
		Selegiline, or the problem of early termination of clinical trials: The clinical questions are not well answered, and probably never will be British Medical Journal 1998 April 18; 316(7139): 582–583.
	www.pdpipeline.org /yy_treatmentdev/selegiline.htm (2043 words)

	Selegiline HCl (Anipryl®) (Site not responding. Last check: 2007-11-04)
		Selegiline is used primarily to treat canine cognitive dysfunction syndrome (senility in older dogs).
		Selegiline should not be used in animals with known hypersensitivity or
		Selegiline is available as 2 mg, 5 mg, 10 mg, 15 mg and 30 mg tablets.
	www.petplace.com /drug-library/selegiline-hcl-anipryl/page1.aspx (665 words)

	selegiline Consumer Drug Information
		Selegiline prevents the breakdown of chemicals in the brain that are often imbalanced in people with depression.
		Selegiline transdermal is used to treat major depressive disorder.
		If you are using any of these drugs, you may not be able to tuse selegiline transdermal, or you may have to stop using the other drugs for a few weeks before you start using selegiline.
	www.drugs.com /MTM/selegiline.html (1695 words)

	SELEGILINE: buy selegiline, discount selegiline, side effects selegiline - Swiftrx (Site not responding. Last check: 2007-11-04)
		Selegiline is usually used in combination with other medicines (e.g., levodopa, carbidopa).
		Selegiline is an enzyme blocker (MAO inhibitor) that works by slowing the breakdown of certain natural substances in the brain (neurotransmitters such as dopamine, norepinephrine, and serotonin).
		Selegiline should be used only when clearly needed during pregnancy.
	www.meds4u.com /quick_search.jsp?criteria=SELEGILINE (1394 words)

	Selegiline (Systemic)
		Selegiline (seh-LEDGE-ah-leen) is used in combination with levodopa or levodopa and carbidopa combination to treat Parkinson's disease, sometimes called shaking palsy or paralysis agitans.
		For the treatment of Parkinson's disease, the usual dose of selegiline is 5 mg two times a day, taken with breakfast and lunch.
		When selegiline is taken at doses of 10 mg or less per day for the treatment of Parkinson's disease, there are no restrictions on food or beverages you eat or drink.
	allnutritionals.com /drugs/s/selegiline-systemic.shtml (1260 words)

	Selegiline - Wikipedia, the free encyclopedia
		Selegiline (l-deprenyl, Eldepryl® or Anipryl® [veterinary]) is a drug used for the treatment of early-stage Parkinson's disease and senile dementia.
		Selegiline is partly metabolized to l-methamphetamine, a stereoisomer of methamphetamine in vivo.
		Possibly due to the structural similarity to illegal stimulants, selegiline has been classified as a controlled substance in Japan and thus can only be obtained with a prescription or special government license.
	en.wikipedia.org /wiki/Selegiline (644 words)

	Treatment with Medicines - Selegiline (Site not responding. Last check: 2007-11-04)
		Selegiline, therefore, increases the amount of dopamine in the striatum and optimizes the ability of the remaining dopamine to cause the signal for movement in patients with PD.
		When selegiline is given to patients with PD who have not yet received any medication for PD, it is effective and can delay the need to take levodopa.
		The long-term use of selegiline therapy may prolong the clinical benefits of levodopa; selegiline therapy can last for up to 36 hours and so it can sometimes reduce the fluctuations in effectiveness of levodopa that people may experience after the first few years.
	www.parkinsonsdisease.com /LWP/lwp7b.htm (532 words)

	Selegiline Does Not Increase Parkinson's Death Rate (Site not responding. Last check: 2007-11-04)
		The study looked at the death rates for people taking levodopa alone, selegiline alone, or selegiline in addition to other antiparkinsonian drugs, and compared the death rates in each of these groups with people who did not have Parkinson's disease.
		But those patients who were taking selegiline in combination with levodopa were no more likely to die during the study than the people without Parkinson's.
		Selegiline has been used as a treatment for Parkinson's for nearly 25 years, but excitement about the drug peaked in the mid-1980s when research suggested that it may have neuroprotective effects, thereby slowing the effects of the disease on the brain.
	www.pslgroup.com /dg/1EE376.htm (523 words)

	Selegiline - Patient UK
		Selegiline is used to relieve the symptoms of Parkinson's disease.
		Selegiline increases the effect of dopamine in the brain and so relieves these symptoms.
		Selegiline may be used together with another drug called levodopa.
	www.patient.co.uk /showdoc/30002357 (759 words)

	Numark \| Selegiline
		Selegiline is used together with levodopa and carbidopa to treat symptoms of Parkinson’s disease.
		One individual taking selegiline together with ephedrine experienced a serious side effect known as hypertensive crisis, in which blood pressure can reach dangerous levels.
		Rarely, people taking selegiline might experience a rapid rise in blood pressure and a severe throbbing headache when the drug is taken with foods that contain tyramine, such as cheese (especially aged); sour cream; yoghurt; alcoholic drinks; meat, fish, and poultry; a variety of
	www.numarkpharmacists.com /hn/Drug/Selegiline.htm (606 words)

	Selegiline. Parkinson's Disease - HolisticOnLine - Your gateway to alternative medicine, complementary medicine, herbs, ...
		Selegiline is a relatively selective, irreversible monoamine oxidase type B (MAO-B) inhibitor.
		Selegiline boosts the symptomatic effect of levodopa by slowing the breakdown of levodopa-derived dopamine.
		Selegiline is beneficial as an adjunct to levodopa for patients who are experiencing a deterioration in the quality of their response.
	www.holistic-online.com /remedies/Parkinson/pd_selegiline.htm (704 words)

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