| | Netrin 1 is required for semicircular canal formation in the mouse inner ear. (Site not responding. Last check: 2007-10-30) |
 | | Netrin 1 is required for semicircular canal formation in the mouse inner ear.The morphogenetic development of the mammalian inner ear is a complex multistep process, the molecular and cellular details of which are only beginning to be unraveled. |
 | | In netrin 1 mutant mice, fusion plate formation is severely affected resulting in a reduced anterior semicircular canal and the complete lack of the posterior and lateral canals. |
 | | Our results suggest that netrin 1 facilitates semicircular canal formation through two different mechanisms: (1) it participates in the detachment of the fusion plate epithelia from the basement membrane, and (2) it stimulates proliferation of the periotic mesenchymal cells which then push the epithelial cell walls together to form the fusion plate. |
| www.pdg.cnb.uam.es /UniPub/iHOP/gp/2116080.html (193 words) |