| | Altweb: Mechanisms of Toxicity |
 | | After waiting 16 - 24 hours for seminiferous tubule fluid to accumulate, the animal is killed, and the testes are removed and weighed; the increased weight of the ligated testis compared to the unligated testis reflects the accumulation of seminiferous tubule fluid. |
 | | Using the lumenal oil droplet method, a statistically significant decrease in seminiferous tubule fluid secretion was observed after 3 weeks of 2,5-hexanedione exposure while 4 weeks of exposure was required before a decrease was observed by efferent duct ligation. |
 | | Exposure to microtubule disrupters which are known testicular toxicants consistently results in decreased seminiferous tubule fluid secretion and germ cell loss, indicating that Sertoli cell microtubules are critical to normal testicular homeostasis. |
| altweb.jhsph.edu /meetings/toxicity/boekelheide.htm (794 words) |