
	Where results make sense

Topic: Semisynthetic

Related Topics

Ergot

LSD

Systematic name

Psychopharmacology

Mushroom

Illusion

The Sixties

Leonhard Euler

	Highbeam Encyclopedia - Search Results for semisynthetic
		a semisynthetic form of penicillin used chiefly to treat infections of the urinary and respiratory tracts.
		The effects of carbenoxolone, a semisynthetic derivative of glycyrrhizinic acid, on peripheral and central ischemia-reperfusion injuries in the skeletal muscle and hippocampus of rats.
		Semisynthetic diets are useful in studies of avian...
	www.encyclopedia.com /searchpool.asp?target=semisynthetic (1095 words)

	eMedicine - Toxicity, Heroin : Article Excerpt by: Rania Habal, MD
		Background: Heroin (diacetylmorphine) is a semisynthetic narcotic that was first synthesized in 1874.
		Pathophysiology: Heroin is a highly addictive semisynthetic opioid that is derived from morphine.
		When used intravenously, heroin is 3-5 times more potent than its parent compound and is able to modulate pain perception and cause euphoria.
	www.emedicine.com /med/byname/toxicity-heroin.htm (669 words)

	Cosmetics Unmasked Ingredients C
		Origin: Semisynthetic compound derived from chitin, a cellulose-like compound found in fungi and in the shells of arthropods.
		Origin: Semisynthetic compound derived from a fatty acid and ethylene oxide.
		Origin: Semisynthetic compounds derived from cholesterol and a fatty acids obtained from macadamia nuts.
	www.gina.antczak.btinternet.co.uk /CU/IC.HTM (4540 words)

	Anti-Aging Therapies
		An examination of his results shows that the control mice on a semisynthetic diet died sooner than those fed a normal commercial diet.
		Evidence for its efffectiveness comes from two experiments, the 1968 experiment by Harman, in which 74 percent of treated LAF mice survived for 20 months on the semisynthetic diet, as compared to 8.8 percent of controls, and the experiment of Comfort with C3H mice.
		Harman's mice were fed semisynthetic diet, which decreases survival; Comfort's experiment studied ethoxyquin on C3H mice, known to have a short lifespan.
	www.lef.org /anti-aging/chap2.html (3219 words)

	Nat' Academies Press, Arsenic in Drinking Water (1999)
		Most of the breeder goats fed the low-arsenic semisynthetic diet were reported to have died suddenly between the 17th and 35th day of their second lactation, and none of the low-arsenic-diet goats survived the second pregnancy.
		The initial concentration of arsenic in the semisynthetic diets fed to goats was approximately 35 ng/g of diet.
		As shown in Table 9-2, the concentrations of arsenic in the semisynthetic diets overlap with the concentrations of arsenic found in standard experimental diets, which range from 5 to 6,200 ng/g, with substantial variation between different batches of the same formulation (Reeves 1993).
	www.nap.edu /books/0309063337/html/251.html (4369 words)

	Effect of vitamin B complex on neurotransmission and neurite outgrowth. (Site not responding. Last check: 2007-11-02)
		The effect of vitamin B complex (vitamin B1, B6 and B12) was studied on nerve conduction velocity in acrylamide-neuropathy rats maintained on refined semisynthetic complete vitamin and vitamin B-deficient diets in vivo and on neurite outgrowth in vitro using cells obtained from dorsal root ganglions of mice.
		Acrylamide neuropathy was clearer in the group maintained on a refined semisynthetic vitamin B-deficient diet than in those on a refined semisynthetic complete vitamin diet.
		No significant difference was found in the groups treated with acrylamide and given vitamin B complex prophylactic-therapeutically and the control (no acrylamide treatment) in the group maintained on a refined semisynthetic vitamin B-deficient diet.
	www.hankintatukku.com /medlineVB-1.html (239 words)

	Semisynthetic derivatives of glucagon. The contribution of histidine-1 to hormone conformation and activity. (Site not responding. Last check: 2007-11-02)
		The deprotected, purified product was chemically identical to N epsilon- acetimidoglucagon and equipotent to N epsilon- acetimidoglucagon and native glucagon in its ability to activate adenylate cyclase and displace [125I] iodoglucagon from rat liver plasma membranes.
		Semisynthetic [ Phe1 ]-, [ Ala1 ]-, and [des- His1 ] glucagons prepared similarly achieved 85, 55, and 35% of the maximal activity and 22, 2, and 6% of the binding potency of N epsilon- acetimidoglucagon.
		The biological assays indicate that the amino group is involved to a greater extent in transduction than in binding, but the aromatic nature and hydrogen bonding capability of the imidazole ring of histidine-1 are important for both binding and transduction.
	www.pdg.cnb.uam.es /UniPub/iHOP/gp/4804327.html (236 words)

	research2
		Semisynthetic DNA-protein conjugates are synthesized by either covalent coupling chemistry, or by means of reversible biomolecular recognition systems.
		In particular, the hybridization of complementary nucleic acids and the high-affinity binding of biotin and streptavidin are utilized to generate supramolecular bioconjugates.
		Analytical methods for the characterization of the semisynthetic DNA-protein conjugates include chromatographic and electrophoretic techniques, SPR affinity measurements, mass spectrometry, electron and scanning-probe microscopy.
	www.chemie.uni-dortmund.de /groups/niemeyer/research2.html (466 words)

	Dorlands Medical Dictionary
		[schwa]-klor) a semisynthetic, second-generation cephalosporin effective against a wide range of gram-positive and gram-negative bacteria, used in the treatment of infections of the urinary and respiratory tracts and of the skin and soft tissues; administered orally.
		t[schwa]n) [USP] a semisynthetic cephamycin derived from cephamycin C and generally classified with the second-generation cephalosporins, effective against a wide range of gram-positive, gram-negative, and anaerobic bacteria.
		zil) [USP] a semisynthetic broad-spectrum cephalosporin effective against a wide range of gram-negative and gram-positive organisms, used in the treatment of infections of the respiratory tract and skin; administered orally.
	www.merckmedicus.com /pp/us/hcp/thcp_dorlands_content.jsp?pg=/ppdocs/us/common/dorlands/dorland/dmd-c-020.htm (1127 words)

	Histidine pKa Shifts Accompanying the Inactivating Asp121{rightarrow} Asn Substitution in a Semisynthetic Bovine ...
		Histidine pKa Shifts Accompanying the Inactivating Asp121{rightarrow} Asn Substitution in a Semisynthetic Bovine Pancreatic Ribonuclease -- Cederholm et al.
		Asn Substitution in a Semisynthetic Bovine Pancreatic Ribonuclease
		A semisynthetic RNase, RNase-(1-118)·(111-124), consisting of a noncovalent complex between residues 1-118 of RNase (obtained from the proteolytic digestion of RNase A), and a synthetic 14-residue peptide containing residues 111-124 of RNase, exhibits 98% of the enzymatic activity of bovine pancreatic ribonuclease A (EC 3.1.27.5).
	www.pnas.org /cgi/content/short/88/18/8116 (466 words)

	Site-Specific Cleavage of Duplex DNA by a Semisynthetic Nuclease Via Triple-Helix Formation -- Pei et al. 87 (24): 9858 ...
		The cleavage pattern is asymmetric and consists of multiple cleavage sites shifted to the 5' side on each strand, centered at the terminal base pair of the binding site.
		Microgram amounts of plasmid pDP20 DNA (4433 base pairs) containing a homopurine-homopyrimidine tract were selectively cleaved by a semisynthetic nuclease with greater than 75% efficiency at room temperature within 1 hr.
		Semisynthetic nucleases of this type should provide a powerful tool in chromosomal DNA manipulations.
	www.pnas.org /cgi/content/abstract/87/24/9858 (470 words)

	Cosmetics Unmasked Ingredients B
		Origin: Semisynthetic compound derived from glycerin and fatty acids.
		Origin: Semisynthetic compound derived from fatty acids obtained from montan wax which is obtained from peat and lignite.
		Origin: Semisynthetic compound derived from fatty acids obtained from candelilla wax.
	www.gina.antczak.btinternet.co.uk /CU/IB.HTM (1226 words)

	Antimicrobial Agents Used in the Treatment of infectious Disease
		A hybrid substance is a semisynthetic antibiotic, wherein a molecular version produced by the microbe is subsequently modified by the chemist to achieve desired properties.
		An unfortunate side effect of aminoglycosides has tended to restrict their usage: prolonged use is known to impair kidney function and cause damage to the auditory nerves leading to deafness.
		Rifampicin is a semisynthetic derivative of rifamycin that is active against Gram-positive bacteria (including Mycobacterium tuberculosis) and some Gram-negative bacteria.
	textbookofbacteriology.net /antimicrobial.html (5028 words)

	Semisynthetic insulin analogues modified in positions B24, B25 and B29. (Site not responding. Last check: 2007-11-02)
		Semisynthetic insulin analogues modified in positions B24, B25 and B29.
		Semisynthetic insulin analogues modified in positions B24, B25 and B29.New semisynthetic analogues of human insulin, modified in the C-terminal region of the B-chain, were prepared to refine our understanding of the importance of particular amino acid residues in the expression of hormone biological properties.
		Biological in vitro potencies (specific binding to cultured human lymphocytes IM-9 and lipogenic potency in isolated rat adipocytes) of the semisynthetic analogues were estimated, ranging from 0.2 to 100% relative to porcine insulin.
	www.pdg.cnb.uam.es /UniPub/iHOP/gp/7998750.html (134 words)

	Medicinal Plants and the Pharmaceutical Industry
		American pharmaceutical firms often seek the semisynthetic and avoid the natural compound, when, at least in some cases, the natural compound might be best.
		Assume that half of our ephedrine, pseudoephedrine, and reserpine are synthetic and that all the steroids are now semisynthetic, subtract and find that, accepting these assumptions and no change in percentages, only 6.4% of our drugs have these natural ingredients, synthetic or semisynthetic compounds having replaced the natural compounds.
		Likewise, the hormones norethindrone, ethinyl estradiol, and conjugated estrogens appear to be wholly synthesized or semisynthetic but they could probably be derived from starting estrogenic compounds in palm and pine pollens or pomegranates.
	www.hort.purdue.edu /newcrop/proceedings1993/v2-664.html (2448 words)

	Dongfeng Qi (Site not responding. Last check: 2007-11-02)
		The combination of computational modeling, recombinant DNA technology and chemical modification provides enormous flexibility for the design of semisynthetic catalysts that could be applied for a variety of purposes.
		Lipid and fatty acid binding proteins are a class of peptides whose structures consist of a conical b-barrel unit with an internal volume of ~600 Å3 and an a-helical lid, which makes the enclosed cavity effectively sequestered from solvent (Figure 1).
		Chemistry performed by the semisynthetic enzymes can be tuned by incorporating catalytically important residues in the cavity, Based on the crystal structure of ALBP-PX (adipocyte lipid binding protein-pyridoxamine conjugate), a Lys residue was introduced into the active site in order to facilitate the protonation/deprotonation steps in the transamination process (Figure 4).
	www.chem.umn.edu /groups/distefano/qi.htm (887 words)

	FDA Clears Semisynthetic Taxol (Site not responding. Last check: 2007-11-02)
		Previously, the only source of pac-litaxel approved for human use was the bark of the Pacific yew, an endangered tree found in the Northwest region of the United States.
		The use of renewable sources completely eliminates the need for Pacific yew bark harvesting and ensures the continuous availability of the agent for patients with metastatic ovarian or breast cancer.
		In clearing semisynthetic paclitaxel, the FDA determined that it is bioequivalent to that produced from yew bark.
	www.cancernetwork.com /journals/oncnews/n9501r.htm (143 words)

	Other Dangerous Drugs - Vermont Drug Threat Assessment
		The abuse of OxyContin, a strong semisynthetic opiate prescribed for pain relief, is of increasing concern to state and local law enforcement officials in several Vermont communities.
		Young adults are the primary abusers of LSD, and the drug frequently is distributed at rock concerts in the state.
		OxyContin is a controlled-release version of oxycodone, a strong, semisynthetic opiate with analgesic potency and abuse potential comparable to morphine.
	www.usdoj.gov /ndic/pubs07/722/odd.htm (1043 words)

	Guidance for Industry BACPAC I: Intermediates in Drug Substance Synthesis Bulk Actives Postapproval Changes: Chemistry, ... (Site not responding. Last check: 2007-11-02)
		Semisynthetic Drug Substance: A drug substance produced by fermentation or biotechnology and synthesis or synthesized from a precursor or structural element of natural origin (e.g., from a plant).
		A notice of availability of a draft version of this guidance was published in the Federal Register on October 1, 1999 (64 FR 53393).
		This exclusion from BACPAC I is intended to focus on those substances derived from natural sources that are the intermediates that begin the synthetic part of a semisynthetic process.
	www.fda.gov /cder/guidance/3629fnl.htm (7082 words)

	A semisynthetic epitope for kinase substrates - Nature Methods
		The ubiquitous nature of protein phosphorylation makes it challenging to map kinase-substrate relationships, which is a necessary step toward defining signaling network architecture.
		To trace the activity of individual kinases, we developed a semisynthetic reaction scheme, which results in the affinity tagging of substrates of the kinase in question.
		Application of this approach, in cells isolated from a mouse that expressed endogenous levels of an analog-specific (AS) kinase (Erk2), allowed purification of a direct Erk2 substrate.
	www.nature.com /doifinder/10.1038/nmeth1048 (411 words)

	Molecular properties of the oxytocin/bovine neurophysin biosynthetic precursor. Studies using a semisynthetic precursor ...
		Studies using a semisynthetic precursor -- Kanmera and Chaiken 260 (14): 8474 -- Journal of Biological Chemistry
		semisynthetic product was verified by amino acid analysis and
		disulfide interchange by dithiothreitol, of semisynthetic precursor but not
	www.jbc.org /cgi/content/abstract/260/14/8474 (434 words)

	iHerb: HerbalGram The Journal of the American Botanical Council
		Taxol is derived from the bark of the Pacific yew tree (Taxus brevifolia).
		After four years of research, the semisynthetic version is being hailed by B-MS as a necessary alternative.
		FDA's approval of the semisynthetic Taxol determined that it is bioequivalent to the Taxol produced directly from the bark.
	www.herbalgram.org /iherb/herbalgram/articleview.asp?a=953 (426 words)

	AOD Thesaurus Annotated Hierarchy: chemical substances by structure ZP ZQ20.4.4
		This generic term applies to alkaloids from the opium poppy, their synthetic analogues, and related compounds synthesized in the body that interact with specific receptors in the brain, have the capacity to relieve pain, and produce a sense of well-being (euphoria).
		Since the Harrison Narcotics Act and the spread of heroin use, the recreational use of morphine has declined, although the subjective effects of the two drugs in equivalent potencies are almost identical.
		A group of alkaloids derived from the opium poppy, Papaver somniferum, that have the properties of inducing analgesia; euphoria; and in higher doses, stupor, coma, and respiratory depression.
	etoh.niaaa.nih.gov /AODVol1/aodhnzp.htm (1259 words)

	CIA - The World Factbook - Notes and Definitions (Site not responding. Last check: 2007-11-02)
		Semisynthetic narcotics include heroin (horse, smack), and hydromorphone (Dilaudid).
		Opium is the brown, gummy exudate of the incised, unripe seedpod of the opium poppy.
		Opium poppy (Papaver somniferum) is the source for the natural and semisynthetic narcotics.
	www.phatnav.com /factbook/docs/notesanddefs.html (9127 words)

	Miscibility of human semisynthetic regular and lente insulin and human biosynthetic regular and NPH insulin -- Olsson ... (Site not responding. Last check: 2007-11-02)
		Miscibility of human semisynthetic regular and lente insulin and human biosynthetic regular and NPH insulin -- Olsson et al.
		Miscibility of human semisynthetic regular and lente insulin and human biosynthetic regular and NPH insulin
		The miscibility of human semisynthetic regular and lente insulins (Actrapid
	care.diabetesjournals.org /cgi/content/abstract/10/4/473 (243 words)

	Vitamin A and benzo(a)pyrene carcinogenesis in the respiratory tract of hamsters fed a semisynthetic diet -- Smith et ... (Site not responding. Last check: 2007-11-02)
		Vitamin A and benzo(a)pyrene carcinogenesis in the respiratory tract of hamsters fed a semisynthetic diet -- Smith et al.
		Vitamin A and benzo(a)pyrene carcinogenesis in the respiratory tract of hamsters fed a semisynthetic diet
		Male Syrian golden hamsters were fed a semisynthetic diet, given 12 weekly
	cancerres.aacrjournals.org /cgi/content/abstract/35/6/1485 (226 words)

	Amikacin
		Relatively rare the following adverse effects can be seen: allergic reaction, nausea, vomiting, stomatitis, blood changes, depression of respiration, and muscle pareses.
		Amikacin is a semisynthetic antibiotic of the aminoglycoside group.
		It possesses a broad antimicrobial spectrum, but the greatest activity is against the Gram-negative bacteria (E. coli, Proteus, Klebsiella) etc. The drug is active also against some staphylococcus strains (Staphylococcus epidermidis and aureus).
	www.sopharma.com /amikacin.phtml (686 words)

	Photoaffinity Analog of the Semisynthetic Echinocandin LY303366: Identification of Echinocandin Targets in Candida ... (Site not responding. Last check: 2007-11-02)
		Photoaffinity Analog of the Semisynthetic Echinocandin LY303366: Identification of Echinocandin Targets in Candida albicans -- Radding et al.
		Photoaffinity Analog of the Semisynthetic Echinocandin LY303366: Identification of Echinocandin Targets in Candida albicans
		Semisynthetic chemical modification of the antifungal lipopeptide echinocandin B (ECB): structure-activity studies of the lipophilic and geometric parameters of polyarylated analogs of ECB.
	aac.asm.org /cgi/content/full/42/5/1187 (4808 words)

	System To Generate Semisynthetic Data Sets of Outbreak Clusters for Evaluation of Outbreak-Detection Performance
		However, because a limited number of persons have been infected with agents of biologic terrorism, such data are virtually nonexistent.
		One approach to evaluation is to present detection algorithms with semisynthetic data sets.
		Conclusions: Automated generation of semisynthetic data sets facilitates evaluation of public health surveillance systems for early detection of outbreaks.
	www.cdc.gov /MMWR/preview/mmwrhtml/su5301a43.htm (527 words)

Try your search on: Qwika (all wikis)