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Topic: Senescence

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  Senescence Theory
For annual plants, yearly senescence can be explained as a way of increasing the number of progeny surviving to reproductive age and/or a way of increasing the amount of turnover and thus the rate of evolution.
Nevertheless, during senescence in soybeans, biological nutrients and minerals are redistributed to the seeds (Nooden, 1980).
Wittenbach (1983a) concluded that senescence in soybeans is a.
www.pruittfamily.com /paul/senescence.htm   (8879 words)

  Senescence - Wikipedia, the free encyclopedia
However, senescence is not universal, and scientific evidence suggests that cellular senescence evolved in certain species as a mechanism to prevent the onset of cancer.
Senescence is studied in gerontology which is the branch of science involved with the aging process.
Recently, early senescence has been alleged to be a possible unintended outcome of early cloning experiments, Most notably, the issue was raised in the case of Dolly the sheep, following her death from a contagious lung disease.
en.wikipedia.org /wiki/Senescence   (3207 words)

 Generations - The Genetics of Aging - Replicative Senescence
However, senescent cells are present at all time points during the lifespan of the culture but are a minor part of the cell population when the culture is young.
Senescent cells are actually resistant to programmed cell death (apoptosis) and in laboratories have been maintained in their nondividing state for as long as three years.
The relationship between the changes in gene expression and cellular senescence has not been definitively established, and it is not known whether any or all of the changes cause senescence or whether senescence results in the changes in gene expression.
www.asaging.org /generations/gen-24-1/senescence.html   (2660 words)

Senescence is a horrible killer, a disease that should be fought with every available weapon.
The gene is involved in a process, called senescence, which is thought to ensure that aging cells do not pass on harmful mutations.
SIRT1 is involved in cellular senescence, or limitation of cells’ reproductive lifespan, a process thought to ensure that aging cells don’t pass on harmful...
www.mongabay.com /igapo/biotech/senescence.html   (1465 words)

 Strategies for Engineered Negligible Senescence
The Strategies for Engineered Negligible Senescence (SENS) are a synthesis of scientific research, existing scientific knowledge, a call to action, and the proposals put forward by biomedical gerontologist Aubrey de Grey.
"Strategies for Engineered Negligible Senescence" means, in plain non-scientific terms, "Strategies to develop a cure for aging." You can find a longer explanation regarding the name, its meaning and why it was chosen at the SENS website.
Certain classes of senescent cell accumulate where they are not wanted, such as in the joints.
www.longevitymeme.org /topics/strategies_for_engineered_negligible_senescence.cfm   (1152 words)

 CELL BIOLOGY: CANCER AND CELL SENESCENCE   (Site not responding. Last check: 2007-10-15)
Cellular senescence is controlled by tumor suppressor genes and seems to involve a checkpoint that prevents the growth of cells at risk for neoplastic transformation.
The "yellowing" of leaves is often referred to in the plant literature as leaf senescence or the "senescence syndrome" -- referring to the process by which nutrients are mobilized from the dying leaf to other parts of the plant to support their growth.
The senescence syndrome is characterized by distinct cellular and molecular changes, with the chloroplast the first part of the cell to undergo disassembly (producing the "yellowing").
www.scienceweek.com /2005/sw050902-2.htm   (1564 words)

 Deletion of Ku86 causes early onset of senescence in mice -- Vogel et al. 96 (19): 10770 -- Proceedings of the National ...
The relationship between chronological age and mortality is an important indicator of senescence (24); therefore, a survival curve was established starting with 3-wk-old mice.
The liver was examined for signs of senescence because genomic rearrangements accumulate in the liver as mice age (9).
the onset of senescence by translocating from telomeres to the
www.pnas.org /cgi/content/full/96/19/10770   (4323 words)

 Early Plant Senescence Theory by Paul Pruitt   (Site not responding. Last check: 2007-10-15)
For annual plants, yearly senescence can be explained as a way of increasing the number of progeny surviving to reproductive age and/or a way of increasing the amount of turnover and thus the rate of evolution.
He actually found the reverse; senescence was faster when the leaves were near the source of Cytokinin and minerals.  The leaves had to be receiving as much of these substances as they needed, yet they were still senescing.
Wittenbach (1983a) concluded that senescence in soybeans is a.
www.socrtwo.info /senescence.htm   (8879 words)

 Tumor Cell Senescence in Cancer Treatment -- Roninson 63 (11): 2705 -- Cancer Research
Doxorubicin-induced senescence in HCT116 colon carcinoma cells (from Ref. 49).
senescence is a specific response of tumor cells.
of senescent cells in the tumor and the relative abundance of
cancerres.aacrjournals.org /cgi/content/full/63/11/2705   (7681 words)

 A Two-Stage, p16INK4A- and p53-Dependent Keratinocyte Senescence Mechanism That Limits Replicative Potential ...
and p53 is necessary to bypass senescence and extend the replicative life span of keratinocytes.
Increased p16 expression with first senescence arrest in human mammary epithelial cells and extended growth capacity with p16 inactivation.
Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts.
mcb.asm.org /cgi/content/full/22/14/5157   (9258 words)

 Telomeres and Telomerase: The Cellular Timekeepers
Indeed, defects in telomere replication have been shown to trigger senescence in yeast (Lundblad and Szostak, 1989) and in the protozoan Tetrahymena (Yu et al., 1990).
Similarly, it was noticed in yeast that certain telomerase-negative strains would senesce with longer telomeres than immortal telomerase-positive strains (Prescott and Blackburn, 1997; Roy et al., 1998).
Lastly, although telomerase may prevent the accelerated clonal senescence of Werner's syndrome cells (Wyllie et al., 2000), it does not appear to fully reverse the WS phenotype (Choi et al., 2001).
www.senescence.info /telomeres.html   (3994 words)

 Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis -- WIEMANN et al. 16 (9): ...
Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis -- WIEMANN et al.
Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis
a consequence of hepatocyte telomere shortening and senescence.
www.fasebj.org /cgi/content/full/16/9/935   (4848 words)

 Nuclear Accumulation of Globular Actin as a Cellular Senescence Marker -- Kwak et al. 64 (2): 572 -- Cancer Research
and that senescent phenotype was reversed by reduction of caveolin
Nuclear accumulation of actin is a universal event in the replicative senescence and the variously induced senescent cells.
actin was responsible for induction of senescence phenotype,
cancerres.aacrjournals.org /cgi/content/full/64/2/572   (6246 words)

 Induced Senescence in HeLa Cervical Carcinoma Cells Containing Elevated Telomerase Activity and Extended Telomeres -- ...
senescence and telomere erosion led to the formulation of the
The rapid and synchronous onset of induced senescence is in
Kang M. K., Guo W., Park N-H. Replicative senescence of normal human oral keratinocytes is associated with the loss of telomerase activity without shortening of telomeres.
cgd.aacrjournals.org /cgi/content/full/12/11/525   (7026 words)

 Cellular senescence in cancer treatment: friend or foe? -- Kahlem et al. 113 (2): 169 -- Journal of Clinical ...
In contrast, feeder-like growth that reflects paracrine activity of senescent cells on their non-senescent neighbors, or escape from senescence based on acquired or preexisting mutations, is considered a detrimental outcome.
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
Hansen, M.H., Nielsen, H., and Ditzel, H.J. The tumor-infiltrating B cell response in medullary breast cancer is oligoclonal and directed against the autoantigen actin exposed on the surface of apoptotic cancer cells.
www.jci.org /cgi/content/full/113/2/169   (3952 words)

 Defining senescence and death -- Thomas et al. 54 (385): 1127 -- Journal of Experimental Botany
Free radical scavenging and senescence in Iris petals.
Oraez D, Granell A. The plant homologue of the defender against apoptotic death gene is down-regulated during senescence of flower petals.
Increases in DNA fragmentation and induction of a senescence-specific nuclease are delayed during corolla senescence in ethylene-insensitive (etr1-1) transgenic petunias
jxb.oxfordjournals.org /cgi/content/full/54/385/1127   (3764 words)

 Senescence Induced by Altered Telomere State, Not Telomere Loss -- Karlseder et al. 295 (5564): 2446 -- Science
Senescence Induced by Altered Telomere State, Not Telomere Loss -- Karlseder et al.
length at senescence, from 7 to 4 kilobases.
Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells.
www.sciencemag.org /cgi/content/abstract/295/5564/2446   (1927 words)

 Dictionary.com/Word of the Day Archive/senescence
Our own bodies are simultaneously and subtly undergoing the same inexorable process that will lead eventually to senescence and death.
Trying to understand the factors that determine maximum possible lifespan is one of the most puzzling aspects of the overall study of senescence and death.
Senescence is from Latin senescere, "to grow old," from senex, "old." It is related to senile.
dictionary.reference.com /wordoftheday/archive/2004/08/10.html   (127 words)

 Senescence and programmed cell death: substance or semantics? -- van Doorn and Woltering 55 (406): 2147 -- Journal of ...
A matrix metalloproteinase gene is expressed at the boundary of senescence and programmed cell death in cucumber.
Goldschmidt E. Regulatory aspects of the chloro-chromoplast interconversions in senescing Citrus fruit peel.
Relationship between root cortical senescence and growth of wheat as influenced by mineral nutrition, Idriella bolleyi (Sprague) von Arx and pruning of leaves.
jxb.oxfordjournals.org /cgi/content/full/55/406/2147   (4298 words)

 2004 GRC on Plant Senescence
Plant senescence is a highly regulated and complex process during which the plant reclaims as many mobilisable nutrients as possible from the senescing tissues.
Additionally, the structure and dynamics of cellular and organismal function have begun to be analysed in the context of senescence and pcd.
Post harvest senescence and consequent loss of nutrients are important economic problems causing substantial losses to producers as well as loss of quality and nutritional value to the consumer.
www.grc.uri.edu /programs/2004/plantsen.htm   (1047 words)

 About Senescence and His Music
Since I actually happen to work on aging and senescence, I felt that Senescence was an appropriate artistic name.
You may download, distribute, reproduce, and publicly display these songs for non-commercial purposes provided the autorship is clearly indicated and they are not modified in any way.
In the context of this website, Senescence refers to João Pedro de Magalhães, the sole copyright owner of this website, its content, and all music contained herein.
music.senescence.info /about.html   (962 words)

 Senescence and the Biology of Human Aging
Aging, or senescence, is the major cause of suffering, disease, and death in Western civilization.
Gerontology, also called biogerontology, is the science that studies the aging process to prevent age-related disease and degeneration, preserve health, and prolong human life.
Cellular Senescence; cellular models of aging and the rationale behind them.
www.senescence.info   (730 words)

 Aging, life span, and senescence -- Guarente et al. 95 (19): 11034 -- Proceedings of the National Academy of Sciences
This "yellowing" of leaves is often referred to in the plant biology literature as leaf senescence or the senescence syndrome
from the senescing leaf is the senescence syndrome.
The senescence syndrome is characterized by distinct cellular and molecular changes.
www.pnas.org /cgi/content/full/95/19/11034   (2443 words)

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