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Topic: Septic shock

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  Shock - Wikipedia, the free encyclopedia
The single most common cause of shock is blood volume loss, resulting from a serious wound or a severe burn leading to hypovolemic shock.
Septic shock is caused by overwhelming infection leading to vasodilation.
Septic shock however, is a grave condition and with a mortality rate between 30% and 50%.
en.wikipedia.org /wiki/Shock   (1033 words)

 Gale Encyclopedia of Medicine: Septic shock   (Site not responding. Last check: 2007-10-08)
Septic shock is a potentially lethal drop in blood pressure due to the presence of bacteria in the blood.
Septic shock is a possible consequence of bacteremia, or bacteria in the bloodstream.
Septic shock is seen most often in patients with suppressed immune systems, and is usually due to bacteria acquired during treatment at the hospital.
www.findarticles.com /p/articles/mi_g2601/is_0012/ai_2601001236   (884 words)

 THE MERCK MANUAL, Sec. 13, Ch. 156, Bacteremia And Septic Shock
Septic shock is characterized by acute circulatory failure, usually with or followed by hypotension, and multiorgan failure.
Septic shock is more often caused by hospital-acquired gram-negative bacilli and usually occurs in immunocompromised patients and those with chronic diseases.
Predisposing factors for septic shock include diabetes mellitus; cirrhosis; leukopenic states, especially those associated with underlying neoplasms or treatment with cytotoxic agents; antecedent infection in the urinary, biliary, or GI tracts; invasive devices, including catheters, drainage tubes, and other foreign materials; and prior treatment with antibiotics, corticosteroids, or ventilatory devices.
www.merck.com /mrkshared/mmanual/section13/chapter156/156c.jsp   (1505 words)

 septic shock   (Site not responding. Last check: 2007-10-08)
Septic shock is a condition caused by a serious infection that involves the blood.
Shock is a word used to describe a certain abnormal state in the body.
One of the causes of shock is sepsis, a serious infection that involves the blood.
www.northmemorial.com /HealthEncyclopedia/content/1762.asp   (528 words)

 ARDS Foundation : Septic Shock of Early or Late Onset
Conclusions: Septic shock is more severe when of early onset, as reflected by more severe organ dysfunction, greater lactic acidosis, and higher vasopressor requirements, yet the outcome is better, as reflected by a shorter duration of the shock episode, shorter ICU stay, and slightly lower mortality rates.
However, development of septic shock in an ICU patient who already has multiple organ failure may portend a very poor outcome, to the extent that vasopressor treatment may become futile.[8] The time of onset of septic shock therefore may be very important in determining outcome, yet clinical trials do not usually report this information.
The onset of septic shock was considered as the start of vasopressor agents (dopamine, norepinephrine, or epinephrine) after a fluid challenge with crystalloid and/or colloids caused no further increase in cardiac index and pulmonary artery occlusion pressure remained between 10 mm Hg and 18 mm Hg.
www.ardsusa.com /cgi-bin/ubbcgi/ultimatebb.cgi?ubb=get_topic&f=31&t=000010   (1927 words)

 Septic Shock: Bacteremia, Sepsis, and Septic Shock: Merck Manual Home Edition
Septic shock is a condition caused by an infection in the bloodstream (sepsis) in which blood pressure falls dangerously low and many organs malfunction because of inadequate blood flow.
Septic shock occurs most often in newborns (see Problems in Newborns: Sepsis), people older than age 50, and people with a weakened immune system.
Septic shock is caused by cytokines (substances made by the immune system to fight an infection (see Biology of the Immune System: Cytokines) and by the toxins produced by some bacteria.
www.merck.com /mmhe/sec17/ch191/ch191c.html   (687 words)

 [No title]   (Site not responding. Last check: 2007-10-08)
Shock caused by systemic response to infection remains one of the most serious problems faced by the clinician and continues to be the most frequent cause of death in the intensive care unit (1).
Septic shock is a continuum along a pathway of worsening homeostasis secondary to bacterial proliferation and ongoing invasion of normally sterile host tissues.
Thus the hemodynamic derangements seen in septic shock are initiated and maintained by endogenous mediators released in response to exogenous toxins released by invading organisms.
gasnet.med.yale.edu /esia/2000/january/septicshock.html   (4703 words)

 Postgraduate Medicine: Optimal management of septic shock
Septic shock is a subset of severe sepsis defined as sepsis-induced hypotension that persists despite fluid resuscitation and is associated with tissue hypoperfusion.
Death from septic shock usually results from rapid and overwhelming progression of sepsis unresponsive to all therapeutic maneuvers, multi-organ failure, or secondary nosocomial infection or complication.
Almost all the interventions in early management of septic shock are aimed at rapidly establishing the diagnosis and restoring mean arterial pressure to 65 to 75 mm Hg to improve organ perfusion.
www.postgradmed.com /issues/2002/03_02/fitch2.htm   (4218 words)

 Septic Shock Gene Identified
Septic shock is a very serious consequence of a bacterial infection.
Shock, clot formation, and bleeding, even though the blood is clotting, are the major signs of septic shock.
There is no effective treatment for septic shock, and about half of all cases of septic shock end in death.
www.suite101.com /article.cfm/microbiology/14842   (332 words)

Shock is a medical emergency in which the organs and tissues of the body are not receiving an adequate flow of blood.
Shock is caused by three major categories of problems: cardiogenic (meaning problems associated with the heart's functioning); hypovolemic (meaning that the total volume of blood available to circulate is low); and septic shock (caused by overwhelming infection, usually by bacteria).
Shock can be avoided by recognizing that a patient who is unable to drink in order to replace lost fluids needs to be given fluids intravenously (through a needle in a vein).
www.healthatoz.com /healthatoz/Atoz/ency/shock.jsp   (938 words)

 American Thoracic Society - Critical Care (CC)   (Site not responding. Last check: 2007-10-08)
Shock reversal was seen in 68%of those treated with hydrocortisone vs. 21% of those treated with placebo (p=0.007).
Forty patients with septic shock were randomized to receive hydrocortisone or placebo for three days followed by crossover to the alternative treatment for an additional three days.
Patterns of corticosteroid binding globulin and the free cortisol index during septic shock and multitrauma.
www.thoracic.org /criticalcare/cccat/steroids.asp   (852 words)

 SIRS to Septic Shock
Septic shock is the most common cause of mortality in the intensive care unit.
It is the 10th leading cause of death overall (2000) and is the most common cause of shock encountered by internists in the U.S. Despite aggressive treatment mortality ranges from 15% in patients with sepsis to 40-60% in patients with septic shock.
Sepsis and septic shock in the immunocompromised patient is associated with a wide variety of bacteria and fungi.
www.kcom.edu /faculty/chamberlain/Website/lectures/lecture/sepsis.htm   (3069 words)

 Institute for Healthcare Improvement: Administer Low-Dose Steroids by a Standard Policy
In a recent crossover study in septic shock patients, mean arterial pressure and systemic vascular resistance increased during low dose hydrocortisone treatment, and heart rate, cardiac index, and norepinephrine requirement decreased significantly.
Cortisol response to corticotropin and survival in septic shock.
Hypocortisolaemia and adrenocortical responsiveness at onset of septic shock.
www.ihi.org /IHI/Topics/CriticalCare/Sepsis/Changes/IndividualChanges/Administerlowdosesteroidsbyastandardpolicy.htm   (1779 words)

 Septic shock   (Site not responding. Last check: 2007-10-08)
The commonest cause of death in hospital intensive care units is septic shock which kills 250,000 people every year in the United States alone.
Septic shock happens when the immune system reacts abnormally and excessively to an infection, causing violent, destructive inflammation.
It is undergoing clinical trials against septic shock caused by meningococcal meningitis at St Mary's Hospital in London.
www.hammersmithresearch.com /specialty/article.asp?Specialty=Infection&art_id=188   (1041 words)

 Septic shock
Sepsis and septic shock are systemic responses to infection.
Approximately 70% of septic shock cases in humans are caused by a Gram-negative cell wall component, lipopolysaccharide (LPS), also known as endotoxin.
Septic shock portends a poor prognosis, with documented mortality rates up to 77%; it is currently the most common cause of death in US intensive care units.
www.mcgill.ca /hostres/diseases/septic   (157 words)

 Septic shock -- Facts, Info, and Encyclopedia article   (Site not responding. Last check: 2007-10-08)
Septic shock kills about 50% of its victims.
The decreased intra (additional info and facts about vascular) vascular volume (plasma volume) results in the above tissue (A very strong drive resulting from a deficiency of available oxygen in the blood and bodily tissues (short of anoxia)) hypoxia.
Antimediator agents may be of some limited use in certain clinical situations.
www.absoluteastronomy.com /encyclopedia/s/se/septic_shock.htm   (176 words)

 MedlinePlus Medical Encyclopedia: Septic shock
Septic shock is a medical emergency, and patients are usually admitted to intensive care.
There are new drugs that act against the hyperinflammatory response seen in septic shock.
Septic shock has a high death rate, exceeding 50%, depending on the type of organism causing the infection and the degree of organ failure.
www.nlm.nih.gov /medlineplus/ency/article/000668.htm   (536 words)

 [No title]
Shock is a failure of the circulatory system and is a life-threatening medical emergency.
Shock can be caused by problems with the heart itself (cardiogenic shock), conditions that block blood flow to or from the heart (extracardiac obstructive shock), severe loss of fluids (hypovolemic shock), or abnormal flow of fluids into the tissues, despite normal or increased heart function (distributive shock).
Depending on the cause of shock, surgery may be required to repair heart valves or rupture of a ventricle, artificially augment blood flow from the heart, or remove an embolism.
www.meta-ehealth.com /site/office/conditions/view_art_print.jsp?article=221   (2136 words)

 Institute for Healthcare Improvement: Serum Lactate Measured
Hyperlactatemia is typically present in patients with severe sepsis or septic shock and may be secondary to anaerobic metabolism due to hypoperfusion.
Experimental and clinical studies on lactate and pyruvate as indicators of the severity of acute circulatory failure (shock).
Blood lactate levels are superior to oxygen derived variables in predicting outcome in human septic shock.
www.ihi.org /IHI/Topics/CriticalCare/Sepsis/Changes/IndividualChanges/SerumLactateMeasured.htm   (521 words)

 [No title]   (Site not responding. Last check: 2007-10-08)
In an ARDS study that compared shock survivors to nonsurvivors--nonsurvivors were found to have higher intake/output ratio (more in than out) and greater weight gains than survivors.
Shock resolved in 67% of patients who received NE and 47% of patients given NE survived.
Appropriate intubation is a crucial component of an effective shock management plan Corticosteroids: High dose steroids are now used only in the setting of acute adrenal insufficiency or in association with acute spinal cord trauma.
www.muhealth.org /~md2003/pbldraft/09-08hat.doc   (1282 words)

 SIRS, Sepsis and Septic Shock   (Site not responding. Last check: 2007-10-08)
Blood pressure and arterial lactate level are early indicators of short-term survival in human septic shock.
Comparison of norepinephrine and dobutamine to epinephrine for hemodynamics, lactate metabolism, and gastric tonometric variables in septic shock: a prospective, randomized study.
Assessment of the safety and efficacy of the monoclonal anti-tumor necrosis factor antibody-fragment, MAK 195F, in patients with sepsis and septic shock: a multicenter, randomized, placebo-controlled, dose- ranging study.
www.umdnj.edu /rspthweb/bibs/sepsis.htm   (1806 words)

 In Septic Shock, Increase Cardiac Output or Leave It Alone?
Not surprisingly, there is also considerable disagreement about how best to help patients with septic shock improve their hemodynamic state.
However, at least some patients with septic shock may no longer be able to mount this hyperkinetic response.
Yet, these studies cannot be taken as proof that it is inappropriate to try to raise cardiac output with fluids or drugs in septic shock patients who cannot mount a hyperkinetic response on their own.
www.pulmonaryreviews.com /may03/pr_may03_septic.html   (1264 words)

 Septic Shock
Septic shock is a life-threatening reaction to a severe infection.
During septic shock, the body tissues and organs do not get enough blood and oxygen.
Septic shock is an emergency that requires treatment in the hospital.
www.healthsquare.com /mc/fgmc0603.htm   (817 words)

 Read about Septic shock at WorldVillage Encyclopedia. Research Septic shock and learn about Septic shock here!   (Site not responding. Last check: 2007-10-08)
distributive shock, shock refers specifically to decreased tissue perfusion resulting in end-organ dysfunction.
sepsis, severe sepsis or sepsis syndrome; septic shock; refractory septic shock; multiple-organ dysfunction syndrome, and
cytokines involved in the development of septic shock include
encyclopedia.worldvillage.com /s/b/Septic_shock   (242 words)

 Hemodynamic Support in Fluid-refractory Pediatric Septic Shock -- Ceneviva et al. 102 (2): 19 -- Pediatrics
Studies in humans suggest that low CO and/or low SVR is deleterious to organ perfusion and survival during septic shock.
septic shock: heart rate as an early predictor of prognosis.
depression in septic shock caused by meningococcal infection.
pediatrics.aappublications.org /cgi/content/full/102/2/e19   (3935 words)

 Early and innovative interventions for severe sepsis and septic shock: taking advantage of a window of opportunity -- ...
Septic shock: an analysis of outcomes for patients with onset on hospital wards versus intensive care units.
Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock.
Septic shock patients with a reduced ejection fraction have a circulating factor that depresses in vitro myocardial cell performance.
www.cmaj.ca /cgi/content/full/173/9/1054   (7160 words)

With septic shock, body tissues and organs do not get enough blood and oxygen.
Medicine and other care will be used to treat septic shock while you are in the hospital.
To help with this plan, you must learn about septic shock and how it can be treated.
www.drugs.com /CG/SEPTIC_SHOCK.html   (430 words)

 Role of Vasopressin Deficiency in the Vasodilation of Septic Shock -- Reid 95 (5): 1108 -- Circulation
Role of Vasopressin Deficiency in the Vasodilation of Septic Shock -- Reid 95 (5): 1108 -- Circulation
Role of Vasopressin Deficiency in the Vasodilation of Septic Shock
Septic shock is a form of distributive shock most commonly caused
circ.ahajournals.org /cgi/content/full/95/5/1108   (1641 words)

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