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Topic: Serine protease

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	Serine protease - Wikipedia, the free encyclopedia
		This is coordinated by the nitrogen of the histidine.
		In effect, serine proteases preferentially bind the transition state and the overall structure is favored, lowering the activation energy of the reaction.
		Serine proteases are inhibited by serine protease inhibitors ("serpins"), a diverse group of inhibitors that form a covalent bond with the serine protease, inhibiting its function.
	en.wikipedia.org /wiki/Serine_protease (1599 words)

	Serpin - Wikipedia, the free encyclopedia
		Serine proteases are defined by the presence of a serine residue in their active domain (e.g.
		Cysteine proteases differ from serine proteases in that they are defined by the presence of a cysteine residue, rather than a serine residue, in their active domain.
		Protease Nexin 1 (PN1 inhibits thrombin and urokinase)
	en.wikipedia.org /wiki/Serine_protease_inhibitor (647 words)

	Gastrulation Defective is a serine protease involved in activating the receptor Toll to polarize the Drosophila embryo ...
		Gastrulation Defective is a serine protease involved in activating the receptor Toll to polarize the Drosophila embryo -- Han et al.
		The candidate catalytic serine in GD is unusual, as it is positioned 8 aa further C terminal in the sequence and lacks a conserved aspartic acid as a neighbor.
		the catalytic serine was mutated to alanine (Fig.
	www.pnas.org /cgi/content/full/97/16/9093 (3927 words)

	Serine Protease Inhibitors
		e are interested in inhibitors for serine proteases (thrombin, Factor Xa, and chymotrypsin), which are light sensitive.
		Derek is currently working on the theoretical design, synthesis, and study of photolabile serine protease inhibitors with large two-photon absorbance cross-sections.
		The design of these inhibitors, including the modelling of their docking with various serine proteases is being done in collaboration with Dr. Jarrod Smith of the Department of Biochemistry.
	www.vanderbilt.edu /AnS/Chemistry/PorterGroup/serineproteases.html (221 words)

	Title of Invention: PB92 serine protease muteins an d their use in detergents
		Preferably, the proteases being expressed are secreted into the culture medium, which facilitates their recovery, or in the case of gram negative bacterial host strains into the periplasmic space.
		The serine protease mutein according to claim 1, wherein said substitution is at amino acid 216 and is from methionine to serine.
		The serine protease mutein according to claim 1, wherein said substitution is at amino acid 116 and is from glycine to valine.
	www.nal.usda.gov /bic/Biotech_Patents/1994patents/05336611.html (9868 words)

	Research Page: Profiling Serine Protease Activities in Breast Cancer (Site not responding. Last check: 2007-10-09)
		While given serine proteases and their endogenous inhibitors clearly show altered expression patterns during breast tumorigenesis, the overall functional outcome of such changes remain unclear.
		Indeed, when data relating serine proteases and their endogenous inhibitors to breast cancer are evaluated, seemingly paradoxical trends emerge.
		Simple static measures of protease and inhibitor quantity are insufficient to explain the dynamic nature of their interactions that occurs in the breast tumor environment.
	www.cbcrp.org /research/PageGrant.asp?grant_id=1905 (1114 words)

	PROTEASE (Site not responding. Last check: 2007-10-09)
		This is an edited discussion of materials presented on proteases and their inhibitors from the internet posted on 29-March-1991 by "BS04@primeb.dundee.ac.uk", and additional notes on the use of inhibitors in our laboratory.
		There are four groups of proteases: serine, cysteine, aspartic and metallo-proteases.
		Protease inhibitors dissolved in DMSO that will be added to live cells should be prepared so that the final DMSO concentration is less than 0.5%.
	www.omrf.ouhsc.edu /~frank/PROTEASE.html (336 words)

	Caspase- and Serine Protease-dependent Apoptosis by the Death Domain of FADD in Normal Epithelial Cells -- Thorburn et ...
		pathway and that the serine protease that is inhibited by AEBSF
		In addition, a serine protease pathway is activated that can be inhibited by AEBSF but not by Bcl-xL, which causes cell death that is associated with cell rounding and detachment.
		Suzuki, Y., Imai, Y., Nakayama, H., Takahashi, K., Takio, K., and Takahashi, R. A serine protease, htra2, is released from the mitochondria and interacts with xiap, inducing cell death.
	www.molbiolcell.org /cgi/content/full/14/1/67 (6262 words)

	Phase-Variable Expression of an Operon Encoding Extracellular Alkaline Protease, a Serine Protease Homolog, and Lipase ...
		Phase-Variable Expression of an Operon Encoding Extracellular Alkaline Protease, a Serine Protease Homolog, and Lipase in Pseudomonas brassicacearum -- Chabeaud et al.
		Phase-Variable Expression of an Operon Encoding Extracellular Alkaline Protease, a Serine Protease Homolog, and Lipase in Pseudomonas brassicacearum
		Biochemical and genetic characterization of an extracellular protease from Pseudomonas fluorescens CY091.
	jb.asm.org /cgi/content/full/183/6/2117 (2131 words)

	Serine protease: Make a sequence set from lists
		Proteases are displayed by alphabetic order per family in the following list.
		ATP-dependent CLP protease proteolytic subunit 1 : synechococcus (strain PCC 7942)
		ATP-dependent CLP protease proteolytic subunit 1 : synechocystis (strain PCC 6803).
	biochem.wustl.edu /~protease/ser_pro_seq_ana_all.html (825 words)

	Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi - Nature Structural ... (Site not responding. Last check: 2007-10-09)
		This mutation eliminated the serine protease activity, which was responsible for the partial degradation of the wild type protein at the high concentrations required for crystallization.
		6 from the serine protease domain and the syntrophin-bound peptide are shown in cyan and dark blue, respectively.
		Homotrimerization is mediated exclusively by the serine protease domain and, in particular, by the N-terminal sequences (Figs 1, 2).
	www.nature.com /uidfinder/10.1038/nsb795 (3507 words)

	CIAP1 and the serine protease HTRA2 are involved in a novel p53-dependent apoptosis pathway in mammals -- Jin et al. 17 ...
		CIAP1 and the serine protease HTRA2 are involved in a novel p53-dependent apoptosis pathway in mammals -- Jin et al.
		CIAP1 and the serine protease HTRA2 are involved in a novel p53-dependent apoptosis pathway in mammals
		Serine protease inhibitor AEBSF blocks p53-dependent CIAP1 cleavage and apoptosis in primary mouse thymocytes.
	www.genesdev.org /cgi/content/full/17/3/359 (5172 words)

	Testisin, a Glycosyl-Phosphatidylinositol-Linked Serine Protease, Promotes Malignant Transformation In vitro and In ...
		Differential expression of a novel serine protease homologue in squamous cell carcinoma of the head and neck.
		Expression of the serine protease matriptase and its inhibitor HAI-1 in epithelial ovarian cancer: correlation with clinical outcome and tumor clinicopathological parameters.
		Hepsin, a cell surface serine protease identified in hepatoma cells, is overexpressed in ovarian cancer.
	cancerres.aacrjournals.org /cgi/content/full/65/3/868 (5192 words)

	Propapoptotic effects of NF-B in LNCaP prostate cancer cells lead to serine protease activation (Site not responding. Last check: 2007-10-09)
		The identification of specific serine proteases involved in apoptosis is not as advanced as identification of caspases.
		We have found that the serine protease inhibitor TLCK is effective at blocking LNCaP cell death to an equal degree as caspase inhibitors.
		Serine protease inhibitor TPCK prevents Taxol-induced cell death and blocks c-Raf-1 and Bcl-2 phosphorylation in human breast carcinoma cells.
	www.nature.com /cdd/journal/v9/n9/full/4401049a.html (4762 words)

	(WO/1988/006621) SERINE PROTEASE AND SERINE PROTEASE GENE (Site not responding. Last check: 2007-10-09)
		(EN) Serine protease showing the bioactivity of a polypeptide having the amino acid sequence, serine protease precursor wherein a splittable peptide or a signal peptide is bound to the N-terminus of the serine protease, and genes coding them are disclosed.
		Serine protease useful in the medical field can be prepared in a large quantity according to this invention.
		A DNA sequence which codes a transcription-controlling region contained in a chromosome gene of serine protease of human myeloid cell origin is also disclosed.
	www.wipo.int /pctdb/en/wo.jsp?WO=1988/06621 (285 words)

	Human protein: O00187 - Mannan-binding lectin serine protease 2 precursor (EC ) (Mannose-binding protein-associated ...
		Mannan-binding lectin serine protease 2 precursor (EC 3.4.21.104) (Mannose-binding protein-associated serine protease 2) (MASP-2) (MBL- associated serine protease 2) [Contains: Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain].
		A truncated form of mannose-binding lectin-associated serine protease (MASP)-2 expressed by alternative polyadenylation is a component of the lectin complement pathway.
		The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome 1p36.2-3.
	harvester.embl.de /harvester/O001/O00187.htm (1236 words)

	The Serine Protease Motif of EspC from Enteropathogenic Escherichia coli Produces Epithelial Damage by a Mechanism ...
		The Serine Protease Motif of EspC from Enteropathogenic Escherichia coli Produces Epithelial Damage by a Mechanism Different from That of Pet Toxin from Enteroaggregative E. coli -- Navarro-García et al.
		to the SPATE (serine protease autotransporters of Enterobacteriaceae)
		An EspC serine protease motif mutant is unable to cleave fodrin.
	iai.asm.org /cgi/content/full/72/6/3609 (6398 words)

	Protein Degradation
		During catalysis, there is nucleophilic attack of the hydroxyl oxygen of a serine residue of the protease on the carbonyl carbon of the peptide bond that is to be cleaved.
		During attack of the serine hydroxyl oxygen, a proton is transferred from the serine hydroxyl to the imidazole ring of the histidine, as the adjacent aspartate carboxyl is H-bonded to the histidine.
		Activation of SREBP involves its translocation to golgi membranes where sequential cleavage by two proteases releases to the cytosol a domain with transcription factor activity.
	www.rpi.edu /dept/bcbp/molbiochem/MBWeb/mb2/part1/protease.htm (1966 words)

	Selective Inhibition of Large-to-Small Surfactant Aggregate Conversion by Serine Protease Inhibitors of the ...
		Influence of synthetic protease inhibitors on the LA-to-SA conversion of BALF (A) and on surface activity of the isolated LA fraction (B).
		Influence of synthetic serine protease inhibitors on surface activity of LA after cycling.
		Influence of the synthetic serine protease Inhibitors 1, 2, 5, 7, and BNPP (10
	ajrcmb.atsjournals.org /cgi/content/full/28/1/95 (3608 words)

	A Second PDZ-Containing Serine Protease Contributes to Activation of the Sporulation Transcription Factor {sigma}K in ...
		A Second PDZ-Containing Serine Protease Contributes to Activation of the Sporulation Transcription Factor {sigma}K in Bacillus subtilis -- Pan et al.
		Carboxyl-terminal processing proteases are members of the SM clan of serine peptidases (28) that exhibit a serine-lysine
		Molecular studies of CtpA, the carboxyl-terminal processing protease for the D1 protein of the photosystem II reaction center in higher plants.
	jb.asm.org /cgi/content/full/185/20/6051 (2927 words)

	TMPRSS2 - transmembrane protease, serine 2
		Serine proteases are known to be involved in many physiological and pathological processes.
		The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage.
		The TMPRSS2 gene encoding transmembrane serine protease is overexpressedin a majority of prostate cancer patients: detection of mutated TMPRSS2form in a case of aggressive disease.
	www.ucsf.edu /pgdb/gene/136.html (153 words)

	Genetic Screen for Monitoring Hepatitis C Virus NS3 Serine Protease Activity -- Martinez and Clotet 47 (5): 1760 -- ...
		Expression of the protease was induced by IPTG treatment for 1 h, and the cells were infected with
		NS3 is a serine protease required for processing of hepatitis C virus polyprotein.
		A central hydrophobic domain of the hepatitis C virus NS4A protein is necessary and sufficient for the activation of the NS3 protease.
	aac.asm.org /cgi/content/full/47/5/1760 (2780 words)

	Cathepsin G, a Neutrophil-Derived Serine Protease, Increases Susceptibility of Macrophages to Acute Human ...
		Serine proteases constitute a gene superfamily of proteolytic enzymes that are characterized by a unique reactive serine side
		Certain members of the serine protease family are capable of stimulating leukocytes to exert a wide array of effector functions,
		Serine protease inhibitor ACT neutralizes the effects mediated by cathepsin G. Macrophages were treated with cathepsin G (CatG, 5 µg/ml) for 30 min before and immediately after infection with the ADA8 strain of HIV-1.
	jvi.asm.org /cgi/content/full/74/15/6849 (4479 words)

	The Adrenal Secretory Serine Protease AsP Is a Short Secretory Isoform of the Transmembrane Airway Trypsin-Like ...
		The Adrenal Secretory Serine Protease AsP Is a Short Secretory Isoform of the Transmembrane Airway Trypsin-Like Protease -- Hansen et al.
		Amino acids that are part of the catalytic triad are marked with a fl arrow, the amino acids flanking the catalytic serine at position -6, 15, 16, 17, and 28, which determine the specificity of the substrate binding pocket are marked with white arrows.
		-melanotropin and a cleft protease, a mitogenic conspiracy in the pituitary?
	endo.endojournals.org /cgi/content/full/145/4/1898 (5267 words)

	Distribution of the Serine Protease Autotransporters of the Enterobacteriaceae among Extraintestinal Clinical Isolates ...
		Distribution of the Serine Protease Autotransporters of the Enterobacteriaceae among Extraintestinal Clinical Isolates of Escherichia coli -- Parham et al.
		of autotransporters, the IgA1 proteases of Neisseria, and Hap
		The Hemophilus influenzae Hap autotransporter is a chymotrypsin clan serine protease and undergoes autoproteolysis via an intermolecular mechanism.
	jcm.asm.org /cgi/content/full/43/8/4076 (3860 words)

	Characterization of Recombinant Mannan-Binding Lectin-Associated Serine Protease (MASP)-3 Suggests an Activation ...
		Cleavage of the third component of complement (C3) by mannose-binding protein-associated serine protease (MASP) with subsequent complement activation.
		Baculovirus-mediated expression of truncated modular fragments from the catalytic region of human complement serine protease C1s: evidence for the involvement of both complement control protein modules in the recognition of the C4 protein substrate.
		Investigation of sequential behavior of carboxyl protease and cysteine protease activities in virus-infected Sf-9 insect cell culture by inhibition assay.
	www.jimmunol.org /cgi/content/full/172/7/4342 (6356 words)

	Streptomyces Serine Protease (DHP-A) as a New Biocatalyst Capable of Forming Chiral Intermediates of ...
		Streptomyces Serine Protease (DHP-A) as a New Biocatalyst Capable of Forming Chiral Intermediates of 1,4-Dihydropyridine Calcium Antagonists -- Arisawa et al.
		Carbomoylmethyl group as an activated group in protease- and base-catalyzed transesterification of 1,4-dihydropyridines: a novel asymmetric synthesis of valnidipine.
		Molecular characterization of a gene encoding extracellular serine protease isolated from a subtilisin inhibitor-deficient mutant of Streptomyces albogriseolus S-3253.
	aem.asm.org /cgi/content/full/68/6/2716 (5134 words)

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