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Topic: Serotonin receptor

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	5-HT receptor - Wikipedia, the free encyclopedia
		In the field of neurochemistry, 5-HT receptors are receptors for the neurotransmitter and peripheral signal mediator serotonin, also known as 5-hydroxytryptamine or 5-HT.
		5-HT receptors are located on the cell membrane of nerve cells and other cell types in animals and mediate the effects of serotonin as the endogenous ligand and of a broad range of pharmaceutical and hallucinogenic drugs.
		With the exception of the 5-HT receptor, a ligand gated ion channel, all other 5-HT receptors are G protein coupled seven transmembrane (or heptahelical) receptors that activate an intracellular second messenger cascade.
	en.wikipedia.org /wiki/5-HT_receptor (400 words)

	DNA encoding serotonin 1C (5HT1c) receptor, isolated 5HT1c receptor, mammalian cells expressing same and uses thereof - ...
		Serotonin receptors are also thought to be linked to the direct modification of ion channel states, and are implicated in mechanisms associated with pain, migraine headaches, and motor control.
		The serotonin receptor is shown to belong to the family of rhodopsin-like signal transducers which are distinguished by their seven-transmembrane configuration and their functional linkage to G-proteins.
		Receptor RNA was not detected in the cerebellum or in liver, kidney, intestine, heart, and lung.
	www.freepatentsonline.com /4985352.html (9121 words)

	Serotonin - Wikipedia, the free encyclopedia
		Serotonin is found extensively in the human gastrointestinal tract (about 90% [1]), as well as in the blood stream.
		The pathway for the synthesis of serotonin from Trp
		Serotonin and 5HIAA are sometimes produced in excess amounts by certain tumors or cancers, and levels of these substances may be measured in the urine to test for these tumors.
	en.wikipedia.org /wiki/Serotonin (1207 words)

	Serotonin
		Serotonin levels in synapses are reduced by two kinds of presynaptic molecules: autoreceptors (orange), which direct the cells to inhibit serotonin production, and reuptake transporters (yellow), which absorb the neurotransmitter.
		The 5-HT gene is on mouse chromosome 5, whereas the 5-HT gene is on chromosome 1.
		These receptors are found in high concentrations peripherally in the gut and centrally in the cortical and limbic regions and in or near the chemoreceptor trigger zone, and have been implicated in the vomiting reflex induced by serotonin as a result of chemotherapy.
	users.belgacom.net /neurobiology/serotonin.htm (5811 words)

	Serotonin (Site not responding. Last check: 2007-10-14)
		Serotonin is found in both the brain and the gut, but it is now widely understood that 95% of the serotonin in the body resides in the gut.
		Serotonin (5-hydroxytryptamine, or 5-HT) is a chemical neurotransmitter (a chemical in the nervous system that helps transmit messages along the nervous system).
		In cell biology, a receptor is a structure on the surface of a cell or inside a cell that selectively receives and binds a specific substance -- such as a hormone or a neurotransmitter.
	www.aboutibs.org /Publications/serotonin.html (546 words)

	HTR1F - 5-hydroxytryptamine (serotonin) receptor 1F
		Since species differences in the pharmacology of serotonin receptors are well known, we compared the pharmacological profiles of the cloned human and guinea pig 5-HT1F receptors in order to validate the usefulness of the in vivo model in predicting anti-migraine activity of compounds targeted for humans.
		The serotonin (5-HT) receptor subtype mediating inhibition of neurogenic dural inflammation in guinea pigs was investigated using a series of serotonin agonists with differing affinities for the 5-HT1B, 5-HT1D and 5-HT1F receptors.
		HTR1F is a homologue of Htr1f (5-hydroxytryptamine (serotonin) receptor 1F) from Mus musculus.
	www.ihop-net.org /UniPub/iHOP/gi/89254.html (862 words)

	Role of the Serotonin 5-HT2A Receptor in Learning -- Harvey 10 (5): 355 -- Learning & Memory
		that the 5-HT receptor agonists quipazine and TFMPP (1-[m-trifluoromethylphenyl]piperazine)
		Serotonin induces EPSCs preferentially in layer V pyramidal neurons of the frontal cortex in the rat.
		Sheldon, P.W. and Aghajanian, G.K. Excitatory responses to serotonin (5-HT) in neurons of the rat piriform cortex: Evidence for mediation by 5-HT receptors in pyramidal cells and 5-HT receptors in interneurons.
	www.learnmem.org /cgi/content/full/10/5/355 (5051 words)

	Anxiety and the Serotonin Receptor
		The receptor structure is similar to that of the G-protein–coupled superfamily of neurotransmitter receptors.
		Activation of the 5-HT receptor in rat hippocampal membranes was noted to inhibit forskolin-induced increases in adenylate cyclase.
		Hypothermia is postulated to reflect presynaptic 5-HT receptor activation, whereas corticoid responses reflect activation of postsynaptic 5-HT receptors.
	www.acnp.org /g4/GN401000125/CH123.html (5318 words)

	Serotonin Receptor Subtypes and Ligands
		5-HT is an indolealkylamine that binds to all populations of 5-HT receptors.
		Evidence was subsequently provided suggesting that 5-HT receptors exist in a high-affinity state and a low-affinity state; under normal conditions, this equilibrium is heavily in favor of the low-affinity state, and the tritiated antagonist ketanserin binds at both states with comparable affinity.
		Serotonin, 5-CT, 5-methoxytryptamine, and 8-OH DPAT reportedly act as agonists, whereas methiothepin, mianserin, mesulergine, ritanserin, spiperone, NAN-190, LY215840 and clozapine act as antagonists.
	www.acnp.org /g4/GN401000039/Ch039.html (13714 words)

	Serotonin Receptor Subtypes and Ligands
		Serotonin binds most populations of 5-HT receptors with low nanomolar affinity.
		A high density of 5-HT4 receptors in the nucleus accumbens has led to speculate that these receptors may be involved in the reward system and may influence self-administration behavior.
		Serotonin and Bulimia - A sign of susceptibility to the eating disorder bulimia: an abnormality in the way the brain processes the neurotransmitter serotonin.
	starklab.slu.edu /neuro/Lecture.htm (1151 words)

	New type of serotonin receptor identified
		If this type of receptor is found in humans, it may become an additional target for drugs designed to treat a wide range of disorders caused by serotonin imbalance, including mood disorders, migraine headaches and obesity.
		The identification of the new serotonin receptor began with experiments designed to probe why certain strains of the roundworm, Caenorhabditis elegans, fail to slow down when they encounter food.
		"Although we had evidence that serotonin is involved in the enhanced slowing response," said Ranganathan, "we did not expect the mod-1 protein to represent an entirely new kind of serotonin receptor." There are two basic types of serotonin receptor, those that trigger fast responses in neurons and those that trigger slow responses.
	www.eurekalert.org /pub_releases/2000-11/HHMI-Ntos-2211100.php (485 words)

	Messenger Ribonucleic Acids Encoding a Serotonin Receptor and a Novel Gene Are Induced in Sertoli Cells by a Secreted ...
		serotonin antagonist on the induction of the serotonin receptor
		The blot was hybridized with cDNAs encoding the serotonin receptor (A) and clone 1 (B).
		Northern blot analysis demonstrating the effects of serotonin, serotonin agonist, and serotonin antagonist on serotonin receptor expression.
	endo.endojournals.org /cgi/content/full/140/12/5754 (3621 words)

	Record: Low serotonin-receptor levels linked to depression
		In the February issue of the journal Biological Psychiatry, Mintun and his colleagues reported that the depressed people actually had fewer serotonin receptors throughout the brain and significantly fewer receptors in a key structure called the hippocampus, an area that acts as a gateway between memory and mood, among other processes.
		Mintun and Sheline say it's still possible that the low number of receptors is related to an underlying abnormality in the serotonin system, but it's also possible that the low number of receptors are the result of damage to the hippocampus that is caused by depressive episodes.
		Mintun said preliminary data from studies of depressed people after treatment indicate that the number of serotonin receptors in the hippocampus appears to be rising and returning to normal.
	record.wustl.edu /news/page/normal/3388.html (965 words)

	FuturePundit: Serotonin Receptor Concentration Correlates With Anxiety
		The finding is the first in humans to show that a receptor, which is pivotal to the action of widely prescribed anti-anxiety medications, may be abnormal in the disorder and help to explain how genes might influence vulnerability.
		Brain scans revealed that the component, a type of serotonin receptor, is reduced by nearly a third in three structures straddling the center of the brain, according to the report in the current issue of The Journal of Neuroscience.
		In the panic disorder patients, including those who also had depression, receptors were reduced by an average of nearly a third in the anterior cingulate in the front middle part of the brain, the posterior cingulate, in the rear middle part of the brain, and in the raphe, in the midbrain.
	www.futurepundit.com /archives/001957.html (711 words)

	Serotonin Receptor antibodies from RDI Divison of Fitzgerald Industries Intl
		The thirteen receptors are grouped in seven subtypes according to operational, structural, and transductional properties.
		The 5-HT2 receptors (5-HT2AR, 5-HT2BR,and 5-HT2CR) may be considered as prototypes for the study of serotonin receptors.
		However, the exact localization of 5-HT2 receptors in the CNS remains to be elucidated.
	www.researchd.com /miscabs/serotonr.htm (564 words)

	5HT1A Serotonin Receptor Agonists Inhibit Plasmodium falciparum by Blocking a Membrane Channel -- Locher et al. 47 ...
		Serotonin receptor ligands inhibit growth of malaria parasites.
		Serotonin receptor ligands are specific for the human malaria parasite P.
		and the serotonin receptor affinity of agonists and antagonists
	aac.asm.org /cgi/content/full/47/12/3806 (2415 words)

	Texas Medicaid Vendor Drug Program, Serotonin 5-HT1D Receptor Agonists (Site not responding. Last check: 2007-10-14)
		Serotonin 5-HT receptor agonists are approved for acute treatment of migraine attacks and may be utilized for extended durations to manage migraine headaches provided that the maximum dosage recommendation is not exceeded in a 24-hour period.
		The use of two or more serotonin 5-HT receptor agonists concurrently is not justified as their vasospastic effects may be additive.
		The concurrent use of serotonin 5-HT1D receptor agonists and agents known to prolong the QT interval may result in potentially life-threatening arrhythmias, including torsades de pointes.
	www.hhsc.state.tx.us /HCF/vdp/Criteria/seroton.html (1189 words)

	Serotonin receptor blockade may treat JCV in AIDS patients (Site not responding. Last check: 2007-10-14)
		NEW YORK (Reuters Health) - Serotonin receptor antagonists may be effective in preventing the spread of the human polyomavirus JCV in the central nervous system, and thereby avert the development or spread of progressive multifocal leukoencephalopathy (PML), according to research published in the November 19th issue of Science.
		"Most drugs that block these serotonin receptors are generally benign, they're generic, and already approved by FDA, so we are in discussion with neurologists to investigate whether or not these compounds will be effective in preventing PML," Dr. Atwood told Reuters Health.
		Other options are serotonin receptor inhibitors used as antidepressants.
	www.aidsmeds.com /news/20041118drgd001.html (466 words)

	Serotonin Receptor
		Serotonin (5-hydroxytryptamine, 5-HT) is unique among the monoamines in that its effects are felt by as many as 13 distinct heptahelical, G-protein-coupled receptors (GPCRs) and one ligand-gated ion channel (or more).
		These receptors are divided into seven distinct classes (5-HT(1) to 5-HT(7)) largely on the basis of their structural and operational characteristics.
		This illustration represents an accurate look at the the receptor structure.
	www.symmation.com /gallery/view.php?id=24 (129 words)

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