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Topic: Serotonin syndrome

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In the News (Mon 24 Sep 18)

  Lexapro.Lexapro truth. Lexapro side effects and Lexapro withdrawal.
When she became agitated, a symptom of serotonin toxicity, and tried to pull out her intravenous tubes, she was restrained, and the resulting muscular tension is believed to have sent her fever soaring to lethal heights.
Serotonin syndrome was first described in medical literature in 1959 in a patient with tuberculosis who was treated with meperidine.
The withdrawal syndrome is real and in fact, it is now known that infants of women who take SSRIs in the last 3 months of pregnancy, may experience symptoms of withdrawal, including convulsions, according to a study published in the February 4, 2005 issue of the journal Lancet.
www.prozactruth.com   (8231 words)

  Sumatriptan in serotonin syndrome
Serotonin is found in high concentrations in enterochromaffin cells in GIS (90%), platelets and certain regions of brain as a neurotransmitter.
Serotonin syndrome is a toxic hyperserotonergic state and is characterized by changes in mental status, myoclonus, agitation, hyper-reflexia, restlessness, diaphoresis, shivering, and tremor, muscle rigidity, hyperthermia and autonomic instability.
Serotonin syndrome is supposed to cause by stimulation of 5-HT-1A and 5-HT2 receptors in the brain stem and spinal cord.
www.priory.com /psych/seurotosyn.htm   (1624 words)

  Lifespan's A - Z Health Information Library - Health Illustrated Encyclopedia - Serotonin syndrome
Serotonin syndrome is a life-threatening drug reaction that causes the body to have too much serotonin, a chemical produced by nerve cells.
Serotonin syndrome most often occurs when two drugs that affect the body's level of serotonin are taken together at the same time.
Serotonin syndrome is not diagnosed until all other possible causes have been ruled out, including infections, intoxications, metabolism problems, and drug withdrawal.
www.lifespan.org /adam/healthillustratedencyclopedia/1/007272.html   (703 words)

  Serotonin syndrome American Family Physician - Find Articles
Serotonin syndrome is an important drug-related complication of psychopharmacologic therapy for depression, bipolar affective disorder, obsessive-compulsive disorder and Parkinson's disease.
Serotonin syndrome is an iatrogenic disorder: it only occurs in the setting of drug therapy that has a net effect of augmenting brain serotonin neurotransmission.
Serotonin syndrome is not associated with abnormalities in cerebrospinal fluid analysis, radiographic studies (including computed tomographic scanning), electroencephalography (excluding seizures) or routine serum electrolyte determinations.
www.findarticles.com /p/articles/mi_m3225/is_n5_v52/ai_17640135   (780 words)

 NMSIS - Neuroleptic Malignant Syndrome Information Service   (Site not responding. Last check: )
The most important risk for developing the syndrome, as reviewed later, may lie in specific medications and combinations of medications that appear to account for a greater proportion of cases described in the literature and for particularly severe and lethal manifestations of the syndrome.
Serotonin syndrome has been reported when an MAOI was used in combination with L-tryptophan, dextromethorphan, or clonazepam.
The phenomenological overlap of serotonin syndrome with NMS is apparent in the last three criteria.
www.nmsis.org /Related_Syndromes.shtml   (2241 words)

 MAPS: Serotonin Syndrome
This syndrome is characterised by a constellation of symptoms (confusion, fever, shivering, diaphoresis, ataxia, hyperelflexia, myoclonus or diarrhoea) in the setting of the recent addition of a serotonergic agent.
Serotonin syndrome is thought to be caused, pharmacologically, by the over-stimulation of 5-HT-1A receptors in the brain stem and spinal cord.
The cases of serotonin syndrome diagnosed at emergency rooms are diagnosed precisely because the victim or their friends reported that they had consumed ecstasy, or MDMA had been discovered in their blood.
www.maps.org /pipermail/maps_forum/1999-October/002083.html   (1149 words)

 Serotonin Syndrome
This syndrome is a toxic hyperserotonergic state whose rate of incidence is unknown, but is on the rise.
The neuroleptic malignant syndrome is a serious condition brought on by the use of the neuroleptic drugs.
It should be apparent that the greater the enhancement of serotonin levels, the greater the chances of producing the serotonin syndrome.
home.tampabay.rr.com /lymecfs/ss.htm   (616 words)

 MedlinePlus Medical Encyclopedia: Serotonin syndrome
Serotonin syndrome is a life-threatening drug reaction that causes the body to have too much serotonin, a chemical produced by nerve cells.
Serotonin syndrome most often occurs when two drugs that affect the body's level of serotonin are taken together at the same time.
Serotonin syndrome is not diagnosed until all other possible causes have been ruled out, including infections, intoxications, metabolism problems, and drug withdrawal.
www.nlm.nih.gov /medlineplus/ency/article/007272.htm   (742 words)

 Antidepressants Facts: Serotonin Syndrome SSRI's, SSNRI's
he Serotonin Syndrome is a potentially lethal condition caused by excessive serotonergic activity and is diagnosed by the presence of at least 3 of 10 symptoms: mental status changes (confusion, hypomania), agitation, myoclonus, hyperreflexia, diaphoresis, shivering, tremor, diarrhea, incoordination, and fever.
In Bio-Psychiatry it is a common thought that SSRI's are believed to have their effect by inhibiting the re-uptake of serotonin (downregulation of transporters) and thereby gradually increasing serotonin outside the tissue cell wall (extracellular) in the synaptic gap between brain cells (neurons) in the brain.
Serotonin syndrome associated to the use of paroxetine.
www.antidepressantsfacts.com /serotonin-syndrome-ADF.htm   (680 words)

 Serotonin Syndrome - Symptoms - Medication Side Effect Lawsuit Claims
Serotonin syndrome symptoms may be caused as a combined side effect of several migrain medications and antidepressants when taken together.
Serotonin Syndrome is a serious, and potentially life threatening, condition which may be caused as a combined side effect of several medications.
The serotonin syndrome lawsuits and legal claims are being investigated for individuals diagnosed with the condition after the combined use of certain migraine medications and antidpressants.
www.youhavealawyer.com /conditions/serotonin-syndrome.html   (688 words)

 Serotonin syndrome - Wikipedia, the free encyclopedia
Serotonin syndrome is caused by increased serotonin in the central nervous system usually as a result of therapeutic drug use, intentional self-poisoning, or inadvertent interactions between drugs.
The dose effect relationship is the term used to describe the effects of progressive elevation of serotonin, either by raising the dose of one drug, or combining it with another serotonergic drug (which may produce large elevations in serotonin levels).
Serotonin syndrome is rare, but it is a serious, potentially life-threatening medical condition.
en.wikipedia.org /wiki/Serotonin_syndrome   (976 words)

Serotonin syndrome is an example of the uncertainty surrounding the safety and tolerability of the newer agents.
However the syndrome itself is not new; the first report was made in 1960 as a reaction between tryptophan and the MAOI phenelzine, and since then over 200 reports have been published in journals worldwide.
The syndrome is still regarded with some scepticism and the main reason for this is the non-specific/symptoms that are associated with it.
www.hospharm.com.au /d81aba7fce533488cfc6354f87971c7f/news/display/31   (652 words)

 PsychoTropical Research - Dr Ken Gillman, Serotonin Syndrome, Mirtazapine, Dual Action Drugs. Serotonin toxicity: 1 ...
Serotonin toxicity illustrates this point further, because there are cumulative effects caused by the end effect of two different drugs producing an additive effect which is much larger than either individual drug is able to produce by itself.
One of the main reasons for using the term serotonin toxicity rather than serotonin syndrome is because this emphasizes that it is a form of poisoning, not an idiosyncratic syndrome: i.e.
For instance, consider the frequent comment “serotonin syndrome is rare….” and then the statement “poisoning is rare”; it is true that poisoning is rare, except in those who ingest poisons.
www.psychotropical.com /Serotonin_toxicity_1_Introduction.shtml   (2580 words)

 Swedish Apert Syndrome Info
Apert's syndrome (acrocephalo syndactyli = high skull plus joined up fingers and toes) is a summarized name for a number of deformaties in the facial bones, hands and feet.
The syndrome is often caused by a temporary change in a hereditary factor and later becomes dominautly hereditary.
Children with apert's syndrome have to undergo skull operations, hand operations, foot operations and ear operations which means escperiencing anaesthesia about 30 times as early as kindergaten age.
www.apert.org /sweden   (880 words)

 Serotonin Syndrome
Rapid reversal of mydriasis in serotonin syndrome by cyproheptadine may serve as a specific suppressive test for the condition, and possibly may add to our understanding of the syndrome.
The diagnosis requires a history of exposure to agents active at serotonin receptors and the presence of alterations in mental status, autonomic instability, and neuromuscular abnormalities such as tremor, hyperreflexia, or myoclonus.
Serotonin syndrome induced by venlafaxine and fluoxetine: a case study in polypharmacy and potential pharmacodynamic and pharmacokinetic mechanisms.
www.modern-psychiatry.com /serotonin_syndrome.htm   (693 words)

 Serotonin syndrome: How to avoid, identify, & treat dangerous drug interactions   (Site not responding. Last check: )
Serotonin syndrome is characterized by changes in autonomic, neuromotor, and cognitive-behavioral function (Table 1) triggered by increased serotonergic stimulation.
Serotonin syndrome symptoms resolved within minutes when IV nitroglycerin was used in a patient with serotonin syndrome and cardiac ischemia.
Serotonin syndrome and the combined use of deprenyl and an antidepressant in Parkinson’s disease.
users3.ev1.net /~drtony/serotnin.htm   (2124 words)

 Public Health Advisory: Drug Combination May Result in Serotonin Syndrome
A life-threatening condition called serotonin syndrome may occur when triptans are used together with a SSRI or a SNRI.
Serotonin syndrome symptoms may include restlessness, hallucinations, loss of coordination, fast heart beat, rapid changes in blood pressure, increased body temperature, overactive reflexes, nausea, vomiting, and diarrhea.
Serotonin syndrome may be more likely to occur when starting or increasing the dose of a triptan, SSRI or SNRI.
www.fda.gov /cder/drug/advisory/SSRI_SS200607.htm   (472 words)

 Ask Erowid : ID 2981 : What is "serotonin syndrome"?
Serotonin syndrome is a condition that is typically induced by drug interactions from taking more than one drug that affects the serotonergic systems.
Serotonin Syndrome is a diagnosis given when there are symptoms which match the profile, the patient has taken a serotonergic drug, and there are no other diagnoses that fit better.
Although Serotonin Syndrome is commonly thought to be diagnosis for cardiovascular hypertension, Cardiovascular parameters are not considered relevant indicators for the serotonin syndrome (e.g.
www.erowid.org /ask/ask.cgi?ID=2981   (670 words)

 Serotonin Syndrome, Serotonin Syndrome Symptom, deficiency serotonin syndrome
Serotonin syndrome is characterized by changes in autonomic, neuromotor, and cognitive-behavioral function triggered by increased serotonergic stimulation.
The serotonin syndrome is a hypersotonergic state which is a very dangerous and a potentially fatal side effect of serotonergic enhancing drugs which can have multiple psychiatric and non-psychiatric symptoms.
Serotonin syndrome has been reported as a result of interactions between MAOIs-including selegiline and reversible MAO-A inhibitors (RIMAs)-and various serotonergic compounds.
www.depression-guide.com /serotonin-syndrome.htm   (716 words)

 Serotonin : by Ray Sahelian, M.D. , Natural Way to Raise Serotonin
Excessive stimulation of serotonin receptors is usually a result of administration of a high dose serotonin agonist to a patient who is already receiving a drug capable of potentiating the serotonin pathways.
Serotonin syndrome, which occurs as a result of enhanced serotonin concentration in the central nervous system, is a well-known adverse effect of serotonin-active medications.
We assayed increasing concentrations (0-10 mm) of N-acetyl- serotonin in testis microsomes and (0-1 mm) of N-acetyl- serotonin in testis mitochondria.
www.raysahelian.com /serotonin.html   (3249 words)

 Serotonin - Wikipedia, the free encyclopedia
Serotonin is found extensively in the human gastrointestinal tract (about 90% [1]), as well as in the blood stream.
The pathway for the synthesis of serotonin from Trp
Serotonin and 5HIAA are sometimes produced in excess amounts by certain tumors or cancers, and levels of these substances may be measured in the urine to test for these tumors.
en.wikipedia.org /wiki/Serotonin   (1352 words)

 Serotonin Syndrome: Recognition and Management
Serotonin syndrome is most often reported in patients taking two or more medications that increase CNS serotonin levels by different mechanisms.
Although there are many reports of "possible" serotonin syndrome reactions in the literature, in many instances the syndrome is not fully developed as there may be question as to whether the symptoms reported are really the result of serotonin syndrome.
While the researchers who reported this case believe it to be the first case of serotonin syndrome reported from the use of nefazodone and paroxetine, they point to other reports involving the use of trazodone and paroxetine.
www.uspharmacist.com /oldformat.asp?url=newlook/files/feat/acf2fa6.htm   (2256 words)

 Serotonin syndrome (Treatment Guide)
SEROTONIN SYNDROME DEFINITION The clinical syndrome resulting from excessive stimulation of central and peripheral serotonergic receptors.
TOXIC CAUSES The serotonin syndrome is most commonly the result of a drug interaction where two or more agents which enhance serotonergic neurotransmission by different mechanisms are administered in combination or taken in overdose.
DIFFERENTIAL DIAGNOSIS Neuroleptic malignant syndrome This is the most important differential diagnosis and is the more likely diagnosis where a neuroleptic agent has been started or increased in dose prior to the onset of signs and symptoms.
www.intox.org /databank/documents/treat/treate/trt44_e.htm   (576 words)

 Zoloft description, Zoloft risks, Zoloft patient information and Zoloft news.
A life-threatening condition called serotonin syndrome (serious changes in how your brain, muscles and digestive system work due to high levels of serotonin in the body) can happen when medicines called selective serotonin reuptake inhibitors (SSRIs), such as Zoloft, and medicines used to treat migraine headaches known as 5-hydroxytryptamine receptor agonists (triptans), are used together.
Serotonin syndrome may be more likely to occur when starting or increasing the dose of an SSRI or a triptan.
If you must take these medicines together, be aware of the possibility of serotonin syndrome, and get medical care right away if you think serotonin syndrome is happening to you.
www.theroadback.org /zoloft-withdrawal.htm   (1672 words)

 Australian Prescriber - Serotonin syndrome
The classic example is a combination of a selective serotonin reuptake inhibitor and a monoamine oxidase inhibitor, but it has occurred with selective serotonin reuptake inhibitors and tramadol.
Clinically, serotonin syndrome is likely to be under-reported because it is often not recognised or may be confused with neuroleptic malignant syndrome; symptoms may be mild, moderate or severe.
Serotonin syndrome appears to be self-limiting, resolving quickly when the offending drugs are discontinued, but occasionally it may be fatal.
www.australianprescriber.com /magazine/25/1/artid/569   (522 words)

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