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In the News (Tue 29 Dec 09)

  
 Serotonin-norepinephrine reuptake inhibitor - Wikipedia, the free encyclopedia
Serotonin norepinephrine reuptake inhibitors (SNRIs) are a class of antidepressant used in the treatment of clinical depression and other affective disorders.
This can be contrasted with the more widely-used selective serotonin reuptake inhibitors (SSRIs), which act only on serotonin.
Although it also works on dopamine somewhat at high dosages, the majority of its effect is on serotonin and norepinephrine.
en.wikipedia.org /wiki/Serotonin-norepinephrine_reuptake_inhibitor   (505 words)

  
 Selective norepinephrine reuptake inhibitor - Wikipedia, the free encyclopedia
The abbreviation "SNRI" is also used to mean serotonin-norepinephrine reuptake inhibitor, which can be confusing.
A selective norepinephrine reuptake inhibitor or SNRI is a drug that inhibits the reuptake of norepinephrine (known as noradrenaline outside of the USA) by neurons, so that more of this neurotransmitter remains in the synapse.
Reboxetine, another norepinephrine reuptake inhibitor unavailable in the United States and Canada, going under the trade name Edronax in the United Kingdom, has also been found to be effective at combating depression.
en.wikipedia.org /wiki/Selective_norepinephrine_reuptake_inhibitor   (151 words)

  
 Cymbalta, Duloxetine Hydrochloride Pharmacology - HealthyPlace.com
Preclinical studies have shown that duloxetine is a potent inhibitor of neuronal serotonin and norepinephrine reuptake and a less potent inhibitor of dopamine reuptake.
Therefore, because duloxetine is an inhibitor of both serotonin and norepinephrine reuptake, it is recommended that duloxetine not be used in combination with an MAOI, or within at least 14 days of discontinuing treatment with an 6 MAOI.
Monoamine Oxidase Inhibitors (MAOI) — In patients receiving a serotonin reuptake inhibitor in combination with a monoamine oxidase inhibitor, there have been reports of serious, sometimes fatal, reactions including hyperthermia, rigidity, myoclonus, autonomic instability with possible rapid fluctuations of vital signs, and mental status changes that include extreme agitation progressing to delirium and coma.
www.healthyplace.com /medications/cymbalta.asp   (4333 words)

  
 Depression Hurts - Patient Resources: Glossary for Depression
SSNRI (selective serotonin and norepinephrine reuptake inhibitor) A class of antidepressants that are thought to relieve the symptoms of depression by helping to correct an imbalance of serotonin and norepinephrine in the brain and body.
SSRI (selective serotonin reuptake inhibitor) A class of antidepressants that are thought to relieve the symptoms of depression by helping to correct an imbalance in the brain's level of serotonin.
Many experts believe that neurotransmitters such as serotonin and norepinephrine play a major role in regulating a person's moods, emotions, and feelings of pain.
www.depressionhurts.com /resources/glossary.jsp?reqNavId=3.7   (475 words)

  
 _691.html
By inhibiting the reuptake of serotonin and norepinephrine, sibutramine keeps serotonin and norepinephrine in the nerve synapse longer, lengthening the time the neurotransmitters can act.
As monoamine reuptake inhibitors, the sibutramine metabolites are active in the dopaminergic pathways.
Serotonin does play a major role in signaling satiety, but it appears that other signals from the digestive organs are required to signal behavioral satiety as well.
sulcus.berkeley.edu /mcb/165_001/papers/manuscripts/_691.html   (3141 words)

  
 Outpatient Management of Depression: The Rational Basis for the Development and Use of Newer Antidepressants
Monoamine oxidase inhibitors (MAOIs) do not directly share any mechanism of action with other classes of antidepressants, although they affect dopamine, norepinephrine, and serotonin neurotransmission via their effects on monoamine oxidase.
Antidepressants which block neuronal uptake pumps for serotonin, norepinephrine and dopamine act as indirect agonists by increasing the concentration of these neurotransmitters at their respective receptors.
Since the binding affinity of amitriptyline for the 5-HT2A and a-1 norepinephrine receptors and the serotonin uptake pump are within an order of magnitude of its affinity for the norepinephrine uptake pump, amitriptyline at usual therapeutic concentrations for antidepressant efficacy will also affect those targets.
www.preskorn.com /books/omd_s6.html   (4269 words)

  
 Food Serotonin Norepinephrine
Serotonin and norepinephrine reuptake inhibitors (SNRIs) - MayoClinic.com SNRIs are a type of antidepressant that can relieve the symptoms of depression.
Serotonin is derived from tryptophan whilst tyrosine is responsible for creating dopamine and norepinephrine...
serotonin and norepinephrine (dopamine) in our brain seems to be directly related to how we feel.
www.serotonin-net.info /serotonin/food+serotonin+norepinephrine.html   (582 words)

  
 biology - Selective serotonin reuptake inhibitor
Mirtazapine also increases levels of norepinephrine and serotonin, but it is a tetracyclic antidepressant, not a SSRI or SNRI.
SSRIs are described as 'selective' because they affect only the reuptake pumps responsible for serotonin, as opposed to earlier antidepressants, which affect other monoamine neurotransmitters as well.
As a result, the serotonin stays in the synaptic gap longer than it normally would, and has the chance to be recognized again (and again) by the receptors of the recipient cell, which can finally be stimulated that way.
www.biologydaily.com /biology/Selective_serotonin_reuptake_inhibitor   (1310 words)

  
 EFFEXOR® XR approved for the treatment of social anxiety disorder
EFFEXOR XR, already approved for the treatment of depression and generalized anxiety disorder (GAD), is the first available serotonin-norepinephrine reuptake inhibitor (SNRI), and is believed to increase the levels of two key brain chemicals thought to be deficient in individuals suffering from depression and anxiety disorders.
Serotonin and norepinephrine are thought to regulate mood and may affect motivation and sense of well-being.
EFFEXOR XR is believed to increase levels of both serotonin and norepinephrine, two of the brain chemicals thought to be implicated in depression and anxiety disorders.
www.eurekalert.org /pub_releases/2003-02/pn-ex021103.php   (705 words)

  
 Serotonin-Norepineprine Reuptake Inhibitors: Venlafaxine (Effexor)
Venlafaxine, a Serotonin-Norepinephrine Reuptake Inhibitor, is a structurally novel anti-depressant prescribed to treat depression, generalized anxiety disorder, and social anxiety disorder (social phobia).
Venlafaxine (Effexor, Efexor), described at greater length on the Venlafaxine page, is a structurally novel anti-depressant called a Serotonin-Norepinephrine Reuptake Inhibitor.
Venlafaxine is thought to work by strongly inhibiting the reuptake of the neurotransmitters serotonin (or 5-HT) and norepinephrine (also called noradrenaline in the United Kingdom) and weakly inhibiting the reuptake of the neurotransmitter dopamine.
counsellingresource.com /medications/medication-types/novel-effexor.html   (191 words)

  
 Company News On Call
The U.S. Food and Drug Administration approved Cymbalta, a balanced and potent selective serotonin and norepinephrine reuptake inhibitor (SSNRI), on Aug. 3 for the treatment of major depression.
The U.S. Food and Drug Administration has approved Cymbalta, a balanced and potent selective serotonin and norepinephrine reuptake inhibitor (SSNRI), for the treatment of major depression.
That I'm able to have fun with my friends and family and that I can live a productive life." Duloxetine hydrochloride also is being studied for the treatment of stress urinary incontinence and diabetic neuropathic pain, conditions believed to respond to treatment with both serotonin and norepinephrine.
www.prnewswire.com /cgi-bin/stories.pl?ACCT=105&STORY=/www/story/08-26-2004/0002239191   (986 words)

  
 Noradrenaline Reuptake Inhibitors
This is largely because of the advent of the selective serotonin reuptake inhibitors, which have facilitated clinical and experimental observation of the roles of serotonin.
However, the recent development of reboxetine, the first selective noradrenaline reuptake inhibitor, has allowed clinical investigation of the role of the noradrenergic system in different aspects of depressive disorders.
Selective noradrenaline reuptake inhibition, as exemplified by reboxetine, therefore offers a significant improvement in antidepressant pharmacotherapy, and an opportunity to increase our understanding of the role of noradrenaline in depression.
www.biopsychiatry.com /rebnoradren.htm   (289 words)

  
 DULOXETINE (MDXexchange)
Duloxetine is a dual-selective serotonin (5HT) and norepinephrine reuptake inhibitor (Wong et al, 1993).
Neonates exposed to serotonin and norepinephrine reuptake inhibitors (SNRIs) late in the third trimester have required prolonged hospitalization, respiratory support, and tube feeding.
All three agents have been demonstrated to inhibit norepinephrine and 5HT uptake in preclinical studies; both duloxetine and venlafaxine were more potent inhibitors of 5HT than norepinephrine reuptake, whereas milnacipran was a more potent inhibitor of norepinephrine uptake (Goodnick, 1999; Artigas, 1995).
www.micromedex.com /products/updates/drugdex_updates/de/duloxetine.html   (3750 words)

  
 Medical Question - Norepinephrine Antidepressant
Serotonin and Norepinephrine Antidepressant Effects* CME Atomoxetine andreboxetine are specific norepinephrine reuptake inhibitors that have not yet
Selective serotonin reuptake inhibitors (SSRIs) specifically prevent the reuptake of
norepinephrine, serotonin, or dopamine at the synapse to restore equilibrium to neurotransmitter activity.
www.scalextricincardiff.com /norepinephrine-antidepressant.htm   (203 words)

  
 Lexapro: Glossary of terms about depression and anxiety.
It is an SNRI (serotonin and norepinephrine reuptake inhibitor) and is believed to help treat depression and the associated symptoms of anxiety by affecting the level of two chemicals in the brain—serotonin and norepinephrine.
Paxil is a selective serotonin reuptake inhibitor (SSRI) that treats the symptoms of these conditions by restoring the balance of serotonin in the brain.
ZOLOFT is a selective serotonin reuptake inhibitor (SSRI) prescription medicine used to treat depression, panic disorder, obsessive-compulsive disorder (also called OCD), and posttraumatic stress disorder (also called PTSD) in adults.
www.lexapro.com /english/resources/glossary.aspx   (1317 words)

  
 How AMORYN Works - HOW AMORYN WORKS - Natural Reuptake Inhibitor - Serotonin, Norepinephrine, Dopamine, GABA
By providing an all-natural boost to serotonin, dopamine, norepinephrine, and GABA, the ingredients in AMORYN can help you feel happy, calm, and confident.
By boosting levels of serotonin, norepinephrine, dopamine, and GABA, AMORYN can help you feel calm and in control.
Serotonin is known as the "feel good" neurotransmitter because it plays an important role in the regulation of mood.
www.amoryn.com /howamorynworks.html   (488 words)

  
 Obstetrics and Gynecology, December 2001
In conclusion, this study showed that venlafaxine, a selective serotonin and norepinephrine reuptake inhibitor, is effective in the treatment of PMDD.
This study evaluated the effects of venlafaxine, a selective serotonin and norepinephrine reuptake inhibitor, on PMDD.
2001;95(5):737-744

Summary

Venlafaxine, a selective serotonin and norepinephrine reuptake inhibitor, is effective in the treatment of premenstrual dysphoric disorder.
www.medscape.com /content/2001/00/41/10/411093/411093.xml   (7474 words)

  
 The Selective Norepinephrine Reuptake Inhibitor, LY368975, Reduces Food Consumption in Animal Models of Feeding -- Gehlert et al. 287 (1): 122 -- Journal of Pharmacology And Experimental Therapeutics
Wong DT, Bymaster FP, Mayle DA, Reid LR, Krushinski JH and Robertson DW (1993) LY248686, a new inhibitor of serotonin and norepinephrine uptake.
Fuller RW, Perry KW and Molloy BB (1974) Effect of an uptake inhibitor on serotonin metabolism in rat brain: studies with 3(p-trifluoromethylphenoxy)-N-methyl-3-phenylproylamine (Lilly 110140).
Wong DT, Horng JS and Bymaster FP (1975) dl-N-methyl-3-(p-methoxyphenoxy)-3-phenylpropylame hydrochloride, Lilly 94939, a potent inhibitor for uptake of norepinephrine into rat brain synaptosomes and heart.
www.jpet.org /cgi/content/full/287/1/122   (3882 words)

  
 Psychiatric Times
Duloxetine, an investigational antidepressant progressing in the Eli Lilly development pipeline as the fluoxetine patent expires, is a dual reuptake inhibitor of serotonin and norepinephrine.
Another noradrenergic agent, reboxetine (Vestra), which is a selective norepinephrine reuptake inhibitor now under review by the U.S. Food and Drug Administration for treating depression, was evaluated for depression, anxiety and panic disorder in three separate studies.
The safety of iloperidone was evaluated for psychotic and behavioral symptoms in elderly patients with dementia in flexible daily doses of 0.5 mg to 6 mg in a placebo-controlled study sponsored by Novartis Pharmaceuticals.
www.psychiatrictimes.com /p011136.html   (1918 words)

  
 DepressionHurts.com - Treatment for depression
Cymbalta is in a class of medications called selective SNRIs (selective serotonin and norepinephrine reuptake inhibitor), and is FDA-approved for the treatment of depression.
Many researchers believe depression is caused by an imbalance of naturally occurring chemicals, serotonin and norepinephrine, in the brain and the body.
If your doctor recommends medication, be sure to talk to your doctor about medications that affect both serotonin and norepinephrine.
www.depressionhurts.com /options/options.jsp?reqNavId=4   (425 words)

  
 Cuddles 'n Kisses: Some Antidepressants in Late Pregnancy May Affect Babies
Women who take selective serotonin reuptake inhibitor (SSRI) or serotonin norepinephrine reuptake inhibitor antidepressants in the last three months of pregnancy increase the chances their babies will suffer respiratory problems, irritability and jitteriness during the first few weeks of life, a new study says.
SSRIs include Paxil and Prozac while Effexor is a serotonin norepinephrine reuptake inhibitor.
Posted by Robin at May 18, 2005 08:13 PM Comments
cuddlesnkisses.com /blog/archives/2005/05/some_antidepres.html   (136 words)

  
 Nutrition Research Newsletter: Treating binge eating disorder with sibutramine - Eating Disorders - serotonin and norepinephrine reuptake inhibitor - Author Abstract
Sibutramine, a serotonin and norepinephrine reuptake inhibitor, commonly used for the treatment of obesity, has been shown to be consistently effective in weight loss across a variety of studies.
Treating binge eating disorder with sibutramine - Eating Disorders - serotonin and norepinephrine reuptake inhibitor - Author Abstract
Nutrition Research Newsletter: Treating binge eating disorder with sibutramine - Eating Disorders - serotonin and norepinephrine reuptake inhibitor - Author Abstract
www.findarticles.com /p/articles/mi_m0887/is_6_22/ai_104439017   (739 words)

  
 Charlotte.com - Your Guide to Charlotte
The royalty payments are based on Lilly's United States sales of Cymbalta(R) (duloxetine hydrochloride), a selective serotonin and norepinephrine reuptake inhibitor approved by the U.S. Food and Drug Administration for the treatment of major depressive disorder and the management of diabetic peripheral neuropathic pain in adults.
Payments of principal and interest on the notes will be made solely out of royalty and other payments to be made under an existing agreement between Quintiles and Eli Lilly and Company (NYSE: LLY) ("Lilly").
Quintiles will sell its rights to the royalty and certain other payments under the agreement to Royalty Sub, which will purchase the rights using the net proceeds from the sale of the notes.
www.prnewswire.com /cgi-bin/stories.pl?ACCT=ncharlotte.story&STORY=/www/story/08-19-2005/0004091228&EDATE=Aug+19,+2005   (521 words)

  
 Efficacy of duloxetine, a potent and balanced serotonin-norepinephrine reuptake inhibitor in persistent pain models in rats -- Iyengar et al., 10.1124/jpet.104.070656 -- Journal of Pharmacology And Experimental Therapeutics
Efficacy of duloxetine, a potent and balanced serotonin-norepinephrine reuptake inhibitor in persistent pain models in rats
Efficacy of duloxetine, a potent and balanced serotonin-norepinephrine reuptake inhibitor in persistent pain models in rats -- Iyengar et al., 10.1124/jpet.104.070656 -- Journal of Pharmacology And Experimental Therapeutics
Serotonin (5-HT) and norepinephrine (NE) are implicated in modulating
jpet.aspetjournals.org /cgi/content/short/jpet.104.070656v1   (351 words)

  
 WebMD Health - Patient Handout for
This medication is an antidepressant (serotonin-norepinephrine reuptake inhibitor type) used in the treatment of depression.
Avoid taking MAO inhibitors (e.g., furazolidone, isocarboxazid, linezolid, moclobemide, phenelzine, procarbazine, selegiline, tranylcypromine) within 2 weeks before or 7 days after treatment with this medication.
Watch for these symptoms especially at a time of antidepressant dosage change, or when an antidepressant medicine is being started.
aolsvc.health.webmd.aol.com /drugs/mono-5047-VENLAFAXINE+-+ORAL.aspx?d...   (1339 words)

  
 Duloxetine: A Dual Reuptake Inhibitor -- Dugan and Fuller 38 (12): 2078 -- The Annals of Pharmacotherapy
Key Words: duloxetine, major depressive disorder, serotoninnorepinephrine reuptake inhibitor
Duloxetine: A Dual Reuptake Inhibitor -- Dugan and Fuller 38 (12): 2078 -- The Annals of Pharmacotherapy
Articles by Dugan, S. Articles by Fuller, M. Duloxetine: A Dual Reuptake Inhibitor
www.theannals.com /cgi/content/abstract/38/12/2078   (297 words)

  
 Selective Serotonin Reuptake Inhibitor (SSRI) « Antidepressant Prescription Drugs & Medications « On-line Pharmacy « BoMi Health Directory
Selective Serotonin uptake Inhibitor (SSRIs)• Prozac (fluoxetine) • Paxil (paroxetine) • Zoloft (sertraline) • Seroxat/Paxil • Celexa (citalopram) • Lexapro (escitalopram) • Luvox (fluvoxamine) • dapoxetine Serotonin and norepinephrine uptake inhibitors: • Effexor (venlafaxine) • Serzone (nefazodone)...
Selective Serotonin Reuptake Inhibitor (SSRI) « Prescription Drugs and Medications for depression, generalised anxiety disorder (GAD), phobias, obsessive-compulsive disorder (OCD), social anxiety disorder (social phobia), panic attack, post traumatic stress disorder (PTSD), compulsions, obsessions, premature ejaculation, shyness, etc....
Stop Premature Ejaculation Drug Therapy SSRI (selective serotonin reuptake inhibitors)...
www.bomi.info /directory/pharmacy/ssri.htm   (217 words)

  
 Venlafaxine Consulting Mental Health News Articles
Effexor is chemically unrelated to other antidepressants, but is sometimes catagorized as a serotonin-norepinephrine reuptake inhibitor (SNRI).
At high dosages, Effexor blocks the reuptake of serotonin and norepinephrine, and has a weak affinity for blocking dopamine reuptake.
At medium dosages, Effexor blocks the reuptake of norepinephrine as well as serotonin.
psych.consultinghealth.com /article_89.html   (275 words)

  
 Boston.com / Your Life / Health & Fitness / British Warn on Antidepressants for Adults
It said treatment with the drug, which is a selective serotonin and norepinephrine reuptake inhibitor, "should only be initiated by specialist mental health practitioners" and "there should be arrangements in place for continuing supervision of the patient." The drug should not be used in patients with heart disease, it said.
The authority took particular issue with an antidepressant that is not an S.S.R.I., Efexor, which is made by Wyeth and marketed in the United States as Effexor, because of its concerns about heart damage and a heightened danger from overdose.
Efexor accounted for $2.7 billion in sales last year and is Wyeth's top-selling drug.
www.boston.com /yourlife/health/other/articles/2004/12/07/british_warn_on_antidepressants_for_adults   (525 words)

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