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Topic: Sertindole

In the News (Tue 29 Dec 09)

Northern Trust

Marvin Harrison

Peter Chernin

Gary Locke

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Mickey Rourke

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Hugh Jackman

	Focus on sertindole - was an antipsychotic agent introduced by Lundbeck
		Sertindole is reported to have an anxiolytic property, to be not sedating and not to impair cognitive functions.
		Sertindole is metabolised in the liver mediated by cytochromes p450 2D6 and P450 3A.
		Sertindole is contraindicated with drugs known to prolong the QT interval like terfenadine, astemizole, thioridazine, quinidine, procainamide, betrylium, sotalol, tricyclic and teteracyclic antidepressants.
	www.priory.com /focus5.htm (1686 words)

	Sertindole: efficacy and safety in schizophrenia.
		Sertindole is an antipsychotic drug with affinity for dopamine D2, serotonin 5-HT2A and 5-HT2C, and alpha1-adrenoreceptors.
		Preclinical studies suggest that sertindole acts preferentially on limbic and cortical dopaminergic neurons and clinical trials have confirmed that sertindole is effective at a low dopamine D2 occupancy level.
		Sertindole should not be used as first-line treatment for first-episode patients with schizophrenia because of the QTc prolongation.
	counsellingresource.com /medications-research/2006/08/25/sertindole-efficacy-and-safety-in-schizophrenia (461 words)

	Sertindole for schizophrenia
		Sertindole was associated with fewer movement disorders than haloperidol, but was shown to cause more weight gain and the possible side effect of male sexual dysfunction.
		Sertindole is an atypical antipsychotic, which is thought to give a lower incidence of extrapyramidal side effects at clinically effective doses than typical antipsychotic drugs.
		Sertindole at 20mg/day was found to be more effective than placebo in terms of BPRS total scores (1 study, n=78, MD 6.2, CI -11.8 to -0.6) and CGI total end point scores (1 study, n=78, MD -0.9, CI -1.6 to -0.2).
	www.cochrane.org /reviews/en/ab001715.html (1301 words)

	Treatments for schizophrenia - Sertindole
		The situation in the UK is that sertindole was given a license again in 2002, subject to strict post-marketing monitoring and under strict guidelines.
		The main effect that sertindole has is to block some dopamine receptors in the brain, reducing the effect of having too much dopamine and correcting the imbalance.
		Sertindole tablets should be swallowed with at least half a glass of water whilst sitting or standing.
	www.nmhct.nhs.uk /pharmacy/dsertind.htm (2305 words)

	SERTINDOLE SHOWS PROMISE IN SCHIZOPHRENIA
		use of Serlect (sertindole) in the treatment of psychosis.
		all doses of sertindole and haloperidol were associated with significant
		As demonstrated in pre-clinical studies, sertindole is a potent
	www.schizophrenia.com /news/sertindole.html (481 words)

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