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Ultane (Sevoflurane) drug description - prescription drugs and medications at RxList Sevoflurane is not corrosive to stainless steel, brass, aluminum, nickel-plated brass, chrome-plated brass or copper beryllium. Sevoflurane degradation and subsequent degradant formation are enhanced by increasing absorbent temperature increased sevoflurane concentration, decreased fresh gas flow and desiccated CO absorbents (especially with potassium hydroxide containing absorbents e.g. In a clinical study in which sevoflurane was administered to patients under low flow conditions for ≥ 2 hours at flow rates of 1 Liter/minute, Compound A levels were measured in an effort to determine the relationship between MAC hours and Compound A levels produced. www.rxlist.com /cgi/generic/sevoflurane.htm   (1041 words)

Sevoflurane - Encyclopedia, History, Geography and Biography Sevoflurane (2,2,2-trifluoro-1-[trifluoromethyl] fluoromethyl ether), also called fluoromethyl, is a sweet-smelling, non-flammable, highly fluorinated methyl isopropyl ether used for induction and maintenance of general anesthesia. In contact with the soda lime in a rebreathing apparatus that serves as carbon dioxide absorber sevoflurane forms at least two degradation products, Compound A [fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether] and Compound B [1,1,1,3,3-pentafluoro-2-(fluoromethoxy)-3-methoxypropane], especially at higher temperatures and when the soda lime is desiccated. As a result, sevoflurane is sometimes administered with a minimum fresh gas flow of 2 liters per minute, making it a relatively expensive choice for maintaining general anesthesia. www.arikah.com /encyclopedia/Sevoflurane   (311 words)

Ultane side effects (Sevoflurane) and drug interactions - prescription drugs and medications at RxList Sevoflurane administration is compatible with benzodiazepines and opioids as commonly used in surgical practice. As is the case with other volatile anesthetics, sevoflurane increases both the intensity and duration of neuromuscular blockade induced by nondepolarizing muscle relaxants. An unusually delayed rise or unexpected decline of inspired sevoflurane concentration compared to the vaporizer setting may be associated with excessive heating of the CO absorbent and chemical breakdown of sevoflurane. www.rxlist.com /cgi/generic2/sevoflurane_ad.htm   (1221 words)

Sevoflurane Vs Desflurane The purpose of this study was to compare the haemodynamic, emergence and recovery characteristics of sevoflurane with those of desflurane in nitrous oxide anaesthesia. End-tidal concentrations of sevoflurane and desflurane were 1.5 % ± 0.4 % and 4.5 % ± 1.5 % respectively, at the end of the operation. The effect of anesthetic duration on kinetic and recovery characteristics of desflurane versus sevoflurane, and on the kinetic characteristics of compaund A, in volunteers. www.ispub.com /ostia/index.php?xmlFilePath=journals/ija/vol9n1/sevoflurane.xml   (2166 words)

MedicineHouse.com Sevoflurane is less of an irritant to the upper respiratory tract than desflurane, causing less coughing and laryngospasm on induction. Sevoflurane attenuates baroreceptor reflex responses (tachycardia) to hypotension and vasomotor reflex responses (increased peripheral resistance) to hypovolemia. Sevoflurane like isoflurane may produce a dose-related decrease in the amplitude and increase in the latency of cortical components of visual and auditory evoked potentials. www.medicinehouse.com /cgi-bin/drug1.php?drug=sevoflurane   (1122 words)

Data Sheet The defluorination of sevoflurane is not inducible by barbiturates. Sevoflurane should not be used in patients with known sensitivity to sevoflurane or to other halogenated agents or with known or suspected genetic susceptibility to malignant hyperthermia. Sevoflurane has been shown to be safe and effective when administered concurrently with a wide variety of agents commonly encountered in surgical situations such as central nervous system agents, autonomic medicines, smooth muscle relaxants, anti-infective agents including aminoglycosides, hormones and synthetic substitutes, blood derivatives and cardiovascular medicines including epinephrine. www.medsafe.govt.nz /Profs/datasheet/s/Sevoraneinh.htm   (3275 words)

Baxter Launches First Sevoflurane in China and Announces Phased Launch in Other Countries in 2006   Baxter's sevoflurane is chemically and therapeutically equivalent to Ultane ® (Abbott Laboratories). Sevoflurane is indicated for induction and maintenance of general anesthesia in adult and pediatric patients for inpatient and outpatient surgery. Inhalational anesthetic agents, including sevoflurane can cause malignant hyperthermia and should not be used in patients with known sensitivity to sevoflurane nor in patients with known or suspected susceptibility to malignant hyperthermia. www.baxter.com /about_baxter/news_room/news_releases/2005/12-12-05-sevoflurane.html   (525 words)

The distribution of sevoflurane in a sevoflurane induced death. Burrows DL, Nicolaides A, Stephens GC, Ferslew KE . ...   (Site not responding. Last check: ) Abstract: The distribution of sevoflurane (fluoromethyl 2,2,2,-trifluoro-1-(trifluoromethyl) ethyl ether) in blood, urine, liver, kidney, vitreous humor, and tracheal aspirate is presented from a subject with a sevoflurane induced death. Sevoflurane is a nonflammable general anesthetic administered by inhalation of vaporized liquid. The official cause of death was respiratory suppression by sevoflurane and the manner of death was unclear. journalsip.astm.org /jofs/PAGES/4463.htm   (304 words)

Reference.com/Encyclopedia/Sevoflurane Sevoflurane (2,2,2-trifluoro-1-[trifluoromethyl]ethyl fluoromethyl ether), also called fluoromethyl, is a sweet-smelling, non-flammable, highly fluorinated methyl isopropyl ether used for induction and maintenance of general anesthesia. Sevoflurane forms at least two degradation products, Compound A [fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether] and Compound B [1,1,1,3,3-pentafluoro-2-(fluoromethoxy)-3-methoxypropane], on contact with the soda lime in a rebreathing apparatus, which absorbs exhaled carbon dioxide, especially at higher temperatures and when the soda lime is desiccated. As a result, sevoflurane is sometimes administered with a minimum fresh gas flow of 2 liters per minute, making it a relatively expensive choice for maintaining general anesthesia. www.reference.com /browse/wiki/Sevoflurane   (311 words)

Sevoflurane Sevoflurane is a potent inhalational agent that is taken up and eliminated nearly as rapidly as desfiurane and nitrous oxide. Although in many respects sevoflurane resembles an ideal anesthetic, it has several problems First, the compound is extremely expensive Second, sevoflurane is metabolized to both fluoride and "compound A.'1 Fluoride appears to be only a theoretical complication, probably because the drug is rapidly eliminated and fluoride levels remain elevated for only a brief interval. Compound A is released by the reaction between sevoflurane and C02 absorbers (soda lime and Baralyme). www.anesth.utmb.edu /Venable/Students/Introduction/22sevo.html   (211 words)

Sevoflurane Drug Information, Professional Sevoflurane increases carbon dioxide tension and decreases ventilatory response to increased carbon dioxide concentrations Sevoflurane is associated with a higher incidence of emergence excitation in children than is halothane, perhaps due to earlier emergence and the resultant earlier experience of pain in children receiving sevoflurane MAC values for sevoflurane in oxygen are 3.3% for neonates, 3% for infants less than 6 months of age, 2.8% for infants and children 6 months to 3 years of age, and 2.5% for children 3 to 12 years of age. www.drugs.com /mmx/sevoflurane.html   (5025 words)

This article is reprinted from: Sevoflurane may be even better for avian species once it becomes more commonly used. Sevoflurane is a new agent and costs about four times more than isoflurane when compared on an ml/ml basis. Facemask induction usually begins with 4-5% of halothane, isoflurane, or 5-8% sevoflurane and continues until the animal is unconscious and able to be intubated. www.vetequip.com /knowledge/knowPharm-Inh_Anes.htm   (1737 words)

Method of elimination of volatile degradation products of sevoflurane during anesthesia - Patent 5492111 In the process of using sevoflurane as a rapid anesthetic, breakdown of the anesthetic to harmful compound A is slowed if not stopped altogether by cooling the CO.sub.2 scrubber to temperatures that still allow it to work effectively as scrubber but avoid sevoflurane degradation. Further, sevoflurane is a volatile liquid, nonflammable in air at ambient temperatures and has a lower flammability limit in oxygen of about 11.8 volume percent, making it safe to use as well. Sevoflurane at an initial concentration of 2.7% (a relatively high anesthetic concentration) was added to the circuit and 100% oxygen was used as the makeup gas. www.freepatentsonline.com /5492111.html   (4059 words)

Carilion - Sevoflurane(Inhalation-Systemic) - [Medication] Sevoflurane is used to cause general anesthesia (loss of consciousness) before and during surgery. Sevoflurane may cause children to become agitated (excited) when it is used to start anesthesia when they are awake. Sevoflurane may cause some people to feel drowsy, tired, or weak for a while after they receive it. www.carilion.com /kbase/htm/mdx-/drde/2027/93/mdx-drde202793.htm   (850 words)

The distribution of sevoflurane in a sevoflurane induced death The distribution of sevoflurane (fluoromethyl 2,2,2,-trifluoro-1-(trifluoromethyl) ethyl ether) in blood, urine, liver, kidney, vitreous humor, and tracheal aspirate is presented from a subject with a sevoflurane induced death. Sevoflurane is a nonflammable general anesthetic administered by inhalation of vaporized liquid. The official cause of death was respiratory suppression by sevoflurane and the manner of death was unclear. www.astm.org /DIGITAL_LIBRARY/JOURNALS/FORENSIC/PAGES/4573.htm   (371 words)

Sevoflurane: The Challenges of Safe Formulation sevoflurane is consistent with the known ability of water to prevent Lewis acid-mediated sevoflurane degradation. The 1996 Lewis acid degradation of original low-water sevoflurane to HF was considered a clinically significant safety issue prompting widespread practitioner notification and reformulation of sevoflurane to contain at least 300 ppm water as a Lewis acid inhibitor. Recent laboratory and clinical case reports that demonstrate degradation of lower-water sevoflurane to toxic and corrosive hydrogen fluoride, and damage to vaporizers, suggest that the higher- and lower-water sevoflurane formulations may not have the same safety profile. www.apsf.org /resource_center/newsletter/2007/fall/03_sevoflurane.htm   (1125 words)

Pharmacology: Inhalation Anesthetics   (Site not responding. Last check: ) Sevoflurane 1) has a lower blood/gas solubility; 2) it does not irritate airway and stimulate excessive secretions; 3) it lacks of pungency and allows animal to accept the inhalant with ease, 4) the vaporizer of sevoflurane can be set as high as 7-8% to pressurize the inhalant into the patient’s lungs. Sevoflurane is a newest inhalant agent and cost about 4-5 times more than isoflurane when compared on a ml/ml basis. Sevoflurane is superior to isoflurane and halothane for inhalant anesthetic induction less irritation to the airway and faster speed of induction, and lack of pungency. www.cvm.okstate.edu /courses/vmed5412/LECT008.htm   (2357 words)

MEDLINE_1966-1995 - Resultado de la búsqueda <página 1> Sevoflurane did not alter heart rate, but decreased mean arterial pressure and mean pulmonary artery pressure. Sevoflurane caused a greater decrease in mean pulmonary artery pressure than did isoflurane, but the cardiovascular effects were otherwise similar. The cardiovascular effects of sevoflurane were similar to those of isoflurane, an anesthetic commonly used in clinical practice since 1981. www.bireme.br /cgi-bin/wxislind.exe/iah/online/?IsisScript=iah/iah.xis&nextAction=lnk&base=MEDLINE_1966-1995&exprSearch=7486177&indexSearch=UI&lang=e   (387 words)

References Economic considerations of the use of new anesthetics: a comparison of propofol, sevoflurane, desflurane, and isoflurane. A comparison of airway responses during desflurane and sevoflurane administration via a laryngeal mask airway for maintenance of anesthesia. The effect of anesthetic duration on kinetic and recovery characteristics of desflurane versus sevoflurane, and on the kinetic characteristics of compound A, in volunteers. www.medscape.com /content/2005/00/49/78/497811/497811_ref.html   (799 words)

Sevoflurane ( Ultane) Following induction of anaesthesia with propofol, awakening from sevoflurane is faster compared to isoflurane, faster or similar compared to propofol and comparable (in the majority of studies) to desflurane. Sevoflurane may also be used to induce anaesthesia, which is generally well-received and causes less hypotension and apnoea compared to propofol. The tolerability and low solubility of sevoflurane facilitate titration of anaesthesia and may reduce the need for opioid analgesia, which in turn may limit the occurrence of nausea and vomiting. www.general-anaesthesia.com /sevoflurane.html   (151 words)

Sevoflurane facts and comparsions at Drugs.com Sevoflurane is usually administered by your doctor or other health care provider during surgery. Using Sevoflurane alone, with certain other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks. Sevoflurane is to be used only by the patient for whom it is prescribed. www.drugs.com /cdi/sevoflurane.html   (777 words)

Nasotracheal Intubation With Sevoflurane / Vecuronium Anesthesia In Elderly Patients Sevoflurane induction is smooth and pleasant for inhalation. Sevoflurane was added slowly one MAC after every three breath up to 5% and ETC02 was maintained at 35±3, induction time were noted after observing loss of eye lash reflex and finger tapping test which was found to be 90 sec. In conclusion, sevoflurane induction and intubation after neuromuscular block with vecuronium bromide in both elderly patients was found to be very stable haemodynamically. www.ispub.com /ostia/index.php?xmlFilePath=journals/ija/vol12n1/sevo.xml   (1273 words)

Sevoflurane Sevoflurane is a general inhalation anesthetic used for induction and maintenance of general anesthesia. Sevoflurane also binds to the GABA receptor, the large conductance Ca activated potassium channel, the glutamate receptor and the glycine receptor. Isoflurane and sevoflurane are currently accepted as the safest gas anesthesia veterinarians have available to their patients. www.mongabay.com /health/medications/Sevoflurane.html   (2703 words)

Sevoflurane versus isoflurane for maintenance of anesthesia: are serum inorganic fluoride ion concentrations of concern?   (Site not responding. Last check: ) Sevoflurane administration can result in increased serum inorganic fluoride ion concentrations, which have been associated with inhibition of renal concentrating ability. Fifty patients were exposed to sevoflurane (< or = 2.4% inspired concentration) or isoflurane (< or = 1.9% inspired concentration) for maintenance of anesthesia as part of a multicenter trial. Mean serum fluoride levels were significantly increased in sevoflurane versus isoflurane groups at all time points; the mean peak serum levels were 28.2 ± 14 mmol/L at 1 h for sevoflurane and 5.08 ± 4.35 mmol/L at 12 h for isoflurane. www.fluoride-journal.com /97-30-2/302-129.htm   (352 words)

Virtual Mass Spectrometry Laboratory   (Site not responding. Last check: ) Also called Ultane, sevoflurane is another volatile liquid anesthetic that is used independently to induce anesthesia. Sevoflurane is used with extreme caution, however, as its reactivity with carbon dioxide (CO) related derivatives can cause kidney damage. Those who are administered sevoflurane for a surgical procedure rise from the state of unconsciousness quickly. chemed.chem.pitt.edu /VMSL/genanes/sevoflurane.html   (69 words)

KSUPET-L   (Site not responding. Last check: ) Diane E. Mason, assistant professor of clinical sciences, says Sevoflurane, a relatively new inhalation anesthetic, is used on various animals at K-State's Veterinary Medical Teaching Hospital and has certain advantages when used on small animals like birds or other wildlife, and large animals like horses. Sevoflurane is delivered through the respiratory system in two ways. An animal may receive an injectable drug so a tube can be inserted in the trachea and Sevoflurane is then inhaled, or a mask may be placed on the animal so it breathes in the drug before any procedures begin. www.iwane.org /ksupet_sevo.htm   (519 words)

Sevoflurane(Inhalation-Systemic) - [Medication]   (Site not responding. Last check: ) Sevoflurane is used to cause general anesthesia (loss of consciousness) before and during surgery. Sevoflurane may cause children to become agitated (excited) when it is used to start anesthesia when they are awake. Sevoflurane may cause some people to feel drowsy, tired, or weak for a while after they receive it. www.luhs.org /health/kbase/htm/mdx-/drde/2027/93/mdx-drde202793.htm   (850 words)

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