
	Where results make sense

Topic: Sialic acid

Related Topics

amino acid

nucleic acid

fatty acid

hydrochloric acid

nitric acid

sulfuric acid

The Acid House

acetic acid

carboxylic acid

citric acid cycle

lactic acid

acid rain

In the News (Thu 16 Feb 12)

EXECUTIVE POWER

Iran

ANALYSIS

Pakistan

Family compact

	Sialic Acid
		Sialic acid is one of the small chemicals which is a component of a number of more complex chemical structures in the human body.
		A disturbance in a gene responsible for sialic acid metabolism may lead to an abnormality reflected in sialic acid concentration in blood, urine and solid tissue.
		Sialic acid can be analyzed in cells cultured from solid tissue such as skin, or can be measured in blood or urine.
	www.ggc.org /Diagnostics/Biochemical/sialic_acid.htm (241 words)

	Sialic acid specific slug lectin
		The sialic acid or sialoprotein specific lectin of the present invention is derived from the slug, Limax flavus, by homogenization of the slug tissue to release the lectin from the slug tissues with which it is associated and is partially purified by ammonium sulfate fractionation.
		The high degree of specificity of the slug lectin for sialic acid and sialoproteins enables the provision of a diagnostic method for quantitating the amount of sialic acid or sialoproteins in a biological liquid by determining its inhibitory effect on the agglutination of erythrocytes by the slug lectin.
		The acid hydrolytic release of AcNeu from glycoproteins was accomplished by incubation of the glycoprotein in 0.1N H.sub.2 SO.sub.4 at 80.degree.
	www.nmbest.biz /scitechcatalog/field_game/sialic_acid_specific_slug_lectin.html (6455 words)

	Sialic acid society
		Sialic acid residues are located at the non-reducing terminals in glycoconjugates, and which considered play important roles at the cell surface as glycoconjugates, such as glycolipids, gangliosides, and glycoproteins.
		Sialic acids are acidic monosaccharides, which are among the most important molecules of higher animals, and occur in some microorganisms.
		Sialic acid substituents strongly influence the activity of catabolic enzymes, in particular the sialidases, and thus the turnover rate of glycoconjugates.
	sialic.hp.infoseek.co.jp /eindex.html (764 words)

	PainOnline.com: Gangliosides, NCAMs, and Sialic Acid in Central Pain, by Karyn McHenry
		Scientists are struggling their way through the sialic acid cycle and there is no better evidence that this is research whose time has arrived than the article on C fibers by El Maarouf et al from Sloan Kettering in the July edition of the Proceedings of the National Academy of Sciences.
		Sialic acid is one of the sugary proteins which stick out from the surface of cells and lead to cell-cell recognition, adhesion, interaction, and plasticity (ability to change).
		These glycoproteins determine to a considerable degree the efficiency of cell cell interaction and confusion and disorder in the sialic acid pathways is felt to be related to deafferentation, central pain, and hypersensitization.
	www.painonline.com /mt-archives/2005/08/gangliosides_an.html (1107 words)

	Lipids in Health and Disease \| Full text \| Relationship between Sialic acid and metabolic variables in Indian type 2 ...
		Plasma sialic acid is a marker of the acute phase response.
		Plasma sialic acid is one of the markers for acute phase response [5].
		Sialic acid is a terminal component of the non-reducing end of carbohydrate chains of glycoproteins and glycolipids [6].
	www.lipidworld.com /content/4/1/15 (2382 words)

	N-Acetylneuraminic acid--R&S PharmChem Co.,Ltd.
		Sialic acid is a derivative of a nine-
		Sialic acid is widely distributed throughout human tissues and found in several fluids, including serum, cerebrospinal fluid, saliva, urine, amniotic fluid, and mother's milk.
		Sialic acid is also found in such other tissues as the skin and testes leading to speculation that disruptions like skin diseases and reproductive problems could be reversed with supplementation of this essential sugar.
	www.rspharmchem.com /acetylneuraminic_acid.htm (1237 words)

	About Us \| Marukin Bio
		N-Acetylneuraminic acid (sialic acid : NeuAc) was prepared from colominic acid by neuraminidase
		Sialic acid assay kit for clinical use was developed.
		Bile acid sulfate assay kit (manual:UBASTEC) for clinical use was developed.
	www.marukin-bio.com /english/company (312 words)

	Rare Pediatric Disease Database (Site not responding. Last check: 2007-09-18)
		The free sialic acid storage diseases are a spectrum of rare, inherited, neurodegenerative disorders that are a result of the abnormal accumulation of a compound known as sialic acid within the body.
		The cause of free sialic acid storage diseases is a defect in a key protein that allows for transport of the sialic acid out of the body’s cells.
		Sialic acid storage diseases are inherited in an autosomal recessive manner, meaning that an affected child must inherit two defective copies of this gene.
	www.madisonsfoundation.org /content/3/1/display.asp?did=445 (450 words)

	Conversion of cellular sialic acid expression from N-acetyl- to N-glycolylneuraminic acid using a synthetic precursor, ...
		Sialic acid concentrations (per mg total cell protein) in the intracellular precursor pool, gangliosides, and glycoproteins are shown as indicated.
		Sialic acids released from bovine submaxillary mucin, which contain primarily O-acetylated forms of NeuAc (as well as NeuAc, NeuGc, and O-acetylated forms of NeuGc) were prepared as described (Varki and Diaz, 1984) and used as positive controls.
		Herrmann,M., von der Lieth,CW., Stehling,P., Reutter,W. and Pawlita,M. (1997) Consequences of a subtle sialic acid modification on the murine polyomavirus receptor.
	glycob.oxfordjournals.org /cgi/content/full/10/1/11 (5712 words)

	Nizet Lab Research - Bacterial Sialic Acid & Host Siglecs
		Ajit Varki, we have embarked on a series of interrelated projects that explore the role of the sugar sialic acid in microbial virulence and innate immunity.
		Sialic acids are a family of sugars present in abundance on the cell surface of all mammalian cells with important roles in biology, development, and evolution.
		Sialic acid O-acetylation is known to have significant effects on the ability of the sugar to engage and activate these leukocyte receptors.
	medicine.ucsd.edu /nizetlab/ResearchPage/SialicAcid/Index.html (590 words)

	The Individualist: Neuraminic acid
		Sialic acid is the group name for the acetylated neuraminic acids, such as N-acetyl neuraminic acid (NANA), N-glycolyl neuraminic acid and Di-acetyl neuraminic acid.
		Old red blood cells have less sialic acid on their surface than young ones, and so it has been postulated that the decrease of sialic acid is the sign responsible for the removal of the older red blood cells from the circulatory system.
		In spite of these striking correlations there is considerable doubt whether the removal of sialic acid and the exposure of galactose units on the surface of the red blood cell are responsible for the removal of senescent red cells from the blood under physiological conditions in vivo.
	www.dadamo.com /wiki/wiki.pl/Neuraminic_acid (500 words)

	Free sialic acid storage disease
		Free Sialic Acid Storage Disease (SSD) or Salla disease is a lysosomal storage disease.
		The disease is caused by a defective sialic acid transporter (called sialin) in the lysosome membrane.
		Biologically, increased urinary excretion and storage of free sialic acid in fibroblasts, the trophoblast, or amniocytes, are diagnostic.
	www.orpha.net /static/GB/free_sialic_acid_storage_disease.html (198 words)

	Sialic Acid - Unexplained Mysteries Discussion Forums
		* Abnormalities in sialic acid metabolism are seen in infants who fail to grow, who regress in development, who have enlarged livers and/or spleens, who show a coarsening of facial features, and who display a failure to produce pigmentation of the skin and hair.
		The alpha-anomeric form of sialic acid is the minimal receptor determinant recognized...
		The N-terminal amino acid sequence of the peptide was analyzed using a Perkin Elmer Applied Biosystems 473A Protein Sequencer.
	www.unexplained-mysteries.com /forum/index.php?showtopic=83964 (3458 words)

	Acetylated sialic acid residues and blood group antigens localise within the epithelium in microvillous atrophy ...
		Acetylated sialic acid residues and blood group antigens localise within the epithelium in microvillous atrophy indicating internal accumulation of the glycocalyx -- Phillips et al.
		sialic acid was identified in goblet cells and in crypt epithelium
		Differences between the O-acetylated sialic acids of the epithelial mucins of human colonic tumors and normal controls: a correlative chemical and histochemical study.
	gut.bmjjournals.com /cgi/content/full/53/12/1764 (4137 words)

	genome.gov \| Huizing Lab
		HIBM is caused by mutations in the gene encoding the enzyme UDP-GlcNAc 2-epimerase/ManNAc kinase.
		Sialic acid is a negatively charged sugar localized at the end of glycoconjugate chains on glycoproteins and glycolipids.
		A third sialic acid-related disease, infantile free sialic acid storage disease, involves a transport malfunction that causes sialic acid to accumulate in lysosomes.
	www.genome.gov /11007099 (597 words)

	Sialic Acid Aldolase (Site not responding. Last check: 2007-09-18)
		Sialic Acid Aldolase (N-Acetylneuraminate pyruvate lyase, EC 4.1.3.3) catalyzes the reversible reaction of sialic acid (N-acetylneuraminic acid) to N-acetylmannosamine and pyruvic acid.
		The enzyme is found in several bacterial strains which use the reverse reaction to degrade N-acetylneuraminic acid (sialic acid).The forward reaction is particularly useful for the determination of sialic acid concentrations by quantitatively converting it to N-acetylmannosamine and pyruvate.
		Since sialic acid is both negatively charged and a non-reducing sugar, its direct analysis is more difficult than conventional sugars.
	glycotools.qa-bio.com /s.nl/it.A/id.161/.f?sc=2&category=26 (340 words)

	Versatile Biosynthetic Engineering of Sialic Acid in Living Cells Using Synthetic Sialic Acid Analogues -- Oetke et al. ...
		Sialic acids are critical components of many glycoconjugates involved in biologically important ligand-receptor interactions.
		Sialic acids are the most prevalent terminal monosaccharides on the surface of eukaryotic cells (1), and they perform important
		Sialic acid analogues are incorporated in cell surface glycoconjugates.
	www.jbc.org /cgi/content/full/277/8/6688 (5740 words)

	Sialic Acid Functions in Enterovirus 70 Binding and Infection -- Alexander and Dimock 76 (22): 11265 -- The Journal of ... (Site not responding. Last check: 2007-09-18)
		Sialic acid is involved in EV70 binding to and infection of susceptible cell lines.
		Sialic acid residues of DAF are not involved in EV70 binding.
		Characterization of the sialic acid binding activity of transmissible gastroenteritis coronavirus by analysis of haemagglutination-deficient mutants.
	jvi.asm.org /cgi/content/full/76/22/11265 (5559 words)

	Is sialic acid in milk food for the brain? (Site not responding. Last check: 2007-09-18)
		One of nature’s richest sources of sialic acid, a vital component of brain gangliosides and the building block of polysialic acid (PSA) on neural cell adhesion molecule (NCAM), is found in human breast milk.
		An exogenous source of sialic acid may be critical under conditions of extremely rapid brain growth, particularly during the first months after birth.
		Here we review the major differences in sialic acid concentration between human milk and infant formulas, and how sialic acid-bearing nutrients are metabolized.
	www.nutritionandfoodsciences.org /Reviews.asp?action=display&openMenu=relatedItems&ReviewID=20321&Year=2006 (240 words)

	Differential Distribution of Sialic Acid in {{alpha}}2,3 and {{alpha}}2,6 Linkages in the Apical Membrane of Cultured ...
		Double staining was performed with a sialic acid-specific lectin (rhodamine) and an antibody detecting a basolateral marker (ß4 integrin for HT-29 5M12 cells and ß1 integrin for MCF-7 and Caco-2 cells) (fluorescein), and was visualized by confocal microscopy.
		Cells were processed as indicated in Fig 1, double stained with sialic acid-specific lectins and an antibody detecting a basolateral marker (ß1 integrin for pancreas cancer cells and E-cadherin for MDCK II cells), and visualized by confocal microscopy.
		2,6 sialic acid is detected in the apical membrane of polarized cells.
	www.jhc.org /cgi/content/full/49/4/501 (4395 words)

	A mutation in human CMP-sialic acid hydroxylase occurred after the Homo-Pan divergence -- Chou et al. 95 (20): 11751 -- ...
		Sialic acids are important cell-surface molecules of animals in the deuterostome lineage.
		The sialic acids are a family of acidic sugars typically found at the outer end of the cell surface and secreted glycoconjugates
		Sialic acids are common structural components of the glycoconjugates of all animals of the deuterostome lineage (23-26) and
	www.pnas.org /cgi/content/full/95/20/11751 (5721 words)

	Varied Mechanisms Underlie the Free Sialic Acid Storage Disorders -- Wreden et al. 280 (2): 1408 -- Journal of ...
		Radiolabeled sialic acid (N-acetylneuraminic acid (NANA)) uptake was measured in HeLa cells expressing sialin with a LL22,23AA mutation (sialin) or an unrelated lysosomal neutral amino acid transporter (LYAAT1).
		C, a representative measurement of transport during the linear phase of uptake (2 min) with increasing concentrations of unlabeled sialic acid demonstrates a saturable activity.
		Amino acid changes corresponding to disease-associated mutations were made in sialin in tandem with the dileucine to dialanine mutation in the putative AP-binding domain.
	www.jbc.org /cgi/content/full/280/2/1408 (5157 words)

	Biochemical engineering of the N-acyl side chain of sialic acid: biological implications -- Keppler et al. 11 (2): 11R ...
		The physiological precursor of all sialic acids is
		N-acyl-modified neuraminic acids in vitro and in vivo.
		by the promiscuous sialic acid biosynthetic pathway and are
	glycob.oxfordjournals.org /cgi/content/full/11/2/11R (4049 words)

	Proton Nuclear Magnetic Resonance Spectroscopic Detection of Sialic Acid Storage Disease -- Sewell et al. 48 (2): 357 ...
		excretion of free sialic acid and an accumulation of free sialic
		Sialic acid storage disease with sialuria: clinical and biochemical features in the severe infantile type.
		Defective lysosomal egress of free sialic acid (N-acetylneuraminic acid) in fibroblasts of patients with infantile free sialic acid storage disease.
	www.clinchem.org /cgi/content/full/48/2/357 (1792 words)

	Infantile Sialic Acid Storage Disease: Serial Ultrasound and Magnetic Resonance Imaging Features -- Parazzini et al. 24 ...
		free sialic acid in the urine (sialic acid, 4068 µg/mg
		A new gene, encoding an anion transporter is mutated in sialic acid storage diseases.
		Infantile sialic acid storage disease: a rare cause of cytoplasmic vacuolation in pediatric patients.
	www.ajnr.org /cgi/content/full/24/3/398 (1211 words)

	Sialic acid content of low density lipoprotein and its relation to lipid concentrations and metabolism of low density ...
		The correlations of the dense LDL sialic acid ratio with
		and the lower is its sialic acid ratio.
		Evaluation of the sialic acid content of LDL as a marker of coronary calcification and extracoronary atherosclerosis in asymptomatic hypercholesterolemic subjects.
	www.jlr.org /cgi/content/full/41/7/1110 (3721 words)

	Relationship Between Plasma Sialic Acid Concentration and Microvascular and Macrovascular Complications in Type 1 ...
		Plasma sialic acid is a marker of the acute-phase response (1,4), acute-phase
		that sialic acid is reduced in the endothelium in atherosclerosis (35)
		Crook M, Earle K, Morocutti A, Yip J, Viberti GC, Pickup JC: Serum, sialic acid, a risk factor for cardiovascular disease, is increased in insulin-dependent diabetic patients with microalbuminuria and clinical proteinuria.
	care.diabetesjournals.org /cgi/content/full/24/2/316 (3519 words)

	Sialic acid content of low density lipoprotein and its relation to lipid concentrations and metabolism of low density ...
		Sialic acid content of low density lipoprotein and its relation to lipid concentrations and metabolism of low density lipoprotein and cholesterol -- Lindbohm et al.
		Sialic acid content of low density lipoprotein and its relation to lipid concentrations and metabolism of low density lipoprotein and cholesterol
		In conclusion, a low LDL sialic acid ratio was associated with
	www.jlr.org /cgi/content/abstract/41/7/1110 (270 words)

	Mouse Model Points to Possible New Strategy For Treating Rare Muscle Disease, Kidney Disorders, June 1, 2007 News ...
		It is caused by a mutation in the GNE gene, which codes for two enzymes that produce sialic acid, a sugar important to muscle development and kidney function.
		They hypothesized that a compound called N-acetylmannosamine, or ManNAc, a sugar that is naturally converted to sialic acid, might have an impact on the muscle weakness caused by HIBM.
		When the researchers supplemented the diets of pregnant transgenic mice with ManNAc, sialic acid production improved in the fetuses, and they were born with markedly improved kidneys.
	www.nih.gov /news/pr/jun2007/nhgri-01.htm (936 words)

	Lipid-Associated Sialic Acid (LASA)
		Preliminary studies have demonstrated that LASA concentrations are indicative of disease status in patients with leukemia, lymphoma, or cancer of the breast, ovary, or colorectum.
		Bhargava AK, et al, “Plasma Lipid-Bound Sialic Acid (LSA) in Cancer and Noncancer Patients,” Clin Chem, 1984, 30:940.
		Horgan IE, “Total and Lipid-Bound Sialic Acid Levels in Sera From Patients With Cancer,” Clin Chim Acta, 1982, 118(2-3):327-31.
	www.labcorp.com /datasets/labcorp/html/chapter/mono/sc033500.htm (587 words)

Try your search on: Qwika (all wikis)