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	Sibutramine - Wikipedia, the free encyclopedia
		Sibutramine (Meridia® in the USA, Reductil® in Europe), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity.
		Sibutramine is classified as a Schedule IV controlled substance in the United States.
		Sibutramine is a neurotransmitter reuptake inhibitor that helps enhance satiety by inhibiting the reuptake of serotonin (by 73%), norepinephrine (by 54%), and dopamine (by 16%); as such it is a satiety enhancer (i.e.
	en.wikipedia.org /wiki/Sibutramine (586 words)

	Diabetes forum : Sibutramine Safety (Site not responding. Last check: 2007-11-04)
		Sibutramine has been associated with a mean increase in blood pressure and heart rate of approximately 1-3 mmHg and 4-5 beats/min, respectively, at doses of 5-10 mg/day.
		Sibutramine should be given with caution to those patients with a history of hypertension and should not be given to patients with uncontrolled or poorly controlled hypertension.
		The incidence of sibutramine causing tachycardia, hypertension/increased blood pressure and palpitation compared with placebo is 2.6% versus 0.6%, 2.1% versus 0.9% and 2.0% versus 0.8% respectively.
	www.diabetesforum.net /eng_treat_Sibutramine_Safety.htm (272 words)

	Howstuffworks "Sibutramine: A Profile of an Antiobesity Drug"
		Sibutramine is used as an appetite suppressant to help you lose weight and maintain weight loss and is used together with a low-calorie diet.
		Sibutramine can be taken with or without food, usually in the morning, or as directed by your doctor.
		Sibutramine should not be taken with medications that may increase blood pressure, such as ephedrine, phenylpropanolamine, pseudoephedrine, or over-the-counter (nonprescription) weight-loss, allergy, asthma, sinus, cough, or cold products.
	health.howstuffworks.com /define-sibutramine.htm (937 words)

	Meridia Side Effects, and Drug Interactions - Sibutramine Hydrochloride Monohydrate - RxList Monographs
		Ecchymosis/Bleeding Disorders: Ecchymosis (bruising) was observed in 0.7% of sibutramine treated patients and in 0.2% of placebo-treated patients in pre-marketing placebo-controlled obesity studies.
		Sibutramine may have an effect on platelet function due to its effect on serotonin uptake.
		)-mediated metabolism of sibutramine was inhibited by ketoconazole and to a lesser extent by erythromycin.
	www.rxlist.com /cgi/generic/sibutramine_ad.htm (1381 words)

	Sibutramine for obesity - [Medication]
		Sibutramine is prescribed to help people who are obese (those with a body mass index [BMI] of 30 or higher) to lose weight.
		Sibutramine is intended to be used along with a weight-loss diet and a regular exercise program.
		A review of studies on sibutramine found that it results in weight loss both in otherwise healthy people who were obese and people who were obese and had type 2 diabetes and high blood pressure.
	www.bchealthguide.org /kbase/topic/detail/drug/aa51180/detail.htm (564 words)

	Sibutramine from Michael D. Myers M.D. Inc.
		Sibutramine acts primarily by diminishing appetite but may also slightly increase resting metabolic rate (the amount of energy consumed while resting) leading to the ability to "burn" extra calories.
		Sibutramine does have other beneficial effects that are independent of the weight loss.
		Sibutramine lowers insulin levels (which should help correct some of the metabolic derangements associated with long-standing obesity) and it significantly raises the level of HDL-cholesterol ("the good cholesterol") which may result in decreasing vascular complication in the future.
	www.weight.com /Medications/sibutramine.html (465 words)

	Obesity Online Slides: sibutramine, Meridia, phentermine, clinical trial (Site not responding. Last check: 2007-11-04)
		Sibutramine is a derivative of the amphetamine precursor Ã-phenylethylamine that has been chemically modified to eliminate its abuse potential.
		Sibutramine enhances satiation (level of fullness during a meal), by blocking the reuptake of monoamine neurotransmitters (serotonin, norepinephrine, and to a lesser extent, dopamine) in the hypothalamus.
		The use of sibutramine is contraindicated in patients with poorly controlled hypertension, coronary heart disease, congestive heart failure, arrhythmias, stroke, severe renal or liver dysfunction, or concomitant monoamine oxidase inhibitor therapy.
	www.obesityonline.org /slides/slide01.cfm?q=sibutramine (1469 words)

	Sibutramine (Meridia) for Obesity from Michael D. Myers, M.D., Inc.
		Sibutramine was developed in the late 80's as an antidepressant.
		Sibutramine acts primarily by diminishing appetite, but may also slightly increase resting metabolic rate (the amount of energy consumed while resting), which leads to the ability to "burn" extra calories.
		Sibutramine has other beneficial effects that are independent of the weight loss.
	www.weight.com /sibutramine.asp (533 words)

	Sibutramine - Meridia - Drug Interactions and Warnings
		Sibutramine was also well tolerated, although it may cause dry mouth, anorexia, and insomnia, and should be used with caution in patients at risk for cardiovascular disease.
		Sibutramine should be used with caution in patients with a history of hypertension and should not be used in those with uncontrolled hypertension and concomitant cardiovascular disease.
		Sibutramine is effective in achieving weight loss in patients with type 2 diabetes but weight loss occurs more slowly than in non-diabetic patients.
	www.personalhealthzone.com /drug_interactions/sibutramine.html (541 words)

	MedlinePlus Drug Information: Sibutramine (Systemic) (Site not responding. Last check: 2007-11-04)
		Sibutramine (si-BYOO-tra-meen) is used together with a reduced-calorie diet to help you lose weight and to help keep the lost weight from returning.
		Sibutramine is thought to work by increasing the activity of certain chemicals, called norepinephrine and serotonin, in the brain.
		Sibutramine may be taken with or without food, on a full or empty stomach.
	www.nlm.nih.gov /medlineplus/druginfo/uspdi/203725.html (1628 words)

	sibutramine Information on Healthline
		Sibutramine affects chemicals in the body that are related to weight maintenance.
		Sibutramine is used as a short-term supplement to diet and exercise in the treatment of obesity.
		Sibutramine is in the FDA pregnancy category C. This means that it is not known whether sibutramine will harm an unborn baby.
	www.healthline.com /multumcontent/sibutramine (678 words)

	TA31 Obesity - sibutramine: Guidance (html) (Site not responding. Last check: 2007-11-04)
		Sibutramine (Reductil ®) is a re-uptake inhibitor of noradrenaline (NA) and serotonin (5-HT).
		Sibutramine reduces food intake by enhancing central NA and 5-HT function; the synergistic effects of neurotransmitters are mediated through a- and b1-adrenoreceptors and 5-HT2A/2C receptors.
		Sibutramine does not cause the release of monoamine neurotransmitters and it is not a monoamine oxidase inhibitor.
	www.nice.org.uk /page.aspx?o=23017 (3833 words)

	Sibutramine - Medical properties
		Sibutramine increases blood pressure in some patients and therefore blood pressure must be monitored during treatment to ensure that it does not become dangerously high.
		Sibutramine is rapidly absorbed from the gastro-intestinal tract and is first metabolised in the liver to DMS and DDMS, with a half-life of 1.1 hours.
		Sibutramine is primarily metabolised by the cytochrome P450(3A
	www.ch.ic.ac.uk /local/projects/rowlands/web/pharmacology.html (629 words)

	European Medicines Agency Completes Comprehensive Assessment Of Abbott's Meridia/Reductil (Sibutramine), Issues ... (Site not responding. Last check: 2007-11-04)
		In studies, sibutramine in combination with diet and exercise was effective in producing and maintaining statistically significant weight loss in the majority of obese patients compared to diet and exercise alone.
		Sibutramine also cannot be taken if patients have anorexia nervosa, are taking other weight loss medications that act on the brain or are hypersensitive to any of the ingredients of sibutramine.
		Sibutramine should not be used in patients with a history of coronary artery disease, arrhythmias, congestive heart failure or stroke.
	www.pslgroup.com /dg/217802.htm (974 words)

	Sibutramine for obesity
		Sibutramine is approved by the U.S. Food and Drug Administration (FDA) for use for longer than 1 year.
		Once you stop taking sibutramine, you may regain some or all of the weight you lost while taking the medicine, unless you have made permanent changes in your eating and exercise habits.
		When taking sibutramine, it is possible to develop "serotonin syndrome," a potentially deadly condition, if you also take dextromethorphan (found in cough syrups), ergot, sumatriptan succinate (found in migraine medicines), lithium, fentanyl, demerol, or certain types of antidepressants (selective serotonin reuptake inhibitors, or SSRIs).
	www.webmd.com /hw/weight_control/aa51180.asp (644 words)

	Sibutramine
		Sibutramine is approved as an obesity treatment to be used in combination with diet and exercise.
		Patients who are currently taking sibutramine are advised to consult with their treating physician if they have any questions or concerns regarding the treatment of their condition with this drug.
		Sibutramine was approved for sale in Italy in April 2001, and since that time 50 adverse reactions have been reported to the Italian authorities.
	www.napra.org /docs/0/310/321.asp (400 words)

	Diabetes Research Summary - Does Sibutramine Help People Lose Weight? Is It Safe? - American Diabetes Association
		Sibutramine is a weight-loss drug that has caused concern over its safety.
		Participants on sibutramine were given one of these daily doses: 10 mg, 15 mg, or 20 mg.
		In 11 studies, participants on sibutramine had an average increase in heart rate of 3.76 beats per minute.
	www.diabetes.org /diabetes-research/summaries/arterburn-sibutramine.jsp (398 words)

	Sibutramine
		SIBUTRAMINE (MeridiaÂ®) is used to control hunger in patients who are overweight.
		Sibutramine is prescribed along with a reduced-calorie diet and, if appropriate, an exercise program.
		Keep in mind that sibutramine was intended to be used in addition to a healthy diet and appropriate exercise.
	www.stjohn.org /HealthInfoLib/swArticle.aspx?26,800 (564 words)

	Ask an Expert: Sibutramine
		Sibutramine (Meridia) is in a class of medications known as serotonin and norepinephrine reuptake inhibitors (SNRI), typically used for appetite suppression.
		Sibutramine should not be taken if you have an arrhythmia, congestive heart failure, coronary artery disease, liver or kidney problems, severe hypertension, stroke, or anorexia nervosa.
		Sibutramine is an effective drug for weight loss, but it does have risks associated with its use.
	www.netwellness.org /question.cfm/33425.htm (453 words)

	Obesity - sibutramine (No. 31)
		Sibutramine should not be prescribed unless the person taking it has regular checks to measure their weight loss and to see if the medicine is causing any other problems (side effects).
		Sibutramine is not recommended for patients who already have high blood pressure (145/90 or above).
		There is no evidence to show that prescribing sibutramine with other drugs used to treat obesity has any benefits for the person with obesity.
	www.nice.org.uk /page.aspx?o=23003 (380 words)

	sibutramine - Healthy Living Overview: Diet Thru Prevention
		Sibutramine blocks the reuptake of the neurotransmitters dopamine, norepinephrine, and serotonin.
		Sibutramine was approved by the FDA in 1997.
		Therefore, sibutramine should not be used with MAO inhibitors, and there should be at least a 2-week interval between stopping an MAO inhibitor and starting sibutramine.
	www.medicinenet.com /sibutramine/article.htm (889 words)

	New Page 0
		Recently, sibutramine (Meridia) has been in the news after a consumer watch group asked the FDA to remove it from the market due to a possible association with deaths in the United States and Europe.
		Sibutramine is an appetite suppressant that can be used in combination with a reduced calorie diet for weight loss and the maintenance of weight loss.
		Sibutramine is being closely observed by the FDA, and we may see further restrictions of the medication in the future.
	www.uic.edu /pharmacy/services/di/meridia.htm (1336 words)

	Anti-obesity drug sibutramine (Reductil) Q&As (Site not responding. Last check: 2007-11-04)
		Sibutramine may increase blood pressure in some people, therefore blood pressure should be monitored regularly.
		sibutramine should only be prescribed for people between the ages of 18 and 65 years, who have made serious attempts to lose weight by dieting, exercise and/or other changes in their behaviour, and who:
		Sibutramine is a treatment for obesity rather than for diabetes so it should be taken in addition to any diabetes medication.
	www.diabetes.org.uk /infocentre/inform/sibutramine.htm (667 words)

	Sibutramine - Meridia
		Sibutramine is a neurotransmitter reuptake inhibitor that helps control appetite by inhibiting the reuptake of serotonin, norepinephrine, and dopamine.
		Sibutramine is used together with a reduced-calorie diet to help you lose weight and to help keep the lost weight from returning.
		Side effects of taking Sibutramine include restlessness or tremors, nervousness or anxiety, headaches or dizziness, insomnia, dry mouth or an unpleasant taste in your mouth or constipation.
	www.mydietmeds.com (530 words)

	BARBARA'S OBESITY MEDS AND RESEARCH NEWS -- Meridia (Reductil -- sibutramine) FAQ
		(sibutramine hydrochloride monohydrate) is the first FDA approved medication of its class for the treatment of weight loss and weight maintenance.
		Sibutramine is an equipotent serotonin and norepinephrine reuptake inhibitor (SNRI), which means it has an equal effect on serotonin (a brain neurotransmitter which generally promotes a calming feeling) and norepinephrine (a stimulant).
		A recent study found that controlled hypertensives who took sibutramine have no more likelihood of increased blood pressure than those who took placebo, although in general, patients do experience a non-significant rise in diastolic and systolic pressure.
	www.barbarahirsch.com /merfaq.htm (1657 words)

	Sibutramine - History
		In particular, the ability of Sibutramine to reduce the uptake of serotonin was of particular interest.
		Sibutramine works by blocking this last mechanism; if the body never recovers the neurotransmitters from the bloodstream, the person continues to feel happy.
		Further to this, sibutramine and more potent derivatives such as demethylsibutramine (DMS) were discovered to have potential in treating sexual dysfunction by Jerussi, et al.
	www.ch.ic.ac.uk /local/projects/rowlands/web/history.html (363 words)

	N101 \| Sibutramine (Site not responding. Last check: 2007-11-04)
		Sibutramine is used for the management of obesity, including weight loss and maintenance of weight loss, and should be used in association with a reduced calorie diet.
		One side effect of sibutramine is high blood pressure.
		Though no studies have investigated whether taking sibutramine together with ephedra might produce an adverse interaction, currently available evidence suggests that this combination should be used with caution.
	www.n101.com /Static/HNs/Drug/Sibutramine.htm (549 words)

	Public Citizen \| Publications - Petition supplement to FDA outlining the rising number of cardiovascular events ...
		None of the control animals that did not get sibutramine had any of these cardiovascular birth defects. In another rat study, pups from untreated females nursed by treated mothers tended to have lower body weights indicating a potential for transfer of drug to the breast milk and adverse effects as a result.
		Since sibutramine was marketed, there has been a continuing series of reports of fetal harm including reports of four babies born with cardiovascular abnormalities.
		We again strongly urge that sibutramine should be banned: the adverse events are serious, the number of victims is rising rapidly, and the efficacy is minimal.
	www.citizen.org /publications/release.cfm?ID=7273 (1768 words)

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