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	How Does Sickle Cell Cause Disease?
		Sickle cell disease is a blood condition seen most commonly in people of African ancestry and in the tribal peoples of India.
		Therefore, the inheritance of sickle cell disease depends totally on the genes of the parents.
		Sickle cell disease is determined at conception, when a person acquires his/her genes from the parents.
	sickle.bwh.harvard.edu /scd_background.html (1588 words)

	Sickle Cell Anemia
		Sickle cell disease is an inherited blood disorder characterized by defective hemoglobin.
		Sickle cell hemoglobin molecules are stiff and form into the shape of a sickle or a scythe.
		Sickle cell disease is an inherited disease caused by a genetic mutation.
	www.umm.edu /blood/sickle.htm (1664 words)

	Sickle Cell Disease
		Sickle cell disease is an inherited disorder of the red blood cells characterized by abnormally shaped red cells.
		He or she can also inherit a sickle cell gene from one parent and a different kind of abnormal gene from the other and end up with a different form of sickle cell disease, such as hemoglobin SC disease and hemoglobin S-thalassemia.
		Symptoms of sickle cell disease vary and range from mild to severe, and symptoms may be less severe or different in children who have inherited a sickle cell gene from one parent and a different abnormal hemoglobin gene from the other.
	kidshealth.org /parent/medical/heart/sickle_cell_anemia.html (1510 words)

	What is Sickle Cell Disease
		Sickle cell disease is an inherited blood disorder that affects red blood cells.
		Sickle Cell trait (AS) is an inherited condition in which both hemoglobin A and S are produced in the red blood cells, always more A than S. Sickle cell trait is not a type of sickle cell disease.
		Sickle cells are destroyed rapidly in the body of people with the disease causing anemia, jaundice and the formation of gallstones.
	www.sicklecelldisease.org /about_scd/index.phtml (924 words)

	Sickle Cell Disease in Cuba
		Sickle cell disease (SCD) is a group of hemoglobin disorders in which the sickle ß globin gene is inherited.
		The sickle ß globin gene is widely spread through Africa, the Middle East, the Mediterranean countries and India; and, due to slave trade, it has also been carried to North America, the Caribbean, Central America and a few countries of South America.
		Incidence of sickle cell trait in the general population was 3.08%, whereas it was 0.6% in whites and 13.2% in fls.
	sickle.bwh.harvard.edu /cuba_scd.html (3887 words)

	What Is Sickle Cell Anemia?
		Sickle cell anemia is a serious disease in which the body makes abnormally shaped red blood cells.
		In sickle cell anemia, the body produces red blood cells that are shaped like a sickle (or crescent).
		Sickle cell anemia is an inherited (genetic) disorder.
	www.nhlbi.nih.gov /health/dci/Diseases/Sca/SCA_WhatIs.html (415 words)

	Sickle
		Sickle was bred by Lord Derby, and was the first foal out of his champion homebred filly Selene.
		Sickle's next out was the July Stakes at Newmarket, in which he was second by three-quarters of a length to another more experienced colt in The Satrap, who continued his undefeated streak on the way to becoming the leader of the juvenile division, with Call Boy (winner of next year's Derby) in third.
		Sickle became acutely ill and died unexpectedly on December 26, 1943 at the age of 19.
	www.tbheritage.com /Portraits/Sickle.html (3885 words)

	Sickle cell and African-Americans
		Sickle cell disease is a generic term for a group of genetic disorders characterized by the predominance of hemoglobin S (Hb S).
		These disorders include sickle cell anemia, the sickle beta thalassemia syndromes, and hemoglobinopathies in which Hb S is in association with another abnormal hemoglobin that not only can participate in the formation of hemoglobin polymers but also is present in sufficient concentration to enable the red cells to sickle.
		The lung, as the recipient of deoxygenated sickle cells that escape from the spleen or bone marrow, may be at special risk for vasoocclusion and infarction.
	www.blackhealthcare.com /BHC/SickleCell/Description.asp (1008 words)

	Sickle Cell Anemia
		Sickle cell anemia occurs when a person inherits two abnormal genes (one from each parent) that cause their red blood cells to change shape.
		Sickle cell anemia is a blood disorder that affects hemoglobin (pronounced: hee-muh-glow-bin), a protein found in red blood cells that helps carry oxygen throughout the body.
		Sickle cell anemia is not contagious, so you can't catch it from someone else or pass it to another person like a cold or other infection.
	kidshealth.org /teen/diseases_conditions/blood/sickle_cell_anemia.html (618 words)

	Genomics\|HuGENet\|e-Journal\|Stroke, children, & sickle cell anemia
		Sickle cell disease is an inherited blood disorder in which red blood cells contain an abnormal subtype of hemoglobin (Hb S allelic variant of the B-globin gene).
		Sickle cell disease is an incurable condition and is associated with significant morbidity and mortality (2,3).
		The results of a recent large-scale study of persons with sickle cell anemia conducted in the United States indicated that children were particular at risk for severe complications; stroke was a complication in 11% and silent cerebral infarction in 17-22% of the children in the study population (4).
	www.cdc.gov /genomics/hugenet/ejournal/strokeSCA.htm (943 words)

	Sickle Cell - Health and Medical Information produced by doctors - MedicineNet.com
		Sickle cell anemia (sickle cell disease) is a disorder of the blood caused by an inherited abnormal hemoglobin (an oxygen-carrying protein within the red blood cells).
		Sickle cell anemia is inherited as an autosomal (meaning that the gene is not linked to a sex chromosome) recessive condition whereas sickle cell trait is inherited as an autosomal dominant trait.
		Sickle cell trait is present in some two million fls in the United States (8% of the U.S. fl population at birth).
	www.medicinenet.com /sickle_cell/article.htm (491 words)

	Genomics\|HuGENet\|Reviews\|Hb S Allele and Sickle Cell Disease\|PubMed ID: 10791557
		Sickle cell disease is inherited in an autosomal recessive manner and therefore, either two copies of the (Hb S) variant or one copy of the (Hb S) variant plus one copy of another beta globin variant (such as Hb C) are required to express the disease.
		In African-Americans, the birth prevalence of sickle cell anemia (Hb SS) is 1/375, of Hb SC is 1/835, of Hb S/beta-thalassemia is 1/1667 and of sickle cell trait (Hb AS) is 1/12 (2).
		Several therapies for sickle cell disease, such as hydroxyurea, are targeted at raising the levels of Hb F in affected individuals.
	www.cdc.gov /genomics/hugenet/reviews/sickle.htm (3441 words)

	Sickle Cell Anemia (Children) \| AHealthyMe.com
		Sickle cell anemia is a disease of red blood cells that is passed from parent to child.
		Scientists think the sickle cell gene is more common in tropical Africa and Asia because the trait protects people from malaria, a disease caused by a parasite that lives in red blood cells and has infected people in those areas since ancient times.
		In a child with sickle cell anemia, however, the risk of a life-threatening infection is so high that you should call a doctor as soon as your child shows any symptoms of illness.
	www.ahealthyme.com /topic/sicklecell (1710 words)

	MedlinePlus Medical Encyclopedia: Sickle cell anemia
		Sickle cell anemia is an inherited disease in which the red blood cells, normally disc-shaped, become crescent shaped.
		Sickle cell anemia is caused by an abnormal type of hemoglobin called hemoglobin S. Hemoglobin is a protein inside red blood cells that carries oxygen.
		Sickle cell anemia is inherited as an autosomal recessive trait, which means it occurs in someone who has inherited hemoglobin S from both parents.
	www.nlm.nih.gov /medlineplus/ency/article/000527.htm (1247 words)

	Racial Reality - Sickle Cell (Site not responding. Last check: 2007-10-08)
		The frequency of sickle cell trait (Hemoglobin S) in Southern European populations is often used to quantify fl ancestry allegedly acquired via large-scale absorption of slaves in recent history.
		Therefore, the S hemoglobin gene is passed on less frequently in these populations, and the incidence of sickle cell anemia and sickle cell trait decreases.
		Sickle cell anemia and even sickle cell trait are enough of a disadvantage in malaria-free parts of the world that their frequency of incidence decreases."
	www.sitesled.com /members/racialreality/sicklecell.html (662 words)

	Sickle Cell Disease - disease information
		Sickle Cell Disease is a hereditary blood disorder that affects the oxygen-carrying component of blood, the red blood cell.
		As sickle cell is a genetic disorder, anyone whose parent has the gene for sickle cell disease has the chance of at least having sickle cell trait.
		As sickle cell disease is a genetic disorder, anyone whose parent has the gene for sickle cell disease has the chance of at least having sickle cell trait.
	www.mckinley.uiuc.edu /Handouts/sickle_cell_disease.html (1038 words)

	Sickle (Site not responding. Last check: 2007-10-08)
		The sickle is another example of an agricultural tool used as a weapon or used as the basis for weapon development.
		Sickles, as an agricultural tool, were used for cutting grass, hay, and clearing foliage.
		Depending on the size of the sickle it could be wielded with one or two hands.
	members.aol.com /dargolyt/TheForge/sickle.htm (111 words)

	Sickle cell anemia - Genetics Home Reference
		Sickle cell anemia is an inherited disorder that affects hemoglobin, a protein that enables red blood cells to carry oxygen to all parts of the body.
		Sickle cell anemia is characterized by a low number of red blood cells (anemia), infection, and periodic episodes of pain, usually beginning in early childhood.
		Mutations in the HBB gene cause sickle cell anemia.
	ghr.nlm.nih.gov /ghr/disease/sicklecellanemia;jsessionid=060EA25EEC0CD006CA2DFD56DD09378A (809 words)

	Medical References: Sickle Cell Disease (Site not responding. Last check: 2007-10-08)
		Sickle cell disease is an inherited disease of red blood cells.
		The symptoms of sickle cell disease are caused by abnormal hemoglobin.
		These are called SS (individuals inherit one sickle cell gene from each parent); SC (the child inherits one sickle cell gene and one gene for another abnormal type of hemoglobin called “C”); and S-beta thalassemia (the child inherits one sickle cell gene and one gene for beta thalassemia, another inherited anemia).
	www.marchofdimes.com /professionals/681_1221.asp (2293 words)

	Sickle cell anemia: Causes - MayoClinic.com
		Sickle cell anemia is caused by a mistake in the gene that tells your body to make hemoglobin — the red, iron-rich protein that gives blood its red color.
		The sickle cell gene is passed from generation to generation in a pattern of inheritance called autosomal recessive inheritance.
		Their blood may contain some sickle cells, but they usually don't experience symptoms unless they're in an area with low oxygen — such as at high altitudes on an airplane or on a mountain.
	www.mayoclinic.com /health/sickle-cell-anemia/DS00324/DSECTION=3& (711 words)

	Sickle Cell Anemia (Site not responding. Last check: 2007-10-08)
		Sickle Cell Anemia (SCA) is caused by a change in the chemical composition of the protein (hemoglobin or Hgb) that carries the oxygen inside of the red blood cells (RBC's).
		At the same time, sickle cell patients are in a continuous state of hyperdynamic circulation and therefore, frequently exhibit systolic murmurs.
		The primary goal of therapy is to reduce the frequency, duration, and severity of the "sickle cell crisis episodes" and to maintain an adequate supply of RBC's to nourish the tissues.
	radlinux1.usuf1.usuhs.mil /rad/home/cases/sickle.html (594 words)

	What is Sickle Cell Anaemia?
		Another problem is that red blood cells containing sickle haemoglobin do not live as long as the normal 120 days and this results in a chronic state of anaemia.
		When a person is found to have a sickle cell disorder it is important that all members of the family be tested.
		Sickle Cell Disorder is a condition which is inherited from both parents.
	www.sicklecellsociety.org /education/sicklecell.htm (853 words)

	Sickle - Wikipedia, the free encyclopedia
		A sickle is a curved, hand-held agricultural tool typically used for harvesting grain crops before the advent of modern harvesting machinery.
		In Greek myths, the sickle was used as a weapon by Cronus and Perseus.
		The Sickle is used as part of the well known symbol of the Hammer and sickle, which is the symbol of Communism or Revolutionary Socialism.
	en.wikipedia.org /wiki/Sickle (252 words)

	Sickle Cell Anemia
		Symptoms and complications may also be experienced by people who have one sickle cell gene copy and one altered gene copy of another abnormal hemoglobin variant (doubly heterozygous), such as hemoglobin C or thalassemia.
		It is unclear what actually causes sickle cell crisis, but it appears that some of the less sickled cells stick to the blood vessels and then the abnormally-shaped cells further block (vaso-occlusion) the small veins of the body.
		Other complications of sickle cell disease may include gallstones, bone necrosis, kidney disease, increased risk of infection, leg ulcers, retinopathy (disease of the retina in the eye), and priapism (sustained erection).
	www.labtestsonline.org /understanding/conditions/sickle.html (705 words)

	Sickle Cell Foundation of Alberta - Home
		The Sickle Cell Foundation of Alberta was founded as a private non-profit organization to educate the public about Sickle Cell Disease and to provide support for carriers of the trait and their families.
		The Sickle Cell Foundation of Alberta is on a campaign to raise money that will be used to research for the treatment and prevention of sickle cell disease, and other haemoglobinopathies.
		You are born with the sickle cell hemoglobin and it is present for life.
	www.sicklecellfoundationofalberta.org (472 words)

	Bible Study - Sickle
		The English word sickle (which is derived from an old Anglo-Saxon word to which scythe also originated) is used to translate the Old Testament Hebrew word pronounced ker-mash and the New Testament Greek word pronounced drep-anon.
		The sickle is mentioned in The Bible in both a literal manner, by humans for harvesting grain, and in a figurative way, by God for the eventual "harvesting" of humanity.
		The sickle is also used symbolically for salvation and judgment that the world awaits in the time of The Return Of Jesus Christ:
	www.keyway.ca /htm2002/20020122.htm (703 words)

	Sickle \| codebunny.org
		Sickle is a general purpose email filter based on Dicemail.
		Sickle is not meant to be user friendly, and has the potential to cause data-loss if handled incorrectly.
		Changes in Sickle or Dicemail may alter the behaviour of your filters, which in turn could cause you to lose mail and make you a sad panda.
	www.codebunny.org /coding/sickle (277 words)

	Hammer and sickle - Wikipedia, the free encyclopedia
		The hammer and sickle is a symbol used to represent communism and communist political parties.
		Since 1917 the hammer and sickle (Russian: серп и молот, serp i molot, "sickle and hammer") was one of the symbols of the RSFSR.
		The hammer and sickle, imposed onto a pair of stylised wings, was used by the Soviet national carrier, Aeroflot.
	en.wikipedia.org /wiki/Hammer_and_sickle (910 words)

	Patient Information
		Sickle Cell Disease is a group of inherited red blood cell disorders.
		sickle cell trait or parents with sickle cell disease.
		Sickle cell patient should be under the care of a medical team that understands
	www.scinfo.org /sicklept.htm (570 words)

	CHC Nurses
		Sickle cell disease are a group of genetically inherited abnormalities affecting red blood cell structure and function.
		The genetic mutation for sickle occurs on the 6th point of the beta globin chain, glutamic acid is replaced by another amino acid called valine.
		Sickling crisis does not occur in the arteries due to the forceful pumping action of the heart, fast rate of blood flow and peripheral resistance of the arterial walls, ie blood pressure.
	www.sickle-thalassaemia.org /CHCNurses.htm (5775 words)

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