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	Signal-recognition particle - Wikipedia, the free encyclopedia
		It has been suggested that this article or section be merged into Signal recognition particle.
		A signal-recognition particle or SRP is a cytosolic particle that transiently binds:
		SRP and its receptor initiate the transfer of the nascent chain across the ER membrane.
	en.wikipedia.org /wiki/Signal-recognition_particle (170 words)

	Publications (Site not responding. Last check: 2007-10-07)
		Krieg, U.C., Walter, P. and Johnson, A.E. Photocrosslinking of the signal sequence of nascent preprolactin to the 54-kilodalton polypeptide of the signal recognition particle.
		Isolation and characterization of the signal recognition particle receptor.
		Signal recognition protein (SRP) causes signal sequence-dependent and site-specific arrest of chain elongation that is released by microsomal membranes.
	walterlab.ucsf.edu /publications.html (4194 words)

	Protein Kinesis
		The decision to enter the ER is dictated by the presence of a signal sequence on the growing polypeptide.
		The signal sequence consists of the first portion of the elongating polypeptide chain (so the signal sequence occurs at the amino terminal of the polypeptide).
		the signal sequence is recognized by and is bound by a signal recognition particle (SRP)
	users.rcn.com /jkimball.ma.ultranet/BiologyPages/P/ProteinKinesis.html (976 words)

	BioMed Central \| Full text \| Identification and comparative analysis of components from the signal recognition particle ...
		The signal recognition particle (SRP) is a ribonucleoprotein complex responsible for targeting proteins to the ER membrane.
		SRP first binds the N-terminal signal sequence of the nascent chain as it appears on the surface of translating ribosomes.
		Interestingly, the Alu domain of Theileria annulata was reminiscent of the SRP RNA Alu domain previously identified in the Ciliophora Tetrahymena [23], in the respect that the helix 4 appeared to be absent.
	www.biomedcentral.com /1471-2164/5/5 (5592 words)

	The Ribosome Regulates the GTPase of the {beta}-subunit of the Signal Recognition Particle Receptor -- Bacher et al. ...
		- and ß-subunit of the SRP receptor (SR).
		A, Cross-linking of radiolabeled GTP to SR in the presence or absence of RNC and/or SRP.
		Dual recognition of the ribosome and the signal recognition particle by the SRP receptor during protein targeting to the endoplasmic reticulum
	www.jcb.org /cgi/content/full/146/4/723 (5164 words)

	Ribosomes on the Rough endoplasmic reticulum
		Once the signal sequence is detected, protein synthesis resumes and the rest of the protein is inserted in the lumen.
		Note that the signal sequence is recognized by a Recognition Particle, or SRP.
		After the protein is synthesized, the ribosome dissociates into large and small subunits and the SRP also looses its attachment to the receptor.
	cellbio.utmb.edu /cellbio/rer2.htm (1158 words)

	Mammalian signal recognition particle
		The affinity of signal recognition particle for presecretory proteins is dependent on nascent chain length.
		Disassembly and Reconstitution of the Signal Recognition Particle.
		Zwieb, C. Recognition of a Tetranucleotide Loop of Signal Recognition Particle RNA by Protein SRP19.
	www.unige.ch /cyberdocuments/theses2003/HuckL/these_back.html (4230 words)

	Signal Recognition Particle-dependent Targeting of Ribosomes to the Rough Endoplasmic Reticulum in the Absence and ...
		incubated with DSS in the absence of PK-RM to crosslink the signal
		displacement of SRP from the signal sequence of the nascent polypeptide.
		of GTP hydrolysis for dissociation of the signal recognition particle
	www.molbiolcell.org /cgi/content/full/9/1/117 (6887 words)

	The Structure of Multiple Polypeptide Domains Determines the Signal Recognition Particle Targeting Requirement of ...
		SRP (51), recognizes proteins on the basis of hydrophobicity.
		Photocrosslinking of the signal sequence of nascent preprolactin to the 54-kilodalton polypeptide of the signal recognition particle.
		The signal sequence of nascent preprolactin interacts with the 54K polypeptide of the signal recognition particle.
	jb.asm.org /cgi/content/full/181/15/4561 (5196 words)

	ChristianZwieb (Site not responding. Last check: 2007-10-07)
		The proteins carry signal sequences which act as "zip codes" that are recognized by the signal recognition particle (SRP), the "post office" of the cell.
		Cooperative Assembly of Signal Recognition Particle RNA with Protein SRP19.
		Recognition of a tetranucleotide loop of signal recognition particle RNA by protein SRP19.
	www.uthct.edu /BIRE/Faculty/ChristianZwieb.htm (983 words)

	The signal recognition particle binds to protein L23 at the peptide exit of the Escherichia coli ribosome -- GU et al. ...
		The signal recognition particle binds to protein L23 at the peptide exit of the Escherichia coli ribosome -- GU et al.
		The SRP in Escherichia coli is composed of a 48-kD
		The affinity of SRP to the ribosome is increased >10-fold
	www.rnajournal.org /cgi/content/full/9/5/566 (4732 words)

	biology - Signal recognition particle
		The signal recognition particle (SRP) is a protein-RNA complex that recognizes and transports specific proteins to the endoplasmic reticulum in eukaryotes and the plasma membrane in prokaryotes.
		The core of the particle is universal, being conserved in all three kingdoms.
		In eukaryotes, it binds to the ER signal sequence found in an emerging secretory protein and subsequently delivers the protein along with the ribosomes creating it to the ER membrane.
	www.biologydaily.com /biology/Signal_recognition_particle (93 words)

	Reconstitution of the signal recognition particle of the halophilic archaeon Haloferax volcanii -- Tozik et al. 30 ...
		Reconstitution of the signal recognition particle of the halophilic archaeon Haloferax volcanii -- Tozik et al.
		Reconstitution of the signal recognition particle of the halophilic archaeon Haloferax volcanii
		the membrane is mediated by the SRP receptor, composed of the
	nar.oxfordjournals.org /cgi/content/full/30/19/4166 (5141 words)

	Structure, function and evolution of the signal recognition particle (Site not responding. Last check: 2007-10-07)
		The signal recognition particle (SRP) is a ribonucleoprotein particle essential for the targeting of signal peptide-bearing proteins to the prokaryotic plasma membrane or the eukaryotic endoplasmic reticulum membrane for secretion or membrane insertion.
		SRP binds to the signal peptide emerging from the exit site of the ribosome and forms a ribosome nascent chain (RNC)−SRP complex.
		The RNC−SRP complex then docks in a GTP-dependent manner with a membrane-anchored SRP receptor and the protein is translocated across or integrated into the membrane through a channel called the translocon.
	www.nature.com /emboj/journal/v22/n14/abs/7590747a.html (191 words)

	Secretion of LamB-LacZ by the Signal Recognition Particle Pathway of Escherichia coli -- Bowers et al. 185 (19): 5697 ...
		SRP homologues are found in all of the domains of life.
		Increasing signal sequence hydrophobicity reroutes LamB to the SRP pathway.
		The presence of a helix breaker in the hydrophobic core of signal sequences of secretory proteins prevents recognition by the signal-recognition particle in Escherichia coli.
	jb.asm.org /cgi/content/full/185/19/5697 (4813 words)

	Accumulation of endoplasmic membranes and novel membrane-bound ribosome-signal recognition particle receptor complexes ...
		The ribosome regulates the GTPase of the beta-subunit of the signal recognition particle receptor.
		SRbeta coordinates signal sequence release from SRP with ribosome binding to the translocon.
		Role of Sec61alpha in the regulated transfer of the ribosome-nascent chain complex from the signal recognition particle to the translocation channel.
	www.jcb.org /cgi/content/full/159/3/403 (3517 words)

	Signal recognition particle assembly in relation to the function of amplified nucleoli of Xenopus oocytes -- ...
		Signal recognition particle assembly in relation to the function of amplified nucleoli of Xenopus oocytes -- Sommerville et al.
		Signal recognition particle assembly in relation to the function of amplified nucleoli of Xenopus oocytes
		SRP RNA was targeted specifically to nucleoli (C), whereas control antisense RNA failed to concentrate in any nuclear structures (F), although autofluorescence is seen from a contaminating yolk platelet (YP).
	jcs.biologists.org /cgi/content/full/118/6/1299 (6025 words)

	A novel precursor recognition element facilitates posttranslational binding to the signal recognition particle in ...
		A novel precursor recognition element facilitates posttranslational binding to the signal recognition particle in chloroplasts -- DeLille et al.
		A novel precursor recognition element facilitates posttranslational binding to the signal recognition particle in chloroplasts
		Signal recognition particles (SRPs) in the cytosols of prokaryotes and eukaryotes are used to target proteins to cytoplasmic
	www.pnas.org /cgi/content/abstract/97/4/1926 (577 words)

	CiteULike: Prediction of signal recognition particle RNA genes. (Site not responding. Last check: 2007-10-07)
		CiteULike: Prediction of signal recognition particle RNA genes.
		We describe a method for prediction of genes that encode the RNA component of the signal recognition particle (SRP).
		Our method for SRP RNA gene prediction is the first convenient tool for this task and should be useful in genome annotation.
	www.citeulike.org /article/118798 (236 words)

	Signal Recognition Particle
		The initial view of signal recognition particle (SRP)* shows the M domain of E.
		The structure of SRP* complex is described by Batey et al.
		(2000) "Crystal structure of the ribonucleoprotein core of the signal recognition particle." Science 287 1232-1239.
	www.bio.cmu.edu /Courses/03438/SRP2000/1dul.htm (154 words)

	Citebase - Human autoantibodies against the 54 kDa protein of the signal recognition particle block function at ...
		Abstract The 54 kDa subunit of the signal recognition particle (SRP54) binds to the signal sequences of nascent secretory and membrane proteins and it contributes to the targeting of these precursors to the membrane of the endoplasmic reticulum (ER).
		At the ER membrane, the binding of the signal recognition particle (SRP) to its receptor triggers the release of SRP54 from its bound signal sequence and the nascent polypeptide is transferred to the Sec61 translocon for insertion into, or translocation across, the ER membrane.
		When the effect of anti-SRP autoantibodies on protein targeting the ER membrane was further investigated, we found that the autoantibodies prevent the SRP receptor-mediated release of ER signal sequences from the SRP54 subunit.
	citebase.eprints.org /cgi-bin/citations?id=oai:biomedcentral.com:ar1895 (526 words)

	Protein gi3322699
		Sequence neighbours to Treponema pallidum protein gi3322699, signal recognition particle protein (ffh)
		Mycoplasma pneumoniae, signal recognition particle protein; similar to Swiss-Prot Accession Number Q01442, from M. mycoides
		signal recognition particle receptor - alpha subunit; Srp101p
	www.sbc.su.se /PhylProM/TPAL/gi3322699.html (156 words)

	[No title]
		(NM_009273) signal recognition particle 14 kDa (homologous Alu RNA binding protein); signal recognition particle 14 kDa (homologous Alu RNA-binding protein) [Mus musculus] refXP_123910.1
		(NM_003134) signal recognition particle 14kD (homologous Alu RNA binding protein); signal recognition particle 14kD (homologous Alu RNA-binding protein) [Homo sapiens] spP37108SR14_HUMAN Signal recognition particle 14 kDa protein (SRP14) (18 kDa ALU RNA binding protein) pirS34196 signal recognition particle 14K chain - human embCAA51838.1
		(NC_001136) Signal recognition particle subunit; Srp14p [Saccharomyces cerevisiae] spP38985SR14_YEAST SIGNAL RECOGNITION PARTICLE 14 KD PROTEIN HOMOLOG (SRP14) pirS51616 signal recognition particle protein SRP14 - yeast (Saccharomyces cerevisiae) gbAAA53402.1
	bio.lundberg.gu.se /srpdb/srp14/srp14.html (2619 words)

	HSLS: SRPDB -- Signal Recognition Particle Database (Site not responding. Last check: 2007-10-07)
		The SRP RNA alignment emphasizes base pairs supported by comparative sequence analysis to derive accurate SRP RNA secondary structures for each species.
		Additional data include polypeptides with established or potential roles in SRP-mediated protein targeting, motifs for the identification of new SRP RNA sequences, 2D representations, 3D models in PDB format, and links to the high-resolution structures of several SRP components.
		New to this version of SRPDB is the introduction of a relational database system and a SRP RNA prediction server (SRP-Scan) which allows the identification of SRP RNAs within genome sequences and also generates secondary structure diagrams.
	www.hsls.pitt.edu /guides/genetics/tools/protein/information/URL1100621570/info (247 words)

	Energy Citations Database (ECD) - Energy and Energy-Related Bibliographic Citations
		and SRP proteins.^One of the 30-kD proteins (SR..beta..) forms a tight complex with SR..cap alpha..
		is an integral component of SRP receptor.^The presence of SR..beta..
		and SR..beta...^The affinity of mp30 for SRP suggests that it may serve a yet unknown function in protein translocation.
	www.osti.gov /energycitations/product.biblio.jsp?osti_id=6590450 (274 words)

	Signal Recognition Particle (Site not responding. Last check: 2007-10-07)
		Other signals: plastid, mitochondrial, ER retention, lysosomes, NLS, NRS, etc.
		SRP proteins (14, 9; 72, 68; 19; 54)
		M: methionine rich, interacts with signal and RNA
	opbs.okstate.edu /~melcher/Lec.htmlfolder/441NAPS.html (211 words)

	The signal recognition particle and related small cytoplasmic ribonucleoprotein particles -- Bovia and Strub 109 (11): ...
		The signal recognition particle and related small cytoplasmic ribonucleoprotein particles -- Bovia and Strub 109 (11): 2601 -- Journal of Cell Science
		The signal recognition particle and related small cytoplasmic ribonucleoprotein particles
		The Trypanosomatid Signal Recognition Particle Consists of Two RNA Molecules, a 7SL RNA Homologue and a Novel tRNA-like Molecule
	jcs.biologists.org /cgi/content/abstract/109/11/2601 (281 words)

	Signal Recognition Particle. (Site not responding. Last check: 2007-10-07)
		Interacts with the signal peptide of the incoming protein
		Interacts with the srp receptor in the ER membrane
		M domain interacts with signal peptide, with srp rna
	www.arches.uga.edu /~bpatham/bcmb8010/feature.htm (65 words)

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