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| | BioMed Central | Full text | Allele frequency misspecification: effect on power and Type I error of model-dependent ... |
 | | For a significance level of 0.0001, the power increased from 39% to 56% when the "true" marker allele frequencies of 0.001, 0.24975, 0.24975, 0.24975, and 0.24975 were misspecified as 0.1, 0.225, 0.225, 0.225, and 0.225, respectively. |
 | | Results are presented in Figure 2 for the 0.0001 significance level, using the marker at a recombination fraction of 0.01. |
 | | As shown in Figure 4 for the 0.01 significance level, an increase in Type I error was usually observed when the frequency of the most common allele(s) was decreased (misspecified downward from the true value) and that of the less common allele(s) increased in analysis using a sample-specific estimated trait model. |
| www.biomedcentral.com /1471-2156/7/21 (3964 words) |
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