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Topic: Simvastatin

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Scandinavian Simvastatin Survival Study

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	Simvastatin Information on Healthline
		Simvastatin is used to reduce the total amounts of cholesterol, LDL (bad) cholesterol, triglycerides (another type of fat), and apolipoprotein B (a protein needed to make cholesterol) in your blood.
		Simvastatin is in the FDA pregnancy category X. This means that simvastatin is known to cause birth defects if it is taken during pregnancy.
		Simvastatin may need to be taken on a long-term basis for the treatment of high cholesterol.
	www.healthline.com /multumcontent/simvastatin (911 words)

	American Heart Association '98 - Merck Simvastatin Symposium
		Simvastatin is a lactone that is readily hydrolyzed in vivo to the corresponding beta-hydroxyacid, a potent inhibitor of HMG-CoA reductase.
		Following administration of simvastatin tablets, the coefficient of variation, based on between-subject variability, was approximately 48 percent for the area under the concentration-time curve (AUC) for total inhibitory activity in the general circulation.
		Simvastatin is metabolized by the cytochrome P450 isoform 3A4.
	members.tripod.com /~APICENTER/AHA98-merck.html (6745 words)

	Zocor - Zocor Side Effects - Zocor Information - Canada Pharmacy - Canada Drugs
		Simvastatin was also found to slow the progression of coronary atherosclerosis in patients with coronary heart disease as part of a treatment strategy to lower total and LDL-cholesterol to target levels.
		In one study in 404 hypercholesterolemic men and women with coronary heart disease, simvastatin monotherapy was shown to significantly slow the progression of coronary atherosclerosis as assessed by quantitative angiography and significantly reduce the development of both new lesions and new total occlusion.
		Simvastatin (5 to 80 mg/day) reduces the levels of total cholesterol (19 to 36%), LDL-cholesterol (26 to 47%), apolipoprotein B (19 to 38%), and triglycerides (12 to 24%), in patients with mild to severe hyperlipidemia (Fredrickson Types IIa and IIb).
	www.rxcarecanada.com /Zocor.asp?prodid=2185 (4321 words)

	MedlinePlus Drug Information: Simvastatin
		Simvastatin is used together with lifestyle changes (diet, weight-loss, exercise) to reduce the amount of cholesterol (a fat-like substance) and certain other fatty substances in your blood.
		Simvastatin is in a class of medications called HMG-CoA reductase inhibitors (statins).
		Simvastatin can harm the fetus.Do not breast-feed while you are taking this medication.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a692030.html (925 words)

	Howstuffworks "Simvastatin: A Profile of a Lipid-Lowering Drug"
		Simvastatin is used to treat hyperlipidemia (high blood-fat levels).
		Simvastatin chemically interferes with an enzyme in the body that is responsible for synthesizing cholesterol.
		Simvastatin can be taken with meals or with a full glass of water if stomach upset occurs (unless your doctor directs you otherwise).
	health.howstuffworks.com /define-simvastatin.htm (804 words)

	simvastatin (Zocor) - drug class, medical uses, medication side effects, and drug interactions by MedicineNet.com
		Simvastatin may interact with cholestyramine (Questran), warfarin (Coumadin), and cimetidine (Tagamet) to alter the blood levels of these medicines.
		When Coumadin is given together with simvastatin, blood clotting times require monitoring to avoid excessive blood thinning and bleeding.
		NURSING MOTHERS: Simvastatin should not be used by nursing mothers because of potential adverse side effects to the nursing infant.
	www.medicinenet.com /simvastatin/article.htm (583 words)

	EZETIMIBE/SIMVASTATIN (MDXexchange)
		Simvastatin is administered as a prodrug, which is hydrolyzed in the liver to the open hydroxy acid, its active form; excretion is primarily via the biliary tract.
		Simvastatin, a prodrug, is hydrolyzed in the liver to the beta-hydroxyacid, the active inhibitor of HMG-CoA reductase (Prod Info Zocor(R), 2003).
		Simvastatin should be temporarily withheld or stopped in patients with a condition suggestive of myopathy or risk factors for developing acute renal failure (ie, severe infection, hypotension, major surgery, trauma, severe metabolic or endocrine disorders, and uncontrolled seizures) (Prod Info Zocor(R), 2002).
	www.micromedex.com /products/updates/drugdex_updates/de/ezetimibe.html (4143 words)

	News: New Study Showed VYTORIN(R) (ezetimibe/simvastatin) Significantly More Effective than Crestor(R) (rosuvastatin) ...
		Simvastatin Simvastatin is a lactone that is readily hydrolyzed in vivo to the corresponding (beta)-hydroxyacid, a potent inhibitor of HMG-CoA reductase.
		Simvastatin In a study including 16 elderly patients between 70 and 78 years of age who received simvastatin 40 mg/day, the mean plasma level of HMG-CoA reductase inhibitory activity was increased approximately 45% compared with 18 patients between 18-30 years of age.
		Simvastatin In a 72-week carcinogenicity study, mice were administered daily doses of simvastatin of 25, 100, and 400 mg/kg body weight, which resulted in mean plasma drug levels approximately 1, 4, and 8 times higher than the mean human plasma drug level, respectively (as total inhibitory activity based on AUC) after an 80-mg oral dose.
	www.genengnews.com /news/bnitem.aspx?name=2678140 (9174 words)

	Ezetimibe with Simvastatin Provided Significantly Greater Reductions in LDL Cholesterol Compared to Lipitor and Zocor ...
		Co-administration of ezetimibe with simvastatin was well tolerated and had an overall safety profile similar to that of simvastatin monotherapy in the study.
		Simvastatin should not be used by anyone allergic to any of its components, with liver disease, or by women who are pregnant, breast-feeding or likely to become pregnant.
		Simvastatin is marketed by Merck and Co., Inc. under the trade name Zocor and is in the class of cholesterol lowering agents known as statins.
	www.burtonsys.com /ezetimibe_simvastatin.htm (8073 words)

	IngentaConnect Simvastatin: a review (Site not responding. Last check: 2007-10-14)
		The only important, although rare, adverse effect of simvastatin is myopathy, an effect shared by all members of the class; when severe, this can take the form of rhabdomyolysis, which may lead to acute renal failure.
		Simvastatin has been studied in two large outcome trials, the Scandinavian Simvastatin Survival Study (4S), and the Heart Protection Study (HPS), both of which demonstrated strikingly beneficial effects on a variety of cardiovascular outcomes, with minimal adverse effects.
		HPS showed that the beneficial effects of simvastatin were obtainable in a broad array of patients with, or at high risk of, coronary heart disease (CHD) in categories previously little studied, including women, the elderly, patients with diabetes without known CHD, and, perhaps most importantly, patients with LDL-C well below the UK population average.
	www.ingentaconnect.com /content/apl/eop/2004/00000005/00000012/art00016 (340 words)

	Ezetimibe/simvastatin for hypercholesterolemia American Family Physician - Find Articles (Site not responding. Last check: 2007-10-14)
		Simvastatin serum levels may be increased when simvastatin is given concomitantly with medications that affect the cytochrome P450 (CYP450) 3A4 enzyme system, increasing the risk of myopathy and rhabdomyolysis.
		Two studies, (3,5) with a total of 1,555 participants, demonstrated ezetimibe/simvastatin to be more effective in lowering low-density lipoprotein (LDL) cholesterol levels than simvastatin monotherapy, with a mean reduction of 51 to 53 percent compared with 37 to 39 percent with simvastatin alone.
		Another two studies, (2,6) with a total of 2,690 participants, showed ezetimibe/simvastatin to be more effective than atorvastatin (lipitor) in lowering LDL cholesterol, resulting in an average reduction of 52 to 53 percent compared with 45 percent in both studies with atorvastatin alone.
	www.findarticles.com /p/articles/mi_m3225/is_10_72/ai_n15999073 (719 words)

	Simvastatin (Site not responding. Last check: 2007-10-14)
		In a preliminary trial, people with high cholesterol who had been taking simvastatin for about three years were able to significantly lower their triglyceride levels and raise their levels of HDL (“good”) cholesterol by supplementing with either 900 mg or 1800 mg of EPA for three months in addition to simvastatin.
		Although there is evidence that some or all of these nutrients may help prevent heart disease, individuals taking simvastatin who wish to take antioxidants should discuss the use of these supplements with their doctor.
		Simvastatin decreases the hepatic secretion of very-low-density lipoprotein apolipoprotein B-100 in heterozygous familial hypercholesterolaemia: pathophysiological and therapeutic implications.
	www.kroger.com /hn/Drug/Simvastatin.htm (1137 words)

	Simvastatin (Site not responding. Last check: 2007-10-14)
		Simvastatin can help lower blood cholesterol for patients who are at risk of getting heart disease or a stroke.
		Your prescriber may decide to temporarily stop taking simvastatin while you are taking a short course of the antibiotic or antifungal therapy.
		Simvastatin is only part of a total cholesterol-lowering program.
	www.stjohn.org /HealthInfoLib/swArticle.aspx?26,565 (643 words)

	SIMVASTATIN - ORAL (Zocor) side effects, medical uses, and drug interactions.
		It is used along with a proper diet to help lower cholesterol and fats (triglycerides) in the blood.
		Simvastatin is used in adults and children (10 years of age and older).
		If you also take certain other drugs to lower your cholesterol (bile acid-binding resins such as cholestyramine or colestipol), take simvastatin at least 1 hour before or at least 2 hours after these medications.
	www.medicinenet.com /simvastatin-oral/article.htm (373 words)

	Simvastatin
		ZOCOR1 (simvastatin) is a lipid-lowering agent that is derived synthetically from a...
		(simvastatin) is a lipid-lowering agent that is derived synthetically from a..
		Simvastatin is the most widely prescribed statin in the United Kingdom,...Similar pages..
	hometown.aol.com /medmagz/simvastatin.html (769 words)

	HealthLINK: Cardiac: Simvastatin cuts heart risks for people with diabetes - Yale-New Haven Hospital
		The study demonstrated that taking a daily dose of 40 mg of simvastatin (Zocor®) reduced the risk of a first nonfatal heart attack and of major coronary events by 27 percent in patients with diabetes regardless of their cholesterol or glucose levels.
		During the five-year study, the overall safety profiles were comparable between patients treated with simvastatin and patients treated with placebo.
		Heart disease is the most significant killer of people with diabetes, and the study shows conclusively that simvastatin can lower that risk no matter what the patient’s age, sex, LDL cholesterol profile or level of blood sugar control.
	www.ynhh.org /healthlink/cardiac/cardiac_8_04.html (1453 words)

	Zocor (simvastatin)
		Rhabdomyolysis from Simvastatin Triggered by Infection - Medscape, 9/8/05
		simvastatin was associated with a 2.79-mm Hg decrease in systolic blood pressure and a 2.67-mm Hg drop in diastolic blood pressure, while pravastatin led to a 2.47-mm Hg decline in systolic blood pressure and a 2.47-drop in diastolic blood pressure"
		Zetia with simvastatin reduced levels of the marker CRP by 33.3 percent compared to simvastatin administered alone (14.3 percent...
	qualitycounts.com /drugs/statins/zocor_simvastatin.html (2527 words)

	HealthLINK: Cardiac: Simvastatin plus niacin lower heart attack risk - Yale-New Haven Hospital
		The study results show that when simvastatin and niacin are combined, heart disease can be slowed, and in some cases reversed.
		Although the study used only simvastatin, Dr. Brown says the results of a combination probably would be similar if one of the other statin drugs was used.
		Although the beneficial effect of using a combination of simvastatin and niacin is not surprising to most doctors, the degree of improvement demonstrated in this very small study is striking.
	www.ynhh.org /healthlink/cardiac/cardiac_1_02.html (1818 words)

	simvastatin (Site not responding. Last check: 2007-10-14)
		If the drug is continued after myopathy has been detected by elevation of creatine phosphokinase (CPK), sever myositis, hrabdomyolysis and acute renal failure can occur.
		Simvastatin may shorten the sleep period by up to 3 hours (up to 18%).
		Simvastatin and resins have synergistic effects because they act on the same system at different points.
	lysine.pharm.utah.edu /netpharm/netpharm_00/druglist/simvastatin.htm (216 words)

	MedlinePlus Drug Information: Ezetimibe and Simvastatin ( Systemic) (Site not responding. Last check: 2007-10-14)
		Ezetimibe and Simvastatin (e-ZET-e-mibe and SIM-va-stat-in) is used to lower cholesterol and triglyceride (fat-like substances) levels in the blood.
		Pregnancy—Ezetimibe and simvastatin should not be used during pregnancy or by women who plan to become pregnant.
		Your doctor may need to monitor the amount of ezetimibe and simvastatin that you are taking when you are taking either of these medicines.
	www.nlm.nih.gov /medlineplus/druginfo/uspdi/500567.html (1223 words)

	Drug points: Simvastatin and impotence -- Jackson 315 (7099): 31 -- BMJ
		trials of simvastatin or in the drug's data sheets.
		Simvastatin may affect the central nervous system directly by
		Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S).
	www.bmj.com /cgi/content/full/315/7099/31/a (318 words)

	Finasteride and Simvastatin (Site not responding. Last check: 2007-10-14)
		Commonly known as Zocor®, Simvastatin is a treatment for high cholesterol.
		Simvastatin binds to the HMG- CoA reductase enzyme.
		Thus, by reducing the levels of cholesterol in the body, Simvastatin can be used to treat patients with high risk of heart problems.
	www.louisville.edu /~mjwell04/details1.htm (371 words)

	Simvastatin Inhibits Inflammatory Properties of Staphylococcus aureus{alpha}-Toxin -- Pruefer et al. 106 (16): 2104 -- ...
		Simvastatin or vehicle was administered intraperitoneally 18 hours before study.
		Simvastatin pretreatment significantly inhibited P-selectin expression in the mesenteric microvasculature.
		Simvastatin Inhibits Leukocyte Accumulation and Vascular Permeability in the Retinas of Rats with Streptozotocin-Induced Diabetes
	circ.ahajournals.org /cgi/content/full/106/16/2104 (3073 words)

	Simvastatin - Drugs & Vitamins - Drug Library - DrugDigest (Site not responding. Last check: 2007-10-14)
		Do not take simvastatin with grapefruit juice; orange juice may be used instead.
		Discuss your drug regimen with your health care provider if you are prescribed certain antibiotics or antifungals which are not recommended to be taken with simvastatin (examples: clarithromycin, erythromycin, itraconazole, ketoconazole).
		If you are going to have surgery tell your prescriber or health care professional that you are taking simvastatin.
	www.drugdigest.org /DD/DVH/Uses/0,3915,609\|Simvastatin,00.html (763 words)

	Lipids Online Slides: simvastatin, 4S, diabetes, LIPID, CARE
		In this analysis, simvastatin therapy was associated with a 42% reduction in major coronary events such as fatal and nonfatal MI, and there was also a significant 48% reduction in revascularizations.
		In this analysis, simvastatin therapy was associated with significant reductions in all four major endpoints: major coronary events, revascularizations, total mortality, and CHD mortality.
		In an economic analysis of the effect of simvastatin on hospital stay in 4S, there was a 55% reduction with simvastatin therapy in patients with diabetes (using the ADA criterion), a 38% reduction in patients with impaired fasting glucose, and a 28% reduction in patients with normal fasting glucose.
	www.lipidsonline.org /slides/slide01.cfm?q=simvastatin (1093 words)

	Simvastatin Drug Information
		Atorvastatin, cerivastatin#, fluvastatin, lovastatin, pravastatin, and simvastatin are used to lower levels of cholesterol and other fats in the blood.
		However, atorvastatin, lovastatin, and simvastatin have been used in a limited number of children under 18 years of age.
		Early information seems to show that these medicines may be effective in children, but their long-term safety has not been studied.
	www.drugs.com /cons/Simvastatin.html (1909 words)

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