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| | Mechanism of action of sodium hypochlorite |
 | | Sodium hypochlorite is the most used irrigating solution in endodontics, because its mechanism of action causes biosynthetic alterations in cellular metabolism and phospholipid destruction, formation of chloramines that interfere in cellular metabolism, oxidative action with irreversible enzymatic inactivation in bacteria, and lipid and fatty acid degradation. |
 | | The worldwide use of sodium hypochlorite as a root canal irrigating solution is due mainly to its efficacy for pulpal dissolution and antimicrobial activity. |
 | | Sodium hypochlorite is recommended and used by the majority of dentists because this solution presents several important properties: antimicrobial effect (3,4,16), tissue dissolution capacity (1-12,15) and acceptable biologic compatibility in less concentrated solutions (17,18). |
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