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Topic: Solid-phase synthesis

    Note: these results are not from the primary (high quality) database.

Selection of papers on solid phase peptide synthesis published after 1996 Sutcliffe-Goulden, J.L., O'Doherty, M.J., & Bansal, S.S. (2000) Solid phase synthesis of [F-18]labelled peptides for positron emission tomography. Varkey, J.T., & Pillai, V.N.R. (1999) Solid phase synthesis of hydrophobic peptides on 1,6-hexanediol diacrylate cross-linked polystyrene resin. Jenkins, K.E., Higson, A.P., Seeberger, P.H. & Caruthers, M.H. (1999) Solid phase synthesis of O-boranophosphopeptides and O-dithiophosphopeptides. www.5z.com /divinfo/spps.html

Papers on solid phase organic synthesis published in 2003 Nakamura,K., Ohnishi,Y., Horikawa,E., Konakahara,T., Kodaka,M., & Okuno,H. (2003) New selenyl linker for solid-phase synthesis of dehydropeptides. His,S., Meyer,C., Cossy,J., Emeric,G., & Greiner,A. (2003) Solid phase synthesis of amides by the Beckmann rearrangement of ketoxime carbonates. Kubo,T., Morikawa,M., Ohba,H., & Fujii,M. (2003) Synthesis of DNA-Peptide Conjugates by Solid-Phase Fragment Condensation. zinc.5z.com /divinfo/spos03.html

Patent 5021550: Method for preventing deletion sequences in solid phase synthesis Solid phase synthesis has already been used to prepare the P2 fragment which has been purified to as high as 90% of the activity present in the natural P2 fragment. Solid phase synthesis has been known for some time for use in the preparation of peptides and other oligomers such as nucleotides. A major disadvantage of solid phase synthetic methods for the preparation of oligomeric materials such as peptides and nucleotides results from the fact that the reactions involved in the scheme are imperfect; no reaction proceeds to 100% completion. www.freepatentsonline.com /5021550.html

Solid-Phase Synthesis of 1,2-Benzophenazine and Some Fused Imidazole Derivatives Thus, the use of the solid-phase method for the synthesis of heterocyclic compounds may significantly simplify preparation of such compounds and provide for the synthesis of derivatives, which cannot be obtained in solution. Thus, we have found that the synthesis of benzo[b]phenazine (1) occurs in 98% yield upon treating a mixture of 1,2-phenylenediamine (lla) and 2,3-naphlho[b]quinone (III) in a vibrational ball mill. The synthesis was carried out analogously to procedure A but using silica gel particles as the working element, mainained for 24 h, treated in VP mixer with steel balls for 2 h. www.ch.ic.ac.uk /ectoc/echet98/pub/097/index.htm

Solid Phase Synthesis Solid phase synthesis has found praise in its ability to separate the resin-attached targets from large amounts of excess reagents and impurities. Linker groups are attached to resin beads in the solid phase and the reactants are passed over in solution to make the intermediates and a final detachment-from-resin reaction is run to get the desired product out of the column. But this area is still growing with respect to isolating target molecules that are smaller than the peptides the synthesis was originally developed for. www.udel.edu /chem/C465/senior/fall00/DrugDiscovery/SolidPhaseSynthesis.htm

Solid phase peptide synthesis In solid phase synthesis, the C-terminal residue is attached covalently to an insoluble resin. A very high efficiency is needed for amino acid synthesis to work properly, since any mistakes made are cumulative. As each new residue is added, the elongation product attached to the solid resin is recovered by filtration (or centrifugation). www.vuw.ac.nz /staff/alan_clark/teaching/courses/221/sequencing/tsld044.htm

Combinatorial Website - New Articles Solid Phase Synthesis of Unsymmetrical Secondary Amines-Application to the Synthesis of Arylethanolamines and Arylpropanolamines Purandare, A. V.; Poss, M. Tetrahedron Lett. Solid Phase Synthesis of Macrocycles by an Intramolecular Ketophosphonate Reaction. Solid-phase synthesis of N-hydroxyindoles and benzo[c]isoxazoles by C-arylation of substituted acetontriles and 1,3-dicarbonyl compounds with polystyrene-bound aryl fluorides H. Stephensen, F. Zaragoza Tetrahedron Lett. www.combinatorial.com /new.html

Solid-phase synthesis The solid phase synthesis of a representative eight-residue polyamide is reported. The solid phase synthesis of sequence specific DNA binding polyamides containing N-methylimidazole (Im) and N-methylpyrrole (Py) amino acids is described. Solid-phase synthesis of sequence specific DNA binding polyamides containing imidazole and pyrrole amino acids www.cco.caltech.edu /~pbdgroup/abstracts/baird1.html

Solid Phase Synthesis of Benzodiazepines Even though the claims are fairly specific in the use of solid phase combi chem techniques to produce libraries of benzodiazepines, this is probably the earliest work describing organic synthesis on the solid phase, the preparation of combi libraries. The prior art in 1992 for solid phase synthesis was limited to peptides and nucleotides as far as I can tell. A General and Expedient Method for the Solid Phase Synthesis of 1,4-Benzodiazepine Derivatives, J. Am. www.lib.uchicago.edu /cinf/218nm/paper55/sld018.htm

Solid phase synthesis The revolutionary principle behind solid phase peptide synthesis (SPPS) as conceived by Merrifield in 1959 is that if the peptide is bound to an insoluble support then any unreacted reagents left at the end of any synthetic step can be removed by a simple wash procedure, greatly decreasing the time required for synthesis. The field of solid phase peptide synthesis has rapidly grown since its inception by Merrifield but is dominated by use of BOC/benzyl and Fmoc/ The traditional resin used for Merrifield synthesis was a chloromethylphenyl substituted resin. www.vuw.ac.nz /staff/paul_teesdale-spittle/peptide-synthesis/pep-syn-files/solid-phase.htm

Solid-phase synthesis of oligopurine deoxynucleic guanidine (DNG) and analysis of binding with DNA oligomers -- Linkletter et al. 29 (11): 2370 -- Nucleic Acids Research 29 Linkletter,B. and Bruice,T.C. (1998) Solid-phase synthesis of oligomeric deoxynucleic guanidine (DNG): a polycationic analogue of DNA. Solid-phase synthesis of oligopurine deoxynucleic guanidine (DNG) and analysis of binding with DNA oligomers -- Linkletter et al. Solid-phase synthesis of oligopurine deoxynucleic guanidine (DNG) and analysis of binding with DNA oligomers nar.oupjournals.org /cgi/content/full/29/11/2370

StratoSpheres Resins for Solid Phase Synthesis Polymer Laboratories (PL) manufactures microporous StratoSpheres™ resins as supports for solid phase synthesis for use in both medicinal and combinatorial chemistry applications as well as traditional phase peptide synthesis. (Hydroxythiophenol resin, Marshall resin, for the synthesis of carboxamide and lactams) (4-Hydroxymethylbenzoic acid AMS resin, a base labile linker for the synthesis of amides, esters and alcohols) www.polymerlabs.com /stratospheres/solphase.htm

Barany Abstracts Incorporation of unprotected phosphotyrosine during the synthesis of peptides with multiple phosphotyrosine residues has been studied as a function of coupling conditions and the absence or presence of intervening amino acid residues. The pyrophosphate-forming side reaction is more severe with increased coupling dimes and/or repetitions of coupling and occurs only when the phosphotyrosine residues are directly adjacent to one another. However when it is used to incorporate consecutive phosphotyrosine residues, a pyrophosphate linkage can form between the two adjacent tyrosines. www.chem.umn.edu /groups/baranygp/old/abstracts/137.html

SPSR Overview The key to automation of solid phase synthesis is controlling the pressure, mixing, and filtering of solvent in the reactor cells in an unattended fashion. The SPS-REG regulator is controlled via its front panel keypad or by a remote PC as part of a robotic solid phase synthesis station. Computer controlled pressure regulator for solid phase synthesis blocks. www.jkem.com /cmre230.html

Press Release - Fmoc Solid Phase Peptide Synthesis The solid phase peptide synthesis (SPPS) was first introduced by Merrifield in 1963 (Merrifield, 1963). Fields GB and Noble RL (1990) Solid phase peptide synthesis utilizing 9-fluorenylmethoxycarbonyl amino acids. Pennington MW and Dunn BM (1994) Peptide Synthesis Protocol. www.synpep.com /Corporate/Press/april0803.htm

Link Technologies Tools For Molecular Biology New products include the Quasar™ Dyes, Black-Hole Quenchers™ (BHQs), and a new 3000Å SynBase™ CPG Solid Support for synthesising long sequences. Molecular biology research, employing DNA and RNA synthesis and modification, demands increasingly complex reagents only sophisticated chemistry can provide. Most links provided are accompanied by a short summary of the site to help you in your searching. www.linktech.co.uk

index John Wiley and Sons, Inc. is pleased to announce plans to publish Solid-Phase Organic Syntheses (SPOS), a new book series that will provide organic chemists with verified solid-phase synthesis procedures that can be repeated in the laboratory. Solid-phase quench methodologies for library generation, while of obvious value, are not considered appropriate for this series; however, the preparation of the resins themselves may be. Though focusing on library synthesis procedures, other issues addressed may include resin preparation, library screening and encoding. chem-faculty.ucsd.edu /siegel

ScienceWeek Toward that end, the authors have synthesized an environment-sensitive fluorescent amino acid, Aladan, and incorporated it site-specifically into proteins by both nonsense suppression and solid-phase synthesis, and the authors have used it to probe the electrostatic character of the B1 domain of streptococcal protein G (GB1) at multiple sites by steady-state and time-resolved fluorescence. These materials are formed by dissolving a salt (for example LiI) in a solid host polymer such as poly(ethylene oxide) (2-5), and may be prepared as both crystalline and amorphous phases. The electrical, optical, and electrochemical properties of conjugated polymers can be modified by chemical synthesis and are strongly affected by relatively small perturbations, including changes in temperature, solvent, or chemical environment. scienceweek.com /2003/sw030919.htm

Solid-Phase Synthesis The Solid-Phase Synthesis database from Synopsys (now Accelrys) contains a selection of relevant material from primary literature, reviews and patents (1963 - present) from nearly 4,000 publications. The Focus is on Chemical transformations, selected to illustrate the variety of reaction types which have been demonstrated on the solid phase. Emphasis is placed on 'small-molecule' transformations but 'state of the art' methods and new developments in the areas of peptide, oligosaccaride and oligonucleotide synthesis are also covered. cds.dl.ac.uk /cds/datasets/orgchem/isis/sps.html

Solid Phase Synthesis Resins Whether you are beginning your discovery process or finalizing your clinical studies, Ambersynth™ CTC provides you the quality, consistency, and volume you require to utilize solid phase peptide synthesis on a commercial multi-ton scale. Ambersynth™ CTC resin has been developed and optimized by Rohm and Haas at the direct request of customers who were not satisfied with the availability or the consistent quality of the solid phase resins they were getting in the marketplace. Rohm and Haas has developed acetate resins to provide solid phase sources for attaching Acetate moieties to terminal amino acids. www.ambersynth.com

James Tour's Publications (149) Morgan, A. B.; Jurs, J. L.; Tour, J. "Synthesis, Flame-Retardancy Testing, And Preliminary Mechanism Studies Of Nonhalogenated Aromatic Boronic Acids: A New Class Of Condensed-Phase Polymer Flame-Retardant Additives For Acrylonitrile-Butadiene-Styrene And Polycarbonate" J. App. (3) Silane compound for use in the synthesis of semiconducting polymers with perpendicular arranged cores. Organic Synthesis for the Construction of Nanoarchitectures", Chem. www.jmtour.com /publication.htm

Organic Synthesis on Solid Phase In recent years many new synthetic methods for solid-phase synthesis have been developed, and this technique is becoming a valuable alternative to traditional synthesis, in particular when large numbers of different compounds in small quantities are needed for screening. Combinatorial chemistry and the production of compound libraries are usually based on solid phase synthesis. The work quickly guides the reader to the best method for preparing a given class of compounds on solid phase. www.angelfire.com /fl2/doerwald/spos4.htm

Theses from Umeå University: 438 - Solid-phase glycoconjugate synthesis F NMR spectral quality for resins commonly used in solid-phase organic synthesis: a study of peptide solid-phase glycosylations. Mogemark, Mickael ; Gustafsson, Linda ; Bengtsson, Chrisoffer ; Elofsson, Mikael ; Kihlberg, Jan: A Fluorinated Selenide Linker for Solid-Phase Synthesis of n- Pentenyl Glycosides.. Solid-phase synthesis, protective groups, linkers, monitoring, gel-phase, 19F NMR spectroscopy, carbohydrates, oligosaccharides, glycopeptides www.diva-portal.org /umu/theses/abstract.xsql?dbid=438

livre innovation and perspectives in solid phase synthesis : peptides, polypeptides and oligonucleotides, composes organiques, synthese et structure des medicaments, pharmacie, edition lavoisier livre innovation and perspectives in solid phase synthesis : peptides, polypeptides and oligonucleotides, composes organiques, synthese et structure des medicaments, pharmacie, edition lavoisier This book contains major contributions on solid phase bio-organic synthesis. Descriptions of recent milestone achievements in the synthesis of specific biological macromolecules are presented alongside state-of-the-art reports of general application and interest. www.lavoisier.fr /notice/fr0946707440.html

Janda Group - Publications Moss, J.A., Dickerson, T.J., Janda, K.D., "Solid phase peptide synthesis on JandaJel resin" Reger, T.S., Janda, K.D., "Parallel suspension polymerization for high-throughput resin synthesis" Cordova, A., Janda, K.D., "Synthesis and catalytic antibody functionalization of dendrimers" www.scripps.edu /cgi-bin/janda/publications.cgi

Development of synthetic tools for the solid-phase synthesis of CNS active compounds The researchgroup at the university of Amsterdam will focus at developing novel N-acyliminium ion chemistry on solid phase, so that new heterocyclic compound classes (with possible CNS activity) will become available via solid support reactions. Despite greatly expanded research efforts in CC in the past three years, the development of new techniques for the synthesis of large numbers of compounds will also be vital in the near future. Combinatorial chemistry (CC) has recently become a major topic in organic synthesis as a result of its potential to develop into an essential tool for the discovery of new pharmaceuticals or catalysts. www.stw.nl /projecten/A/ach4597.html

Accelrys: Chemical Databases Solid Phase Synthesis (SPS) 2005.1 for Accord Database Explorer (ADE) is now available >>> SPS contains a wealth of cross-referenced information with 25,989 reactions abstracted from the primary literature, growing approximately 2,655 reactions from the previous release. Produced in association with J.W. Wiley and Sons, the database currently consists of over 95,000 reactions www.accelrys.com /chem_db/sps.html

Optimization of Solid-Phase Combinatorial Synthesis Optimization of Solid-Phase Combinatorial Synthesis addresses the key topic in combinatorial synthesis—how to optimize the quality of a combinatorial library—by determining the usefulness of synthesized compounds, the reliability of biological assay results, and analyzing academic and industrial applications, real-world examples, and case studies of successful and unsuccessful technologies. With contributions from nearly 30 experts in library synthesis strategy, purification, and characterization, Optimization of Solid-Phase Combinatorial Synthesis is an essential reference for organic, analytical, medicinal, pharmaceutical, computational, protein, and peptide chemists and biochemists; pharmacists; pharmacologists; molecular biologists; molecular and vibrational spectroscopists; and upper-level undergraduate and graduate students in these disciplines. Key Factors in the Translation of Solution-Phase Chemistry to the Solid Phase www.chipsbooks.com /optsolid.htm

Molecular Diversity Combinatorial Chemistry and Solid Phase Synthesis Patents granted in the area of molecular diversity and solid phase synthesis Molecular Diversity Combinatorial Chemistry and Solid Phase Synthesis Selection of papers on solid phase peptide synthesis published after 1996 www.5z.com /divinfo

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