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Topic: Somatic gene therapy

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	Gene therapy - Wikipedia, the free encyclopedia
		Gene therapy is the insertion of genes into an individual's cells and tissues to treat a disease, and hereditary diseases in particular.
		Gene C is the "normal" or "desirable" gene we want in the place of gene B. Thus, by re-engineering the virus so that gene B is replaced by gene C, while allowing gene A to properly function, this virus could introduce your 'good gene'- gene C into the host cell's genome without causing any disease.
		Gene therapy trials to treat severe combined immunodeficiency (SCID) were halted or restricted in the USA when leukemia was reported in three of eleven patients treated in the French Therapy X-linked SCID (XSCID) gene therapy trial.
	en.wikipedia.org /wiki/Gene_therapy (3799 words)

	General Information on Gene Therapy
		Somatic gene therapy consists of introducing a gene into the somatic cells of an individual with the expectation that the gene will be expressed and that its product will exert a therapeutic effect.
		Somatic gene therapy may be performed in vitro on explanted autologous cells, syngeneic (patient's twin) cells, or even on allogeneic (human) or xenogeneic (non-human) cell lines.
		The term "gene therapy" is usually understood to mean the process by which a new gene is introduced into the somatic cells of an individual with the aim of producing some therapeutic effect.
	www.wiley.com /legacy/wileychi/genmed/clinical/general.html (1046 words)

	Gene Therapy
		Genes can be altered before conception in the sperm or egg, after conception in the embryo, or even after the baby is born.
		In somatic treatment, genes are inserted into the diploid cells of the patient through the use of "lipids and virus-mediated systems" called vectors (Lemoine 2).
		Gene therapy faces many of the same issues that are faced "whenever a powerful new technology is developed" (www.cancernet).
	homepage.mac.com /belacqua/eng190_F2000/student_papers/sec30/weber.html (1793 words)

	Somatic Gene Therapy (Site not responding. Last check: 2007-11-03)
		Somatic Gene therapy is provided by introducing a new therapeutic gene (transgene) into the diseased cells of a patient.
		The first approved somatic gene therapy was in 1990 to treat ADA deficiency (an ex-vivo treatment of white blood cells), and the technology has spread rapidly.
		It is now generally accepted that the main limitations to widespread somatic gene therapy are simply the technical ones of devising effective vectors and transgenes.
	www.ess.ucla.edu /huge/somatic.html (541 words)

	Gene Therapy and Children (Site not responding. Last check: 2007-11-03)
		Gene therapy carries the excitement of a cure-all for a host of diseases, the controversy surrounding the altering of human genes, and the promise of a type of medical treatment most of us would never imagine possible.
		Somatic gene therapy involves introducing a "good" gene into targeted cells with the end result of treating the patient - but not the patient's future children because these genes do not get passed along to offspring.
		Gene therapy's potential to revolutionize medicine in the future is exciting, and its expectations for curing and preventing childhood diseases is encouraging.
	kidshealth.org /parent/system/medical/gene_therapy.html (1305 words)

	Untitled Document
		The uses of somatic gene therapy are being developed at an astonishing rate, and it is beyond the scope of this website to discuss all its current or anticipated uses.
		Somatic gene therapy is also being used to treat cancer, and it is hopeful that eventually the number of diseases subject to treatment by somatic gene therapy will increase exponentially.
		Because somatic gene therapy does not affect the germ cells and therefore the genetic alterations will not be passed on to the next generation, it does not raise the same sort of ethical questions that germline gene therapy raises.
	www.brown.edu /Courses/BI0032/gentherp/IIAB.htm (590 words)

	Gene Therapy
		Genes, which are carried on chromosomes, are the basic physical and functional units of heredity.
		Gene therapy for treating children with X-SCID (sever combined immunodeficiency) or the "bubble boy" disease is stopped in France when the treatment causes leukemia in one of the patients.
		In cases of somatic gene therapy, the procedure may have to be repeated in future generations.
	www.ornl.gov /hgmis/medicine/genetherapy.html (2280 words)

	Somatic gene therapy. Present situation and future perspective.
		Gene therapy is characterized by the transfer of genetic information to a patient through the use of recombinant DNA technology.
		Human gene therapy must, however, be limited to manipulations affecting somatic, differentiated cells to prevent the transferred gene from being transmitted to the individual's descendants.
		A comparison of the different regulatory situations of gene therapy in Europe and the United States demonstrates that for the European countries a uniform regulation is desired.
	www.aegis.com /aidsline/1999/mar/a9930001.html (670 words)

	Human Gene Therapy
		Gene therapy is the use of genes to treat disease.
		The term gene therapy originally referred to proposed treatments of genetic disorders that would involve replacing a defective gene with its normal counterpart Current usage of the term now extends to include all treatments in which there is an introduction of genetic material into body cells to treat a variety of diseases.
		When we use viruses for gene therapy we disable them so that they are unable to cause disease and we engineer them in such a way that they pick up and deliver the genes of our choice rather than their own genes.
	www.ndsu.nodak.edu /instruct/mcclean/plsc431/students99/oberoi.htm (2665 words)

	Gene therapy (Site not responding. Last check: 2007-11-03)
		Gene therapy is a rapidly growing field of medicine in which genes are introduced into the body to treat diseases.
		Gene therapy seeks to provide genes that correct or supplant the disease-controlling functions of cells that are not, in essence, doing their job.
		Gene therapy also is being considered as an approach to solving a problem associated with a surgical procedure known as balloon angioplasty.
	www.healthatoz.com /healthatoz/Atoz/ency/gene_therapy.jsp (4727 words)

	NFP37GT adverse event
		If there is a concern with gene therapy, Dr. Rao said, "is it a general concern, or should it be limited?" The French study was once hailed as one of the first breakthroughs in gene therapy: 10 children suffering from a rare immune disorder were largely cured.
		The French gene therapy death was tragic, but as many as 50% of those treated with the best available alternatives to gene therapy will either die of their disease or suffer lifelong complications from the therapy, Parkman said.
		Gene therapy was heralded as a major breakthrough when researchers began work in the early 1990s, with hopes that it would lead to cures for a variety of genetic disorders, such as cancer, Parkinson's disease and cystic fibrosis.
	www.unifr.ch /nfp37/adverse.html (7711 words)

	Report and Recommendations of the Panel to Assess the NIH Investment in Research on Gene Therapy. This report concerns ... (Site not responding. Last check: 2007-11-03)
		Somatic gene therapy is a logical and natural progression in the application of fundamental biomedical science to medicine and offers extraordinary potential, in the long-term, for the management and correction of human disease, including inherited and acquired disorders, cancer, and AIDS.
		The Panel urges gene therapy investigators and their sponsors--be they academic, governmental, private, or industrial-to be more circumspect regarding the aims and accomplishments of clinical protocols when discussing their work with the scientific community, the public, and the media.
		Anderson outlined a variety of gene therapy research studies at his institution, suggesting that this locally concentrated diversity of interests and ideas is another sign that this field is healthy and populated with creative young investigators.
	www.nih.gov /news/panelrep.html (16879 words)

	Gene Therapy: Genetics: Merck Manual Home Edition
		However, germline therapy is generally considered an inappropriate way to deal with genetic diseases because of ethical issues, cost, lack of research in humans, lack of knowledge about whether changes would be maintained in the growing embryo, and the relative ease of using somatic therapy.
		A totally different approach to gene therapy is the use of antisense technology, in which, rather than altering abnormal genes, the abnormal genes are simply switched off (antisense drugs combine with specific sequences on the DNA that prevent the affected genes from functioning).
		Gene therapy is also being studied experimentally in transplantation surgery; by altering the genes of the transplanted organs, the organ recipient would not need to receive immunosuppressive drugs, which have significant side effects.
	www.merck.com /mmhe/au/print/sec01/ch002/ch002d.html (399 words)

	NFP37 somatic gene therapy
		This WEB site is meant as an information source for all interessees (be them expert or not)
		in the progress of and in the debates around 'gene therapy'.
		Third leukaemia case in Paris' gene therapy trial
	www.unifr.ch /nfp37/welcome.html (130 words)

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