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Topic: Somnolence

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	Letter - Mirapex
		While somnolence is a common occurrence in patients receiving MIRAPEX and many clinical experts believe that falling asleep while engaged in activities of daily living only occurs in the context of pre-existing somnolence, many patients who have fallen asleep have perceived no warning.
		Since somnolence is a frequent adverse event with potentially serious consequences, patients should neither drive a car nor engage in other potentially dangerous activities until they have gained sufficient experience with MIRAPEX to gauge whether or not it affects their mental and /or motor performance adversely.
		Patients should be advised that if increased somnolence or episodes of falling asleep during activities of daily living (e.g., watching television, passenger in a car, etc.) are experienced at any time during treatment, they should not drive or participate in potentially dangerous activities and should contact their physician.
	www.fda.gov /MEDWATCH/safety/1999/mirape.htm (779 words)

	X-Men/new comers -RESTARTED- - RPG Chat (Site not responding. Last check: 2007-10-20)
		Somnolence twiddled a piece of fl hair between his thumb and index fingers, grey-blue eyes watching every jerk of the clock's hand.
		Somnolence finally released his attention from the clock and stood, sliding down the long sleeves of his shirt.
		Somnolence thought about it for a moment, the back of his mind only catching slight and blurred scenes of memory from the said project.
	forums.rpgchat.com /showthread.php?t=44525 (4820 words)

	[No title] (Site not responding. Last check: 2007-10-20)
		Somnolence is a common unwanted side effect of most antihistamines and is dose related.
		Therefore, any azelastine that penetrates the back of the throat and the mouth is orally absorbed, contributing to the central nervous system effects of somnolence and also accounts for the bitter taste experienced by patients.
		As demonstrated by the examples, this lower dose reduces the incidence of somnolence, and because the active ingredient remains at the target organ and does not accumulate in the back of the throat and mouth, this formulation does not impart a bitter taste.
	www.wipo.int /cgi-pct/guest/getbykey5?KEY=01/52818.010726&ELEMENT_SET=DECL (4346 words)

	People Living With Cancer - Managing Side Effects - Sleeping Problems: Hypersomnia, Somnolence Syndrome, and Nightmares (Site not responding. Last check: 2007-10-20)
		Hypersomnia, also called somnolence, excessive daytime sleepiness, or prolonged drowsiness, is a condition characterized by excessive sleeping, or the inability to maintain wakefulness when desired.
		Somnolence syndrome is a type of hypersomnia associated with cranial radiation (radiation treatment to the head) in children.
		Symptoms of somnolence syndrome include excessive drowsiness, prolonged periods of sleep (up to 20 hours a day), headaches, low-grade fever, nausea, vomiting, and irritability.
	www.plwc.org /plwc/MainConstructor/1,1744,_12-001011-00_15-001000-00_17-001029-00_18-0038362-00_19-0038365-00_20-001-00_21-008,00.asp (763 words)

	Penn State Faculty Research Expertise Database (FRED) (Site not responding. Last check: 2007-10-20)
		The effect of topical nasal fluticasone on objective sleep testing and the symptoms of rhinitis, sleep, and daytime somnolence in perennial allergic rhinitis.
		Recent data suggested that daytime somnolence in patients with allergic rhinitis was secondary to disrupted sleep caused by nasal congestion.
		The objective of this 8-week, double-blind, placebo-controlled study was to determine if topical nasal fluticasone is effective at decreasing subjective congestion and daytime somnolence and improving sleep and if this improvement correlated with a change in overnight sleep testing (polysomnography).
	fred.hmc.psu.edu /ds/retrieve/fred/publication/12635578 (329 words)

	Pharmacy Times: GERD Is Associated with Daytime Somnolence
		Epidemiologic studies have suggested a relationship between gastroesophageal reflux disease (GERD) and daytime somnolence, perhaps due to nighttime sleep disturbances and frequent awakenings caused by nocturnal heartburn and regurgitation of gastric contents.
		The influence of GERD on daytime cognitive function was examined by Pál Demeter, MD, and colleagues in a study of 134 patients undergoing upper panendoscopy.
		Mild somnolence (8 on the ESS) occurred in only 29% of the GERD 0 group (mild GERD) but was noted in 39% of the GERD I group and in 46% of the GERD II group.
	www.pharmacytimes.com /article.cfm?ID=1422 (214 words)

	Psychoactive Herbs - NAVBAR_TITLE
		These effects were followed by somnolence and a short sleep during which lively dreams were reported by the majority of the volunteers.
		The cats stared for long periods of time and 30 min after the administration of the zacatechichi extracts somnolence and sleep were frequently observed.
		Somnolence was observed during the appearance of these changes.
	psychoactiveherbs.com /catalog/article_info.php?articles_id=24 (3404 words)

	Paxil Side Effects, and Drug Interactions - Paroxetine Hydrochloride - RxList Monographs
		The most commonly observed adverse events associated with the use of paroxetine (incidence of 5% or greater and incidence for PAXIL at least twice that for placebo, derived from Table 2) were: Asthenia, sweating, decreased appetite, libido decreased, tremor, abnormal ejaculation, female genital disorders, and impotence.
		The most commonly observed adverse events associated with the use of paroxetine (incidence of 5% or greater and incidence for PAXIL at least twice that for placebo, derived from Table 2) were: Sweating, nausea, dry mouth, constipation, decreased appetite, somnolence, tremor, libido decreased, yawn, abnormal ejaculation, female genital disorders, and impotence.
		In a fixed-dose study comparing placebo and 20 and 40 mg of PAXIL in the treatment of posttraumatic stress disorder, for most of the adverse events, there was no clear relationship between adverse events and the dose of PAXIL to which patients were assigned, except for impotence and abnormal ejaculation.
	www.rxlist.com /cgi/generic/parox_ad.htm (2675 words)

	Topamax Side Effects, and Drug Interactions - Topiramate - RxList Monographs
		The adverse events in the controlled trial that occurred most commonly in adults in the 400 mg/day group and at a rate higher than the 50 mg/day group were: paresthesia, weight decrease, somnolence, anorexia, dizziness, and difficulty with memory NOS [see Table 4].
		The adverse events in the controlled trial that occurred most commonly in children (10 years up to 16 years of age) in the 400 mg/day group and at a rate higher than the 50 mg/day group were: weight decrease, upper respiratory tract infection, paresthesia, anorexia, diarrhea, and mood problems [see Table 5].
		These adverse events were: psychomotor slowing (4.0%), difficulty with memory (3.2%), fatigue (3.2%), confusion (3.1%), somnolence (3.2%), difficulty with concentration/attention (2.9%), anorexia (2.7%), depression (2.6%), dizziness (2.5%), weight decrease (2.5%), nervousness (2.3%), ataxia (2.1%), and paresthesia (2.0%).
	www.rxlist.com /cgi/generic2/topiram_ad.htm (1990 words)

	Dictionary.com/Word of the Day Archive/somnolent
		[I]n his case, restrained ultimately meant boring, as the audience was lulled into a somnolent state.
		Meanwhile, many a somnolent local authority has been stirred into action by Davidson's blunt approach.
		Somnolent is from Latin somnolentus, from somnus, "sleep." A related word is insomnia (in-, "not" + somnus).
	dictionary.reference.com /wordoftheday/archive/2005/07/08.html (106 words)

	Dr. Koop - Neurontin Side Effects & Drug Interactions
		The most commonly observed adverse events associated with the use of Neurontin ® in adults, not seen at an equivalent frequency among placebo-treated patients, were dizziness, somnolence, and peripheral edema.
		The most commonly observed adverse events associated with the use of Neurontin ® in combination with other antiepileptic drugs in patients >12 years of age, not seen at an equivalent frequency among placebo-treated patients, were somnolence, dizziness, ataxia, fatigue, and nystagmus.
		The adverse events most commonly associated with withdrawal in patients >12 years of age were somnolence (1.2%), ataxia (0.8%), fatigue (0.6%), nausea and/ or vomiting (0.6%), and dizziness (0.6%).
	www.drkoop.com /druglibrary/93/neurontin-side_effects_drug_interactions.html (1164 words)

	ASHP News: Sudden Somnolence Associated With Permax
		Lilly has revised the product's labeling to more explicitly alert health care providers about the drug-related somnolence, a common adverse event associated with the product.
		In some cases, sudden somnolence occurred up to a year after the patient began using the drug.
		The revised labeling advises patients who suffer "increased somnolence" while taking the drug, or who begin to fall asleep during routine activities such as watching television, to consult a physician about the advisability of driving or performing other "potentially dangerous activities."
	www.ashp.org /news/ShowArticle.cfm?id=3698 (176 words)

	Somnolence definition - Medical Dictionary definitions of popular medical terms
		Somnolence: Sleepiness, the state of feeling drowsy, ready to fall asleep.
		A person experiencing somnolence is somnolent and is acting somnolently.
		Somnolence, somnolent, and somnolently go back to the Latin "somnus" meaning (please don't yawn) "sleep."
	www.medterms.com /script/main/art.asp?articlekey=13097 (193 words)

	Kleine-Levin syndrome (www.whonamedit.com)
		Hypersomnia periodica, hibernation syndrome, hypersomnia-bulmia syndrome, hypersomnia-megaphagia syndrome, periodic hypersomnia-megaphagia syndrome, periodic somnolence, periodic somnolence and morbid hunger syndrome.
		Periodic somnolence and morbid hunger: A new syndrome.
		The syndrome of periodic somnolence and morbid hunger (Kleine-Levin syndrome).
	www.whonamedit.com /synd.cfm/1398.html (205 words)

	Microsleep during a Simplified Maintenance of Wakefulness Test . A Validation Study of the OSLER Test -- PRIEST et al. ...
		Daytime somnolence is both a symptom in many patients and a prevalent complaint in the general population, but its objective
		Excessive daytime somnolence is a frequent complaint, with severity varying from mild and unobtrusive to severe and disabling.
		The notion of somnolence is difficult to comprehend in quantitative terms.
	ajrccm.atsjournals.org /cgi/content/full/163/7/1619 (5535 words)

	UCB's Anti-Epileptic Keppra(R) Meets Primary End-Point in Monotherapy Trial
		In adults, Keppra(R) use is associated with the occurrence of central nervous system adverse events including somnolence and fatigue, coordination difficulties, and behavioral abnormalities, as well as hematological abnormalities.
		In pediatric patients 4 to 16 years of age, Keppra(R) is associated with somnolence, fatigue, and behavioral abnormalities, as well as hematological abnormalities.
		In pediatric patients 4 to 16 years of age, the most common adverse events associated with Keppra(R) in combination with other AEDs were somnolence, accidental injury, hostility, nervousness, and asthenia.
	www.prnewswire.com /cgi-bin/stories.pl?ACCT=104&STORY=/www/story/09-15-2005/0004107951&EDATE= (503 words)

	Pharmacy Update, January-February 2001 (Site not responding. Last check: 2007-10-20)
		Adverse effects reported at a frequency of 2% when compared to placebo included somnolence (7%); asthenia (6%); dizziness (5%); infection (5%); ataxia (2%); depression (2%); emotional liability (2%); nervousness (2%); pharyngitis (2%); and vertigo (2%).
		Asthenia, somnolence, and dizziness appeared to occur predominantly during the first 4 weeks of treatment.
		The potential for serious interactions between levetiracetam and other medications is low, but patients should be cautioned that they may experience dizziness and somnolence while taking this drug.
	www.cc.nih.gov /phar/updates/page4-marapr01.html (648 words)

	Parkinson’s drugs may cause sudden sleepiness - More Health News - MSNBC.com (Site not responding. Last check: 2007-10-20)
		The side effect has been reported previously in people with Parkinson’s disease being treated with dopamine agonists, including Mirapex and Requip, “but controversy persists concerning their nature, severity, and frequency,” according to a report in the Archives of Neurology.
		Jerry Avorn and colleagues from Harvard Medical School, in Boston, quantified the risk of sudden uncontrollable somnolence in 929 patients taking drugs for Parkinson’s disease.
		Of the 206 subjects who reported at least one episode, 34 percent had a small number of events (one to four) and 37 percent reported many frequent events (26 or more).
	www.msnbc.msn.com /id/6448213/did/9067851 (446 words)

	Letter - Mirapex
		Patients treated with MIRAPEX have reported falling asleep while engaged in activities of daily living, including the operation of motor vehicles which sometimes resulted in accidents.
		Somnolence is a common occurrence in patients receiving MIRAPEX at doses above 1.5 mg/day.
		Many clinical experts believe that falling asleep while engaged in activities of daily living always occurs in a setting of pre-existing somnolence, although patients may not give such a history.
	www.fda.gov /MedWatch/safety/1999/mirape.htm (779 words)

	[No title]
		Depression: The most commonly observed adverse events associated with the use of paroxetine (incidence of 5% or greater and incidence for paroxetine HCl at least twice that for placebo, derived from TABLE 3A and TABLE 3B) were: asthenia, sweating, nausea, decreased appetite, somnolence, dizziness, insomnia, tremor, nervousness, ejaculatory disturbance and other male genital disorders.
		The prescriber should be aware that these figures cannot be used to predict the incidence of side effects in the course of usual medical practice where patient characteristics and other factors differ from those which prevailed in the clinical trials.
		In a fixed-dose study comparing placebo and paroxetine HCl 20, 40, and 60 mg in the treatment of social anxiety disorder, for most of the adverse events, there was no clear relationship between adverse events and the dose of paroxetine HCl to which patients were assigned.
	www.best-meds.com /drugdescription/paxil_sideeffects.htm (2469 words)

	Sleep Disorders
		The initial point to establish in the history is to attempt to classify the patient into one of three categories:
		Excessive daytime somnolence (EDS), without insomnia, severe enough to cause significant impairment, i.e., falling asleep while driving or while actively engaged in an activity.
		Snoring, without excessive daytime somnolence or a history of apnea.
	www-nmcp.med.navy.mil /Neurology/guideslp.asp (1189 words)

	somnolence - OneLook Dictionary Search
		Somnolence : Online Plain Text English Dictionary [home, info]
		SOMNOLENCE : Lay Terms for Consent Forms [home, info]
		Phrases that include somnolence: somnolence syndrome, somnolence s
	www.onelook.com /?w=somnolence (180 words)

	Hospital Statistics for Coma - WrongDiagnosis.com
		0.02% (2,499) of hospital consultant episodes were for somnolence, stupor and coma in England 2002-03 (Hospital Episode Statistics, Department of Health, England, 2002-03)
		47% of hospital consultant episodes for somnolence, stupor and coma were for men in England 2002-03 (Hospital Episode Statistics, Department of Health, England, 2002-03)
		53% of hospital consultant episodes for somnolence, stupor and coma were for women in England 2002-03 (Hospital Episode Statistics, Department of Health, England, 2002-03)
	www.wrongdiagnosis.com /c/coma/hospital.htm (672 words)

	The Upper Airway Resistance Syndrome -- Exar and Collop 115 (4): 1127 -- Chest
		although no assessment of daytime somnolence was included.
		and a small retroglossal posterior airspace in somnolent patients.
		By definition, daytime somnolence is a component of UARS and
	www.chestjournal.org /cgi/content/full/115/4/1127 (7240 words)

	Somnolence to Palestinian Atrocities (by Girard Newkirk) - Media Monitors Network
		Somnolence to Palestinian Atrocities (by Girard Newkirk) - Media Monitors Network
		The last week in the Middle East has with pristine clarity illuminated the bias of the American media regarding the Israeli-Palestinian conflict.
		Vote for it to win in MMN Contest
	www.mediamonitors.net /girardnewkirk4.html (478 words)

	Definition of perjury,lithotype,somnolence,presentiment,caucus,profligacy,shuffle,bromine,ecstasy,fallacy
		Definitions of perjury, lithotype, somnolence, presentiment, caucus, profligacy, shuffle, bromine, ecstasy, fallacy
		Somnolence Define somnolence Meaning of somnolence What does somnolence mean?
		Explanation of perjury, lithotype, somnolence, presentiment, caucus, profligacy, shuffle, bromine, ecstasy, fallacy
	www.english-test.net /sat/vocabulary/words/074/sat-definitions.php (816 words)

	EFFICACY OF THE TOPICAL NASAL STEROID BUDESONIDE ON IMPROVING SLEEP AND DAYTIME SOMNOLENCE IN PATIENTS WITH PERENNIAL ...
		To determine the efficacy of topical nasal corticosteroids in
		the improvement of sleep and daytime somnolence among patients
		rhinitis have significantly more difficulty with daytime somnolence
	pediatrics.aappublications.org /cgi/content/full/114/2/S1/525-a (361 words)

	Energy Citations Database (ECD) - Energy and Energy-Related Bibliographic Citations
		Energy Citations Database (ECD) Document #6302513 - Somnolence syndrome in leukemic children following reduced daily dose fractions of cranial radiation
		Availability information may be found in the Availability, Publisher, Research Organization, Resource Relation and/or Author (affiliation information) fields and/or via the "Full-text Availability" link.
		Somnolence syndrome in leukemic children following reduced daily dose fractions of cranial radiation
	www.osti.gov /energycitations/product.biblio.jsp?osti_id=6302513 (129 words)

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