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	Sotalol - Wikipedia, the free encyclopedia
		Sotalol is a drug used in individuals with rhythm disturbances (cardiac arrhythmias) of the heart.
		Sotalol is used to treat ventricular tachycardias as well as atrial fibrillation.
		Some evidence suggests that sotalol should be avoided in the setting of decreased ejection fraction due to heart attack.
	en.wikipedia.org /wiki/Sotalol (207 words)

	Sotalol - AFF
		Sotalol is a special type of beta blocker that prevents irregular heart rhythms in addition to slowing the heart rate and lowering the blood pressure.
		Sotalol has been shown to reduce the frequency of recurrence of atrial fibrillation, as well as to slow the ventricular rate during atrial fibrillation.
		Sotalol prolongs the QT interval on the electrocardiogram.
	www.affacts.org /Medications/sotalol.html (616 words)

	Sotacor - Sotacor Side Effects - Sotacor Information - Canada Pharmacy - Canada Drugs (Site not responding. Last check: 2007-10-21)
		Sotalol is a racemic mixture of d-and l-sotalol.
		Sotalol may also be used for the treatment of patients with documented symptomatic ventricular arrhythmias when the symptoms are of sufficient severity to require treatment.
		Sotalol, like some antiarrhythmic agents, has been associated with a specific form of arrhythmia, torsades de pointes, which is defined as a polymorphic ventricular tachycardia with prolongation of the QT interval and QRS complexes of changing amplitude that appear to twist around the isoelectric axis.
	www.rxcarecanada.com /Sotacor.asp?prodid=1596 (5293 words)

	Data Sheet
		Although sotalol hydrochloride is usually well tolerated haemodynamically, caution should be exercised in patients with marginal cardiac reserve as deterioration in cardiac performance may occur.
		Sotalol hydrochloride crosses the blood-brain barrier poorly, with cerebrospinal fluid concentrations being 5%-28% of those observed in plasma.
		Sotalol is actively excreted in breast milk (milk/plasma ratio = 5.4/1) and therefore should not be administered to breastfeeding mothers.
	www.medsafe.govt.nz /profs/datasheet/a/aposotaloltab.htm (3306 words)

	Sotalol -- Facts, Info, and Encyclopedia article (Site not responding. Last check: 2007-10-21)
		Sotalol is a (A substance that is used as a medicine or narcotic) drug used in individuals with rhythm disturbances ((An abnormal rate of muscle contractions in the heart) cardiac arrhythmias) of the (The hollow muscular organ located behind the sternum and between the lungs; its rhythmic contractions pump blood through the body) heart.
		Sotalol is used to treat (Click link for more info and facts about ventricular tachycardia) ventricular tachycardias as well as (Fibrillation of the muscles of the atria of the heart) atrial fibrillation.
		Some evidence suggests that sotalol should be avoided in the setting of decreased (Click link for more info and facts about ejection fraction) ejection fraction due to (A sudden severe instance of abnormal heart function) heart attack.
	www.absoluteastronomy.com /encyclopedia/s/so/sotalol.htm (309 words)

	Sotalol kinetics in renal insufficiency. (Site not responding. Last check: 2007-10-21)
		Sotalol kinetics in renal insufficiency.In patients receiving dialysis, elimination t 1/2 rose to 33.9 +/- 27.1 hr.
		Kinetics of sotalol, a beta adrenoceptor blocker, was studied in 20 patients with varying renal function.
		In subjects with creatinine clearance (Clcr) greater than or equal to 39 ml/min/m2, sotalol plasma clearance (x +/- SD) was 71 +/- 31 ml/min/m2, elimination half-life (t 1/2) was 8.1 +/- 3.4 hr, and renal clearance was 46 +/- 26 ml/min/m2.
	www.pdg.cnb.uam.es /UniPub/iHOP/gp/3787487.html (126 words)

	Sotalol (Site not responding. Last check: 2007-10-21)
		Sotalol is initially given in the hospital where your condition can be monitored closely.
		Sotalol comes in tablets and is usually taken twice a day on an empty stomach, at least 2 hours after or 1 hour before breakfast and your evening meal.
		Before sotalol is prescribed, tell your health care provider about any other medicines you may be taking, including vitamins, herbals, dietary supplements, and other prescription and nonprescription (over-the-counter) medications.
	clevelandclinic.org /health/health-info/docs/0700/0734.asp?...&src=news (719 words)

	Sotalol Indications (Site not responding. Last check: 2007-10-21)
		Sotalol prevents relapses of ventricular arrhythmias (ventricular fibrillation, persistant ventricular tachycardia) better than class I anti-arrhythmic agents (e.g.
		In a small comparative study, sotalol was as effective against ventricular arrhythmias as amiodarone.
		The FDA only allows sotalol to be used for the treatment of life-threatening ventricular arrhythmias.
	www.infomed.org /100drugs/sotaind.html (144 words)

	MedlinePlus Drug Information: Sotalol
		Sotalol is in a class of medications called antiarrhythmics.
		Sotalol (Betapace) is usually taken twice a day and sotalol (Betapace AF) is usually taken once or twice a day on an empty stomach, at least 2 hours after or 1 hour before breakfast and your evening meal.
		If sotalol is stopped suddenly, it may cause chest pain or heart attack.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a693010.html (780 words)

	An open label, randomised, crossover study comparing sotalol and atenolol in the treatment of symptomatic paroxysmal ...
		The rationale for the preferential use of sotalol in the prevention of supraventricular arrhythmias lies in the presence of
		Propafenone and sotalol: long-term efficacy and tolerability in the prevention of paroxysmal atrial fibrillation.
		Multicentre comparative study of the efficacy and safety of sotalol in the prophylactic treatment of patients with paroxysmal supraventricular tachyarrhythmias.
	www.heartjnl.com /cgi/content/full/82/2/170 (3629 words)

	Sotalol, Betapace
		Two individuals taking sotalol developed a side effect of the drug (a heart arrhythmia known as torsades de pointes) which was effectively treated with intravenous magnesium.
		Therefore, sotalol should be taken an hour before or two hours after a meal or milk.
		Sotalol associated torsades de pointes tachycardia in a 15-month-old child: successful therapy with magnesium aspartate.
	www.truestarhealth.com /Notes/1498006.html (745 words)

	Data Sheet
		As sotalol is primarily excreted by the kidneys, dosage adjustment is necessary in patients with moderate renal impairment.
		Sotalol is actively excreted in breast milk (milk/plasma ratio = 5.4/1) and therefore should not be administered to nursing mothers.
		Sotalol hydrochloride 10 mg/mL is stable in 0.9% sodium chloride intravenous infusion and 5% glucose intravenous infusion at concentrations of 0.01 mg/mL and 2.0 mg/mL for 24 hours at room temperature (< 20°C) or for 6 days under refrigeration (2-8°C).
	www.medsafe.govt.nz /profs/Datasheet/s/sotacortabinj.htm (3909 words)

	Betapace Indications, Dosage, Storage, Stability - Sotalol Hcl - RxList Monographs
		Sotalol elimination is predominantly via the kidney in the unchanged form.
		Use of sotalol in any age group with decreased renal function should be at lower doses or at increased intervals between doses.
		This is to ensure that the amount of inactive solid particles per dose remains constant throughout the duration of use.
	www.rxlist.com /cgi/generic/betapaceaf_ids.htm (2151 words)

	sotalol (oral) - [Medication]
		Sotalol is not appropriate for everyone with irregular heartbeats.
		In some patients treated with sotalol for atrial fibrillation, sotalol may cause a different type of abnormal heartbeat that can be dangerous, and in rare instances can even cause death.
		Sotalol is in the FDA pregnancy category B. This means that it is not expected to be harmful to an unborn baby.
	www.peacehealth.org /kbase/multum/d00371a1.htm (1692 words)

	PillStore.MD - Sotalol (Site not responding. Last check: 2007-10-21)
		Because SOTALOL can cause irregular heartbeats, it should only be started while you are in a hospital where your condition can be closely monitored for at least 3 days.
		SOTALOL is a beta-blocking agent used to treat serious heart rhythm disturbances (arrhythmias).
		SOTALOL should be used only if clearly needed during pregnancy.
	www.pillstore.md /sotalol.html (661 words)

	BETAPACE AF in the News
		When transferring patients from BETAPACE or generic sotalol to BETAPACE AF, patients do not need to be hospitalized and may continue to be treated as outpatients if the dose is not increased.
		Sotalol is also indicated for the treatment of documented life-threatening ventricular arrhythmias and is marketed under the brand name BETAPACE.
		Sotalol is also indicated for the maintenance of normal sinus rhythm (delay in time to recurrence of atrial fibrillation/atrial flutter (AFIB/AFL)) in patients with symptomatic AFIB/AFL who are currently in sinus rhythm and is marketed under the brand name BETAPACE AF.
	www.betapaceaf.com /patient/in_the_news/pr1.jsp (1024 words)

	Sotalol - Drugs & Vitamins - Drug Library - DrugDigest
		SOTALOL (Betapace AF™) belongs to a group of medicines called beta-blockers.
		Betapace AF™ is a brand of sotalol tablets given only to patients with an atrial heart arrhythmia (irregular heartbeat) such as atrial fibrillation.
		Because your condition and the use of sotalol carry some risk, it is a good idea to carry an identification card, necklace or bracelet with details of your condition, medications, and prescriber or health care professional.
	www.drugdigest.org /DD/DVH/Uses/0,3915,612\|Sotalol,00.html (862 words)

	1233 -- Is Oral Sotalol Effective in Converting Atrial Fibrillation to Sinus Rhythm? (Site not responding. Last check: 2007-10-21)
		Since class III agents increase action potential duration and refractoriness in atrial tissue without affecting conduction, they are theoretically considered ideal agents for the treatment of reentrant arrhythmias such as AF.
		Sotalol was significantly inferior to quinidine in converting AF of recent onset (< 48 hrs) to sinus rhythm.
		In patients with duration of AF of more than 48 hours, sotalol was significantly less effective than quinidine and comparable with placebo.
	www.accp.com /pharmacotherapy/Abs17_6/1233.htm (237 words)

	BestBETs: Is Sotalol more effective than standard beta-block... (Site not responding. Last check: 2007-10-21)
		He showed doses needed to be increased in 18% of the ß-blocker and 10% of the Sotalol group, the final doses being 54±14 mg Metoprolol group and 40±0 mg in the sotalol group.
		The incidence of AF was 13.9% and 18.8% in the low dose Sotalol and Propranalol groups, respectively, and 10.9% and 13.7% in the high dose Sotalol and Propranalol groups.
		AF was seen in 5/50 (10%) of the Sotalol group and in 11/40 (27.5%) of patients on half their pre op ß blocker dose and in 4/11 (36%) patients on no treatment.
	www.bestbets.org /cgi-bin/bets.pl?record=00527 (1536 words)

	Low-dose oral sotalol for monomorphic ventricular tachycardia: effects during programmed electrical stimulation and ...
		The effects of oral sotalol were compared with the findings obtained in the baseline study of a group of 26 consecutive patients with sustained monomorphic ventricular tachycardia or ventricular fibrillation and inducible ventricular tachycardia.
		After the first administration of oral sotalol, two patients developed polymorphic ventricular tachycardia or torsade de pointes and one suffered from left ventricular failure.
		Long-term treatment with sotalol was given to 15 non-inducible patients, and two inducible patients, combined with an AICD or a pacemaker.
	www.eurheartj.org /cgi/content/abstract/10/3/218 (268 words)

	Sotalol - Patient UK
		Sotalol is used to treat and prevent certain types of arrhythmia's (irregular heartbeats).
		Sotalol is available in tablet and injection form.
		Sotalol may cause you to experience fainting or dizziness when getting up from a lying or sitting position.
	www.patient.co.uk /showdoc/30002624 (654 words)

	Sotalol Hydrochloride (Site not responding. Last check: 2007-10-21)
		Beta-blockers such as sotalol work by preventing--or blocking--nerve impulses from exerting an accelerating or intensifying effect on specific parts of the body, especially the blood vessels and heart.
		Sotalol passes into breast milk; consult your doctor about its use during nursing.
		People with the following conditions should consult their doctor before using sotalol: allergies or asthma; diabetes mellitus; heart or blood vessel disease (including congestive heart failure and peripheral vascular disease); hyperthyroidism; irregular (slow) heartbeat; a history of mental depression; myasthenia gravis; psoriasis; respiratory problems such as bronchitis or emphysema; kidney or liver disease.
	www.wholehealthmd.com /refshelf/drugs_view/1,1524,569,00.html (557 words)

	Tachycardia: Sotalol increased conversion to sinus rhythm.
		Patients who had supraventricular tachycardia and were given 1.0 mg/kg sotalol, were more likely to have conversion to sinus rhythm than those given placebo (NNT = 2 at 30 minutes).
		Sotalol 1.0 mg/kg is as effective as 1.5 mg/kg.
		Sung RJ, Tan HL, Karagounis L, et al: Intravenous sotalol for the termination of supraventricular tachycardia and atrial fibrillation and flutter: A multicenter, randomized, double-blind, placebo-controlled study.
	www.eboncall.org /CATs/419.htm (243 words)

	MedWatch - October 2001 Safety-Related Drug Labeling Changes (Site not responding. Last check: 2007-10-21)
		Both the Class III and beta-blocking effects of sotalol were linearly related with the plasma concentrations.
		of sotalol was administered in the single dose study and daily doses of 30, 90 and 210 mg/m
		As in adults BETAPACE (sotalol hydrochloride should be used with particular caution in children if the QT is greater than 500 msec on therapy and serious consideration should be given to reducing the dose or discontinuing therapy when QT exceeds 550 msec.
	www.fda.gov /medwatch/safety/2001/oct01.htm (7890 words)

	ELECTROPHYSIOLOGIC PROPERTIES OF CARDIOCYCLIDE, A NEW III-CLASS ANTIARRHYTHMIC DRUG, IN COMPARISION WITH SOTALOL IN ...
		Sotalol, which also has class III antiarrhythmic properties and produces beta-blocking activity, exerts more pronounced inhibiting effect on sinus node function and conduction as compared to that of Cardiocyclide.
		Sotalol has the frequency-dependent action due to blockade of rapid activating component (IKr) of delayed rectified potassium current only.
		Sotalol ability to inhibit conduction and suppress sinus node automaticity while on isoproterenol infusion remains.
	www.incart.spb.ru /vestnic/n26/kaverina-reze.htm (210 words)

	Product Information on Sotalol Hcl
		The potency of the active ingredient(s), Sotalol Hydrochloride.
		The date Sotalol Hcl was approved as stated in the FDA approval letter to the applicant.
		The group or category of approved drugs Sotalol Hcl is in.
	newdruginformation.com /Sotalol_Hcl_36.htm (146 words)

	Amiodarone maintained sinus rhythm better than sotalol or placebo in atrial fibrillation, but adverse effects were more ...
		Amiodarone maintained sinus rhythm better than sotalol or placebo in atrial fibrillation, but adverse effects were more frequent
		Low dose amiodarone and sotalol in the treatment of recurrent, symptomatic atrial fibrillation: a comparative, placebo controlled study.
		Sotalol, 160 mg (80 mg twice/d), is approximately
	ebm.bmjjournals.com /cgi/content/full/6/2/42 (587 words)

	Positive and Negative Inotropic Effects of DL-Sotalol and D-Sotalol in Failing and Nonfailing Human Myocardium Under ...
		The hemodynamic effects of sotalol and quinidine: analysis of rest and exercise gated radionuclide angiography.
		Multicenter trial of sotalol for suppression of frequent, complex ventricular arrhythmias: a double-blind, randomized, placebo-controlled evaluation of two doses.
		Comparative effects of sotalol and propranolol on contractility of papillary muscles and adenylcyclase activity of myocardial extracts of cat.
	circ.ahajournals.org /cgi/content/full/92/10/2904 (3081 words)

	Chest : Torsade de pointes and prolonged QT interval from surreptitious use of sotalol: use of drug levels in ... (Site not responding. Last check: 2007-10-21)
		In a patient presenting with torsade de pointes and a long QTc interval of unknown cause, a serum sotalol level was used to secure an otherwise difficult diagnosis.
		The diagnosis was made by serum levels of sotalol determined on the admission blood analysis.
		Serum levels of sotalol are a rarely used clinical assay.
	static.highbeam.com /c/chest/august011997/torsadedepointesandprolongedqtintervalfromsurrepti/index.html (247 words)

	Electrophysiological Effects of MS-551, a New Class III Agent: Comparison with dl-Sotalol in Dogs -- Sen et al. 285 ...
		The changes in the RVERP induced by MS-551 and sotalol were compared after complete AV block was established.
		Cui G, Sen L, Sager P, Uppel P and Singh BN (1994) Effects of amiodarone, sematilide and sotalol on QT dispersion.
		Kamiya J, Ishii M and Katakami T (1992) Antiarrhythmic effects of MS-551, a new class III antiarrhythmic agent, on canine models of ventricular arrhythmias.
	jpet.aspetjournals.org /cgi/content/full/285/2/687 (5112 words)

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