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| | MedlinePlus Medical Encyclopedia: Niemann-Pick |
 | | The four forms of Niemann-Pick Disease are all characterized by an accumulation of sphingomyelin and cholesterol in cells, particularly in the cells of major organs, such as the liver and the spleen. |
 | | The four most commonly recognized forms of the disease are types A, B, C, and D. Each subtype involves different organs and may or may not involve the central nervous system or respiratory system. |
 | | If ASM is absent or not functioning properly, sphingomyelin cannot be broken down (metabolized) properly and accumulates within the cells, eventually causing cell death and the malfunction of major organ systems such as the liver, brain, and lung. |
| www.nlm.nih.gov /medlineplus/ency/article/001207.htm (1427 words) |
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