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Topic: Spondyloarthropathies

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	Spondyloarthropathies-Topic Overview
		Spondyloarthropathies are a family of long-term (chronic) diseases of joints.
		Spondyloarthropathies are more likely to run in families than other forms of rheumatic disease, such as lupus or rheumatoid arthritis.
		Spondyloarthropathies are diagnosed through a medical history, laboratory tests, and by symptoms of joint and tissue inflammation, morning stiffness, and other symptoms unique to a specific spondyloarthropathy (such as scaly skin in psoriatic arthritis).
	www.webmd.com /hw/arthritis/tp21142.asp (831 words)

	Spondyloarthropathies (Site not responding. Last check: 2007-11-01)
		Spondyloarthropathies are a family of long-term (chronic) diseases of joints.
		Spondyloarthropathies are more likely to run in families than other forms of rheumatic disease, such as lupus or rheumatoid arthritis.
		Spondyloarthropathies are diagnosed through a medical history, laboratory tests, and by symptoms of joint and tissue inflammation, morning stiffness, and other symptoms unique to a specific spondyloarthropathy (such as scaly skin in psoriatic arthritis).
	www.bcbswny.com /kbase/topic/special/hw87580spec/sec1.htm (695 words)

	Arthritis Research Campaign \| What's in a name? (Site not responding. Last check: 2007-11-01)
		The spondyloarthropathies are a family of similar diseases that usually cause joint and spine inflammation, and are quite distinct from rheumatoid arthritis.
		Because of this, use of 'seronegative arthritis' is declining and being replaced by 'seronegative spondyloarthropathy' and 'seronegative rheumatoid arthritis' respectively.
		In spondyloarthropathy it is likely that the joint damage is at the edge of the joint, caused by inflammation where the joint capsule joins the bone.
	www.arc.org.uk /newsviews/arctdy/116/spondyartho.htm (1024 words)

	Spondyloarthropathies: Joint Disorders: Merck Manual Professional
		Reactive arthritis is an acute spondyloarthropathy that is often related to an infection, usually GU or GI.
		Spondyloarthropathy associated with urethritis or cervicitis, conjunctivitis, and mucocutaneous lesions (previously called Reiter's syndrome) is one type of reactive arthritis.
		Juvenile-onset spondyloarthropathy is an asymmetric, mostly lower extremity spondyloarthropathy that begins most commonly in boys aged 7 to 16.
	www.merck.com /mmpe/sec04/ch034/ch034d.html (2584 words)

	Spondyloarthropathies American Family Physician - Find Articles
		Enthesitis is believed to be the primary lesion in the spondyloarthropathies, whereas synovitis is the main lesion in rheumatoid arthritis.
		Infection with an unknown organism or exposure to an unknown antigen in a genetically susceptible patient (HLA-B27-positive) is hypothesized to result in the clinical expression of a spondyloarthropathy.
		The prevalence of ankylosing spondylitis, the most common spondyloarthropathy, is 0.1 to 0.2 percent in the general U.S. population (possibly as high as 1 percent in certain groups) and is related to the prevalence of HLA-B27.
	www.findarticles.com /p/articles/mi_m3225/is_12_69/ai_n6159455 (817 words)

	Arthritis Research Campaign \| Seronegative Spondyloarthropathies (Site not responding. Last check: 2007-11-01)
		The combined prevalence of spondyloarthropathy in the general population is estimated to be approximately 1%, comparable to that of rheumatoid arthritis.
		Spondyloarthropathies are responsible for a number of children with juvenile idiopathic arthritis (JIA).
		Uveitis associated with inflammatory bowel disease, psoriasis and undifferentiated spondyloarthropathy may be less characteristic in its presentation, with a higher tendency to posterior uveitis, bilateral involvement and chronicity.
	www.arc.org.uk /about_arth/med_reports/series4/tr/6604/6604.htm (3124 words)

	FRISC > Faculty Profiles > Joel D. Taurog, M.D.
		A hypothesis for the HLA-B27 immune dysregulation in spondyloarthropathy: contributions from enteric organisms, B27 structure, peptides bound by B27, and convergent evolution.
		[Spondyloarthropathies and HLA-B27 subtypes in the populations of the Russian North]
		Enteropathic arthritis, Whipple's disease, juvenile spondyloarthropathy, uveitis, and SAPHO syndrome.
	invention.swmed.edu /frisc/faculty/taurog/profile.shtml (3303 words)

	Update on Spondyloarthropathies -- Khan 136 (12): 896 -- Annals of Internal Medicine (Site not responding. Last check: 2007-11-01)
		Spondyloarthropathies are a cluster of interrelated and overlapping
		In conclusion, spondyloarthropathies are a cluster of interrelated
		Spondyloarthropathy is underestimated in inflammatory bowel disease: prevalence and HLA association J Rheumatol.
	www.annals.org /cgi/content/full/136/12/896 (6193 words)

	Ankylosing Spondylitis
		Complications of ankylosing spondylitis may include inflammation of the coloured part of the eye (iris) called iritis, or difficulty breathing due to curving of the upper body and stiffening of the chest wall.
		Examples of spondyloarthropathies include psoriatic arthritis, Reiter's syndrome, and arthritis associated with inflammatory bowel disease.
		Most people with this condition or other spondyloarthropathies are born with a particular gene, HLA-B27.
	www.bchealthguide.org /kbase/topic/mini/tr4496/overview.htm (600 words)

	Online CME
		Spondyloarthropathies are often diagnosed late in the course of disease and treatment options have been limited, but new therapies are emerging with potential to offer significant relief and improve structural and functional outcomes.
		The spondyloarthropathies (SpA) are a diverse group of chronic inflammatory conditions linked by distinctive clinical, radiographic, and genetic features.
		Inflammatory back pain and enthesitis (inflammation at sites where tendons and ligaments attach to bone) are hallmarks of this family of disorders that affect the spine and sacroiliac and peripheral joints.
	www-cme.erep.uab.edu /onlineCourses/uab_insight/winter05/spondyloarthropathies/ID0228.htm (1183 words)

	MERSI Ocular Immunology and Uveitis Foundation\| Medical Professionals \| Articles \| Case Reports
		The spondyloarthropathies also show considerable clinical overlap, so that sometimes it may be difficult to distinguish between them.
		Although opinions vary as to the importance of the diagnostic testing for the HLA-B27 gene, we believe that all patients with recurrent anterior uveitis and the absence of another clear etiologic agent, must be tested for HLA-B27, because of its prognostic implications and because it may help in therapeutic planning.
		Patients who give a history suggestive of a spondyloarthropathy should be tested for the HLA-B27 gene irrespective of the location of the uveitis and the number of episodes.
	www.uveitis.org /medical/articles/case/hlab27.html (2085 words)

	Normal Intestinal Bacteria Play a Role in Some Forms of Arthritis (Site not responding. Last check: 2007-11-01)
		In a novel study on the causes of some forms of arthritis, researchers have now shown in animals that both a bacterial trigger and genetic susceptibility are necessary for the disease to occur.
		Researchers already know that some forms of spondyloarthropathies, termed reactive arthritis, are triggered by certain types of infections, particularly in individuals with HLA-B27.
		Spondyloarthropathies comprise a spectrum of rheumatic diseases, most of which affect the joints of the spine.
	www.niams.nih.gov /ne/press/1994/11_30.htm (1031 words)

	spondyloarthropathies, Primary Sclerosing Cholangitis Literature (Site not responding. Last check: 2007-11-01)
		Reveille JD 1998 HLA-B27 and the seronegative spondyloarthropathies.
		Schaller JG 1979 The seronegative spondyloarthropathies of childhood.
		Solau-Gervais E, Legrand JL, Cortet B, Duquesnoy B, Flipo RM 2006 Magnetic resonance imaging of the hand for the diagnosis of rheumatoid arthritis in the absence of anti-cyclic citrullinated peptide antibodies: a prospective study.
	home.insightbb.com /~rhodesdavid/spondylo.htm (2550 words)

	What You Need to Know About the Spondyloarthropathies
		Spondyloarthropathies are a group of arthritic diseases that share several common features.
		They commonly cause inflammation of the spine; however other joints may be affected.
		Like the other spondyloarthropathies, the patient needs physical therapy and exercise.
	www.clevelandclinic.org /arthritis/treat/facts/spondyloarthropathy.htm (1249 words)

	Juvenile Spondyloarthopathy
		Some types of arthritis involve the spine as well as tendons, especially at the spots where the tendons attach to the bone (enthesis or enthesopathy).
		This family of disorders is called seronegative spondyloarthropathies.
		It is important to determine if your child has arthritis or one of the arthritis-related conditions that affect children because treatments vary for each type.
	www.arthritis.org /conditions/DiseaseCenter/juvenilespondyloarthopathy.asp (278 words)

	Spondyloarthropathies (Site not responding. Last check: 2007-11-01)
		Spondyloarthropathy occurs in up to 20 percent of patients who have inflammatory bowel disease (IBD).
		Extra-articular manifestations of IBD-associated spondyloarthropathy include uveitis, which is usually bilateral, and chronic skin lesions, such as erythema nodosum and pyoderma gangrenosum.
		The term "undifferentiated spondyloarthropathy" is used to describe manifestations of a spondyloarthropathy in patients who do not meet criteria for any of the well-defined spondyloarthropathies.
	www.arabmedmag.com /issue-15-01-2005/rheumatology/main01.htm (3489 words)

	[No title] (Site not responding. Last check: 2007-11-01)
		Juvenile spondyloarthropathy is a potentially disabling condition, so diagnosis and treatment needs to be rapid and effective.
		Clinical manifestations of spondyloarthropathies arise, at least in part, through the balance of cytokines expressed by the patient.
		Nevertheless, a study that enrolled children whose spondyloarthropathy was in remission suggested that physical fitness declined as they got older.
	www.docguide.com /news/content.nsf/NewsPrint/E30479B4835A9EA985256935004F82AB (258 words)

	Seronegative Spondyloarthropathies - DynoMed.com (Site not responding. Last check: 2007-11-01)
		Types of spondyloarthropathies include: Reiter’s syndrome; ankylosing spondylitis; psoriatic arthritis; and inflammatory bowel disease. Only two appear to affect the bones. Both cause pain, swelling, redness, and heat in the joints.
		Arthritis of inflammatory bowel disease (sometimes known as Crohn’s disease) usually causes symptoms before age 21, but only 15 percent of patients are diagnosed before 15.
		A distinguishing feature of juvenile spondyloarthropathies is purple discoloration that may occur around a joint. A child with ankylosing spondylitis may have inflammation of a tendon or ligament insertion site, including patellar tendinitis, Achilles tendinitis, or plantar fasciitis.
	www.dynomed.com /encyclopedia/encyclopedia/arthritis/Seronegative_Spondyloarthropathies.html (310 words)

	Englische Kurzfassung zum Inhalt von Bechterew-Brief Nr. 83 (Dezember 2000)
		The article by J. BRAUN (Berlin, after January 1st 2001 in Herne) on the question whether an antibiotic treatment of spondyloarthropathies is suitable, has been translated from the newsletter of the Spondylitis Association of America.
		The author concludes that an antibiotic treatment is only effective in the case of septic arthritis or Lyme disease, that it might be helpful in the case of a spondyloarthritis associated with chlamydial urethritis, but is of no help in the case of AS or reactive arthritis after enteritis.
		Highlights for those interested in spondyloarthropathies were a session on spondyloarthropathies chaired by S. VAN DER LINDEN and J. BRAUN, and a “Meet the expert” discussion on spondyloarthropathies with H. In many lectures, the anti-TNF-alpha treatment was considered to be a break-through in the treatment of inflammatory rheumatic diseases.
	www.bechterew.de /83english.htm (525 words)

	Core Curriculum - POSNA (Site not responding. Last check: 2007-11-01)
		The spondyloarthropathies, or sero-negative spondyloarthropathies as they are sometimes known, since the rheumatoid factor is negative, are probably more commmon in children than previously thought.
		It is likely that many children with spondyloarthropathies have been diagnosed as having oligoarticular juvenile arthritis.
		The spondyloarthropathies are presently treated with nonsteriodal agents and physical therapy.
	www.posna.org /index?service=page/coreCurriculum&article=spondyloarthropathies.html (529 words)

	Juvenile Arthritis (Juvenile Rheumatoid Arthritis, JRA) Symptoms, Diagnosis and Treatment on MedicineNet.com
		The typical findings of a spondyloarthropathy are early involvement of the hips and other large joints.
		It is important to recognize the spondyloarthropathies as different from juvenile rheumatoid arthritis because the optimal treatment, monitoring, and outcome is likely to be different.
		Unfortunately, we have only recognized children with spondyloarthropathies as being "different" since the middle 1970s, so no good long term follow-up data is available yet.
	www.medicinenet.com /juvenile_arthritis/page3.htm (714 words)

	Welcome to Physical.com - Information on American Family Physician - Spondyloarthropathies
		Although diagnostic criteria for the spondyloarthropathies have been developed for research purposes, the criteria rarely are used in clinical practice.
		Evidence of sacroiliitis or spondylitis may be seen on radiographs of the pelvis and lumbar spine.
		Although the spondyloarthropathies are grouped together, they display distinct clinical features.
	www.physical.com /Physical-therapy-exercises/American-Family-Physician----Spondyloarthropathies.htm (264 words)

	frequent sprains and strains in childhood
		However, this is often the initial story for children with spondyloarthropathies.
		Spondyloarthropathies typically present in boys or girls from ages 10 and up.
		If you have a child or young adult whom you suspect might have a spondyloarthropathy or who has been labeled with juvenile ankylosing spondylitis, give us a call.
	www.goldscout.com /enthesitis.html (1262 words)

	Undifferentiated Spondyloarthropathies
		Because the symptoms tend to be general, a person may be mistakenly diagnosed as being anxious or depressed or having fibromyalgia.
		As in reactive arthritis, many people with undifferentiated spondyloarthropathies have the HLA-B27 genetic marker, which suggests there is an inherited element of this disease.
		Undifferentiated spondyloarthropathies, like its related rheumatic disorders, is a chronic condition that requires the active participation of the patient as well as the doctor to manage.
	www.csmc.edu /9808.html (602 words)

	UW CME Course (Site not responding. Last check: 2007-11-01)
		Patient Demographics - The spondyloarthropathies include ankylosing spondylitis, Reiter’s syndrome, psoriatic arthritis, and arthritis associated with inflammatory bowel disease.
		Systemic Features - There are a variety of extraarticular features that are clues to the spondyloarthropathies including inflammatory eye involvement (uveitis or iritis), nonpainful stomatitis, hyperkeratotic skin rashes, Achilles tendonitis and plantar faciitis, and inflammatory type low back pain.
		Family history is frequently positive for a similar type of spondyloarthropathy.
	uwcme.org /site/courses/legacy/knee/spondyloarthropathy.php (271 words)

	Spondyloarthropathies: Theories of Pathogenesis
		The spondyloarthropathies are variably associated with the HLA class I antigen B27.(3) The histocompatibility or HLA complex is responsible for antigen recognition, allowing the distinction between self and nonself.
		Bacterial antigens are thought to play a role in the pathogenesis of reactive arthritis.(13) Further studies are needed to establish their exact role in the pathogenesis of reactive arthritis and related arthritides.
		The system most commonly used to classify spondyloarthropathies for diagnostic purposes (10) is the European Spondyloarthropathy Study Group (ESSG) criteria,(10) which have a sensitivity of 83.5% and a specificity of 95.2%.
	www.spineuniverse.com /rtbarticle.php/article2854.html (564 words)

	Etanica Medical Review: Spondyloarthropathy
		Although a very common form of arthritis, spondyloarthropathies may go undiagnosed for as long as 10 years from the onset of symptoms.
		These are a group of inflammatory arthritis that can cause joint pain and stiffness in not only the upper and lower extremities but also pain and stiffness in the neck, upper and lower back.
		The reason for such a long delay is the absence of specific tests to diagnose these conditions (this is why these conditions are classified as seronegative or conditions with negative serology or negative tests) and possibly the unfamiliarity of some physicians with Spondyloarthropathies.
	www.etanica.com /health/spon.html (475 words)

	Arthritis Research & Therapy \| Full text \| Expanding the armamentarium for the spondyloarthropathies
		The spondyloarthropathies are chronic, autoimmune, inflammatory joint diseases that are second in prevalence to rheumatoid arthritis (RA) among the rheumatic diseases [1,2].
		The seronegative (that is, negative for autoantibodies) spondyloarthropathies include ankylosing spondylitis (AS), psoriatic arthritis, Reiter's syndrome (reactive arthritis), arthritis associated with inflammatory bowel disease, and undifferentiated spondyloarthropathies [3].
		AS, the prototypical spondyloarthropathy, is an often painful disorder that impairs physical functioning and can lead to lost productivity, loss of employment, and impaired quality of life [5-7].
	arthritis-research.com /content/6/S2/S36 (5056 words)

	Patient Education - Spondyloarthritis
		Spondyloarthritis (or spondyloarthropathy) is the overall name for a family of inflammatory rheumatic diseases that can affect the spine and joints, ligaments and tendons.
		The term spondyloarthritis (also known as spondyloarthropathy) covers a group of closely related inflammatory diseases including arthritis of the spine (sacroiliitis or spondylitis) and peripheral joints; as well as inflammation in the area where ligaments and tendons attach to bones (enthesitis or enthesopathy).
		There is also a vast array of drug treatment options for spondyloarthropathy, starting with nonsteroidal anti-inflammatory drugs (NSAIDs), such as naproxen, ibuprofen, diclofenac or indomethacin given at the outset of the disease symptoms.
	www.rheumatology.org /public/factsheets/spondylitis_new.asp (1304 words)

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