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| | Squamous Cell Carcinoma from Dermatology / Malignant Neoplasms (Site not responding. Last check: 2007-10-08) |
 | | SCC in situ is characterized by severe atypia of the basal layer, buckshot scatter of atypical cells, intraepidermal nests of atypical cells, or full-thickness intraepidermal proliferation of atypical keratinocytes with or without involvement of follicular structures. |
 | | Because spindle cell carcinoma is a lesion derived from keratinocytes, antibody staining for CK and epithelial membrane antigen (EMA) characterizes it. |
 | | In general, metastasis from SCC of the forehead, the temples, the eyelids, the cheeks, and the ears is to the parotid nodes, whereas metastasis from SCC of the lips and the perioral region is primarily to the submental and submaxillary (upper cervical) nodes. |
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