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Topic: Statin

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Simvastatin

Scandinavian Simvastatin Survival Study

Atorvastatin

Cholesterol

Hypercholesterolemia

Heart protection study

LDL

Hypolipidaemic agent

Competitive inhibitor

Low density lipoprotein

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	Statin - Wikipedia, the free encyclopedia
		Statins exhibit action beyond lipid-lowering activity in the prevention of atherosclerosis.
		While some patients on statin therapy report myalgias, muscle cramps, or far less-frequent gastrointestinal or other symptoms, similar symptoms are also reported with placebo use in all the large statin safety/efficacy trials and usually resolve, either on their own or on temporarily lowering/stopping the dose.
		Indeed, a 2005 trial showed that patients taking statins for over 5 years reduced their risk of colorectal cancer by 50%; this effect was not exhibited by fibrates.
	en.wikipedia.org /wiki/Statin (1559 words)

	WOWT \| Statin Options (Site not responding. Last check: 2007-09-20)
		Statin drugs are very effective at lowering cholesterol but the medications can have serious side effects, including muscle and liver damage, memory problems and fatigue.
		Statins are also rarely associated with an increased risk for two serious problems – elevated liver enzymes (an indication of problems with liver function) and statin myopathy (muscle pain and tenderness caused by breakdown of muscle cells).
		He says statin users who are gaining good control over their cholesterol and don’t have any side effects may not want to make any changes in their treatment.
	www.wowt.com /news/features/2/2764336.html (1272 words)

	Statins And Other Drugs To Lower Cholesterol - Patient UK
		Statins are a group of drugs that are commonly used to reduce the level of cholesterol in the blood.
		Statins work by blocking the action of a certain enzyme (chemical) in the liver which is needed to make cholesterol.
		Statin drugs are available on prescription and funded by the NHS if your risk of developing an atheroma-related disease is high.
	www.patient.co.uk /showdoc/27000367 (1099 words)

	Statin Cholesterol Drugs Lower Stroke Risk
		"Statin therapy should now be considered routinely for all patients at high risk of stroke, irrespective of their initial cholesterol concentrations or the presence of heart disease," writes lead researcher Rory Collins, PhD, an epidemiologist with Radcliffe Infirmary in Oxford, England.
		Before statins were available, cholesterol-lowering drugs and diets had only modest effect on cholesterol and heart disease but did not seem to alter stroke risk, he explains.
		Statins have shown promise in stroke prevention, but this is the first large study of this effect.
	www.webmd.com /content/article/83/97662.htm (464 words)

	Statin Drugs Side Effects Rhabdomyolysis- Statin Drug Lawsuit. Info on Crestor, Lipitor, Zocor, Mevacor, Pravachol, and ...
		Statin's are a class of drugs used to lower blood cholesterol.
		On August 8, 2001 Bayer recalled their statin drug called Baycol as a result of 31 deaths that were linked to Baycol.
		The statin drug lawyers of Ennis and Ennis specialize in statin drug lawsuits resulting from Crestor side effects, Lipitor side effects, Zocor side effects, Mevacor side effects, and Pravachol side effects.
	www.statindruglawyer.com (892 words)

	Bad News About Statin Drugs - Share The Wealth
		Women told to take statin drugs should be aware of this risk found in the CARE trial: There were 12 cases of breast cancer in the women taking Pravachol, compared with only one case in the untreated (control) group.
		Statin drug proponents dismissed this worrisome finding as a fluke, said Dr. Ravnskov, because the control group would be expected to have had more than one case of breast cancer.
		I have been taking Statin Lipitor for the last 4 years, and zocor for 10 years earlier,I can now confirm that I am experiecing a loss of memory, and I thought it was due to age (I am 62 years of age) I do not eat any meat or chicken and I exercise regulary.
	newmediaexplorer.org /chris/2003/11/07/bad_news_about_statin_drugs.htm (15253 words)

	\|\| DukeMedNews \|\| Early Statin Use Refined
		Currently, physicians routinely prescribe statins to heart attack patients at or shortly after discharge from the hospital if their levels of LDL-cholesterol, the so-called "bad" form of cholesterol, are 130 milligrams per deciliter (mg/dL) or greater.
		Statins work by slowing down the liver?s production of cholesterol, high levels of which are implicated in atherosclerosis, a disease process that leads to clogging of the arteries.
		Typically, heart attack patients are given one of the five Food and Drug Administration-approved statins at the time of discharge or within months of discharge from the hospital as a preventative measure against future heart attacks.
	dukemednews.duke.edu /news/article.php?id=5574 (786 words)

	Side Effects of Lipitor, Zocor, and other Statin Drugs
		While statin drugs such as Lipitor®, Zocor® and Lovastatin® are beneficial to lower high blood cholesterol, they also have the effect of blocking the body’s natural production of Coenzyme Q10.
		Statin drugs such as Zocor®, Lipitor® and Lovastatin® block cholesterol production in the body by inhibiting the enzyme called HMG-CoA reductase in the early steps of its synthesis in the mevalonate pathway.
		It is important to note that Coenzyme Q10 supplementation does not interfere with the very important cholesterol-lowering effect of statin drugs such as Lovastatin®, Lipitor® and Zocor®.
	www.discount-vitamins-herbs.net /statin_side-effects.htm (1597 words)

	Study Says Higher Statin Doses = Lower Cholesterol
		Conflicting results from the makers of various statin drugs mean that the jury is still out on how well each addresses this problem.
		Hatahet noted that knowing how the body metabolizes particular statins is an important factor in determining which drug to use in order to minimize drug-drug and drug-disease interactions and side effects experienced by the individual patient.
		Hatahet said that the newest study is part of a growing body of evidence that will likely cause the guidelines for LDL levels to be lowered even further and speed doctors' acceptance of using higher doses of statin drugs to reach goal levels.
	healthlink.mcw.edu /article/1031002393.html (1107 words)

	Statin Alert Homepage - StatinAlert.org
		It is becoming increasingly apparent that a large number of statin users suffer side effects but are ignored or dismissed by their doctors--doctors who evidently appear incapable of accepting that these so-called 'miracle' drugs could in any way be harmful.
		Over the past five years, statins have become more potent, are being prescribed in higher doses, and are being used with reckless abandon in the elderly and in patients with "normal" cholesterol levels.
		The last consideration should be especially clear before statins are recommended to MS patients, because this group is in no way immune to their harmful effects: two of the thirty patients had "clinically important" elevations in liver enzymes, another three experienced muscle weakness "possibly related to study drug".
	www.statinalert.org /mainpage.html (2355 words)

	Statin Adverse Effects
		Of course, since people on statin drugs are often older, and may be experiencing age-related loss of memory, it makes it difficult to know whether the drugs are responsible.
		Matthew Muldoon, at the University of Pittsburgh, showed that statin drugs on average reduces “cognition,” that is to say, people who were on a statin drug did worse on tests of thinking and memory ability, even though they started out the same as those who were put on a placebo pill.
		There is published scientific evidence that statins lower coQ10 levels in a dose-dependent fashion; that low levels of coQ10 relate to muscle and brain pathology; and that restoration of coQ10 may lead to diminution of symptoms in those with muscle or cognitive problems.
	medicine.ucsd.edu /SES/adverse_effects.htm (1493 words)

	Statin Drug Danger (Site not responding. Last check: 2007-09-20)
		Statin cholesterol-lowering drugs are the top selling class of prescription medications and they earn their makers more than $20 billion annually.
		Statins and the Risk of Polyneuropathy, a disorder that involves the slow progressive (or recurrent) inflammation of multiple nerves
		Artificial statins (HMG-CoA) reductase inhibitors, as a class cause skeletal myopathy, but depletion of CoQ10 may not be the primary cause...
	vitamincfoundation.org /statinalert (5632 words)

	Le Magazine, November 2004 - Report: Cholesterol & Statin Drugs
		The Scandinavian study and similar trials solidly bolster the argument that statins reduce LDL and thereby lower the risk of heart attacks in people who have suffered prior heart attacks, as well as in people at risk for a first heart attack.
		The fundamental flaws in focusing on cholesterol and statin agents are the perceptions that cholesterol identifies hidden heart disease and that lowering cholesterol is the way to a future free of heart attacks.
		In this case, a statin agent is a necessity and should be used along with natural therapies.
	www.lef.org /magazine/mag2004/nov2004_report_statin_01.htm (2160 words)

	Statin Dialogues
		For years patients have been interpreting deterioration of memory shortly after starting statin medications as simply coincidental presenility or the earliest harbingers of Alzheimers, never making the association that these symptoms might be a side effect of a medication their physicians have prescribed.
		Lack of physician and patient awareness of possible relationships between cognitive side effects and the use of statin drugs almost guarantees that no instances of accident and statin drug use will be reported to you.
		His ignorance of a possible relationship between his statin prescriptions and the subsequent decline in mental faculties of his patients is because you have buried this information in your PDR rather than effectively presenting it.
	www.spacedoc.net /statin_dialogues.htm (4241 words)

	Statin Article Endnote Links (Site not responding. Last check: 2007-09-20)
		Giving a statin drug to a person with LDL cholesterol of 140 or below, as is frequently done today, would result in a 30 to 60% reduction in his or her LDL cholesterol, potentially placing him or her at increased risk for heart attack if his or her lipoprotein-associated phospholipase A2 is high.
		"That statin treatment works in patient and age groups in whom a high cholesterol concentration is not a risk factor for cardiovascular disease shows that the benefit is not the result of cholesterol lowering.
		"And finally, the statins protected against coronary heart disease whether the cholesterol was high or low although most studies have shown that a normal or low cholesterol is no risk factor for coronary disease." They also protected against strokes, although high cholesterol is not considered a risk factor for stroke.
	home.earthlink.net /~mbabco/statinlink.html (3038 words)

	Healing foods beat statin drugs for lowering high cholesterol
		We already saw a huge scandal with Vioxx and the Cox-2 inhibitors, and how drug companies have been pushing those drugs onto the population even though they were fully aware, as we now know, of the dangerous cardiovascular effects of those drugs.
		Down the road, this is going to go public, and statin drugs are going to be pulled off the market or seriously restricted in their use.
		Statin drugs are sold because they generate profits.
	www.newstarget.com /008310.html (2472 words)

	Reduce Cholesterol - Aggressive Statin Therapy May Reverse Atherosclerosis
		Intensive cholesterol-lowering therapy using Crestor -- a powerful (and controversial) member of the statin family of drugs -- not only reduced LDL or "bad" cholesterol levels but actually reversed atherosclerosis, better known as hardening of the arteries.
		The introduction of cholesterol-lowering drugs called statins in 1987 brought the hope that atherosclerosis could one day be reversed.
		Crestor is the most recently introduced and one of the most potent of the statin family of drugs.
	www.reducecholesterol.org /ms/news/531506/main.html (1137 words)

	Duane Graveline - Former NASA Scientist Astronaut
		own statin associated transient global amnesia this former astronaut and retired family doctor reveals to his readers the critical importance of cholesterol for proper brain function and memory and the reasons for the damage statin drugs do to our muscles, nerves and heart and even our personalities.
		The unacceptable legacy of statin drug use at today’s high doses is a trail of chronic aches and pains, numbness, weakness, confusion, fatigue, shortness of breath and even heart failure in hordes of unsuspecting victims.
		Many physicians have themselves become victims of statin drug use and, like the author, now suspect the message of persuasive drug “reps” may not be the entire truth.
	www.spacedoc.net (217 words)

	Definition of statin - NCI Dictionary of Cancer Terms
		Any of a group of drugs that lower the amount of cholesterol and certain fats in the blood.
		Statins inhibit a key enzyme that helps make cholesterol.
		Statin drugs are being studied in the prevention and treatment of cancer.
	www.cancer.gov /Templates/db_alpha.aspx?CdrID=390255 (78 words)

	Statin Drugs & Memory Loss - Share The Wealth
		I went off the statins for a while and took Policosanol, because I had read that it was as effective as statins, but without the side-effects.
		As for the cholesterol (250 off the statin, 199 on it), a radical change in diet and increased exercise will be applied to bring it under control, although, from what I read, it may all be a wild goose chase anyway.
		The adverse effect of the statin drugs is also my concern because our medical practitioners here in the Philippines are also prescribing Crestor (rosuvastatin) or symbastatin to their patients who are on high cholesterol and triglycerides.
	www.newmediaexplorer.org /chris/2003/12/05/statin_drugs_memory_loss.htm (17221 words)

	Statin-CoQ10
		Baycol was taken off the market in August of 2001 voluntarily by the Bayer Company, but the rest of the statin drugs are still out there.
		does not interfere with the important function of the statin drugs; that being the lowering of cholesterol levels.
		These patents were issued in May and June of 1990 to one of the world’s largest pharmaceutical companies and the producer of the second largest selling statin drug.
	www.bowtechforhealth.com /news/statin-coq10.htm (1077 words)

	The UCSD Statin Study Homepage (Site not responding. Last check: 2007-09-20)
		The randomized-controlled trial of the UCSD Statin Study is now closed.
		If you are inquiring about study results, we are still in the process of data analysis and paper-writing.
		We are currently interested in the experiences of people presently or formerly on statins, who have noticed changes in any element of well-being or health while on these drugs.
	medicine.ucsd.edu /statin/index.htm (84 words)

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