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Topic: Stavudine

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	[No title]
		Stavudine was approved by the FDA on June 24, 1994, for use in combination with other antiretroviral agents and is indicated for the treatment of HIV-1 infection in adults and pediatric patients.
		Stavudine is also used in conjunction with other antiretroviral agents for postexposure prophylaxis in health care workers and other individuals exposed occupationally to blood, tissues, or other body fluids associated with a risk for transmission of the HIV virus.
		Stavudine is phosphorylated by cellular kinases to the active metabolite stavudine triphosphate.
	aidsinfo.nih.gov /DrugsNew/DrugDetailT.aspx?int_id=43 (2415 words)

	Howstuffworks "Stavudine: A Profile of an Antiviral Drug"
		Stavudine may cause lactic acidosis and a condition known as peripheral neuropathy, which is numbness, pain, burning, or tingling, usually in the hands or feet.
		Stavudine may cause a condition known as peripheral neuropathy, which is tingling, burning, pain, or numbness in the hands or feet.
		Before taking stavudine, be sure to tell your doctor about any medical problems you may have, especially liver or renal problems, problems with the pancreas, or tingling, numbness, burning, or pain in the hands or feet.
	health.howstuffworks.com /define-stavudine.htm (929 words)

	AEGiS-RITA!: NRTI: STAVUDINE (Zerit) - March 2000
		Stavudine is a nucleoside reverse transcriptase inhibitor (NRTI).
		Stavudine is indicated in combination with other antiretrovirals for the treatment of HIV infection.
		Stavudine capsules should be stored in a closed container and kept at a temperature of 59° to 86°F. Side effects and toxicity.
	www.aegis.com /pubs/rita/2000/RI000308.html (761 words)

	Zerit Online, Description, Chemistry, Ingredients - Stavudine - RxList Monographs
		The solubility of stavudine at 23°C is approximately 83 mg/mL in water and 30 mg/mL in propylene glycol.
		The n-octanol/water partition coefficient of stavudine at 23°C is 0.144.
		Mechanism of Action: Stavudine, a nucleoside analogue of thymidine, is phosphorylated by cellular kinases to the active metabolite stavudine triphos-phate.
	www.rxlist.com /cgi/generic/stavudin.htm (660 words)

	Stavudine (D4T or “Zerit®”) Anti Retroviral drugs for paediatric use (Site not responding. Last check: 2007-09-10)
		The dose of Stavudine is based on your child’s weight, so it is important that your child is weighed every time they come to clinic.
		As it is very important that the amount of Stavudine in the blood remains steady, try to give the doses as close to every 12 hours as you can.
		Stavudine capsules must be stored at room temperature (not in the fridge).
	www.bhiva.org /chiva/drugs/stavudine.html (481 words)

	[No title]
		Stavudine was approved by the FDA on June 24, 1994, for use in combination with other antiretroviral agents for the treatment of HIV infection in adults and children.
		Stavudine may also be used to prevent health care workers and others from getting HIV infection after they accidentally come into contact with the virus on the job; however, this practice does not have FDA approval.
		Stavudine does not cure or prevent HIV infection or AIDS and does not reduce the risk of passing the virus to other people.
	www.aidsinfo.nih.gov /drugs/htmldrug_nt.asp?int_id=0043 (418 words)

	Stavudine
		Stavudine, when used alone or in combination with other antiviral medications, may cause serious and possibly deadly damage to the liver and pancreas and a life-threatening condition called lactic acidosis.
		Stavudine is used in combination with other antiviral medications to treat human immunodeficiency virus (HIV) infection in patients with or without acquired immunodeficiency syndrome (AIDS).
		Stavudine is in a class of antiviral medications called nucleoside analogue reverse transcriptase inhibitors (NRTIs).
	www.safemedication.com /displaydrug.cfm?id=694033 (861 words)

	Zerit (stavudine) or Crixivan (indinavir)-containing Regimens Are Associated with an Increased Risk of Diabetes ...
		However, the median duration of exposure was similar among stavudine and other reverse transcriptase inhibitors, as it was among indinavir, saquinavir and ritonavir.
		As for stavudine, this is the first report suggesting that this drug may be an independent and strong risk factor for the onset of DM.
		Stavudine or indinavir-containing regimens are associated with an increased risk of diabetes mellitus in HIV-infected individuals.
	www.hivandhepatitis.com /recent/nrtis/090803c.html (770 words)

	STAVUDINE (D4T)
		Stavudine is an antiretroviral (anti-HIV) drug that is part of the nucleoside reverse transcriptase inhibitor (NRTIs or Nukes) family.
		Stavudine may cause tingling, burning or numbness in the hands and feet (peripheral neuropathy). These symptoms can disappear if recognized quickly and if the dose of the drug is decreased or if the drug is stopped. If you develop any of these symptoms, please inform your doctor or pharmacist.
		For example, stavudine should never be taken with zidovudine (Retrovir®) as the efficacy of each drug may be decreased. Also, taking other drugs that cause tingling, burning and numbness in the hands and feet (peripheral neuropathy) may increase the risk of developing this adverse effect.
	www.tthhivclinic.com /FactSheets/html/STAVUDINE.html (798 words)

	Stavudine
		Pharmacokinetics of stavudine are not significantly altered during pregnancy; dose adjustments are not needed.
		The Perinatal HIV Guidelines Working Group considers stavudine to be an alternative NRTI in dual nucleoside combination regimens; use with didanosine only if no alternatives are available, do not use with zidovudine.
		Stavudine is a thymidine analog which interferes with HIV viral DNA dependent DNA polymerase resulting in inhibition of viral replication; nucleoside reverse transcriptase inhibitor
	www.metagenics.com /ADAM/41/118250.html (1202 words)

	Stavudine effective in pregnant women with HIV
		NEW YORK (Reuters Health) - Stavudine, given with or without lamivudine (3TC), is a safe and effective alternative to zidovudine for treating pregnant women and their infants, researchers report in the December 15th issue of The Journal of Infectious Diseases.
		None of the women or their children developed serious toxicities that necessitated changing the dose of stavudine or discontinuing it, and all of the infants were born HIV-negative.
		Maternal plasma and umbilical cord stavudine concentrations were similar, suggesting the drug readily crossed the placenta.
	www.aidsmeds.com /news/20041220clin008.html (385 words)

	Stavudine
		stavudine (d4T), a synthetic thymidine nucleoside analogue, active against the Human Immunodeficiency Virus (HIV).
		Stavudine is a white to off-white crystalline solid with the molecular formula C
		The solubility of stavudine at 23°C is approximately 83 mg/mL in water and 30 mg/mL in propylene gly-col. The n-octanol/water partition coefficient of stavudine at 23°C is 0.144
	www.topsun-pharm.com /html_en/stavudine.htm (55 words)

	Zerit - Drugs & Vitamins - Drug Library - DrugDigest (Site not responding. Last check: 2007-09-10)
		Stavudine may reduce the amount of HIV in the blood and increase the number of CD4 cells (T-cells) in the blood.
		Stavudine is used in combination with other drugs to treat the HIV virus.
		Stavudine will not cure HIV and you can still get other illnesses or complications associated with your disease.
	www.drugdigest.org /DD/DVH/Uses/0,3915,616\|Zerit,00.html (717 words)

	[No title]
		Suspend therapy with agents toxic to the pancreas (including stavudine, didanosine, or hydroxyurea) in patients with suspected pancreatitis.
		Risk of pancreatitis or lactic acidosis and severe hepatomegaly is increased with concurrent use of didanosine and hydroxyurea.
		Stavudine may decrease the activity of zidovudine (based on in vitro data).
	www.musc.edu /pharmacyservices/Drugs/S/Stavudine.doc (535 words)

	A Multiple Drug Interaction Study of Stavudine with Agents for Opportunistic Infections in Human Immunodeficiency ...
		Figure 1 depicts the mean stavudine concentration-time profiles during each phase of the study.
		Stavudine has been shown to be well tolerated in clinical trials (17) and during this 8-week study.
		Stavudine and didanosine combination therapy in HIV-infected subjects: antiviral effect and safety in an ongoing pilot randomized double-blinded trial.
	aac.asm.org /cgi/content/full/43/3/647 (2184 words)

	Stavudine (Zerit, d4T) \| The New Mexico AIDS InfoNet
		Stavudine is also known as d4T or didehydro-deoxythymidine.
		Stavudine is a nucleoside analog reverse transcriptase inhibitor,or nuke.
		Stavudine was approved in 1994 as an antiretroviral drug (ARV) for people with HIV infection from newborns through adults.
	www.aidsinfonet.org /articles.php?articleID=414 (849 words)

	Stavudine - Wikipedia, the free encyclopedia
		Stavudine (2'-3'-didehydro-2'-3'-dideoxythymidine, d4T, brand name Zerit®) is a nucleoside analog reverse transcriptase inhibitor (NARTI) active against HIV.
		Stavudine triphosphate inhibits the HIV reverse transcriptase by competing with natural substrate, thymidine triphosphate.
		Approximately half of stavudine is actively secreted unchanged into the urine and the other half is eliminated through endogenic pathways.
	en.wikipedia.org /wiki/Stavudine (299 words)

	Stavudine (Site not responding. Last check: 2007-09-10)
		Stavudine is used to treat human immunodeficiency virus (HIV) infections.
		A 30-year-old woman who was taking stavudine developed a rare side effect called lactic acidosis, which was successfully treated with intravenous thiamine.
		Severe peripheral neuropathy (painful sensations due to nerve damage in the hands and feet) often develops in people taking stavudine or other drugs in its class.
	www.kroger.com /hn/Drug/Stavudine.htm (427 words)

	Tenofovir vs d4T + EFV/3TC, study 903: 144 weeks in men & women
		The primary objective of this study was to assess the equivalence of tenofovir DF vs stavudine in combination with lamivudine and efavirenz for the treatment of patients infected with HIV who were antiretroviral naive as determined by the proportion of patients in each regimen with plasma HIV RNA levels of less than 400 copies/mL.
		Tenofovir DF or stavudine were also used as a subsequent drug in patients who were originally randomized to those treatment groups since investigators were blinded to treatment assignment or patients may have discontinued due to non--tenofovir DF or non--stavudine-related toxicities such as efavirenz intolerance.
		Although both tenofovir DF and stavudine performed equally well with respect to antiviral potency, the 3-year results indicate that tenofovir DF was associated with less toxicity than stavudine.
	www.natap.org /2004/Bangkok/bangkok_31.htm (3578 words)

	Stavudine (Systemic)
		The combination of stavudine and didanosine should be used with caution during pregnancy.
		Stavudine has not been studied in pregnant women.
		It is not known whether stavudine passes into the breast milk.
	allnutritionals.com /drugs/s/stavudine-systemic.shtml (1479 words)

	Healthopedia.com Drugs Information - Stavudine (Zerit, d4T)
		Stavudine (STAV-yoo-deen) (also known as d4T) is used in the treatment of the infection caused by the human immunodeficiency virus (HIV).
		Stavudine (d4T) will not cure or prevent HIV infection or AIDS; however, it helps to keep HIV from reproducing and appears to slow down the destruction of the immune system.
		Stavudine will not keep you from spreading HIV to other people.
	www.healthopedia.com /drugs/detailed/stavudine (337 words)

	ASPEN STAVUDINE
		Stavudine triphosphate inhibits the activity of HIV reverse transcriptase both by competing with the natural substrate, deoxythymidine triphosphate, and by its incorporation into viral DNA causing the termination of DNA chain because stavudine lacks the essential 3’-OH group necessary for DNA elongation.
		Stavudine absorption is not affected by the presence of food.
		Since Aspen Stavudine is taken in combination with other antiretrovirals, it is difficult to distinguish whether the side-effects are due to Aspen Stavudine, the disease itself, or to other therapies.
	home.intekom.com /pharm/aspen-p/a-stavud.html (1618 words)

	Simple FactSheet: stavudine (d4T, Zerit)
		Stavudine (trade name Zerit, also known as d4T) is an anti-HIV treatment in the class of drugs called Nucleoside Reverse Transcriptase Inhibitors (NRTIs).
		The body breaks down these drugs into chemicals that stop HIV from infecting uninfected cells in the body, but they do not help cells that have already been infected with the virus.
		Bristol-Myers Squibb, the maker of stavudine (Zerit), has a patient assistance program for people having problems getting the drug.
	www.aegis.com /factshts/network/simple/stav.html (602 words)

	stavudine - HIV: health and medical information about HIV and AIDS
		Specifically, stavudine is converted within the body to its active form (stavudine triphosphate).
		Stavudine does not kill existing HIV virus and it is not a cure for HIV.
		Stavudine damages nerves and can cause a severe peripheral neuropathy, a condition in which sensation in the legs and/or arms is altered or lost.
	www.medicinenet.com /stavudine/article.htm (582 words)

	Gilead -- 96-Week Data from Phase III Study Show Long-Term Efficacy with Reduced Risk of Lipid and Metabolic Changes ... (Site not responding. Last check: 2007-09-10)
		Study 903 is an ongoing three-year, randomized, double-blind trial designed to compare the efficacy and safety of a treatment regimen of Viread, lamivudine (3TC) and efavirenz to a regimen of stavudine, lamivudine and efavirenz in 600 antiretroviral-naïve patients with HIV infection.
		Increases in low-density lipoprotein cholesterol (LDL or "bad" cholesterol) were 82 percent higher for patients receiving stavudine, with an increase of 11 mg/dL in the Viread arm and an increase of 20 mg/dL in the stavudine arm (p<0.001).
		In addition, 10 percent of patients in the stavudine arm added a lipid-lowering drug during the study compared to two percent in the Viread arm.
	www.gilead.com /wt/sec/pr_1044928267 (1533 words)

	Healthopedia.com - Stavudine (Oral) (Zerit) - Drugs Information, Side Effects, & Interactions
		Stavudine does not cure HIV or AIDS, but combinations of drugs may slow the progress of the disease.
		Stavudine is taken with other medicines to treat HIV infection.
		Rarely, stavudine may cause two very serious side effects, lactic acidosis and severe liver enlargement.
	www.healthopedia.com /drugs/quick/stavudine (757 words)

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