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Topic: Stevioside

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	KFDA - Korea Food Additives Code
		Stevioside is obtained from leaves of Stevia rebaudiana Bertoni.
		Stevioside is white or grayish white powder or crystalline powder with sweet taste.
		(1) 1 g of Stevioside is dissolved in 100 ml of distilled water by heating in a water bath.
	fa.kfda.go.kr /standard/egongjeon_standard_view.jsp?SerialNo=64&GoCa=2 (1009 words)

	stevioside - Selling Leads for stevioside - Manufacturers, Exporters, Suppliers, Traders, Companies, Factories
		This page is your stevioside one-stop source for the competitive price and quality.
		Global stevioside buyers find suppliers here every day.
		If you are a manufacturer or supplier who want more international buyers, join EC21 for free now, and get your products listed here.
	www.ec21.com /offers/stevioside.html (316 words)

	933. Sweetening agent: Stevioside (WHO Food Additives Series 42)
		Stevioside was perfused at a concentration of 0.2 or 0.5 mmol/L (equivalent to 0.16 and 0.4 mg/ml) into rat livers and was recirculated for 2 h.
		Stevioside (1 mmol/L, equivalent to 0.8 mg/ml) inhibited oxidative phosphorylation and the activity of ATPase (50% inhibition), succinate oxidase (8% inhibition), and succinate dehydrogenase (10% inhibition).
		Stevioside inhibited the action of atractyloside, a known inhibitor of the adenine nucleotide carrier of mitochondria and in consequence an inhibitor of energy metabolism, in isolated perfused rat liver.
	www.inchem.org /documents/jecfa/jecmono/v042je07.htm (9027 words)

	Godshaer.co.uk :: Stevioside - unnatural Stevia
		Stevioside was first considered by the SCF for approval for use as a sweetener within the EU in 1985 and the review was updated in 1989.
		The researchers' objective was to study the consequences of daily ingestion of stevioside -- the main active sweetening agent in the stevia plant -- in hamsters and its effects on two subsequent generations.
		The first group was fed a daily stevioside dosage of 500 mg/kg; the second group received a higher dose at 1,000 mg/kg; and the third group dosage was the highest at 2,500 mg/kg.
	www.godshaer.co.uk /stevioside.php (5901 words)

	Stevioside as a potential useful drug in the treatment of type 2 diabetes and the metabolic syndrome (Site not responding. Last check: )
		Stevioside tended to decrease glucagon levels, while it did not significantly alter the area under the insulin, glucagon-like peptide 1, and glucose-dependent insulinotropic polypeptide curves.
		In conclusion, stevioside enjoys a dual positive effect by acting as an antihyperglycemic and a blood pressure-lowering substance; effects that may have therapeutic potential in the treatment of type 2 diabetes and the metabolic syndrome.
		In conclusion, stevioside exerts antihyperglycaemic, insulinotropic, and glucagonostatic actions in the type 2 diabetic GK rat, and may have the potential of becoming a new antidiabetic drug for use in type 2 diabetes.
	www.freestevia.de /gesund/steviosid_as_a_useful_drug.htm (1123 words)

	FAQ - Heritability for Yield, Leaf:stem Ratio and Stevioside Content Estimated from a Landrace Cultivar of Stevia ...
		Stevioside, the major sweetener present in leaf and stem tissue, was first seriously considered as a sugar substitute in the early 1970's by a Japanese consortium formed for the purpose of commercializing stevioside and stevia extracts (Kinghorn and Soejarto, 1985).
		Stevioside concentration (Table 1) was high relative to the subtropical regions of the world (Kinghorn and Soejarto 1985), a fact that may be related to cultivation under long days.
		Furthermore, stevioside concentrations were uncorrelated to yield or leaf:stem ratio (data not shown) indicating that concurrent improvement of agronomic and chemical characteristics is possible.
	sci.agr.ca /london/faq/cjps_e.htm (1670 words)

	Roongthip Boondao (Site not responding. Last check: )
		Stevioside is a high intensity sweetener, 250-300 times sweeter than sucrose, intended to be used as a non-nutritive sweetener in food products and beverages.
		In vitro metabolism of stevioside at concentrations of 2.5, 5.0 and 7.5 mM were incubated with caecal bacterial glycosidases in rats for 10 min at 37°C. The results showed that stevioside significantly decreased the metabolic activity of ß-glucosidase in rats, but it had no effect on ß-glucosidase and ß-galactosidase activities.
		The effect of stevioside on intestinal bacterial glycosidase activities was found to be dose independent and it was not dependent on preincubation times after the mixtures were preincubated for 10-60 min.
	www.cri.or.th /~estm/abstract/sctx-4136706.htm (493 words)

	Calorie Control Council \| Reduced-Calorie Sweeteners
		Stevioside is derived from Stevia rebaudiana, a South American plant.
		In Japan, stevioside is used alone or in combination with other sweeteners in beverages, tabletop sweeteners, chewing gums, pickles, dried seafoods, flavorings and confectioneries.
		Stevioside may be used as a dietary supplement in the U.S. but no reference to sweetness can be made.
	www.caloriecontrol.org /stevioside.html (258 words)

	La Leva di Archimede (ENG): Stevia - Safety evaluation of food additives 2006
		Stevioside and/or steviol affected a variety of biochemical parameters in models in vitro, indicating possible mechanisms of antihypertensive and antiglycaemic effects that involve modulation of ion channels.
		Stevioside also affected a variety of biochemical parameters in different animal species in vivo, mostly with parenteral administration; these studies were considered by the Committee to be of limited relevance to dietary exposure.
		The Committee concluded that stevioside and rebaudioside A are not genotoxic in vitro or in vivo and that the genotoxicity of steviol and some of its oxidative derivatives in vitro is not expressed in vivo.
	www.laleva.org /eng/2006/12/stevia_safety_evaluation_of_food_additives_2006.html (1681 words)

	FAQ - Heritability for Yield, Leaf:stem Ratio and Stevioside Content Estimated from a Landrace Cultivar of Stevia ...
		Stevioside, the major sweetener present in leaf and stem tissue, was first seriously considered as a sugar substitute in the early 1970's by a Japanese consortium formed for the purpose of commercializing stevioside and stevia extracts (Kinghorn and Soejarto, 1985).
		Stevioside concentration (Table 1) was high relative to the subtropical regions of the world (Kinghorn and Soejarto 1985), a fact that may be related to cultivation under long days.
		Furthermore, stevioside concentrations were uncorrelated to yield or leaf:stem ratio (data not shown) indicating that concurrent improvement of agronomic and chemical characteristics is possible.
	res2.agr.gc.ca /london/faq/cjps_e.htm (1670 words)

	Extracted from WHO Technical Report Series 891
		Stevioside is a sweet glycoside of the diterpene derivative steviol (ent-13-hydroxykaur-16-en-18-oic acid).
		After intravenous administration, stevioside is rapidly distributed throughout the body, partially secreted by the renal tubular epithelium, and excreted in the urine.
		Stevioside may also act as a calcium antagonist, showing a hypotensive effect and inducing diuresis, natriuresis and a fall in reabsorption of glucose in the renal tubules.
	www.fehd.gov.hk /safefood/report/stevioside/who.html (832 words)

	stevia rebaudiana stevioside
		Stevioside has the characteristics of high sweetness and low calorific value so it will not have any negative impact on the quality and flavor of the products to replace 50-60% of sucrose with stevioside when processing fruit preserves and cakes, but it will make them favored by more consumers.
		Stevioside can replace part or all of the sucrose in medicines to improve their taste because it is safe and reliable and doesn't have any toxic or side effects.
		Stevioside can first be dissolved in such organic solvents as alcohol and propylene glycol and then can be sprayed on shredded tobacco or tobacco leaves.
	www.gzstevia.com /english/yingyong.htm (900 words)

	Stevia
		Stevioside is an extract from the leaf of a plant native to Paraguay, Stevia rebaudiana Bertoni.
		Stevioside Helps Hypertension: In an earlier DB PC study of 106 Taiwanese hypertensives, 250 mg (1/4 teaspoon) 3 times a day was effective throughout the one year study and lowered the average systolic from 166 to 152 and the diastolic from 104 to 90.
		Stevioside, if used in place of an artificial sweetener, is less expensive than any currently on the market in the U.S. Coenzyme Q10 is better researched than stevioside and costs 30-60 cents per day for 100-120 mg once a day dose.
	www.modern-psychiatry.com /stevia.htm (958 words)

	IMPORT ALERT IA4506
		Stevioside is reportedly 250-300 times sweeter than sugar and contributes no calories to the diet.
		If review of the labeling or import paperwork reveals stevia leaves, stevioside, or products containing stevioside, districts may detain these items without physical examination, unless explicitly labeled as a dietary supplement, or for use solely as a dietary ingredient in the manufacture of a dietary supplement product.
		447-451, "Simultaneous Determination of Stevioside, Rebaudioside A and C and Dulcoside A on Foods by High-Performance Liquid Chromatography." A laboratory must assure that recommended methodologies are reliable and accurate by utilizing appropriate validation procedures.
	www.fda.gov /ora/fiars/ora_import_ia4506.html (704 words)

	Worldwide, independent, unbiased research indicates the benefits of stevia rebaudiana are numerous
		Stevioside acts directly on pancreatic beta cells to secrete insulin: actions independent of cyclic adenosine monophosphate and adenosine triphosphate-sensitive K+-channel activity.
		The effect of stevioside on blood pressure and plasma catecholamines in spontaneously hypertensive rats.
		Efficacy and tolerability of oral stevioside in patients with mild essential hypertension: a two-year, randomized, placebo-controlled study.
	www.sweevia.com /html/stevia_research.html (373 words)

	KANSAL AGRO-TECH (PVT.) LTD
		In another set ofexperiments, stevioside or steviol were given to the rats in the drinking water at the beginning of the fasting periods.
		A study was undertaken to reveal the mechanism for the blood glucose-lowering effect of stevioside and steviol, using normal mouse islets and the betacell lines.
		The researchers state, "It was concluded that neither stevioside nor rebaudioside A is cariogenic [cavity causing] under the conditions of this study." It appears that the chemicals within the stevia plant that impart its sweetness are not fermentable, and thus do not cause tooth cavities.
	www.kansalagro.net /phyto.htm (1923 words)

	Utilization of stevioside, a new natural, non-caloric feed sweetener, in feeds for dogs.
		Prolonged heating of a stevioside solution resulted in a decrease of the stevioside in the solution by 16.7 % after 12 hours at 100 °C in a neutral solution and 46.0 to 53.8 % after 4 hours in acidic solutions.
		The concentration of stevioside in the feed was 90 mg per kg feed, which corresponds with 2.7 % of sugar added to the diet.
		Evaluation of the genotoxicity of stevioside and steviol using six in vitro and one in vivo mutagenicity assays.
	www.vds-afs.be /stepadog.htm (1908 words)

	Safety of stevioside debated
		China has grown into the world's largest exporting country of stevioside, with a volume exceeding 85 per cent of the overall amount of stevioside used in the world.
		Although there is no solid evidence to prove that stevioside is harmful, yet some scientific research has found that a certain substance in it may transform into a special material, which may lead to cancer and sterility.
		Some Chinese and Japanese experts, from their research, concluded that stevioside would be excreted from the body after being consumed, causing no harm to people.
	app1.chinadaily.com.cn /star/2002/0328/fo7-1.html (721 words)

	Sweetener stevioside is a safe sugar substitute
		Stevioside, the main sweet component in the leaves of the Stevia plant, tastes about 300 times sweeter than table sugar, which means only a small amount is needed for sweetening purposes.
		Stevioside has numerous benefits as a sweetener: it is 100% natural, stable, contains no calories and promotes good dental health by reducing sugar intake.
		One of the centre’s goals is to develop a European quality label for stevioside, which should lead eventually to the lifting of the European ban on stevioside.
	www.innovations-report.com /html/reports/medicine_health/report-38242.html (448 words)

	Utilization of stevioside, a new natural, non-caloric feed sweetener, in feeds for dogs.
		Prolonged heating of a stevioside solution resulted in a decrease of the stevioside in the solution by 16.7 % after 12 hours at 100 °C in a neutral solution and 46.0 to 53.8 % after 4 hours in acidic solutions.
		The concentration of stevioside in the feed was 90 mg per kg feed, which corresponds with 2.7 % of sugar added to the diet.
		Evaluation of the genotoxicity of stevioside and steviol using six in vitro and one in vivo mutagenicity assays.
	www.lni.unipi.it /stevia/stevia/stepadog.htm (1889 words)

	FAQ's (Site not responding. Last check: )
		Oral administration of stevioside at a dietary concentration of 2.5% to rats for two years, equal to 970 and 1100 mg kg-1 BW per day in males and females, respectively, had no significant effect.
		In case of hypoglycemia, Stevia or stevioside are of course unable to substitute for sugar.
		The advantages of stevioside as a dietary supplement for human subjects are manifold: it is stable, it is non-calorific, it helps maintain good dental health by reducing the intake of sugar and opens the possibility for use by diabetic and phenylketonuria patients and obese persons.
	www.stepa.be /faqs.html (2449 words)

	Organica News -- Health: Beyond Sugarcoating
		So, in recipes that call for a cup of sugar, a 1/4 teaspoon of stevioside is recommended as a substitute.
		Today, stevioside is widely used throughout the Orient and South America to sweeten many of the products for which sugar use is more common stateside.
		Of course, when visiting sites which are put up by companies that deal in selling Stevia and stevioside, you might want to take the information with a grain of salt, if not sugar.
	www.organicanews.com /news/article.cfm?story_id=24 (701 words)

	Stevia is Safe
		The advantages of stevioside as a dietary supplement (daily intake estimated to be below 200 mg) for human subjects are manifold: it is stable, non-calorific and it maintains good dental health by reducing the intake of sugar and it opens the possibility for use by diabetic and phenylketonuria patients and obese persons.
		Recently it was demonstrated that oral intake of stevioside causes a clear-cut reduction in the glycaemic response to a test meal.
		In 2000, the European Commission refused to accept Stevia or stevioside as a novel food or food additive respectively because of a lack of critical scientific reports on Stevia and the discrepancies between cited studies with respect to possible toxicological effects of stevioside and especially its aglycon steviol.
	www.web-outpatients.com /Articles.asp?Article_Id=99&category=Nutrition (868 words)

	stevia, steviosidey
		In reproductive toxicity studies, administration of stevioside at doses of up to 2500mg/kg of body weight per day to hamsters and 3000mg/kg of body weight per day to rats had no effect.
		In several studies, the material tested (stevioside or steviol) was poorly specified or of variable quality, and no information was available on other constituents or contaminants.
		Before reviewing stevioside again, the Committee considered that it would be necessary to develop specifications to ensure that the material tested was representative of the commercial product.
	alternativehealing.org /stevia.htm (869 words)

	Bodybuilding.com - Clayton South - Clayton's Health Facts: Stevia.
		The Stevioside that is extracted from the plant comes from the leaves.
		The Stevia plant yields its major glycosides, stevioside, rebaudioside A, rebaudioside C and dulcoside A, from its leaves.
		The main glycoside, stevioside, is between 110 and 270 times sweeter than sugar.
	www.bodybuilding.com /fun/southfacts_stevia.htm (1045 words)

	Sweetener stevioside is a safe sugar substitute
		Stevioside, the main sweet component in the leaves of the Stevia plant, tastes about 300 times sweeter than table sugar, which means only a small amount is needed for sweetening purposes.
		Stevioside has numerous benefits as a sweetener: it is 100% natural, stable, contains no calories and promotes good dental health by reducing sugar intake.
		One of the centre’s goals is to develop a European quality label for stevioside, which should lead eventually to the lifting of the European ban on stevioside.
	www.innovations-report.de /html/berichte/medizin_gesundheit/bericht-38242.html (436 words)

	IMPORT ALERT IA4506
		Stevioside is reportedly 250-300 times sweeter than sugar and contributes no calories to the diet.
		If stevia is to be used in a dietary supplement for a technical effect, such as use as a sweetener or flavoring agent, and is labeled as such, it is considered an unsafe food additive.
		447-451, "Simultaneous Determination of Stevioside, Rebaudioside A and C and Dulcoside A on Foods by High-Performance Liquid Chromatography." A laboratory must assure that recommended methodologies are reliable and accurate by utilizing appropriate validation procedures.
	www.summerlands.com /crossroads/uploads/IMPORT_ALERT_IA4506.html (703 words)

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