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Topic: Strategies for Engineered Negligible Senescence

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	Life extension - Wikipedia, the free encyclopedia
		The primary life extension strategy currently is to apply available anti-aging methods in the hope of living long enough to benefit from a complete cure to aging once it is developed, which given the rapidly advancing state of biogenetic and general medical technology, could conceivably occur within the lifetimes of people living today.
		Senescent cells, can be removed by activating the immune system against them.
		For cancer (the most lethal consequence of mutations) the strategy is to use gene therapy to delete the genes for telomerase and to eliminate telomerase-independent mechanisms of turning normal cells into "immortal" cancer cells.
	en.wikipedia.org /wiki/Life_extension (5762 words)

	Longevity: Essential Concepts -Taking the LONG View (Site not responding. Last check: 2007-11-03)
		Aubrey de Grey's "engineered negligible senescence" proposes to substantially extend human lifespan with a short series of particular cellular therapies.
		Cellular Aging and Cell Death by Nikki J. Holbrook, George R. Martin, Richard A. Lockshin -provides a thorough understanding of the mechanisms responsible for cellular aging, covering the recent research on programmed cell death and senescence, and describing their role in the control of cell proliferation and the aging process.
		Individual chapters discuss such topics as the role and regulation of apoptosis in development, the potential impact of cell death on such postmitotic tissues as nerve and muscle, and suggest that programmed cell death plays an important role in both pathological and nonpathological aspects of aging, including neurodegenerative diseases.
	longevity.essential-facts.com (3551 words)

	The Cryonics Society: Cryonics And Longevity (Site not responding. Last check: 2007-11-03)
		These capabilities will almost surely include improved means for repairing and regenerating tissue that may have suffered injury stemming from cryopreseration.
		A non-technical overview of how far those limits may be pushed back by nanotechnology, and an discussion of the high likelihood that nanotechnology may be able to restore patients properly cryopreserved even today, is available for free in the chapter on cryonics, or biostasis, in Eric Drexler's book, Engines of Creation.
		Cryobiology: The Study of Life and Death at Low Temperatures
	www.cryonicssociety.org /splash_pages/science.html (926 words)

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