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Topic: Streptokinase

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	STREPTOKINASE AS PLASMINOGEN ...
		In this case streptokinase was acting as the inhibitor of fibrinolysis.
		For the sake of prevention, the wife was indicated antichlamydial enzyme therapy course with streptokinase.
		Inhibition of fibrinolysis and the secondary-induced hypercoagulaemia are not dependant on the pharmacokinetic properties of streptokinase but depend on the disease, the inflammation process and the degradation level of the fibrinogen molecule.
	www.expo.lv /gailes/streptokinase1.htm (2077 words)

	EBM Syllabi - EBM in Developing Countries - MI-streptokinase
		'streptokinase' [MESH] and 'myocardial infarction' [MESH] and 'mortality' [MESH] from Cochrane Library
		From the whole process, you were able to determine the importance of the evidence and more significantly, appreciate its application in clinical practice.
		The data you gathered can now be used in convincing the hospital board on the effectiveness of streptokinase in decreasing in-hospital mortality.
	www.cebm.utoronto.ca /syllabi/devl/therapy/mi.htm (345 words)

	HHMI News: Streptococcus Infects Humans by Thwarting Blood Clotting
		To develop the “humanized” mouse that would be vulnerable to bacterial streptokinase, Sun attached the gene for human plasminogen to a regulatory DNA sequence that normally activates the gene for a mouse blood protein, albumin.
		In further experiments, the researchers found that when they removed the streptokinase gene from group A streptococci bacteria, there was little difference in their infectivity between normal and the transgenic mice.
		Streptokinase's importance to group A streptococci may generalize to many other human-specific bacteria that have evolved their own distinctive plasminogen-activating enzymes, said Ginsburg.
	www.hhmi.org /news/ginsburg2.html (1028 words)

	Intraventricular streptokinase after intraventricular hemorrhage in newborn infants
		Bleeding into the ventricles of the brain is a serious complication of premature birth and large hemorrhages often lead to hydrocephalus, the process by which fluid accumulates under pressure inside the brain, expanding the head excessively and damaging the brain tissue.
		Streptokinase is a "clot-busting" agent which has been successfully used to unblock coronary arteries.
		This form of therapy is based on the hypothesis that multiple blood clots in the CSF are the initial cause of post-hemorrhagic ventricular dilatation and lysis of clots could reopen the pathways of circulation and re-absorption of CSF.
	www.cochrane.org /reviews/en/ab000498.html (481 words)

	BIO.COM: Biotechnology Pharmaceutical Therapeutics, Vaccines, Diagnostics, Discovery - Biotech, Pharma, Biomedical (Site not responding. Last check: )
		To develop the "humanized" mouse that would be vulnerable to bacterial streptokinase, Sun attached the gene for human plasminogen to a regulatory DNA sequence that normally activates the gene for a mouse blood protein, albumin.
		In further experiments, the researchers found that when they removed the streptokinase gene from group A streptococci bacteria, there was little difference in their infectivity between normal and the transgenic mice.
		Streptokinase's importance to group A streptococci may generalize to many other human-specific bacteria that have evolved their own distinctive plasminogen-activating enzymes, said Ginsburg.
	www.bio.com /newsfeatures/newsfeatures_research.jhtml?cid=3900001 (928 words)

	Angiographic patency study of an albumin-free recombinant streptokinase formulation in acute myocardial infarction.
		Albumin is present in most of the streptokinase formulation as a stabilizer but it is not known whether it plays a role in the product's efficacy and safety profiles.
		Streptokinase (SK) is a commonly used fibrinolytic agent whose efficacy with regard to mortality reduction in patients with acute myocardial infarction (AMI) was demonstrated in large, placebo-controlled trials (1, 2).
		Streptokinase was well tolerated and only one patient required discontinuation of infusion because of arterial hypotension.
	www.ualberta.ca /~csps/JPPS7(3)/B.Betancourt/rSK.htm (2918 words)

	STREPTOKINASE
		Streptokinase acts by stimulating the conversion of plasminogen to plasmin.
		* Use of streptokinase for inferior infarcts to be discussed with cardiologist/physician.
		* Absence of contraindications to streptokinase and aspirin.
	www.medicineau.net.au /clinical/ICU/procedures/streptas.html (652 words)

	CiteULike: Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of ...
		Streptokinase was associated with an excess of bleeds requiring transfusion (0.5% vs 0.2%) and of confirmed cerebral haemorrhage (0.1% vs 0.0%), but with fewer other strokes (0.6% vs 0.8%).
		An excess of non-fatal reinfarction was reported when streptokinase was used alone, but this appeared to be entirely avoided by the addition of aspirin.
		The differences in vascular and in all-cause mortality produced by streptokinase and by aspirin remain highly significant (2p less than 0.001 for each) after the median of 15 months of follow-up thus far available.
	www.citeulike.org /user/journal06/article/882852 (702 words)

	BioMed Central \| Full text \| Pharmacovigilance program to monitor adverse reactions of recombinant streptokinase in ...
		Streptokinase (SK) is an effective fibrinolytic agent for the treatment of acute myocardial infarction (AMI).
		Streptokinase (SK) is an indirect fibrinolytic agent that interacts with plasminogen, forming an active complex with protease activity that converts plasminogen to plasmin [1].
		This was not done for practical reasons, since there was only one NNP member at each hospital and thus the evaluation had to be done by this person considering the criteria from the reporting physician, with the subsequent bias derived from application of subjective scales.
	www.biomedcentral.com /1472-6904/5/5 (4152 words)

	Streptokinase for acute ischemic stroke
		The trial was halted prematurely because of excess early mortality and cerebral hemorrhage in the streptokinase groups.
		From the data presented here, it seems reasonable to say that 1.5 M units of streptokinase administered to patients presenting within 6 hours of an acute ischemic stroke causes an increase in early mortality and cerebral hemorrhage.
		MAST-E, from France and the UK, was a double-blind trial of 1.5 M IU of streptokinase vs. placebo (no aspirin arms) and was also halted prematurely, after randomization of 310 patients, because of excess 10-day mortality (34% vs. 18.2 %) and intra-cerebral bleeding in the treatment group.
	www.journalclub.org /vol1/a9.html (1112 words)

	Thrombolytic Therapy in Acute Myocardial Infarction : Comparison of Procoagulant Effects of Streptokinase and Alteplase ...
		In acute myocardial infarction (AMI), streptokinase and front-loaded
		regimen with streptokinase and front-loaded alteplase on the kallikrein–contact-phase
		Br Heart J. 1990;64:118–120.The procoagulant effects of the 2 currently used streptokinase and alteplase regimens in relation to kallikrein and plasmin stimulation were examined in acute myocardial infarction.
	circ.ahajournals.org /cgi/content/full/98/23/2527 (3547 words)

	Crystal Structure of the Catalytic Domain of Human Plasmin Complexed with Streptokinase -- Wang et al. 281 (5383): 1662 ...
		Streptokinase is a plasminogen activator widely used in treating blood-clotting disorders.
		Role of the Streptokinase {alpha}-Domain in the Interactions of Streptokinase with Plasminogen and Plasmin.
		Streptokinase Triggers Conformational Activation of Plasminogen through Specific Interactions of the Amino-terminal Sequence and Stabilizes the Active Zymogen Conformation.
	www.sciencemag.org /cgi/content/abstract/281/5383/1662 (986 words)

	Plasminogen Activation by Streptokinase via a Unique Mechanism -- Young et al. 273 (5): 3110 -- Journal of Biological ...
		Plasminogen Activation by Streptokinase via a Unique Mechanism -- Young et al.
		Plasminogen Activation by Streptokinase via a Unique Mechanism
		The mechanism of human plasminogen (HPlg) activation by streptokinase (SK)-type activator was investigated with recombinant
	www.jbc.org /cgi/content/abstract/273/5/3110 (525 words)

	Streptase (Streptokinase) drug description - prescription drugs and medications at RxList
		Streptase (Streptokinase) drug description - prescription drugs and medications at RxList
		Streptase®, Streptokinase, is a sterile, purified preparation of a bacterial protein elaborated by group C (beta) -hemolytic streptococci.
		It is supplied as a lyophilized white powder containing 25 mg cross-linked gelatin polypeptides, 25 mg sodium L-glutamate, sodium hydroxide to adjust pH, and 100 mg Albumin (Human) per vial or infusion bottle as stabilizers.
	www.rxlist.com /cgi/generic2/streptokinase.htm (135 words)

	STREPTOKINASE - INJECTION (Kabikinase, Streptase) side effects, medical uses, and drug interactions.
		STREPTOKINASE - INJECTION (Kabikinase, Streptase) side effects, medical uses, and drug interactions.
		USES: This medication is an enzyme which works to break up and dissolve blood clots which can block arteries.
		MedicineNet does not provide medical advice, diagnosis or treatment.
	www.medicinenet.com /streptokinase-injection/article.htm (420 words)

	A catalytic switch and the conversion of streptokinase to a fibrin-targeted plasminogen activator -- Reed et al. 96 ...
		A catalytic switch and the conversion of streptokinase to a fibrin-targeted plasminogen activator -- Reed et al.
		Communicated by Gregory A. Petsko, Brandeis University, Waltham, MA, June 11, 1999 (received for review January 18, 1999)
		Plasminogen (Pg) activators such as streptokinase (SK) save lives by generating plasmin to dissolve blood clots.
	www.pnas.org /cgi/content/abstract/96/16/8879 (599 words)

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