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Topic: Structural biology

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  Encyclopedia: Structural-biology
Structural biology is a branch of molecular biology concerned with the study of the architecture and shape of biological macromolecules--proteins and nucleic acids in particularĂ¢Â€”and what causes them to have the structures they have.
See also: primary structure, secondary structure, tertiary structure, quaternary structure, structural domain, structural motif, protein subunit, cooperativity, chaperonin, structural genomics, Important publications in structural biology A protein primary structure is a chain of amino acids.
In structural biology, a protein subunit or subunit protein is a single protein molecule that assembles (or coassembles) with other protein molecules to form a multimeric or oligomeric protein.
www.nationmaster.com /encyclopedia/Structural_biology   (1100 words)

 Structural Biology
The high-resolution structures of proteins, DNA, RNA, and small molecules are the "blueprints" for both the structure and function of cells.
A rapidly emerging area of study in structural biology is the field of membrane proteins.
A major focus for the CMM and the Center for Structural Biology is on the proteins that comprise these signal transduction pathways.
www.cmm.sunysb.edu /structuralbiolog.html   (385 words)

 Structural Biology   (Site not responding. Last check: 2007-11-07)
Aging and cancer are caused partly by the abnormal functioning of DNA and proteins involved in regulating expression of a person’s genetic pattern.
Knowing the individual structures of these macromolecules will aid understanding of the chemical nature of disease at the atomic level, as well as the chemical mechanisms of genetic regulation.
The space-filling stippled structures on the protein stick model are hydrating water molecules.
www.sns.gov /aboutsns/biology.htm   (668 words)

 Structural biology -- Facts, Info, and Encyclopedia article   (Site not responding. Last check: 2007-11-07)
These methods include (The branch of science that studies the formation and structure of crystals) crystallography, (Resonance of protons to radiation in a magnetic field) NMR, (Microscopy with the use of electron microscopes) Electron Microscopy, Cyrogenic-Electron Microscopy (Cryo-EM), and (Click link for more info and facts about circular dichroism) circular dichroism.
A third approach that structural biologists take to understanding structure is (Click link for more info and facts about bioinformatics) bioinformatics to look for patterns among the diverse (Serial arrangement in which things follow in logical order or a recurrent pattern) sequences that give rise to particular shapes.
Researchers often can deduce aspects of the structure of (Click link for more info and facts about integral membrane protein) integral membrane proteins based on the (Click link for more info and facts about membrane topology) membrane topology predicted by (Click link for more info and facts about hydrophobicity analysis) hydrophobicity analysis.
www.absoluteastronomy.com /encyclopedia/s/st/structural_biology.htm   (342 words)

 PSB: Partnership for Structural Biology home page
However, detailed information on the structure, function and interaction of the tens of thousands of proteins encoded by these genomes is required in order to fully exploit this new panoply of data for novel human disease treatments.
Structural Biology is a fundamental aspect of modern biology which aims to determine the three-dimensional atomic structure of biological molecules, especially proteins, and hence give insight to the function of these molecules in the living cell.
Rapidly increasing the numbers of known atomic structures of proteins, which is one of the aims of the PSB, will have a number of strategic benefits for European medical research, basic and applied.
psb.esrf.fr   (646 words)

 Structural Genomics   (Site not responding. Last check: 2007-11-07)
Structural genomics is a worldwide initiative aimed at determining a large number of protein structures in a high throughput mode.
The objective of the Structural Genomics Group of the JBIRC is to develop techniques for the structure determination of human membrane proteins and for the analysis of ligand-protein interactions.
Structural Proteomics In Europe (SPINE) is an integrated research project which brings together some of the top European structural biology institutions in a collaborative effort to develop new methods and technologies for high-throughput structure determination.
www.rcsb.org /pdb/strucgen.html   (2637 words)

 Beese, Crystallography, Structural Biology and Crystallography   (Site not responding. Last check: 2007-11-07)
A major focus of the lab is on understanding the structural enzymology of the protein prenyltransferase family of lipid modifying enzymes (Fig1).
Structural studies of macromolecular assemblies central to DNA replication are ongoing.
A common theme of the laboratory is the study of enzyme mechanisms at near atomic resolution by determining three-dimensional structures that represent stages along the reaction pathway.
www.biochem.duke.edu /Beese/beese.html   (962 words)

 Structural Biology   (Site not responding. Last check: 2007-11-07)
The Department of Structural Biology was established in 1996 to bring this expertise and these techniques to St. Jude Children's Research Hospital.
Structural biology is a discipline that benefits greatly from interactions with other research groups.
The Department of Structural Biology at St. Jude is chaired by Stephen White, DPhil.
www.stjude.org /structural-biology   (528 words)

 Structural biology - Encyclopedia.WorldSearch   (Site not responding. Last check: 2007-11-07)
See also: primary structure, secondary structure, tertiary structure, quaternary structure, structural domain, structural motif, protein subunit, cooperativity, chaperonin, structural genomics, Important publications in structural biology
Structural Bioinformatics (Methods of Biochemical Analysis, V. Structural and Functional Relationships in Prokaryotes
Structural Stability and Morphogenesis an Outline of a General Theory of Models (Advanced book classics)
encyclopedia.worldsearch.com /structural_biology.htm   (335 words)

 Structural Biology
The Structural Biology Group is part of the Life Sciences Department of the Paul Scherrer Institute (PSI).
We aim to provide detailed structural insights into the molecular interactions and mechanisms that are essential for the biological function of the proteins and macromolecular complexes under study.
We are very well equipped for molecular biology and protein purification work and we are in the process of building up a technology platform with robotic equipment for the efficient cloning and expression/solubility screening of protein constructs.
sb.web.psi.ch   (222 words)

 Sloan-Kettering - Structural Biology
The aims of the Structural Biology Program are to understand biological function at the structural and mechanistic levels, to determine the structural basis of disease-related alterations in biological macromolecules, and to aid the development of novel anti-tumor agents through collaborative studies.
These areas are studied through interdisciplinary approaches that include not only the core structural biology methods of x-ray crystallography, NMR spectroscopy and optical imaging, but also biochemical, cellular biological and genetic methods.
Research involving three-dimensional structural information focuses on (i) macromolecular assemblies that represent a cellular machinery or signal-processing unit, (ii) the elucidation of function of newly discovered cancer-related proteins, and (iii) experimental anti-tumor drugs bound to their protein or DNA targets.
www.mskcc.org /mskcc/html/15047.cfm   (176 words)

 structural biology
The modern field of Structural Biology essentially originated at Caltech in the 1940's with Linus Pauling.
Pauling pioneered the structure -based approach to the study of biological systems that has formed the basis for most subsequent advances in understanding the molecular mechanisms of biological systems.
The objective of the present Structural Biology group at Caltech is to continue in the tradition established by Pauling to use the information obtained from high resolution structures to understand the molecular basis of biological processes.
www.its.caltech.edu /~bjorker/strubio.html   (159 words)

 DOE Structural Biology   (Site not responding. Last check: 2007-11-07)
A major component of the structural biology program of the Office of Biological and Environmental Research is the support of user facilities for studies in structural biology.
A research objective of the structural biology program of the Office of Biological and Environmental Research is the improvement of instrumentation available for studies in structural biology.
In addition, support is provided for research using the full suite of structural biology techniques, aimed at determining the three-dimensional structures of important proteins, nucleic acids, and other biological materials.
www.er.doe.gov /production/ober/helsrd_s.html   (155 words)

 Sloan-Kettering - Structural Biology: Nikola Pavletich
Our research group is interested in the structural biology of pathways that are altered in cancer, with particular emphasis on pathways that control the growth and proliferation of the cell.
In cancer, mutations and other alterations in these pathways lead to the uncoupling of cell growth from growth-regulatory signals and contribute to the unrestricted proliferation of the tumor cell.
The aim of our research group is to understand, at the structural and mechanistic level, how growth-regulatory proteins are altered in cancer function; how their alteration contributes to cancer; and how they can be targeted by novel chemotherapeutic compounds.
www.mskcc.org /mskcc/html/10848.cfm   (140 words)

 Structural Biology - Overview
The Structural Biology Roadmap is a strategic effort to create a "picture" gallery of the molecular shapes of proteins in the body.
Measurements of the intensity of scattered rays are fed into a computer, which uses a mathematical equation to calculate the exact position of every atom in the protein molecule.
A critical goal of the Structural Biology Roadmap will be the development of a broad inventory of protein structures for research as well as sophisticated new computer-based methods to analyze these data.
nihroadmap.nih.gov /structuralbiology/index.asp   (748 words)

 Cornell U/Sloan-Kettering - Graduate Biomedical Sciences - Biochemistry & Structural Biology
The Biochemistry and Structural Biology program offers opportunities to develop research training in the areas of molecular structure determination, molecular mechanism of membrane trafficking, protein folding, signal transduction, mechanisms, gene structure and nucleic acid chemistry.
Hao Wu is studying the structural mechanisms of receptor signal transduction for the TNF family receptors in cell survival and cell death using x-ray crystallography.
Esther Breslow is currently studying how the structure of a pituitary protein, neurophysin, relates to exytocin and vasopressin binding and function.
biomedsci.cornell.edu /graduate_school/html/14579.cfm   (640 words)

 The Center of Excellence for Structural Biology
The mission of the UT Center of Excellence for Structural Biology (CESB) is to expand the frontiers of knowledge in biomolecular structural and functional research.
The center will provide state-of-the-art infrastructure and education for scientists in all relevant departments at UT. The Center brings together a large group of structural molecular biologists working on a wide range of biological molecules, biomolecular assemblies and complexes.
Its participants represent specialties in all of the current major techniques for high-resolution structure determination of large molecules, including X-ray crystallography, NMR spectroscopy and a battery of sophisticated biophysical tools including mass spectrometry and other spectroscopic techniques.
web.bio.utk.edu /cesb   (199 words)

 NCCR Structural Biology - Education - Symposium 2005   (Site not responding. Last check: 2007-11-07)
This conference series provides a yearly update on current structural biology themes and new developments in the field.
Invited lectureres, all of them among the leaders in their field, and selected NCCR principal investigators present new results and trends in one-hour lectures.
The surroundings of the ETH main building and a conference size of 200 to 400 participants are ideal to facilitate interesting discussions between scientists from both academia and industry that share the interest an structural biology.
www.structuralbiology.unizh.ch /symposium05.asp   (166 words)

 Princeton University - Department of Molecular Biology
The Department of Molecular Biology is a center for research in the life sciences at Princeton University.
Graduate Program: The graduate program offers each entering student the opportunity, with the help of faculty advisors, to create an intellectual program that matches and supports his or her particular scientific interests.
Princeton's commitment to a cutting-edge multidisciplinary approach to biology is highlighted by last year's opening of the new Carl Icahn Laboratory housing the Lewis-Sigler Institute for Integrative Genomics, the new program in Quantitatiive and Computational Biology, and the new initiatives in neuroscience.
www.molbio.princeton.edu   (284 words)

 NIMR, London :: Structural Biology
The Structural Biology Group studies the actions and the three dimensional structures of a range of biologically active and medically important molecules.
To do this biochemical and biophysical methods such as optical and mass spectrometry are allied to structural methods like NMR, X-ray crystallography and molecular modelling.
With this information the mechanisms inside and outside the cell, through which biological processes are effected, can be analysed at the atomic and molecular levels.
www.nimr.mrc.ac.uk /strbiol   (99 words)

 CCSB - Welcome   (Site not responding. Last check: 2007-11-07)
The Cleveland Center for Structural Biology (CCSB) is an association of researchers at different Cleveland institutions, who study structure-function relationships and properties of large molecules that are involved in disease states.
The center serves as a focal point to bring together researchers with interest in Structural Biology, to generate a stimulating research and educational environment, and to facilitate and promote interactions between structural biologists and medical colleagues.
Further roles of the CCSB are in attracting high caliber faculty, research associates and students to the area and in generating resources for major research equipment.
structuralbiology.cwru.edu   (119 words)

Structures of proteins and nucleic acids determined by x-ray crystallography and NMR (Rutgers University)
This document is a graphical summary of hydrogen bonding in a dataset of high-resolution protein structures.
NRL_3D is a sequence--structure database derived from the 3 dimensional structure of proteins deposited with the Brookhaven National Laboratory's Protein Data Bank.
www.fccc.edu /research/labs/dunbrack/molecularmodeling.html   (1428 words)

 Amazon.com: Books: Introduction to Protein Architecture: The Structural Biology of Proteins   (Site not responding. Last check: 2007-11-07)
Explains the general characteristic underlying the variety of structures, functions, and interactions of proteins observed in nature.
Visually stunning is only the most obvious aspect of this amazing introduction to structural genomics (proteinomics): the systematic study of protein structures.
The weblems underscore the fact that structural genomics, a branch of bioinformatics, is a hot topic in the biotech arena.
www.amazon.com /exec/obidos/tg/detail/-/0198504748?v=glance   (1102 words)

 About Current Opinion in Structural Biology
The Current Opinion journals were developed out of the recognition that it is increasingly difficult for specialists to keep up to date with the expanding volume of information published in their subject.
The views of experts on current advances in structural biology in a clear and readable form.
The subject of structural biology is divided into twelve major sections, each of which is reviewed once a year.
www.current-opinion.com /jstb/about.htm?jcode=jstb   (559 words)

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