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| | Faculty Research - Schlegel (Site not responding. Last check: 2007-11-07) |
 | | The two leaflets of the plasma membrane bilayer of blood cells differ markedly in composition, with the choline phospholipids, phosphatidylcholine (PC) and sphingomyelin (Sph), concentrated in the outer leaflet and the aminophospholipids, phosphatidylserine (PS) and phosphatidylethanolamine (PE), concentrated in the inner leaflet (Figure 1). |
 | | Representatives of this new subfamily are found in yeast, nematodes, mammals and plants, and recently, mutations in one of the genes in the subfamily have been identified as responsible for two forms of human inherited cholestasis, or inpaired bile flow. |
 | | Current research is directed toward elucidating the functions of the other numerous members of the subfamily. |
| www.bmb.psu.edu /faculty/rschlegel/schlegel.html (576 words) |
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