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Topic: Substance P

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	Substance P - Wikipedia, the free encyclopedia
		In neuroscience, Substance P is a neuropeptide: a short-chain polypeptide that functions as a neurotransmitter and as a neuromodulator.
		The endogenous receptor for Substance P is neurokinin 1 receptor (NK1-receptor, NK1R).
		Substance P is involved in the transmission of pain impulses from peripheral receptors to the central nervous system.
	en.wikipedia.org /wiki/Substance_P (361 words)

	Substance P (Site not responding. Last check: 2007-10-14)
		Following the chronic thyroxine injections, the substance P level was increased in the nucleus caudatus putamen and the tractus diagonalis and was decreased in the area ventralis tegmenti.
		Substance P receptor is found not only in areas of the brain that are associated with depression, anxiety and stress, but also those parts that interfere with the effects of rewards such as food and drugs.
		Stephen P. Hunt of University College, London, and colleagues examined the effects of the substance P receptor gene in mice to determine its role in morphine and cocaine addiction.
	www.ithyroid.com /substance_p.htm (1244 words)

	Substance P antibodies from RDI Divison of Fitzgerald Industries Intl
		Substance P- containing tumors arising in the ileum are often associated with the "carcinoid syndrome", characterized by flushing of the skin, diarrhea broncho-constriction and sudden drops in blood pressure.
		Substance P-containing tumors arising in the ileum are often associated with the carcinoid syndrome, characterized by flushing of the skin, diarrhea, broncho-constriction and sudden drops in blood pressure.
		Substance P is commonly found in the midgut carcinoids and some of the symptoms may be related to this peptide.
	www.researchd.com /miscabs/pro16069.htm (707 words)

	BioMed Central \| Full text \| Substance P selectively decreases paired pulse depression in the rat hippocampal slice
		Substance P did however cause a selective reduction in the paired pulse depression of population spikes evoked by paired stimulation at interpulse intervals of 20–80 msec.
		The neurokinin-1 receptor agonist substance P methyl ester was selected because it had been previously found to effectively mimic the effects of substance P in the mouse hippocampus, where it was effective in a concentration range of 10 nM–5 μM, with the maximum depressant action on field potentials observed using 0.1 μM [9].
		However, the fact that repeated perfusion of substance in the presence of the NK2 and NK3 antagonists produced substantially the same effect suggest that this is not the case, and that the reduced effect of substance P in the presence of SR140333 is due to antagonism of neurokinin-1 receptors.
	www.biomedcentral.com /1471-2202/6/66 (4522 words)

	physics - Substance P
		Substance P is an 11-amino acid polypeptide with the sequence: Arg Pro Lys Pro Gln Gln Phe Phe Gly Leu Met.
		In central nervous system substance P has been associated in the regulation of mood disorders, anxiety, stress, reinforcement, neurogenesis, neurotoxicity, nausea / emesis and pain.
		Substance P antagonist (SPA) aprepitant is available in the market in the treatment chemotherapy induced of nausea / emesis.
	www.physicsdaily.com /physics/Substance_P (192 words)

	SUBSTANCE P (Site not responding. Last check: 2007-10-14)
		In neuroscience, Substance P is a neuropeptide: a short-chain polypeptide that functions as a neurotransmitter.
		The endogenous receptors for Substance P belong to the tachykinin sub-family of GPCRs.
		Since the amount of substance P in the body can decrease over time, it has been theorized that this is the reason why frequent curry-eaters seem more comfortable eating spicy foods.
	www.faktoen.com /wiki/en/su/Substance%20P.htm (193 words)

	Roles Of Substance P
		Substance P (SP), an undecapeptide, is abundant both in the periphery and in the CNS, where it is usually co-localised with one of the classical neurotransmitters, most commonly serotonin (5-HT).
		Approximately 10% of all the neurons in the amygdala are substance P neurons.
		Morphological characterization of substance P receptor-immunoreactive neurons in the rat spinal cord and trigeminal nucleus caudalis.
	www.angelfire.com /journal2/sadhelp/substanceP.htm (7669 words)

	The Visualization Group, Inc. (Site not responding. Last check: 2007-10-14)
		In this stage substance P can be decisive in increasing the strength of the pain signal to a new level.
		But if the signal is strong, and enough glutamate and substance P are present in the NMDA receptors on your Stage 2 nerve cells, NMDA is activated and the pain signal is seriously increased.
		Through visualization statements it may be possible to focus your subconscious on reducing the impact of substance P in the pain process.
	www.thevisualizationgroup.com /articles/Substance_P.php (557 words)

	The Substance P Connection
		Substance P can be found in Serum, Urine, CSF, Synovial Fluid and soft-tissues of the body, and is taken from these sites in a research environment only for investigation.
		Substance P is very involved in the transmission of pain signals to the brain.
		The N-Terminal peptide of Substance P is also found to be elevated in FMS patients, indicating that excessive Substance P is being produced, which in turn highly exacerbates pain signals.
	www.fmsni.org.uk /ijonruss.htm (890 words)

	Substance P (Site not responding. Last check: 2007-10-14)
		The understanding of substance P has evolved beyond the original concept as the pain transmitter of the dorsal horn.
		Animal and genetic research, recent developments of nonpeptide substance P antagonists, and important changes in the understanding of neurotransmission have each contributed to the current understanding of substance P After 7 decades, the physiologic role of substance P is known as a modulator of nociception, involved in signaling the intensity of noxious or aversive stimuli.
		Genetic studies in mice and development of substance P antagonists provide more recent results that support the redefinition of the central role of substance P Evidence suggests that this neuropeptide is an integral part of central nervous system pathways involved in psychologic stress.
	www.biopsychiatry.com /substance-p.html (171 words)

	Substance P dependence of endosomal fusion during bladder inflammation -- Hammond et al. 278 (3): 440 -- AJP - Renal ...
		Western blot analysis of substance P receptor in bladder endosomes reveals a single band at the predicted molecular masses for the mature receptor as described in other tissues (22).
		Role of substance P and the neurokinin 1 receptor in acute pancreatitis and pancreatitis-associated lung injury.
		The substance P receptor is necessary for a normal granulomatous response in murine schistosomiasis mansoni.
	ajprenal.physiology.org /cgi/content/full/278/3/F440 (6954 words)

	April 09, 2000: MED: Substance P (Site not responding. Last check: 2007-10-14)
		For Chilli peper, capsaicin and the release of substance P, pleaase go to: http://www.ultranet.com/~jkimball/BiologyPages/P/Pain.html In short: In pain transduction: C fibers: unmyelinated and thus conduct impulses slowly Link to a discussion of the role of myelin in speeding the conduction of nerve impulses.
		Substance P preferentially binds to NK-1, a receptor of the neurokinin family, but how the receptor-elicited signal is translated into inflammatory gene expression is not yet understood.
		If you read the articles at: http://www.med.ufl.edu/med/rheum/russell.html http://www.coloradohealthnet.org/fibro/fibro_denver97.html Substance P is supsected to be a crutial denominator in FMS, either primary or secondary to lupus and some other autoimmune diseases.
	www.hamline.edu /~lupus/arch2000/msg01782.html (494 words)

	Neurochemical Substance P is Key to Understanding Pain Process
		Substance P binds itself to a receptor Russell identifies as NK1.
		When Substance P is released in the presence of the brainâs suppressive chemicals two events may occur.
		Substance P may bind to an NK1 receptor and carry on the message of pain, or it may be broken into two by an enzyme released by the brain.
	www.fibromyalgiasupport.com /library/showarticle.cfm/id/3097 (646 words)

	Substance P (Site not responding. Last check: 2007-10-14)
		Substance P is a neuropeptide derived from preprotachinin.
		Substance P is widely distributed in the central and peripheral nervous system.
		The role of substance P in sensory transmission has been studied extensively, and its involvement in nociception and chronic pain is well established.
	www.neuromics.com /ittrium/visit?path=A1x66x1y1x9fx1y1x246x1y1x3d5x1x82y1x40ax1x7f (142 words)

	C&EN: CRITTER CHEMISTRY - NAKED MOLE-RATS
		Substance P is a neuropeptide that plays a role in transmitting pain signals to the central nervous system.
		The lack of Substance P could be an adaptation to eliminate aggressive individuals from the population.
		This type of pain is signaled by Substance P. To avoid living in constant pain, the naked mole-rats may have evolved to eliminate the neurotransmitter.
	pubs.acs.org /cen/critter/8202molerats.html (867 words)

	IL-4 and IFN-{gamma} Up-Regulate Substance P Receptor Expression in Murine Peritoneal Macrophages -- Marriott and Bost ...
		Substance P innervation of spleen in rats: nerve fibers associate with lymphocytes and macrophages in specific compartments of the spleen.
		Substance P (NK1)- and neurokinin A (NK2)-receptor gene expression in inflammatory airway diseases.
		Substance P binds to the formylpeptide chemotaxis receptor on the rabbit neutrophil.
	www.jimmunol.org /cgi/content/full/165/1/182 (7726 words)

	Substance P, Fibromyalgia and chronic pain how are they linked?
		Substance P has been shown to exist in higher levels in Fibros.
		The higher the level of Substance P the more efficient our system is at pain transmission, it is that transmission which makes little pains feel horrible to Fibros.
		It is not as simple as that, Serotonin, Substance P and the rest of the body’s chemistry is a complex chain and Serotonin production requires more than a simple pill to fix it.
	www.suite101.com /article.cfm/11513/83772 (587 words)

	Substance P treatment for immunostimulation (US5945508)
		Substance P aerosols are effective in replenishing immune systems compromised by environmental toxicants.
		Boichot et al., "Inhaled Substance P Induces Actgivation of Alveolar Macrophages and Increases Airway Responses in the Guinea-Pig", Neorpeptides 25(307-313 (1993).
		Jurjus A, Walsh R, "Detection of substance P positive cells and nerve fibers in the rat thymus, " The Faseb Journal, 11(3):A201, 1997.
	www.delphion.com /details?pn=US05945508__ (562 words)

	Synaptically Evoked Membrane Potential Oscillations Induced by Substance P in Lamprey Motor Neurons -- Svensson et al. ...
		Substance P belongs to the tachykinin family of neuropeptides.
		In the presence of low-potassium Ringer, the amplitude of the depolarization was increased.
		C.-Y. Chen, P. Munch, A. Quail, and A. Bonham
	jn.physiology.org /cgi/content/full/87/1/113 (5114 words)

	CAMB: Faculty: Steven D. Douglas, M.D.
		Douglas has been investigating substance P, a neurotransmitter long known to be active in the brain and nervous system.
		He and colleagues discovered in 1997, that immune cells produce substance P and its receptor, neurokinin-1, and later showed that incubation with substance P raised HIV levels in immune cell cultures.
		One is the full-length receptor, and the other a shortened version with fewer amino acids with the addition of substance P to cell cultures, the cells both responded with an increase in calcium ions, but used distinct signaling pathways.
	www.med.upenn.edu /camb/faculty/gt/douglas.html (459 words)

	ImmuneRegen Biosciences - Substance P Research (Site not responding. Last check: 2007-10-14)
		Substance P, discovered in 1931, is a naturally occurring small (1348 D molecular weight) neuropeptide of 11 amino acids that is found throughout the body.
		Relevant to our current studies, Substance P is localized to the nerves in the airways of many species, including humans.
		In an attempt to find a commercially viable Substance P analog with similar or expanded capabilities, scientists, including our co-founder, Dr. Mark Witten, working in the area of Substance P and pulmonary function developed a Substance P analog (Sar 9, Met (O 2) 11-Substance P).
	www.immuneregen.com /products.htm (470 words)

	Substance P (Site not responding. Last check: 2007-10-14)
		Substance P is a neurotransmitter found in both the peripheral and central nervous systems.
		Substance P is involved in the perception of painful stimuli throughout the body.
		One of the large drug companies has recently done a study with a substance P blocking agent to see if it has clinically useful antidepressant effects and to see how it compared with Prozac and other antidepressants.
	www-personal.engin.umich.edu /~edaneshv/Hockey (120 words)

	Enhancement of Angiogenesis by Endogenous Substance P Release and Neurokinin-1 Receptors During Neurogenic Inflammation ...
		Synovial endothelial cell proliferation increased by substance P. Endothelial cell PCNA index in synovia 24 h after intra-articular injection of normal saline or substance P, arithmetic means (± S.E.M.) of six rats.
		Dose-dependent inhibition of 10 nmol substance P-enhanced endothelial cell proliferation by the NK receptor antagonist SR140333
		Increases in knee diameter and macrophage infiltration 24 h after intra-articular injection of 10 nmol of substance P (+) or 0.5% capsaicin (+), compared with normal saline (–), were not inhibited by coadministration of NK or NK receptor antagonists.
	jpet.aspetjournals.org /cgi/content/full/306/1/8 (2965 words)

	fibromyalgia and substance p
		Decreased blood flow to certain area of the brain responsible for pain perception and modulation of pain signaling have also been seen.
		Substance P is a tachykinin, a peptide (protein) that has biological activity as a pain inducer.
		Studies have indicated that patients with FM have elevated levels of Substance P in the serum, urine, spinal fluid, and soft tissues.
	www.arthritis-treatment-and-relief.com /fibromyalgia-and-substance-p.html (242 words)

	substance P [Archive] - HealthBoards
		As he was prescribing an another medication to play with my daughter's brain chemistry, he says that it would be better if we had something that would influence the level of substance P, but we don't.
		of Substance P. I also read in an FMS quarterly newsletter I get that they are working on a pill that will reduce the production of Sub.
		P, but it will quite a few years after it is perfected before it would hit the market.
	www.healthboards.com /boards/archive/index.php/t-53936.html (239 words)

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