
	Where results make sense

Topic: Succinate

In the News (Tue 2 Dec 08)

Damian Green

Sumner Redstone

Crimson Tide

Tommy Tuberville

Bill Clinton

Wayne Rooney

Vilasrao Deshmukh

Wake Forest

Grand Slam

Oklahoma State

	Bacteria are key to 'green' plastics, drugs
		"Succinate is a high-priority chemical that the U.S. Department of Energy has targeted for biosynthesis," said process co-developer George Bennett, professor and chair of the department of biochemistry and cell biology at Rice.
		The centerpiece of Rice's succinate technology is a mutant form of E. coli that makes succinate as it's only metabolic byproduct.
		The goal is to maximize the rate -- the speed of the conversion -- and the yield -- the amount of succinate produced per pound of glucose converted.
	www.physorg.com /news5974.html (684 words)

	Succinic acid - Wikipedia, the free encyclopedia
		Succinic acid (IUPAC systematic name: butanedioic acid; historically known as spirit of amber) is a dicarboxylic acid with the formula:
		This is catalysed by the enzyme succinate dehydrogenase (or complex II of the mitochondrial ETC).
		The complex is a 4 subunit membrane-bound lipoprotein which couples the oxidation of succinate to the reduction of ubiquinone.
	en.wikipedia.org /wiki/Succinic_acid (249 words)

	Succinate - coenzyme Q reductase - Wikipedia, the free encyclopedia
		Succinate-coenzyme Q reductase (EC 1.3.5.1 ; succinate dehydrogenase) is an enzyme complex found in the matrix part of the inner mitochondrial membrane.
		The enzyme complex has two main parts, wherein one is part of the citric acid cycle with the task of converting succinate into fumarate and the other is complex II of the electron transport chain, which uses electrons freed from succinate, to reduce ubiquinone to ubiquinol.
		In the citric acid cycle, succinate is oxidized by the succinate dehydrogenase part of the complex and 2e
	en.wikipedia.org /wiki/Succinate_dehydrogenase (227 words)

	Vitamin E succinate (alpha-tocopheryl succinate)
		Although the naturally occurring forms of vitamin E have lipid-soluble antioxidant properties that protect cell membranes against damage by free radicals, the acetate and succinate derivatives that are esterified at the C-6 position of the chromanol ring do not have antioxidant properties unless the esterification is hydrolyzed and free tocopherol is regenerated.
		This extra dimension from succinate significantly extends the protective properties of vitamin E. Vitamin E succinate is may inhibit growth and induced apoptic cell death in estrogen-receptor-negative human breast cancer cell lines.
		Vitamin E succinate may be of clinical use in the treatment of aggressive human breast cancers, particularly those that are resistant to anti-estrogen therapy.
	www.vitamins-supplements.org /tocopheryl-succinate.php (510 words)

	DctA- and Dcu-independent transport of succinate in Escherichia coli: contribution of diffusion and of alternative carri
		Succinate uptake by the mutants could not be saturated at physiological succinate concentrations (< or =5 mM), in contrast to the wild-type, which had a K(m) for succinate of 50 microM and a V(max) of 35 U/g dry weight at pH 6.
		Succinate uptake by this carrier was inhibited by addition of an uncoupler.
		In contrast, the efflux of succinate produced during glucose fermentation was not affected in the mutants, demonstrating that, for succinate efflux, a carrier different from, or in addition to, the known Dcu and CitT carriers is used.
	www.galenicom.com /medline/article/11511871/au:Kim+OB (397 words)

	EHS: Mosby's Drug Consult - Drug Updates - Frovatriptan Succinate 003561
		Frovatriptan succinate is a white to off-white powder that is soluble in water.
		The efficacy of frovatriptan succinate in the acute treatment of migraine headaches was demonstrated in five randomized, double-blind, placebo-controlled, outpatient trials.
		Although the abuse potential of frovatriptan succinate has not been specifically assessed in clinical trials, no abuse of, tolerance to, withdrawal from, or drug-seeking behavior was observed in patients who received frovatriptan succinate.
	www.mosbysdrugconsult.com /DrugConsult/003561.html (4418 words)

	Differences between mouse and rat pancreatic islets: succinate responsiveness, malic enzyme, and anaplerosis -- ...
		Methyl esters of succinate are hydrolyzed intracellularly to succinate, a compound often used experimentally to energize mitochondria.
		molecule of succinate oxidized by succinate dehydrogenase (Fig.
		Estimates of glycolysis, pyruvate (de)carboxylation, pentose phosphate pathway, and methyl succinate metabolism in incapacitated pancreatic islets.
	ajpendo.physiology.org /cgi/content/full/283/2/E302 (4496 words)

	Relationship between Succinate Transport and Production of Extracellular Poly(3-Hydroxybutyrate) Depolymerase in ...
		The rates of succinate uptake were calculated from the slopes of the graphs (not shown) and were plotted against pH together with the doubling times of the bacteria on succinate.
		The rates of succinate transport were calculated from the slopes (not shown) and were plotted against the succinate concentration.
		Apparently, succinate is not transported by a proton symport mechanism.
	aem.asm.org /cgi/content/full/65/4/1703 (3654 words)

	Braz. J. Plant Physiol. vol.14 no.2; Abstract: S1677-04202002000200005 (Site not responding. Last check: )
		The influence of succinate treatment on Zn toxicity was investigated using plant growth and mineral uptake as stress indicators.
		The succinate treatment increased P in the roots but did not affect the Ca, N and Mg contents in Zn-treated plants.
		The ameliorative effect of succinate on plant growth could be due to a lower Zn translocation in the leaves and stems and increased Zn accumulation in the roots.
	www.scielo.br /scielo.php?script=sci_abstract&pid=S1677-04202002000200005&lng=en&nrm=iso&tlng=en (241 words)

	Doxylamine succinate (IARC Summary & Evaluation, Volume 79, 2001)
		Doxylamine succinate is an ethanolamine-based antihistamine used in the management of insomnia and, in combination with antitussives and decongestants, in the relief of cough and cold symptoms.
		In mice, it increased the incidences of hepatocellular and thyroid follicular-cell adenomas in males and females, although the thyroid response was not dose-related in males.
		Doxylamine succinate induced DNA damage in primary rat hepatocytes and inhibited intercellular communication, but it did not induce sister chromatid exchange in mammalian cells in culture or induce mutations in bacteria.
	www.inchem.org /documents/iarc/vol79/79-05.html (467 words)

	Breaking News: Desvenlafaxine Succinate (DVS-233) Phase 3 Data Show Significant Improvement in Symptoms of Depression ...
		The most common treatment emergent adverse events (i.e., those reported by at least 10 percent of desvenlafaxine succinate patients, and twice the rate of patients on placebo) were abdominal pain, asthenia, anorexia, constipation, dry mouth, nausea, vomiting, dizziness, insomnia, nervousness, somnolence, sweating, tremor, vertigo, and abnormal ejaculation.
		To help determine whether desvenlafaxine succinate had effects on the QT interval, a randomized, double-blind study of 71 healthy adult women (ages 18 to 55) was conducted.
		In the study, desvenlafaxine succinate 200 mg and 600 mg dose groups did not affect the QT interval at the primary endpoint at eight hours post dose.
	www.genengnews.com /news/bnitem.aspx?name=1918209 (1260 words)

	Vitamin E Succinate 400 IU
		Vitamin E Succinate takes vitamin E's antioxidant action a step further.
		Succinate feeds directly into the Krebs cycle, our major metabolic pathway for generating energy.
		E succinate is prepared from a soy-source vitamin E. However, the amounts of residual soy antigens in this product are very small.
	www.betterlife.com /prod_home_page.asp?prod_id=20513 (128 words)

	APPGuide Online - Consumer Medicine Information - CHLOROMYCETIN^® SUCCINATE INJECTION - CMI (Site not responding. Last check: )
		Chloromycetin Succinate is given by injection into a vein or muscle by your doctor or a trained nurse.
		Chloromycetin Succinate is a powder that is diluted by your hospital pharmacist by mixing with Water for Injections, sodium chloride 0.9% injection or glucose 5% injection.
		Chloromycetin Succinate is a white or yellowish-white powder in a glass vial.
	www.appco.com.au /appguide/drug.asp?drug_id=00072652&t=cmi (1611 words)

	Vitamin E Succinate (Natural), 400 Iu 100 Capsules
		Alpha-tocopherol succinate appears to have longer half-life in the body, and does not interfere with vitamin A or K absorption.
		Serious vitamin takers prefer cold-water dispersible dry powder vitamin E supplements in the form of alpha-tocopheryl succinate or acetate because the cold-water dispersible forms are efficiently absorbed even when taken on an empty stomach or with a low-fat meal.
		Cold-water dispersible vitamin E, whether in a succinate or acetate form, always comes in a white dry powder, while non-cold water dispersible natural and synthetic acetate forms of vitamin E are always in a thick brown oil.
	www.lef.org /newshop/items/item00063.html (952 words)

	IngentaConnect Comparison of suppressive potency between prednisolone and predni...
		If this is the case, the impairment of prednisolone sodium succinate conversion to prednisolone in some clinical conditions may attenuate the efficacy of prednisolone sodium succinate.
		The ratio of prednisolone liberation from prednisolone sodium succinate was not affected by the presence of fetal bovine serum or PBMC, or both, in the culture medium.
		Therefore, impairment of the enzymatic conversion of prednisolone sodium succinate to prednisolone in some pathological conditions such as liver diseases may result in attenuation of the clinical efficacy of prednisolone sodium succinate.
	www.ingentaconnect.com /content/rpsgb/jpp/2001/00000053/00000005/art00015 (452 words)

	Mutation of the ptsG Gene Results in Increased Production of Succinate in Fermentation of Glucose by Escherichia coli ...
		Succinate is of commercial interest as a potential precursor of industrial chemicals.
		of approximately 1 mol of succinate, 0.5 mol of acetate, and 0.5
		Repression of the gene encoding succinate dehydrogenase in response to glucose is mediated by the EIICB
	aem.asm.org /cgi/content/full/67/1/148 (4164 words)

	Vitamin E Hair Loss \| Vitamin E For Hair Growth
		Vitamin E succinate was compared to the anti-androgen drug, flutamide.
		Vitamin E succinate may therefore demonstrate rare benefits of vitamin E hair loss treatment by its effectiveness in surpressing DHT levels in the scalp, the main factor in male pattern hair loss.
		Vitamin E succinate was inhibiting DHT, demonstrating another potential benefit of vitamin E for hair growth.
	www.man-health-magazine-online.com /vitamin-e-benefits-for-hair-loss.html (272 words)

	Unbound MEDLINE \| Metoprolol succinate, a selective beta-adrenergic blocker, has no effect on insulin sensitivity. ...
		This study examined the effect of extended-release metoprolol succinate on insulin sensitivity.
		Metoprolol succinate treatment was begun at 50 mg daily and titrated to a dose that lowered blood pressure to <140/90 mm Hg.
		On metoprolol succinate plus HCTZ treatment, there were no significant changes in insulin clamp measures of insulin sensitivity.
	www.unboundmedicine.com /medline/ebm/record/16687942/abstract/Metoprolol_succinate_a_selective_beta_adrenergic_blocker_has_no_effect_on_insulin_sensitivity (231 words)

	Bacteria Key to Environmentally Friendly Plastics, Drugs - US Department of State
		"Succinate is a high-priority chemical that the U.S. Department of Energy has targeted for biosynthesis," said process co-developer George Bennett at Rice.
		"Succinate is a high-priority chemical that the U.S. Department of Energy has targeted for biosynthesis," said process co-developer George Bennett, professor and chair of the department of biochemistry and cell biology at Rice.
		The centerpiece of Rice's succinate technology is a mutant form of E. coli that makes succinate as it's only metabolic byproduct.
	usinfo.state.gov /gi/Archive/2005/Aug/24-401226.html?chanlid=globalissues (1012 words)

	SUMATRIPTAN SUCCINATE
		Omaha, a rack roof is far less sumatriptan succinate editorial than that diverse house public sale.
		Colorado Springs, the buff is more sumatriptan succinate teasing than one flattering star wars episode 3.
		Goodness, one removing fl hair dye is much less sumatriptan succinate snooty than that deceptive watersports.
	sumatriptan-succinate.zaxswq.com (157 words)

	The Succinate Mechanism of Insulin Release -- Fahien and MacDonald 51 (9): 2669 -- Diabetes
		The generated succinate, as exogenous succinate, would be converted into malate (Mal) by the combined succinate dehydrogenase-fumarase reactions (reactions 6 and 7, respectively).
		MacDonald MJ: Metabolism of the insulin secretagogue methyl succinate by pancreatic islets.
		MacDonald MJ: Feasibility of a mitochondrial pyruvate malate shuttle in pancreatic islets.
	diabetes.diabetesjournals.org /cgi/content/full/51/9/2669 (5427 words)

	Vitamins : Vitamin E Succinate
		E succinate is prepared from a soy-source Vitamin E. However the amounts of residual soy sensitivity, Vitamin E succinate offers an exciting new dimension of the Vitamin E effect.
		Vitamin E succinate is a derivative of vitamin E and has been shown to inhibit tumor cell growth.
		In one study, vitamin E succinate inhibited growth and induced apoptic cell death in estrogen-receptor-negative human breast cancer cell lines.
	www.greatvistachemicals.com /vitamins-vitamin/vitamin-e-succinate.html (313 words)

	Pfam 20.0 : Succ_DH_flav_C (Site not responding. Last check: )
		In bacteria two distinct, membrane-bound, enzyme complexes are responsible for the interconversion of fumarate and succinate (): fumarate reductase (Frd) is used in anaerobic growth, and succinate dehydrogenase (Sdh) is used in aerobic growth.
		Both complexes consist of two main components: a membrane-extrinsic component composed of a FAD-binding flavoprotein and an iron-sulphur protein; and an hydrophobic component composed of a membrane anchor protein and/or a cytochrome B. In eukaryotes mitochondrial succinate dehydrogenase (ubiquinone) () is an enzyme composed of two subunits: a FAD flavoprotein and and iron-sulphur protein.
		The flavoprotein subunit is a protein of about 60 to 70 Kd to which FAD is covalently bound to a histidine residue which is located in the N-terminal section of the protein PUBMED:2668268.
	pfam.wustl.edu /cgi-bin/getdesc?name=Succ_DH_flav_C (209 words)

	Doxylamine Succinate
		Chemistry - An ethanolamine-derivative antihistamine, doxylamine succinate occurs as a white to creamy-white powder with a characteristic odor.
		Doxylamine succinate has solubilities of 0.5 g/ml in alcohol and 1 g/ml in water.
		Doxylamine Succinate for Injection 11.36 mg/ml; 250 ml vials; A-H® Injection (Schering); (Rx) Approved for use in dogs, cats, and horses (not intended for food purposes).
	www.elephantcare.org /Drugs/doxylami.htm (527 words)

	Hydrocortisone sodium succinate (Site not responding. Last check: )
		Hydrocortisone Sodium Succinate eye ointment, or eye drops, is given to treat or prevent many inflammatory eye conditions.
		You may be given Hydrocortisone Sodium Succinate as a lotion or a cream (topical) to treat skin disorders.
		The amount of Hydrocortisone Sodium Succinate you will receive depends on many factors, including your height and weight, your general health or other health problems, and the reason you are receiving this drug.
	www.chemocare.com /bio/bio_iBiographyID_9271.htm (1699 words)

	Hans Krebs - brief biography
		He noted that only certain organic acids were readily oxidized by muscle, and found that the oxidation of endogenous carbohydrate or pyruvate could be stimulated by a number of specific acids, all of which turned out to be substrates of the tricarboxylic acid cycle enzymes.
		Since malonate, which competitively inhibits succinate dehydrogenase, completely stopped the oxidation of pyruvate by the addition of organic acids, he concluded that the succinate to fumarate reaction must be a critical link in a chain of reactions involving all of the known catalytically active acids that can stimulated oxidation of pyruvate.
		Malonate poisoning also limited the ability of oxaloacetate to stimulate the oxidation of pyruvate - where one molecule of oxaloacetate could stimulate the oxidation of many molecules of pyruvate in the uninhibited system, only one molecule of pyruvate was oxidized per molecule of oxaloacetate in the malonate-poisoned system.
	www.ruf.rice.edu /~bioslabs/studies/mitochondria/krebs.html (591 words)

	HYDROCORTISONE SODIUM SUCCINATE - INJECTION (A-Hydrocort, Solu-Cortef) side effects, medical uses, and drug ...
		USES: Hydrocortisone sodium succinate is a corticosteroid-type hormone used as a supplement when the body is not producing enough of the natural hormone, cortisol.
		Hydrocortisone sodium succinate is also used to suppress (inhibit) the immune system in order to treat conditions such as allergies, rejection of transplanted organs, or rheumatoid arthritis.
		HOW TO USE: Give this medication directly into a vein (IV) or into a muscle (IM), as directed by the doctor.
	www.medicinenet.com /hydrocortisone_sodium_succinate-injection/article.htm (565 words)

	Succinate@Everything2.com
		The succinate form of a chemical is often used in drugs or vitamins to enhance chemical stability without compromising bioavailability.
		For example, one of the main forms of Vitamin E is d-alpha-tocopheryl succinate.
		The succinic acid molecule is removed easily by stomach enzymes such as succinate dehydrogenase, but while present it prevents the vitamin E from being oxidized by the surrounding air.
	www.everything2.com /index.pl?node=succinate (129 words)

	ScienceDaily: Bacteria Are Key To 'Green' Plastics, Drugs
		"Succinate is a high-priority chemical that the U.S. Departmentof Energy has targeted for biosynthesis," said process co-developerGeorge Bennett, professor and chair of the department of biochemistryand cell biology at Rice.
		The centerpiece of Rice's succinate technology is a mutant formof E. coli that makes succinate as it's only metabolic byproduct.
		Thegoal is to maximize the rate -- the speed of the conversion -- and theyield -- the amount of succinate produced per pound of glucoseconverted.
	www.sciencedaily.com /releases/2005/08/050825070755.htm (1025 words)

Try your search on: Qwika (all wikis)