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Topic: Succinylcholine

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	Succinylcholine Chloride
		Succinylcholine is metabolized by plasma pseudocholinesterases to succinylmonocholine and choline and 10% of it is excreted unchanged in the urine.
		As succinylcholine can exacerbate the effects of hyperkalemia, it should be used with extreme caution in patients who have suffered traumatic wounds or burns, are receiving quinidine or digitalis therapy, have preexisting hyperkalemia or electrolyte imbalances, as arrhythmias or cardiac arrest may occur.
		Eur J Pharm Sci 15:(3):251-260 Abstract: The phenomenon of slow onset of succinylcholine (Sch) effect in elephants was investigated by analyzing blood concentrations of Sch and its metabolite choline in elephant and impala.
	www.elephantcare.org /Drugs/succinyl.htm (2141 words)

	succinylcholine (Site not responding. Last check: 2007-10-15)
		Succinylcholine has the briefest duration of action of all neuromuscular blocking drugs, making it a drug of choice for such procedures as terminating laryngospasm, endotracheal intubation, and electroconvulsive shock therapy.
		Succinylcholine may exacerbate hyperkalemia in trauma patients (hours post-trauma).
		Children are not as sensitive to succinylcholine on a weight basis as adults and may require higher doses.
	www.templejc.edu /dept/ems/drugs/succinylcholine.html (235 words)

	Letter - Succinylcholine
		Succinylcholine is contraindicated in patients after the acute phase of injury following major burns, multiple trauma, extensive denervation of skeletal muscle, or upper motor neuron injury because succinylcholine administration to such individuals may result in severe hyperkalemia which may result in cardiac arrest.
		Succinylcholine remains the drug of choice when emergency intubation or immediate securing of the airway is indicated.
		Cardiac arrest during induction of anesthesia with halothane and succinylcholine in an infant.
	www.fda.gov /medwatch/SAFETY/1997/succin.htm (612 words)

	Rocuronium versus succinylcholine for rapid sequence induction intubation
		Intravenous succinylcholine is commonly used to temporarily paralyze laryngeal muscles to enable placement of an endotracheal tube for ventilation of patients in emergency situations.
		Succinylcholine is the most common muscle relaxant used because it has a fast onset and a short duration.
		Comparisons were made with succinylcholine based on the dose of rocuronium, use of a narcotic, emergent versus elective intubation, age group and the induction agent used.
	www.cochrane.org /reviews/en/ab002788.html (518 words)

	Anectine (Succinylcholine Chloride) drug description - prescription drugs and medications at RxList
		RISK OF There have been rare reports of acute rhabdomyolysis with hyperkalemia followed by ventricular dysrhythmias, cardiac arrest, and death after the administration of succinylcholine to apparently healthy children who were subsequently found to have undiagnosed skeletal muscle myopathy, most frequently Duchenne's muscular dystrophy.
		Therefore, when a healthy appearing infant or child develops cardiac arrest soon after administration of succinylcholine not felt to be due to inadequate ventilation, oxygenation, or anesthetic overdose, immediate treatment for hyperkalemia should be instituted.
		Succinylcholine chloride is a white, odorless, slightly bitter powder and very soluble in water.
	www.rxlist.com /cgi/generic2/succinyl.htm (336 words)

	035. Death by SUCCINYLCHOLINE
		She was finally sentenced to 99 years for the murder of one patient and 60 years for the attempted murder of a second.
		Succinylcholine may be regarded as a sister chemical to acetylcholine.
		Since succinylcholine depolarizes the muscle, it is known as a depolarizer or a depolarizing agent.
	members.tripod.com /Prof_Anil_Aggrawal/poiso035.html (1697 words)

	Comprehensive Quelicin information, uses and side effects.
		Succinylcholine is a diquaternary base consisting of the dichloride salt of the dicholine ester of succinic acid.
		Succinylcholine chloride is indicated as an adjunct to general anesthesia, to facilitate tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
		Succinylcholine is contraindicated in persons with personal or familial history of malignant hyperthermia, skeletal muscle myopathies and known hypersensitivity to the drug.
	www.drugs.com /pro/Quelicin.html (4376 words)

	Succinylcholine
		Succinylcholine is a short--acting depolarizing muscle relaxant that is used for intubation.
		The side effects of succinylcholine include bradycardia, especially in children, and hyperkalemia in patients with bums, paraplegia, quadriplegia, and massive trauma.
		Succinylcholine, when combined with a volatile agent, is also implicated in triggering malignant hyperthermia (MH) in susceptible individuals.
	www.anesth.utmb.edu /Venable/Students/Introduction/30succ.html (150 words)

	ASA: Succinylcholine, Rocuronium Equivalent in Intubation of Trauma Patients (Site not responding. Last check: 2007-10-15)
		Succinylcholine does, however, remain the drug of choice at the University of Maryland School of Medicine emergency ward, where the study was carried out, unless there is a clear reason to avoid it, said Christopher Boehm, MD, of the medical school's shock trauma center.
		Reporting on October 23rd at the American Society of Anesthesiologists, Dr. Boehm reported on the study of 60 patients, explaining that the rough equivalence between the 2 drugs might be a result of the small size of the study.
		Succinylcholine has some problematic side effects, Dr. Boehm said, including the risk of cardiac arrest in patients with a previous neurological injury, seizure-like muscle tremors, and increased intraocular pressure.
	www.pslgroup.com /dg/247586.htm (461 words)

	Succinylcholine (Site not responding. Last check: 2007-10-15)
		This is probably why succinylcholine, despite its many and partly life-threatening side-effects, is still considered to be indispensable by many anaesthetists and emergency doctors.
		The main indication for succinylcholine--the facilitation of endotracheal intubation in patients considered to be at an increased risk of aspiration of gastric fluid, e.g.
		The routine use of succinylcholine as a relaxant for intubation is questionable, mainly because there are a number of modern anaesthetic techniques (laryngeal mask airway) and new drugs (rocuronium, mivacurium, remifentanil) which make succinylcholine quite dispensable except for a few situations (e.g.
	www.general-anaesthetics.com /succinylcholine.html (254 words)

	effect of oral pyridostigmine bromide nerve agent prophylaxis on return of twitch height in persons receiving ...
		We conclude that the recovery from neuromuscular blockade after succinylcholine is prolonged while the intubating conditions remain unaffected.
		Succinylcholine is preferred in these situations because of its fast onset and short duration of action.
		Although studies have demonstrated a decrease in serum cholinesterase activity after the administration of pyridostigmine, their applicability to combat anesthesia is limited.5-8 In these studies, pyridostigmine was administered as a single intravenous bolus, in contrast to the chronic oral administration used for nerve agent prophylaxis.
	www.findarticles.com /p/articles/mi_qa3912/is_200004/ai_n8891706 (810 words)

	Suxamethonium chloride - Wikipedia, the free encyclopedia
		Succinylcholine does not produce unconsciousness or anesthesia, and its effects may cause considerable psychological distress while simultaneously making it impossible for a patient to communicate.
		This drug has occasionally been used as a paralyzing agent for executions by lethal injection, although pancuronium bromide is the preferred agent today because of its longer duration of effect and its absence of fasciculations as a side effect.
		Succinylcholine is the drug that is suspected to have been used to murder Nevada State Controller Kathy Augustine.
	en.wikipedia.org /wiki/Succinylcholine (720 words)

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