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Topic: Sufentanil

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	Sufentanil - Wikipedia, the free encyclopedia
		Sufentanil is a synthetic opioid analgesic drug approximately 5 to 10 times more potent than fentanyl.
		Sufentanil is marketed for use by specialist centres under different trade names, such as Sufenta and Sufentil (India, by Claris Lifesciences Ltd.).
		The main use of this medication is in operating suites and critical care where pain relief is required for a short period of time.
	en.wikipedia.org /wiki/Sufentanil (218 words)

	Abstract Summary: Intranasal Benzodiazepines for seizure control
		The results of this study show that sufentanil, when administered intranasally, is rapidly and effectively absorbed from the human nasal mucosa, so that this route may be an attractive alternative for a premedicant, avoiding the discomfort of an intravenous or intramuscular injection.
		To evaluate nasally administered sufentanil, 1.5-4.5 micrograms/kg, for pre-induction (i.e., pre-medication/induction) of anesthesia in pediatric patients, the authors studied ASA PS 1 or 2 patients scheduled for elective surgery.
		Patients given sufentanil were more likely to separate willingly from their parents and be judged as calm at or before 10 min compared to those given saline.
	www.wolfetory.com /education/intranasal_opiates.htm (3602 words)

	ABSTRACT SUMMARY:
		BACKGROUND: Intranasally administered midazolam was compared with sufentanil as a premedicant for 60 patients, aged 1/2 to 6 years, undergoing outpatient surgery of 2 hours or less.
		The sufentanil group appeared to be more sedated and more cooperative during induction of anesthesia.
		Sufentanil was associated with more nausea and vomiting than midazolam (34% versus 6%, p < 0.02).
	www.wolfetory.com /education/midazolam_for_sedation.htm (3129 words)

	MedicineHouse.com
		Sufentanil may produce a dose dependent bradycardia probably by stimulation of the vagal nucleus in the medulla.
		Depression of ventilation is due to a decrease in response of the respiratory centers in the brain stem to increases in CO2.
		Sufentanil (and fentanyl) are more lipophilic than morphine and segmentation of epidural analgesia reflects rapid vascular uptake as well as incorporation in the lipid structures of the spinal space (epidural fat and white matter).
	www.medicinehouse.com /cgi-bin/drug.php?drug=sufentanil (896 words)

	Dannemiller Memorial Educational Foundation
		Sufentanil is not specifically labeled for breakthrough cancer pain.
		Physico-chemical properties of sufentanil and the concentrations available suggest that it may be the most suitable of the available opioids for use by the transmucosal route of administration.
		In all patients that reported good pain relief, IN sufentanil was rated as much better than their usual opioid breakthrough pain medication, both in speed of onset and efficacy.
	www.dannemiller.com /gfile_sample.cfm (441 words)

	Baylor Health Care System: Anesthesia for the 21st century
		Sufentanil is the most potent opioid available today and is perhaps closer to the future than any of the other drugs available to clinicians.
		In a study in volunteers that evaluated equipotent doses of sufentanil and fentanyl to determine any differences in analgesia and respiratory effects, we found that at peak effect (approximately 5 minutes after administration) both drugs produced an equal degree of analgesia (11).
		If this really is true and if additional compounds are produced that are even more specific for the mu receptor or for the analgesic component of the mu receptor, we will begin to see, as the potency continues to increase, further and further separation of the analgesic effects of opioids from their respiratory depressant effects.
	www.baylorhealth.edu /proceedings/13_1/13_1_stanley.html (3593 words)

	References for the Incident Pain and Incident Dyspnea Protocol
		A comparison of intranasal sufentanil and midazolam to intramuscualr meperidine, promethazine, and chlorpromazine for consciuos sedation in children.
		CONCLUSIONS: Fentanyl, sufentanil, and alfentanil are potent synthetic opioids that are used for anesthesia and postoperative analgesia.
		Sufentanil at 1.5 micrograms/kg was noted to produce much more heavily sedated children (mean score 7), with a high incidence of significant oximetry desaturation (80%) and prolonged recovery room duration (58 +/- 40 min).
	www.palliative.info /References.htm (5776 words)

	Critical Care \| Full text \| Comparison of sufentanil with sufentanil plus magnesium sulphate for sedation in the ...
		Sufentanil allows rapid emergence from sedation and less respiratory depression than occurs with other sedative agents, and it maintains haemodynamic stability [8].
		The sufentanil infusion and the sufentanil plus magnesium infusion were well tolerated by all patients, and no adverse effects were noted.
		Wappler and coworkers [22] found that continuous infusion of sufentanil (1 μg/kg per hour was given initially) for analgesia and sedation is suitable for intensive care patients with a short stay in the ICU.
	ccforum.com /content/7/5/R123 (3533 words)

	Postmortem Determination of the Biological Distribution of Sufentanil and Midazolam after an Acute Intoxication. ... (Site not responding. Last check: 2007-10-31)
		Sufentanil was extracted from basified fluids and tissue homogenates with hexane:ethanol (19:1).
		Sufentanil concentrations were: blood 1.1 ng/mL, urine 1.3 ng/mL, vitreous humor 1.2 ng/mL, liver 1.75 ng/g, and kidney 5.5 ng/g.
		Cause of death was attributed to an acute sufentanil/midazolam intoxication and manner of death a suicide.
	www.astm.org /jforensicsci/PAGES/1172.htm (241 words)

	Areastematicas.com - Opioides
		Sufentanil, a potent mu-opioid agonist, historically has not been been given systemically to treat chronic pain.
		In that transdermal fentanyl may be a useful intermediary to estimate the appropriate sufentanil dose before implant, accurate information is needed about the relative analgesic potency of sufentanil and fentanyl during continuous infusion.
		During titrated, intermediate-term infusions in patients previously treated with opioids for chronic pain, sufentanil is approximately 7.5 times as potent as fentanyl.
	www.areastematicas.com /www/areatematicaopi/contenidos/2/92.htm (282 words)

	DURECT: Transdermal Sufentanil Patch
		Our transdermal sufentanil patch (TRANSDUR-Sufentanil) under development is based on our proprietary TRANSDUR transdermal technology and is intended to provide continuous delivery of sufentanil for up to seven days from a single application, as compared to the three days of relief provided by currently available opioid patches.
		Sufentanil is an off-patent, highly potent opioid that is currently used in hospitals as an analgesic.
		We anticipate that the small size of our sufentanil patch (potentially as small as 1/5th the size of currently marketed transdermal fentanyl patches for a therapeutically equivalent dose) and longer duration of delivery may offer improved convenience and compliance for patients.
	www.durect.com /wt/durect/page_name/trans_sufentanil (695 words)

	News - Sufentanil Injections Relieve Postoperative Pain in Patients Undergoing Diagnostic Knee Arthroscopy
		Sufentanil is a highly lipophilic opioid that has been proposed to have a more rapid onset of analgesia than morphine based on its lipophilic character.
		Specifically, in patients given sufentanil VAS at rest improved from 12 mm preoperatively to 58 mm at 30 minutes postoperatively to 37 mm by the next morning.
		The authors conclude from this study that "sufentanil induces a postoperative analgesia if administered intra-articularly at the dose of 10 µ." "We detected a fast onset of analgesia with the effect lasting until the morning after surgery," they added.
	www.docguide.com /news/content.nsf/news/8525697700573E1885256DCD005E08DD?OpenDocument (528 words)

	Janssen Biotech SUFENTANIL RIA Kit for Pharmacokinetic Studies available from RDI Divison of Fitzgerald Industries Intl
		Depending on the sufentanil plasma concentration, the RIA can be performed in two ways.Higher-concentrated plasma samples are assayed as such but it is strongly advised to extract lower-concentrated plasma or serum samples (< 1 na/ml) to enhance the sensitivity and specificity of the assay method.
		Because of sufentanil's low therapeutic plasma levels, no comparison could be made between its RIA and an alternative assay.However, there is strong evidence for the specificity of the assay when applied directly to plasma (3).
		the amount of sufentanil that causes at least a 10% decrease of the initial tracer binding ability, is 0.02ng contained in 1.0 ml of sample.
	www.researchd.com /janssen/1020823.htm (2532 words)

	MEDNEMO.net - Abstracts di Anestesia
		Analgesia and plasma sufentanil concentrations were evaluated in 20 postoperative patients randomly assigned to patient-controlled epidural or IV sufentanil.
		This indicates that the bioavailability of epidurally-administered sufentanil is reduced and suggests that a large proportion of the drug may be absorbed into the epidural fat.
		These data suggest that when sufentanil is administered in small-dose boluses, much of the drug is absorbed into the epidural fat and that the primary mechanism by which epidurally administered sufentanil produces analgesia is via systemic absorption.
	www.mednemo.it /abstracts/dolore/2001/agosto/240801pain.htm (4636 words)

	Fentanyl
		Sufentanil addition did not significantly improve the quality of epidural anaesthesia with ropivacaine 1.0% for Caesarean section.
		Epidural Thoracic Analgesia: Sufentanil No Better than Bupivacaine with Adrenaline: In a DB study of 30 patients undergoing lateral thoracotomy, there was no difference in pain relief between sufentanil 50 mcg and bupivacaine 0.5% with adrenaline 5 mcg/ml (dose 40 mg) although both were superior to placebo.
		Head Injury (Severe): Ketamine as Good as Sufentanil Combined with Midazolam in Maintaining Perfusion: In a DB study of patients with severe head injury being mechanically ventilated, sedation with a continuous infusion of ketamine-midazolam was just as effective in maintaining intracranial pressure and cerebral perfusion as a continuous infusion of sufentanil-midazolam.
	www.modern-psychiatry.com /fentanyl.htm (3571 words)

	Drug Information: Sufentanil Citrate Injection (Print Version)
		Your doctor has ordered sufentanil, a strong analgesic (painkiller), to relieve your pain.
		If you are receiving sufentanil intravenously (in your vein), you probably will be told to store it in the refrigerator.
		If you are receiving sufentanil in your vein or under your skin, you need to know the symptoms of a catheter-related infection (an infection where the needle enters your vein or skin).
	www.nlm.nih.gov /medlineplus/print/druginfo/medmaster/a684066.html (694 words)

	BioWorld Today
		Brown said its sufentanil patch might offer some benefits over JandJ's fentanyl product because it's "about a fifth of the size, and lasts for a full week, over twice as long." Durect's patch also may cause less of an irritation.
		Sufentanil is approved for use in hospitals as an analgesic, and it is the active ingredient in Durect's Chronogesic.
		That product, which was in Phase III trials, hit a roadblock in late 2003, when preclinical studies showed a small number of units using the system experienced a stoppage in delivery of the drug.
	www.bioworld.com /servlet/com.accumedia.web.Dispatcher?next=bioWorldHeadlines_article&forceid=34927 (792 words)

	SUFENTANIL Analytical Research Standards
		Sufentanil will not volatilize from soil, from water or bioconcentrate in aquatic organisms.
		Based on measured water solubilities at 35 deg C of 3,930 mg/L at pH 5.31 and 3.3 mg/L at pH 7.98, soil adsorption, (and adsorption to sediment), may depend on the pH of the environment with higher mobility in soil, (and with higher adsorption to sediment), occurring under cationic conditions.
		Sufentanil contains an amide group and may be susceptible to slow environmental chemical hydrolysis.
	bulkpharm.mallinckrodt.com /_attachments/msds/SUFTI.htm (1858 words)

	Continuous spinal anaesthesia and analgesia in high-risk patients undergoing abdominal surgery Gulcin O, Kaya Mensure, ...
		In addition, the safety and efficacy of continuous intrathecal infusion of Sufentanil combined with Bupivacaine for postoperative pain relief was investigated.
		Sufentanil is well suited for use via continuous intrathecal infusion, for postoperative analgesia.
		Large-dose intrathecal sufentanil prevents the hormonal stress response during major abdominal surgery: A comparison with intravenous sufentanil in a prospective randomized trial.
	www.indianjsurg.com /article.asp?issn=0972-2068;year=2006;volume=68;issue=2;spage=73;epage=79;aulast=Gulcin (3940 words)

	DURECT Initiates Phase I Trial for Its Proprietary Transdermal Sufentanil Patch
		The objectives of the clinical study are to determine the safety and tolerability of DURECT's transdermal sufentanil patch as well as evaluate the pharmacokinetics of sufentanil following transdermal administration.
		Sufentanil is a pain relief medication that is currently FDA-approved for use in hospitals as an analgesic and is the active ingredient in DURECT's CHRONOGESIC(R) product under development.
		DURECT's transdermal sufentanil product is intended to provide extended chronic pain relief for up to seven days, as compared to the three days of relief provided with currently available patches.
	www.prnewswire.com /cgi-bin/stories.pl?ACCT=104&STORY=/www/story/10-22-2004/0002292227&EDATE= (590 words)

	The Analgesic Effect of Sufentanil Combined with Ropivacaine 0.2% for Labor Analgesia: A Comparison of Three Sufentanil ...
		sufentanil in doses of 5, 10, and 15 µg prolonged the
		sufentanil doses to epidural ropivacaine 0.2% for labor analgesia.
		Anesthesia and Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams and Wilkins with the assistance of Stanford University Libraries' HighWire Press®.
	www.anesthesia-analgesia.org /cgi/content/abstract/92/1/180 (388 words)

	PTCommunity.com - Daily News Briefing
		The objectives of the Phase II program are to evaluate the pharmacokinetics, efficacy, and safety of repetitive applications of our sufentanil patch in chronic pain patients for a period of up to four weeks.
		DURECT's TRANSDUR-based transdermal sufentanil product is intended to provide extended chronic pain relief for up to seven days, as compared to the three days of relief provided with currently available opioid patches.
		Further, we anticipate that the small size of our sufentanil patch (potentially as small as 1/5th the size of currently marketed transdermal fentanyl patches for a therapeutically equivalent dose) may offer improved convenience for patients.
	www.formkit.com /Daily/DailyDetail.cfm?chosen=63891 (265 words)

	Palliative Care Incident Pain and Incident Dyspnea Protocol
		The fentanyl and sufentanil preparations used in this protocol are extremely potent opioids (approximately 100x and 1000x the potency of morphine, respectively...
		The short acting opioid (fentanyl or sufentanil) is administered sublingually 10-15 minutes prior to anticipated activity.
		If the maximum number of doses (three) has been given, and the patient remains in discomfort with activity that must be undertaken presently, the physician should be contacted for consideration of immediately proceeding to the next step of the Incident Pain and Incident Dyspnea Protocol.
	palliative.info /IncidentPain.htm (908 words)

	Publication Details - Sheila E. Cohen - Stanford University School of Medicine
		Placental transfer and neonatal effects of epidural sufentanil and fentanyl administered with bupivacaine during labor.
		Although administered in a ratio of 5.7:1, fentanyl and sufentanil MV plasma concentrations were in the ratio of 27:1.
		Neonatal condition was good and generally similar in all groups, with the exception of a lower NACS at 24 h in group B-F. CONCLUSIONS: Although the degree of placental transfer of sufentanil appeared greater than that of fentanyl, lower MV sufentanil concentrations resulted in less fetal exposure to sufentanil.
	med.stanford.edu /profiles/frdActionServlet?choiceId=showPublication&pubid=15088&fid=3796 (325 words)

	(S-287) COMPARISON OF ANALGESIC AND UNTOWARD EFFECTS OF INTRATHECAL FENTANYL VERSUS SUFENTANIL AT EQUIPOTENT DOSES FOR ... (Site not responding. Last check: 2007-10-31)
		This investigation, unlike others, was designed to compare the analgesic effects of intrathecal fentanyl and sufentanil at their respective analgesic ED dose.
		Each patient was randomized to receive the ED dose of either intrathecal fentanyl or sufentanil; 22 patients received 17.4 mcg of fentanyl and 18 patients received 8.9 mcg of sufentanil.
		Fetal bradycardia was seen in 11% of parturients receiving sufentanil as opposed to none with fentanyl.
	www.iars.org /abstracts/abstracts/S279/S287.htm (487 words)

	Labtec Begins Phase I Trials for Seven Day Transdermal Sufentanil Patch
		Unlike most backing films used in transdermal systems, the material is non-occlusive and allows the skin to breathe and maintain its integrity throughout the application period of one week.
		Sufentanil is one of the most potent drug in its class, seven times more potent than fentanyl and at the same time offers various advantages in terms of safety and efficacy for chronic pain treatment with a transdermal system,” says Labtec´s founder Dr. Günter Cordes.
		sufentanil; sufentanil tds; transdermal; patch; tds; chronic pain; opioid; labtec; lehrke;
	www.prweb.com /releases/2006/7/prweb409499.htm (418 words)

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