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Topic: Sulfamethoxazole

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	[No title]
		The presence of 10 mg percent sulfamethoxazole in plasma decreases the protein binding of trimethoprim by an insignificant degree; trimethoprim does not influence the protein binding of sulfamethoxazole.
		Both trimethoprim and sulfamethoxazole distribute to sputum, vaginal fluid and middle ear fluid (for tablets and suspensions only); trimethoprim also distributes to bronchial secretion, and both pass the placental barrier and are excreted in breast milk.
		A report of "Resistant to sulfamethoxazole; trimethoprim" indicates that the infection is unlikely to respond to therapy with sulfamethoxazole; trimethoprim.
	www.best-meds.com /druginfo/bactrim_clinical.htm (864 words)

	Bactrim side-effects - Septra side-effects - Sulfamethoxazole
		Sulfamethoxazole should be given with care to patients with renal or hepatic impairment and is contra-indicated in patients with severe renal or hepatic failure or with blood disorders.
		Sulfamethoxazole should not be given to patients with a history of hypersensitivity to sulfonamides as cross-sensitivity may occur between drugs of this group.
		Sulfamethoxazole and other sulfonamides are not usually given to infants within 1 to 2 months of birth because of the risk of kernicterus; for the same reason, they are generally contra-indicated in women prior to delivery, and in breast-feeding mothers.
	briandeer.com /septrin/bactrim-martindale.htm (791 words)

	MedForumsLive.com - sulfamethoxazole, Gantanol (Site not responding. Last check: 2007-10-08)
		PRESCRIBED FOR: Sulfamethoxazole is used for the treatment of malaria (in combination with quinine sulfate and pyrimethamine), conjunctivitis (inflammation of the conjunctiva of the eye) due to chlamydia, toxoplasmosis (in combination with pyrimethamine), and urinary tract infections (UTI).
		Sulfamethoxazole should be stopped at the first appearance of a skin rash since the rash may become severe.
		Sulfamethoxazole may form crystals in the urine which may damage the kidney and cause bleeding into the urine.
	www.medforumslive.com /drugs/s/sulfamethoxazole.html (503 words)

	MedlinePlus Drug Information: Sulfonamides and Trimethoprim (Systemic) (Site not responding. Last check: 2007-10-08)
		Sulfamethoxazole and trimethoprim combination is used to treat infections, such as bronchitis, middle ear infection, urinary tract infection, and traveler's diarrhea.
		Sulfamethoxazole and trimethoprim combination should not be given to infants less than 2 months of age unless directed by the child's doctor.
		Adults and children older than 2 months—The usual dose is 18.75 to 25 mg of sulfamethoxazole and 3.75 to 5 mg of trimethoprim per kg (8.5 to 11.4 mg of sulfamethoxazole and 1.7 to 2.3 mg of trimethoprim per pound) of body weight.
	www.nlm.nih.gov /medlineplus/druginfo/uspdi/202781.html (2486 words)

	National MS Society \| Bactrim; Septra (Sulfamethoxazole) (Site not responding. Last check: 2007-10-08)
		Sulfamethoxazole and trimethoprim combination is used in multiple sclerosis to treat (and sometimes to prevent) urinary tract infections.
		Sulfamethoxazole and trimethoprim combination has not been reported to cause birth defects or other problems in humans.
		Less common side effects that should be reported to your physician immediately: itching; skin rash; aching of muscles and joints; difficulty in swallowing; pale skin; redness, blistering, peeling, or loosening of skin; sore throat and fever; unusual bleeding or bruising; unusual tiredness or weakness*; yellow eyes or skin.
	www.nationalmssociety.org /Meds-Sulfamethoxazole.asp (538 words)

	Direct, MHC-dependent presentation of the drug sulfamethoxazole to human alphabeta T cell clones.
		Sulfamethoxazole, like most drugs, is not chemically reactive per se, but is thought to gain the ability to covalently bind to proteins after intracellular drug metabolism.
		The purpose of this study was to investigate how sulfamethoxazole is presented in an immunogenic form to sulfamethoxazole-specific T cell clones.
		The continuous presence of sulfamethoxazole was required during the assay period since pulsing of the APC was not sufficient to induce proliferation or cytotoxicity.
	www.aegis.com /aidsline/1997/oct/M97A1132.html (475 words)

	Health Library - (Site not responding. Last check: 2007-10-08)
		Sulfamethoxazole and trimethoprim is in the FDA pregnancy category C. This means that it is not known whether sulfamethoxazole and trimethoprim will harm an unborn baby.
		Sulfamethoxazole and trimethoprim is not approved for use in children younger than 2 months of age.
		Sulfamethoxazole and trimethoprim may increase the effects of oral anticoagulants such as warfarin (Coumadin) and lead to bleeding.
	myhealth.barnesjewish.org /library/healthguide/drugguide/topic.asp?hwid=multumd00124a1 (1225 words)

	Bactrim, Trimethoprim, Sulfamethoxazole, side effects, drug interactions, overdose, dosage
		Bactrim, an antibacterial combination drug, is prescribed for the treatment of certain urinary tract infections, severe middle ear infections in children, long-lasting or frequently recurring bronchitis in adults that has increased in seriousness, inflammation of the intestine due to a severe bacterial infection, and travelers' diarrhea in adults.
		Sulfamethoxazole, an ingredient in Bactrim, is one of a group of drugs called sulfonamides, which prevent the growth of bacteria in the body.
		The recommended dosage is 15 to 20 milligrams of trimethoprim and 75 to 100 milligrams of sulfamethoxazole per 2.2 pounds of body weight per 24 hours divided into equal doses every 6 hours for 14 to 21 days.
	www.pdrhealth.com /drug_info/rxdrugprofiles/drugs/bac1046.shtml (1132 words)

	[No title]
		Sulfamethoxazole; trimethoprim is not indicated for prophylactic or prolonged administration in otitis media at any age.
		Pneumocystis Carinii Pneumonia: Sulfamethoxazole; trimethoprim IV is indicated in the treatment of Pneumocystis carinii pneumonia in pediatric patients and in adults.
		Shigellosis: Sulfamethoxazole; trimethoprim IV is indicated in the treatment of enteritis caused by susceptible strains of Shigella flexneri and Shigella sonnei in pediatric patients and adults.
	www.best-meds.com /druginfo/bactrim_indications.htm (1422 words)

	Sulfamethoxazole (IARC Summary & Evaluation, Volume 79, 2001) (Site not responding. Last check: 2007-10-08)
		In one hypothesis-seeking epidemiological study, statistically significant positive associations were noted between sulfamethoxazole use and the risks for cancers of the lung and cervix and multiple myeloma and the combination of lymphomas and leukaemias.
		Sulfamethoxazole is metabolized to its potentially toxic hydroxylamine in both humans and experimental animals.
		Administration of sulfamethoxazole to patients at therapeutic doses in combination with trimethoprim increased the number of micronuclei in their bone-marrow cells but did not increase the frequency of chromosomal aberrations.
	www.inchem.org /documents/iarc/vol79/79-10.html (285 words)

	Sulfamethoxazole-Trimethoprim (Site not responding. Last check: 2007-10-08)
		Sulfamethoxazole and trimethoprim are both antibiotics that treat different types of bacterial infections.
		Sulfamethoxazole and trimethoprim is used to treat infections such as urinary tract infections, bronchitis, ear infections (otitis), traveler's diarrhea, and Pneumocystis carinii pneumonia.
		Sulfamethoxazole and trimethoprim may also be used for purposes other than those listed in this medication guide.
	www.prescriptiondrugchat.com /showthread.php?t=497 (329 words)

	Trimethoprim/Sulfamethoxazole (Site not responding. Last check: 2007-10-08)
		Both trimethoprim and sulfamethoxazole kill or inhibit growth of bacteria by disrupting their ability to make necessary proteins.
		Nonetheless, trimethoprim with sulfamethoxazole remains valuable for treating a number of problems associated with this disease.
		Use of sulfamethoxazole may cause complications in patients with liver or kidney disease, since these organs work together to remove the medication from the body.
	www.wholehealthmd.com /refshelf/drugs_view/0,1524,622,00.html (579 words)

	Sulfamethoxazole, Gantanol
		Sulfamethoxazole is a member of the sulfonamide family of
		Sulfonamides, including sulfamethoxazole, can interfere with the activity of folic acid, vitamin B6, and vitamin K. This is generally not a problem when taking sulfamethoxazole for two weeks or less.
		A common side effect of antibiotics is diarrhea, which may be caused by the elimination of beneficial bacteria normally found in the colon.
	www.truestarhealth.com /Notes/1503009.html (1018 words)

	Septra DS Tablets Drug Information Septra DS Tablets
		Both trimethoprim and sulfamethoxazole distribute to sputum, vaginal fluid, and middle ear fluid; trimethoprim also distributes to bronchial secretions, and both pass the placental barrier and are excreted in human milk.
		A report of "Resistant to trimethoprim and sulfamethoxazole" indicates that the infection is unlikely to respond to therapy with SEPTRA.
		Because trimethoprim and sulfamethoxazole may interfere with folic acid metabolism, SEPTRA should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
	www.drugs.com /pdr/septra_ds_tablets.html (3828 words)

	N101 \| Sulfamethoxazole (Site not responding. Last check: 2007-10-08)
		Sulfamethoxazole is a member of the sulfonamide family of antibiotics.
		It is used for people with infections caused by a variety of bacteria and protozoa.
		This is generally not a problem when taking sulfamethoxazole for two weeks or less.
	www.n101.com /HealthNotes/HNs/Drug/Sulfamethoxazole.htm (1192 words)

	Sulfamethoxazole - Drugs & Vitamins - Drug Library - DrugDigest
		If you get an unusual reaction stop using sulfamethoxazole at once and call your prescriber or health care professional for advice.
		To reduce the risk of dizzy or fainting spells, do not sit or stand up quickly, especially if you are an older patient.
		If you are going to have surgery, tell your prescriber or health care professional that you are using sulfamethoxazole.
	www.drugdigest.org /DD/DVH/Uses/0,3915,626\|Sulfamethoxazole,00.html (708 words)

	Trimethoprim and Sulfamethoxazole are Selective Inhibitors of CYP2C8 and CYP2C9, Respectively -- Wen et al. 30 (6): 631 ...
		34% of sulfamethoxazole are unbound in plasma (Dollery, 1999
		Cribb AE, Spielberg SP and Griffin GP (1995) N4-hydroxylation of sulfamethoxazole by cytochrome P450 of the cytochrome P4502C subfamily and reduction of sulfamethoxazole hydroxylamine in human and rat hepatic microsomes.
		Dierks EA, Stams KR, Lim HK, Cornelius G, Zhang H and Ball SE (2001) A method for the simultaneous evaluation of the activities of seven major human drug-metabolizing cytochrome P450s using an in vitro cocktail of probe substrates and fast gradient liquid chromatography tandem mass spectrometry.
	dmd.aspetjournals.org /cgi/content/full/30/6/631 (2817 words)

	sulfamethoxazole and trimethoprim - HIV: health and medical information about HIV and AIDS
		DRUG CLASS AND MECHANISM: Cotrimoxazole is a combination of sulfamethoxazole and trimethoprim in a ratio of 5:1 or 1:2.
		Trimethoprim and sulfamethoxazole both block the production of folic acid, a necessary chemical for both bacteria and humans, and each is an effective antibiotic when used alone.
		Read 14 more sulfamethoxazole and trimethoprim related articles...
	www.medicinenet.com /sulfamethoxazole_and_trimethoprim/article.htm (462 words)

	Bactrim (Sulfamethoxazole) - Buy Online Without Prescription Needed
		Sulfamethoxazole is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
		Your health care provider (doctor, nurse, or pharmacist) may measure the effectiveness and side effects of your treatment using laboratory tests and physical examinations.
		If you are receiving Sulfamethoxazole and trimethoprim in your vein or under your skin, you need to know the symptoms of a catheter-related infection (an infection where the needle enters your vein or skin).
	www.1meds.com /bactrim.html (791 words)

	Septra Online, Description, Chemistry, Ingredients - Trimethoprim and Sulfamethoxazole - RxList Monographs
		Each SEPTRA DS (double strength) Tablet contains 160 mg trimetho-prim and 800 mg sulfamethoxazole and the inactive ingredients docusate sodium (0.8 mg per tablet), FDandC Red No. 40, magnesium stearate, povidone, and sodium starch glycolate.
		Each teaspoonful (5 mL) of SEPTRA Suspension contains 40 mg trimethoprim and 200 mg sulfamethoxazole and the inactive ingredients alcohol 0.26%, methylparaben 0.1% and sodium benzoate 0.1% (added as preservatives), carboxymethylcellulose sodium, citric acid, FDandC Red No.40 and Yellow No.6, flavor, glycerin, microcrystalline cellulose, polysorbate 80, saccharin sodium, and sorbitol.
		Each teaspoonful (5 mL) of SEPTRA Grape Suspension contains 40 mg trimethoprim and 200 mg sulfamethoxazole and the inactive ingredients alcohol 0.26%, methylparaben 0.1%, and sodium benzoate 0.1% (added as preservatives), carboxymethylcellulose sodium, citric acid, FDandC Red No. 40 and Blue No. 1, flavor, glycerin, microcrystalline cellulose, polysorbate 80, saccharin sodium, and sorbitol.
	www.rxlist.com /cgi/generic/trisulf.htm (273 words)

	ADAP drugs: sulfamethoxazole (Site not responding. Last check: 2007-10-08)
		Brownish coloration of urine, skin rashes, hives, itching, localized swelling, reddened eyes, headache, dizziness, ringing in ears, loss of appetite, irritation of mouth and tongue, nausea, abdominal pain, and diarrhea.
		Sulfamethoxazole comes in oral suspension form and tablets of 500 mg and 1 gram.
		Sulfamethoxazole can be taken with milk to minimize GI irritation.
	www.atdn.org /access/drugs/sulfame.html (281 words)

	Oral Treatment with Trimethoprim-Sulfamethoxazole and Zidovudine Suppresses Murine Accessory Cell-Dependent Immune ...
		Anderson, R., Grabow, G., Oosthuizen, R., Theron, A., and van Rensburg, A. Effects of sulfamethoxazole and trimethoprim on human neutrophil and lymphocyte functions in vitro: in vivo effect of co-trimoxazole.
		Cribb, A. E., Spielberg, S. P., and Griffin, G. N4-hydroxylation of sulfamethoxazole by cytochrome P450 of the cytochrome P4502C subfamily and reduction of sulfamethoxazole hydroxylamine in human and rat hepatic microsomes.
		Hess, D. A., Bird, I. A., Almawi, W. Y., and Rieder, M. The hydroxylamine of sulfamethoxazole synergizes with FK506 and cyclosporin A, inhibiting T-cell proliferation.
	toxsci.oxfordjournals.org /cgi/content/full/55/2/335 (4956 words)

	sulfamethoxazole and trimethoprim Side Effects, Interactions and Information - Drugs.com (Site not responding. Last check: 2007-10-08)
		Generic Name: sulfamethoxazole and trimethoprim (sul fa meth OX a zole and trye METH oh prim)
		Take sulfamethoxazole and trimethoprim with food or milk if it upsets your stomach.
		Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
	sulfamethoxazole.and.trimethoprim.drugs.com (1278 words)

	Trimethoprim/Sulfamethoxazole
		Trimethoprim (Proloprim, Trimpex) is commonly combined with sulfamethoxazole (Gantanol) for an antibiotic combination that gives a one-two punch against bacteria.
		Both trimethoprim and sulfamethoxazole interfere with folate: The sulfamethoxazole makes it hard for invading bacteria to manufacture folate, and the trimethoprim makes it hard for bacteria to use the folate.
		On this basis, it might not be advisable to combine white willow with trimethoprim or sulfamethoxazole.
	healthlibrary.epnet.com /GetContent.aspx?token=e0498803-7f62-4563-8d47-5fe33da65dd4&chunkiid=21402 (432 words)

	Gantanol Online, Description, Chemistry, Ingredients - Sulfamethoxazole - RxList Monographs
		(sulfamethoxazole) is an intermediate-dosage antibacterial sulfonamide available in tablets.
		Each tablet contains 0.5 g sulfamethoxazole plus cornstarch, polyvinyl acetate, polyvinyl alcohol, magnesium stearate, FDandC Blue No. 1 Lake, FDandC Yellow No. 6 Lake and DandC Yellow No. 10 Lake.
		It is an almost white, odorless, tasteless compound with a molecular weight of 253.28.
	www.rxlist.com /cgi/generic3/gantanol.htm (95 words)

	N101 \| Trimethoprim/Sulfamethoxazole (Site not responding. Last check: 2007-10-08)
		The antibiotic combination of trimethoprim and sulfamethoxazole (TMP/SMX) is used to treat a wide variety of bacterial infections and some infections due to parasites.
		People with AIDS-related pneumonia given TMP/SMX had a worse survival rate when folinic acid, an activated form of folic acid, was added.
		PABA may interfere with the action of sulfamethoxazole.
	www.n101.com /Static/HNs/Drug/Trimethoprim_Sulfamethoxazole.htm (1120 words)

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