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Topic: Sulforaphane

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	Sulforaphane
		Sulforaphane is produced from sulforaphane glucosinolate via the action of the enzyme myrosinase (thioglucoside glucohydrolase), an enzyme present in cruciferous vegetables that is activated upon maceration of the vegetables.
		Sulforaphane's possible anticarcinogenic activity is accounted for by its ability to induce phase II detoxication enzymes, such as glutathione S-transferase and quinone reductase [NAD(P)H: (quinone-acceptor) oxidoreductase].
		Sulforaphane, in the form of its glucosinolate glucoraphanin, is abundant in three-day old broccoli sprouts, which are available in the marketplace.
	www.pdrhealth.com /drug_info/nmdrugprofiles/nutsupdrugs/sul_0243.shtml (599 words)

	N101 \| Sulforaphane (Site not responding. Last check: 2007-10-11)
		Sulforaphane is a compound that was identified in broccoli sprouts by scientists at the Johns Hopkins University School of Medicine in Baltimore, MD.
		Sulforaphane and other isothiocyanates are antioxidants and potent stimulators of natural detoxifying enzymes in the body.
		Sulforaphane is found in highest concentrations in broccoli sprouts, but it is also found in mature broccoli and other cruciferous vegetables, such as cauliflower, cabbage, and kale.
	www.n101.com /Static/HNs/Supp/Sulforaphane.htm (926 words)

	Olympus MIC-D: Polarized Light Gallery - Sulforaphane
		When your grandmother told you to eat all your broccoli from the dinner plate, she did not anticipate the findings of biochemists and oncologists that the controversial green vegetable is loaded with sulforaphane, a naturally occurring sulfur-containing isothiocyanate derivative.
		Known to biochemists as (R)-1-isothiocyanto-4-methyl-sulfonyl butane, sulforaphane is related to the indoles and is hydrolyzed from its precursor when plant tissues are crushed or chewed.
		Sulforaphane induces a series of proteins known as phase 2 detoxification enzymes to scavenge for carcinogens before they damage DNA and promote cancer.
	www.olympusmicro.com /micd/galleries/polarized/sulforaphane2.html (329 words)

	Eat Your Veggies: Indirect Anti-Oxidants Provide Long-Term Protection
		It turns out that sulforaphane's anti-cancer properties and its indirect anti-oxidant effects are both due to its ability to make cells create a diverse group of enzymes, called "phase 2" enzymes, that protect against cancer by blocking select chemicals from becoming carcinogens.
		Studying a variety of cell types and oxidants in laboratory experiments, the scientists discovered that sulforaphane triggers a cellular response that protects cells against oxidants for two or three days, according to a report of the work in a recent issue of the Proceedings of the National Academy of Sciences.
		First isolated from broccoli, sulforaphane is especially concentrated in three-day-old broccoli sprouts and belongs to a class of molecules called isothiocyanates.
	www.hopkinsmedicine.org /press/2001/DECEMBER/011218A.htm (730 words)

	Acupuncturetoday.com \| tell me about Sulforaphane (Site not responding. Last check: 2007-10-11)
		Sulforaphane is a compound that was discovered quite by accident by a group of scientists in the United States in the mid-1990s.
		Sulforaphane is considered an antioxidant, and also helps promote the production of detoxifying enzymes, which are believed to reduce the risk of cancer.
		Animal studies have shown that sulforaphane extracts can reduce the frequency, size and amount of cancerous tumors in rats, but these results have yet to be duplicated in humans.
	www.acupuncturetoday.com /herbcentral/sulforaphane.html (355 words)

	Sulforaphane : by Ray Sahelian, M.D.
		Sulforaphane is found in cruciferous vegetables such as broccoli sprouts.
		In conclusion, the results of the present study indicate that Sulforaphane -induced apoptosis in prostate cancer cells is initiated by ROS generation and that both intrinsic and extrinsic caspase cascades contribute to the cell death caused by this highly promising cancer chemopreventive agent.
		This study was conducted to test whether sulforaphane, a naturally occurring isothiocyanate that is highly concentrated in broccoli sprouts, induces Thioredoxin in retinal tissues and whether pretreatment with sulforaphane protects against light-induced retinal damage in mice.
	www.raysahelian.com /sulforaphane.html (526 words)

	Vitamin Depot Online's Blog
		Sulforaphane is an isothiocyanate found in broccoli and other cruciferous vegetables that has been shown to help protect against chemically-induced tumors.
		Five hundred micrograms per kilogram body weight sulforaphane was administered to one group of mice at the same time as the tumor cells were injected, while two other groups received the compound 10 days prior to and 10 days after the cells were injected.
		Sulforaphane given simultaneously with the tumor cells was the most effective mode of administration, being associated with an inhibition of 95.5 percent of metastases, and an increase in lifespan of 94 percent compared to the control group.
	www.vitamindepotonline.com /blog.html (2029 words)

	Sulforaphane
		Sulforaphane is a phytochemical belonging to the family of isothiocyanates, which means it contains the typical NCS group.
		Sulforaphane occurs in plants bound to a sugar molecule: sulforaphane glucosinolate.
		Sulforaphane glucosinolate is found in cruciferous vegetables such as broccoli, cauliflower, cabbage and kale.
	www.phytochemicals.info /phytochemicals/sulforaphane.php (262 words)

	BroccoSprouts: Sprout FAQs
		Sulforaphane levels vary widely among different broccoli plants and cannot be detected except through scientific analysis.
		Sulforaphane in its natural glucosinolate precursor is a phytochemical found naturally in some plant foods.
		Sulforaphane activates the enzymes in the body that detoxify reactive forms of oxygen.
	www.broccosprouts.com /sprouts/faq.htm (2286 words)

	Mixing foods may protect against cancer
		Sulforaphane is found in high concentrations in broccoli, cabbage, sprouts, watercress and salad rocket.
		Sulforaphane is a plant chemical that is also associated with cancer prevention and it is being investigated as a potential cancer drug.
		When selenium and sulforaphane were combined, they were found to have a nearly 13 times greater impact on the genes that control cancer development than when used individually.
	www.bupa.co.uk /health_information/html/health_news/110403veg.html (1944 words)

	Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and ...
		Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors -- Fahey et al.
		Sulforaphane was isolated from broccoli seeds (33, 38).
		Eradication of intracellular bacterial infection in cultured HEp-2 cells after treatment with sulforaphane (SF) at 0.5×, 1×, and 5× the MIC for a clinical isolate (A, LBN201; 1, 2, and 10 µg/ml) and a reference strain (B, 26695; 2, 4, and 20 µg/ml) of H.
	www.pnas.org /cgi/content/full/99/11/7610 (5012 words)

	Sulforaphane
		Sulforaphane is a naturally occurring sulfur-containing isothiocyanate derivative that helps to mobilize the human body's natural cancer-fighting resources and reduces the risk of developing cancer.
		Within hours of being ingested, sulforaphane enters the bloodstream where it circulates widely to trigger the immune system response to carcinogens.
		Broccoli, one of the least popular vegetables, contains relatively high concentrations of sulforaphane and appears especially beneficial in detoxifying enzymes in the body.
	www.tjclarkco.com /phytochemicals/sulforaphane.htm (324 words)

	ARS \| Publication request: Induction of Heptic Thioredoxin Reductase Activity by Sulforaphane, Both in Hepalclc7 Cells ...
		We have investigated whether this enzyme may be "turned on" in animals by minor compounds present in plants, and whether this is part of an overall response to reduce cancer risk in animals.
		We have demonstrated that the amount of thioredoxin reductase in cells can be increased by feeding the minor plant compounds sulforaphane (found in large concentrations in broccoli) to rats or added directly to the growth medium of cultured cells.
		Sulforaphane induces a battery of detoxification enzymes that may be part of a coordinated host-defense response.
	www.ars.usda.gov /research/publications/Publications.htm?seq_no_115=135858 (429 words)

	Cancer Protection Compound Abundant in Broccoli Sprouts
		In a paper published in tomorrow's issue of the Proceedings of the National Academy of Sciences, Talalay and his coworkers describe their successful efforts to build on their 1992 discovery of sulforaphane's chemoprotective properties.
		Sulforaphane "is a very potent promoter of Phase 2 enzymes," says Jed Fahey, plant physiologist and manager of the Brassica Chemoprotection Laboratory at Hopkins, and broccoli contains unusually high levels of glucoraphanin, the naturally-occurring precursor of sulforaphane.
		However, tests reported in the new study showed that glucoraphanin levels were highly variable in broccoli samples, and there was no way to tell which broccoli plants had the most without sophisticated chemical analysis.
	www.hopkinsmedicine.org /press/1997/SEPT/970903.HTM (737 words)

	Purification of sulforaphane from Brassica oleracea seed meal using low
		Sulforaphane is an isothiocyanate that is present naturally in widely consumed Brassica oleracea vegetables and has been shown to block the formation of tumors.
		The contents of sulforaphane in five groups of B. oleracea seeds (broccoli, Brussels sprouts, cabbage, cauliflower and kale) were determined by RP-HPLC using linear gradient of acetonitrile in water.
		Crude sulforaphane was first separated from B. oleracea seed meal by using immiscible solvent extraction with ethyl acetate, 10% ethanol and hexane, and the crude sulforaphane was used as raw materials to prepare high purity sulforaphane by low-pressure column chromatography of silica gel (200-300 mesh) with different eluents and elution modes.
	www.sproutnet.com /Nutrition/Research/purification_of_sulforaphane_fro.htm (217 words)

	Brassica Press Release: Sulforaphane's Protective Properties Beneficial Against Prostate Cancer, Cardiovascular Disease ...
		In a series of experiments, rats with high blood pressure (hypertension) that were treated with sulforaphane showed a significant reduction in the tendency to develop artery-narrowing plaques.
		Sulforaphane may, therefore, interrupt the progression of plaque development to strokes.
		Paul Talalay and his colleagues at Johns Hopkins (Dr. Talalay first demonstrated the efficacy of sulforaphane as an antioxidant in protecting against cancers) describe new studies showing that treatment with low concentrations of sulforaphane protects human retinal (eye) cells against a variety of severe oxidative challenges.
	www.brassica.com /press/pr0012.htm (592 words)

	BBC NEWS \| Health \| Food combining 'fights cancer'
		Combining two food components called sulforaphane and selenium make them up to 13 times more powerful in attacking cancer together than they are alone, they suggested.
		Sulforaphane, a plant chemical which could be used to prevent and treat cancer, is found at high concentrations in broccoli, sprouts, cabbage, watercress and salad rocket.
		When combined, sulforaphane and selenium had a bigger impact on the genes than they did alone.
	news.bbc.co.uk /2/hi/health/2903739.stm (364 words)

	Broccoli Sprouts sulforaphane : by Ray Sahelian, M.D. health benefits
		Sulforaphane is a chemical found in cruciferous vegetables such as broccoli, sprouts and kale.
		Sulforaphane is a potent inducer of protective enzymes that provide defense against cancer-causing chemicals.
		Sulforaphane, an isothiocyanate is believed to stimulate enzymes in the body.
	www.raysahelian.com /broccolisprouts.html (926 words)

	BroccoSprouts: SGS (Sulforaphane Glucosinolate) Fact Sheet
		In 1992, researchers at Johns Hopkins University School of Medicine identified sulforaphane, a compound that occurs naturally in broccoli.
		Johns Hopkins researchers believe that many phytochemicals, including sulforaphane, may help explain why diets rich in fruits and cruciferous vegetables are associated with a reduced risk of cancer.
		Sulforaphane, in the form of its natural precursor - sulforaphane glucosinolate (SGS™) - is also found in foods such as kale and cabbage.
	www.broccosprouts.com /health/sgsfactsheet.htm (482 words)

	Brassica Press Release: Research Summary: A Look at Sulforaphane Glucosinolate (SGS) and Preliminary Evidence for Its ...
		Their scientific findings relating to SGS™ (sulforaphane glucosinolate), a compound found in broccoli, may help to explain the widely recognized scientific evidence indicating that populations consuming a diet rich in fruits and vegetables, and especially cruciferous vegetables such as broccoli, have a reduced risk of developing several types of cancers.
		They found sulforaphane to be the most potent booster of Phase 2 enzymes, which stimulate the ability of animal cells to protect against disease.
		Sulforaphane exists in cruciferous vegetables such as broccoli and cabbage.
	www.brassica.com /press/pr0002.htm (1449 words)

	Maximizing the Anti-Cancer Power of Broccoli
		She is a professor in the Department of Food Science and Human Nutrition at the U of I. "As scientists, we learned that sulforaphane is maximized when broccoli has been heated 10 minutes at 140 degrees Fahrenheit," said Jeffery.
		Jeffery said that sulforaphane is one of the most powerful anticarcinogens found in food.
		Sulforaphane is linked to a sugar molecule through a sulfur bond.
	www.aces.uiuc.edu /news/stories/news2746.html (535 words)

	The Johns Hopkins Gazette: May 28, 2002
		In their laboratory experiments, the scientists discovered that purified sulforaphane even killed helicobacter that was resistant to commonly used antibiotics.
		Sulforaphane was initially isolated from broccoli at Johns Hopkins because of its ability to protect cells against cancer by boosting their production of "phase 2" enzymes, a family of proteins that detoxify certain cancer-causing agents and damaging free radicals.
		Sulforaphane can protect against chemically induced stomach cancer in mice, the research team also found, but more studies are needed to know whether it can do the same against helicobacter-induced stomach cancer and whether dietary sulforaphane, rather than pure sulforaphane, will do the trick.
	www.jhu.edu /~gazette/2002/28may02/28ulcers.html (527 words)

	Broccoli, Cancer Protection - Depending On Your Genes, You May Need To Eat More Than Other People, Or Consume 'super ... (Site not responding. Last check: 2007-10-11)
		People who gain less protection from cancer by eating broccoli may be able to compensate for the difference in their genetic make-up by eating ‘super broccoli', a variety with higher levels of the active plant chemical sulforaphane, or by eating larger portions.
		However, if you consume larger portions of broccoli, or broccoli with higher levels of sulforaphane, such as the ‘super broccoli', you may be able to retain as much sulforaphane in your body as those who have the gene.
		Sulforaphane is the main isothiocyanate derived from broccoli.
	www.medicalnewstoday.com /medicalnews.php?newsid=34785 (733 words)

	Potent Induction of Phase 2 Enzymes in Human Prostate Cells by Sulforaphane -- Brooks et al. 10 (9): 949 -- Cancer ...
		Sulforaphane is known to bolster the defenses of cells against
		QR response to sulforaphane is abolished in a reduced environment.
		Sulforaphane Induces Modest Increases of Expression of Glutathione Transferases.
	cebp.aacrjournals.org /cgi/content/full/10/9/949 (4551 words)

	Efficacy of Sulforaphane in Eradicating Helicobacter pylori in Human Gastric Xenografts Implanted in Nude Mice -- ...
		Efficacy of Sulforaphane in Eradicating Helicobacter pylori in Human Gastric Xenografts Implanted in Nude Mice -- Haristoy et al.
		For this isolate, the MIC of sulforaphane was 4 µg/ml,
		Sulforaphane inhibits extracellular, intracellular and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors.
	aac.asm.org /cgi/content/full/47/12/3982 (2010 words)

	Brassica: Papers and Publications (Site not responding. Last check: 2007-10-11)
		This important new research describes the ability of sulforaphane to cause cancer cells to self-destruct (programmed cell death or apoptosis.) The multidimensional ability of sulforaphane to remove carcinogens AND kill cells with potential cancer causing mutations is a major breakthrough in our understanding of this chemoprotectant.
		Following this, sulforaphane was applied topically to the test group for 11 weeks and compared to untreated controls.
		The authors suggested that sulforaphane could offer several advantages as a therapeutic agent, as it can boost several enzymes involved in cellular defense, allowing it to act at multiple targets and also due to its long-lasting activity, might reduce the need for multiple dosages.
	www.brassica.com /sci/papers.htm (2745 words)

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