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Topic: Sulfoxide


In the News (Tue 2 Dec 08)

  
  Dimethyl sulfoxide - Wikipedia, the free encyclopedia
OS), also known as methyl sulfoxide, dimethyl sulphoxide, dimethylsulfoxide, methylsulfinylmethane or sulfinylbismethane, is a sulfur-containing organic compound.
Dimethyl sulfoxide is a by-product of wood pulping and is frequently used as solvent in a number of chemical reactions.
The methyl hydrogens of DMSO are somewhat acidic in character (pKa=35) due to the stabilization of the resultant anions by the sulfoxide group.
en.wikipedia.org /wiki/Dimethyl_sulfoxide   (622 words)

  
 HHMI Lab Safety: LCSS: DIMETHYL SULFOXIDE   (Site not responding. Last check: 2007-10-18)
Dimethyl sulfoxide is relatively nontoxic by skin absorption, but can cause itching, scaling, and a transient burning sensation.
Dimethyl sulfoxide has not been found to be carcinogenic or to show reproductive or developmental toxicity in humans.
Excess dimethyl sulfoxide and waste material containing this substance should be placed in an appropriate container, clearly labeled, and handled according to your institution's waste disposal guidelines.
www.hhmi.org /about/labsafe/lcss/lcss33.html   (473 words)

  
 sulfoxide --  Encyclopædia Britannica
The best-known sulfoxide is dimethyl (or methyl) sulfoxide (DMSO), which is prepared by aerial oxidation of dimethyl sulfide (a by-product of paper…
Sulfoxides are easily reduced to sulfides with a variety of reducing agents such as lithium aluminum hydride.
a drug made with dimethyl sulfoxide, a compound obtained as a by-product of wood-pulp manufacture; prescribed in treatment of interstitial cystitis; investigated as a topical anti-inflammatory agent in orthopedic sports injuries; rapidly absorbed into skin; possible side effects include gastrointestinal disturbance, headache, garliclike body odor, dry mouth, and local...
www.britannica.com /eb/article-9070247?tocId=9070247   (433 words)

  
 Dimethyl Sulfoxide (Mucosal) - MayoClinic.com   (Site not responding. Last check: 2007-10-18)
Dimethyl sulfoxide (dye-METH-il sul-FOX-ide) is a purified preparation used in the bladder to relieve the symptoms of the bladder condition called interstitial cystitis.
Claims that dimethyl sulfoxide is effective for treating various types of arthritis, ulcers in scleroderma, muscle sprains and strains, bruises, infections of the skin, burns, wounds, and mental conditions have not been proven.
Although other preparations of dimethyl sulfoxide are available for industrial and veterinary (animal) use, they must not be used by humans, because of their unknown purity.
www.mayoclinic.com /health/drug-information/DR202196   (791 words)

  
 Dimethyl Sulfoxide
Dimethyl sulfoxide or DMSO is a very hygroscopic, sulfur-containing organic compound.
Absorption, distribution and elimination of labeled dimethyl sulfoxide in man and animals.
The absorption, metabolism and excretion of dimethyl sulfoxide by Rhesus monkeys.
www.pdrhealth.com /drug_info/nmdrugprofiles/nutsupdrugs/dim_0098.shtml   (1288 words)

  
 Jacob Laboratories - Studies
Dimethyl Sulfoxide Antagonizes Hypotensive, Metabolic, and Pathologic Responses Induced by Endotoxin
Dimethyl sulfoxide is a hydroxyl radical scavenger that readily penetrates cell membranes.
Treatment with dimethyl sulfoxide (6.5 g/kg; i.p.) evoked significant decreases in cardiac output, stroke volume, and central venous pressure and increases in heart rate, systemic vascular resistance, mean aortic pressure, respiration rate, and concentrations of blood glucose and plasma lactate.
www.jacoblab.com /Studies.htm   (3361 words)

  
 Dimethyl Sulfoxide (DMSO) Blocks Conduction in Peripheral Nerve C Fibers: a Possible Mechanism of Analgesia
Lockie, L.M. and Norcross, B.M., A clinical study on the effects of dimethyl sulfoxide in 103 patients with acute and chronic musculoskeletal injuries and inflammations.
Matsumoto, J., Clinical trials of dimethyl sulfoxide in rheumatoid arthritis patients in Japan.
Sawada, M. and Sato, M., The effect of dimethyl sulfoxide on the neuronal excitability and cholinergic transmission in Aplysia ganglion cells.
www.dmso.org /articles/nerves/nerve_c.htm   (2471 words)

  
 Selenoprotein R is a zinc-containing stereo-specific methionine sulfoxide reductase -- Kryukov et al. 99 (7): 4245 -- ...
Selenoprotein R is a zinc-containing stereo-specific methionine sulfoxide reductase -- Kryukov et al.
For utilization of methionine sulfoxides (D), cultures were diluted to 0.2, 0.02, 0.002, and 0.0002 OD and 10 µl of each cell suspension was applied to spots.
R and S isomers of methionine sulfoxide (chiral centers are located on sulfur as indicated in the figure) are formed directly or indirectly in free and protein methionines in response to oxidants, such as hydrogen peroxide.
www.pnas.org /cgi/content/full/99/7/4245   (4243 words)

  
 INTESTINAL CLEARANCE OF H2-ANTAGONISTS   (Site not responding. Last check: 2007-10-18)
In the course of an in situ rat jejunal perfusion study investigating the effects of mucosal microclimate pH on cimetidine ionization and absorption (3), a substantial quantity of metabolite was detected by HPLC analysis of the exiting perfusate.
Drug sulfoxidation in animal small intestinal microsomal preparations was first documented for phenothiazines in 1977 (4) and intestinal sulfoxidation of the anthelmintic drug, albendazole has recently been reported (5).
The lumenal appearance of H2-antagonist sulfoxide metabolite was quantitated as the molar ratio of sulfoxide to parent drug in the exiting perfusate.
www-personal.umich.edu /~fleisher/cv/publn/p23.html   (2027 words)

  
 Methionine Sulfoxide Reduction in Mammals: Characterization of Methionine-R-Sulfoxide Reductases -- Kim and Gladyshev ...
Methionine sulfoxide reductases catalyze reduction of free and
Bar-Noy, S., and Moskovitz, J. Mouse methionine sulfoxide reductase B: effect of selenocysteine incorporation on its activity and expression of the seleno-containing enzyme in bacterial and mammalian cells.
Kryukov, G.V., Kumar, R.A., Koc, A., Sun, Z., and Gladyshev, V.N. Selenoprotein R is a zinc-containing stereo-specific methionine sulfoxide reductase.
www.molbiolcell.org /cgi/content/full/15/3/1055   (5068 words)

  
 Sulfur -- Facts, Info, and Encyclopedia article   (Site not responding. Last check: 2007-10-18)
A sulfone is a molecule with an R-S(=O)-R' functional group where R and R' are organic groups.
A sulfoxide is a molecule with an R-S(=O)(=O)-R' functional group where R and R' are organic groups.
A common example of a sulfoxide is (additional info and facts about DMSO) DMSO.
www.absoluteastronomy.com /encyclopedia/s/su/sulfur.htm   (3682 words)

  
 Methionine sulfoxide reductases protect Ffh from oxidative damages in Escherichia coli -- Ezraty et al. 23 (8): 1868 -- ...   (Site not responding. Last check: 2007-10-18)
Methionine oxidation is reversed by methionine sulfoxide reductases
sulfoxide residues, (iii) oxidized Ffh is a substrate for MsrA
Methionine Sulfoxide Reduction and Assimilation in Escherichia coli: New Role for the Biotin Sulfoxide Reductase BisC
embojournal.npgjournals.com /cgi/content/abstract/23/8/1868   (294 words)

  
 Peptide methionine sulfoxide reductase (MsrA) is not a major virulence determinant for the oral pathogen Actinobacillus ...
Peptide methionine sulfoxide reductase (MsrA) is not a major virulence determinant for the oral pathogen Actinobacillus actinomycetemcomitans -- Mintz et al.
Chromosomal localization of the mammalian peptide-methionine sulfoxide reductase gene and its differential expression in various tissues.
Cloning and the expression of a mammalian gene involved in the reduction of methionine sulfoxide residues in proteins.
mic.sgmjournals.org /cgi/content/full/148/11/3695   (4618 words)

  
 Arabidopsis Peptide Methionine Sulfoxide Reductase2 Prevents Cellular Oxidative Damage in Long Nights -- Bechtold et ...
Peptide methionine sulfoxide reductase (PMSR) is a ubiquitous
Gabbita, S.P., Aksenov, M.Y., Lovell, M.A., and Markesbery, W.R. Decrease in methionine sulfoxide reductase in Alzheimer's disease brain.
Sadanandom, A., Poghosyan, Z., Fairbairn, D.J., and Murphy, D.J. Differential regulation of plastidial and cytosolic isoforms of peptide methionine sulfoxide reductase in Arabidopsis.
www.plantcell.org /cgi/content/full/16/4/908   (5523 words)

  
 Multiple methionine sulfoxide reductase genes in Staphylococcus aureus: expression of activity and roles in tolerance ...
Multiple methionine sulfoxide reductase genes in Staphylococcus aureus: expression of activity and roles in tolerance of oxidative stress -- Singh and Moskovitz 149 (10): 2739 -- Microbiology
Abbreviations: MetO, methionine sulfoxide; Msr, methionine sulfoxide reductase
Kryukov, G. V., Kumar, R. A., Koc, A., Sun, Z. and Gladyshev, V. Selenoprotein R is a zinc-containing stereo-specific methionine sulfoxide reductase.
mic.sgmjournals.org /cgi/content/full/149/10/2739   (4601 words)

  
 Methionine Sulfoxide Reductase A antibody (ab16803) datasheet   (Site not responding. Last check: 2007-10-18)
If Methionine Sulfoxide Reductase A antibody (ab16803) does not perform as described on this datasheet, notify us within 90 days of delivery using this form, so that we can help you or offer you a replacement or a refund.
Methionine sulfoxide reductase (MSRA) reduces methionine sulfoxide(MetO) residues in proteins and free MetO to Methionine (Met).
Repair of oxidized calmodulin by methionine sulfoxide reductase restores ability to activate the plasma membrane Ca-ATPase.
www.abcam.com /?datasheet=16803   (487 words)

  
 Differential Regulation of Plastidial and Cytosolic Isoforms of Peptide Methionine Sulfoxide Reductase in Arabidopsis ...
Brot N, Weissbach L, Werth J, Weissbach H (1982a) The biochemistry of methionine sulfoxide residues in proteins.
Doke N (1983b) Involvement of superoxide anion generation in hypersensitive response of potato tuber tissues to infection with an incompatible race of Phytophthora infestans.
Moskovitz J, Weissbach H, Brot N (1996b) Cloning and expression of a mammalian gene involved in the reduction of methionine sulfoxide residues in proteins.
www.plantphysiol.org /cgi/content/full/123/1/255   (5538 words)

  
 China Chemical Reporter: Sulfoxide chloride output increase. (Market Report).(Brief Article)@ HighBeam Research   (Site not responding. Last check: 2007-10-18)
China has 14 sulfoxide chloride producers with a total capacity of around 15 000 t/a.
Due to the high proportion of units using the chlorosulfonic acid process, however, the product quality is poor, the production cost is high and full-load production can hardly be made in some producers.
Stimulated by good market prospect, several 10 000 t/a sulfoxide chloride units were constructed in China around 2000.
highbeam.com /library/doc0.asp?DOCID=1G1:86139973&...   (196 words)

  
 Transition Metal Complexes of Dimethyl Sulfoxide
The nature of dimethyl sulfoxide (DMSO, (CH SO) as a monodentate ligand is explored in this set of experiments.
The method of bonding in the complex can be determined with the use of infrared spectroscopy, and the nature of the ligand and its complexes can be explored using molecular modeling software from CAChe Scientific (see appendix of this manual).
This experiment was adapted from Microscale Inorganic Chemistry, by Z. afran, R. Pike, and M. Singh, John Wiley: New York, 1991 and from a laboratory experiment developed by John C. Kotz of SUNY at Oneonta.
www.chem.binghamton.edu /chem445/dmso/dmso.htm   (1042 words)

  
 Encyclopedia: Dimethyl sulfoxide   (Site not responding. Last check: 2007-10-18)
Updated 109 days 19 hours 5 minutes ago.
OS), also known as methyl sulfoxide, dimethyl sulphoxide, dimethylsulfoxide, methylsulfinylmethane or sulfinylbismethane, is a sulfur-containing organic chemical compound.
IUPAC nomenclature is a systematic way of naming organic chemical compounds as recommended by the International Union of Pure and Applied Chemistry (IUPAC).
www.nationmaster.com /encyclopedia/Dimethyl-sulfoxide   (1046 words)

  
 Structure of Mycobacterium tuberculosis Methionine Sulfoxide Reductase A in Complex with Protein-Bound Methionine -- ...
Structure of Mycobacterium tuberculosis Methionine Sulfoxide Reductase A in Complex with Protein-Bound Methionine -- Taylor et al.
Structure of Mycobacterium tuberculosis Methionine Sulfoxide Reductase A in Complex with Protein-Bound Methionine
Sequence and Activity Characteristics, Comparison of the Expression with Plastidic Methionine Sulfoxide Reductase A, and Induction by Photooxidative Stress.
jb.asm.org /cgi/content/abstract/185/14/4119   (405 words)

  
 Sulfoxide   (Site not responding. Last check: 2007-10-18)
Bathroom and says, they had a Sulfoxide happy enough, not Sulfoxide.
Commercial bakery theres a Sulfoxide Sulfoxide themselves veins.
Five days fertility says, they had a Sulfoxide of Sulfoxide flutter.
drug-overdose.net /mad/Sulfoxide   (274 words)

  
 DMSO, Dimethyl Sulfoxide
Use of our encyclopedia will enable you to make well-informed, responsible decisions for the promotion of your own health and wellness.
DMSO (dimethyl sulfoxide) is a colorless, slightly oily liquid that is primarily used as an industrial solvent.
Dimethyl sulfoxide: a perspective of its use in rheumatic diseases.
www.truestarhealth.com /Notes/2839006.html   (804 words)

  
 Thiol-disulfide exchange is involved in the catalytic mechanism of peptide methionine sulfoxide reductase -- Lowther et ...
Thiol-disulfide exchange is involved in the catalytic mechanism of peptide methionine sulfoxide reductase -- Lowther et al.
Thiol-disulfide exchange is involved in the catalytic mechanism of peptide methionine sulfoxide reductase
Peptide Methionine Sulfoxide Reductase (MsrA) Is a Virulence Determinant in Mycoplasma genitalium
www.pnas.org /cgi/content/abstract/97/12/6463   (1104 words)

  
 Topical Alpha-Interferon Ointment with Dimethyl Sulfoxide in the Treatment of Recurrent Genital Herpes Simplex
In the present study dimethyl sulfoxide was combined with
Recently, the incidence of genital herpes simplex infections in the United States has risen dramatically.
Fisher A.A.: Dimethyl sulfoxide as a vehicle for food allergy patch tests.
www.dmso.org /articles/herpes/gherpes.htm   (2742 words)

  
 sulfoxide - OneLook Dictionary Search
Tip: Click on the first link on a line below to go directly to a page where "sulfoxide" is defined.
sulfoxide : The American Heritage® Dictionary of the English Language [home, info]
Phrases that include sulfoxide: dimethyl sulfoxide, aldicarb sulfoxide, biotin sulfoxide reductase, dimethyl sulfoxide reductase, disulfoton sulfoxide, more...
www.onelook.com /?w=sulfoxide&ls=all   (143 words)

  
 Search Results   (Site not responding. Last check: 2007-10-18)
Spector D, Etienne F, Brot N, Weissbach H. New membrane-associated and soluble peptide methionine sulfoxide reductases in Escherichia coli.
Residues 267-298 are 68% similar to a (REDUCTASE PEPTIDE METHIONINE SULFOXIDE) protein domain (PD186368) which is seen in YE55_HAEIN.
FN0188 is paralogously related to FN0803 (peptide methionine sulfoxide reductase/cytochrome C -type biogenesis protein ccdA) (1e-114).
hpv-web.lanl.gov /cgi-bin/gene_id_search.cgi?dbname=fnuc&gene_id=FN0188   (368 words)

  
 DMSO (Dimethyl Sulfoxide)   (Site not responding. Last check: 2007-10-18)
DMSO (Dimethyl Sulfoxide) Benefits, Side Effects and Information
Dimethyl sulfoxide or DMSO is a colorless, sulfur-containing organic compound (liquid) with a faint scent of sulfur and mixes readily with a wide range of water-insoluble and water-soluble substances.
DMSO is rapidly absorbed into the body if ingested or even if touched by the hands, very quickly producing a garlic-like taste.
www.nutrasanus.com /dmso.html   (291 words)

  
 Aldicarb sulfoxide Registration
Aldicarb sulfoxide - Registration, import consent and bans
For detailed chemical information see the chemical detail page.
, Propanal, 2-methyl-2-(methylsulfinyl)-, O-((methylamino)carbonyl)oxime, Propionaldehyde, 2-methyl-2-(methylsulfinyl)-, O-(methylcarbamoyl)oxime, Temik sulfoxide
www.pesticideinfo.org /Detail_ChemReg.jsp?Rec_Id=PC34138   (371 words)

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