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Topic: Sulindac

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	MedlinePlus Drug Information: Sulindac
		Sulindac is used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints), rheumatoid arthritis (arthritis caused by swelling of the lining of the joints), and ankylosing spondylitis (arthritis that mainly affects the spine).
		Sulindac also is used to treat pain in the shoulder caused by bursitis (inflammation of a fluid-filled sac in the shoulder joint) and tendinitis (inflammation of the tissue that connects muscle to bone).
		Sulindac is also sometimes used to reduce the number of polyps (abnormal growths) in the colon (large intestine) and rectum in patients with familial adenomatous polyposis (a condition in which hundreds or thousands of polyps form in the colon and cancer may develop).
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a681037.html (1095 words)

	Sulindac (Site not responding. Last check: 2007-10-09)
		Sulindac is used to treat rheumatoid arthritis, osteoarthritis and ankylosing spondylitis, a rheumatic disorder involving the spine and large joints.
		Sulindac is in a class of medications known as non-steroidal anti-inflammatory drugs (NSAIDs).
		Test tube studies have shown catechins, which are compounds found in green tea, significantly enhance the ability of sulindac to cause the death of and inhibit the growth of lung cancer cells.
	www.kroger.com /hn/Drug/Sulindac.htm (790 words)

	sulindac (Clinoril) - drug class, medical uses, medication side effects, and drug interactions by MedicineNet.com (Site not responding. Last check: 2007-10-09)
		PRESCRIBED FOR: Sulindac is used for the treatment of inflammation and pain that results from rheumatoid arthritis, ankylosing spondylitis, gouty arthritis, and osteoarthritis, as well as soft tissue injuries such as tendinitis and bursitis.
		Sulindac is generally used with caution in patients taking blood thinning medications (anticoagulants) such as warfarin (Coumadin), because of an increased risk of bleeding.
		Sulindac should be discontinued prior to elective surgery because of a mild interference with clotting that is characteristic of this group of medicines.
	www.medicinenet.com /sulindac/article.htm (674 words)

	Sulindac
		Sulindac is available now as a generic prescription at a cost of $50-$75/mo. When it is ingested, sulindac metabolizes to two derivatives, most of which is SS.
		A laboratory study (in vitro) indicated that sulindac causes growth inhibition in both normal and cancerous prostate cells, but that apoptosis is induced only in the cancerous cells, not in the normal cells.
		Piazza, G.A., et al., "Apoptosis primarily acounts for the growth-inhibitory properties of sulindac metabolites and involves a mechanism that is independent of cyclooxygenase inhibition, cell cycle arrest, and p53 induction," Cancer Res, 57(12), 2452-9, 1997.
	www.hrpca.org /sulindac.html (2052 words)

	Clinoril Online, Description, Chemistry, Ingredients - Sulindac - RxList Monographs (Site not responding. Last check: 2007-10-09)
		Sulindac is a non-steroidal, anti-inflammatory indene derivative designated chemically as (Z)-5-fluoro-2-methyl-1-[[ p -(methylsulfinyl)phenyl]methylene]-1 H -indene-3-acetic acid.
		Sulindac, a yellow crystalline compound, is a weak organic acid practically insoluble in water below pH 4.5, but very soluble as the sodium salt or in buffers of pH 6 or higher.
		Following absorption, sulindac undergoes two major biotransformations reversible reduction to the sulfide metabolite, and irreversible oxidation to the sulfone metabolite.
	www.rxlist.com /cgi/generic3/sulindac.htm (311 words)

	Sulindac Seems To Lack Anti-Colon-Cancer Properties
		"Despite prior evidence that sulindac is effective in older, symptomatic patients, investigators found no statistical difference between the two groups in thwarting the development of polyps or subsequent colon cancer," concludes Frank Giardiello, M.D., division director of gastroenterology/hepatology, professor of medicine and oncology, and director of the study.
		Sulindac is a type of nonsteriodal anti-inflammatory drug (NSAID) that works by blocking two enzymes, cyclooxygenase (COX) 1 and 2.
		FAP is an inherited disease caused by mutations of the adenomatous polyposis coli (APC) gene.
	unisci.com /stories/20022/0405025.htm (595 words)

	Medication Guide: Sulindac
		In rats, sulindac was found to cross placental barrier minimally, and to also be found excreted in rat maternal milk.
		Sulindac is found to be excreted in urine.
		Sulindac (like other medications of similar characteristics) should be discontinued prior to any type of surgery, in rats, due to mild interference with clotting.
	ratguide.com /meds/nsaids/sulindac.php (423 words)

	Sulindac in Managing Familial Adenomatous Polyposis - July 15, 2002 - American Family Physician
		Sulindac, a nonsteroidal anti-inflammatory drug, has been found to reduce the size and quantity of rectal adenomatous polyps.
		Few adverse effects of sulindac use were noted, although in six of the 12 patients, rectal mucosal erosions were reported at the IRA site.
		Treatment with sulindac requires regular endoscopic examination to (1) follow polyp response, (2) adjust sulindac dosing appropriately, and (3) identify the occasional cases of rectal cancer.
	www.aafp.org /afp/20020715/tips/4.html (551 words)

	Inhibition of rat colon tumors by sulindac and sulindac sulfone is independent of K-ras (codon 12) mutation -- de Jong ...
		Inhibition of rat colon tumors by sulindac and sulindac sulfone is independent of K-ras (codon 12) mutation -- de Jong et al.
		The effect of sulindac and sulindac sulfone treatment on tumor volume is illustrated in Table 2.
		Inhibition of colon cancer precursors in the rat by sulindac sulphone is not dependent on inhibition of prostaglandin synthesis.
	ajpgi.physiology.org /cgi/content/full/278/2/G266 (4245 words)

	sulindac - [Medication]
		Sulindac works by reducing hormones that cause inflammation and pain in the body.
		Sulindac should not be taken late in pregnancy (the third trimester) because a similar drug is known to affect the baby's heart.
		Sulindac may increase the sensitivity of the skin to sunlight.
	www.peacehealth.org /kbase/multum/d00033a1.htm (1188 words)

	sulindac Consumer Drug Information
		Sulindac is in a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs).
		Sulindac is used to reduce the pain, inflammation, and stiffness caused by rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout, tendinitis and bursitis.
		If you are taking sulindac as needed, take the missed dose if it is needed, then wait the recommended or prescribed amount of time before taking another dose.
	www.drugs.com /MTM/sulindac.html (1249 words)

	Sulindac Inhibits Activation of the NF-kappa B Pathway -- Yamamoto et al. 274 (38): 27307 -- Journal of Biological ...
		Sulindac is a non-steroidal anti-inflammatory agent that is related both structurally and pharmacologically to indomethacin.
		sulindac, or the sulfide and sulfone metabolites of sulindac (Fig.
		Sulindac Inhibits IKK Activity in Colon Carcinoma Cell Lines-- It was important to analyze the concentrations of sulindac that were necessary to inhibit endogenous IKK activity.
	www.jbc.org /cgi/content/full/274/38/27307 (4605 words)

	Sulindac - Wikipedia, the free encyclopedia
		Sulindac seems to have a property, independent of COX-inhibition, in reducing the growth of polyps and precancerous lesions in the colon, especially in association with familial adenomatous polyposis.
		Sulindac is an effective tocolytic and may be used in the treatment of preterm labour.
		In common with other NSAIDs, sulindac is currently being investigated for its role in the treatment of Alzheimer's disease.
	en.wikipedia.org /wiki/Sulindac (369 words)

	Sulindac Inhibits {beta}-Catenin Expression in Normal-Appearing Colon of Hereditary Nonpolyposis Colorectal Cancer and ...
		Sulindac sulfide-induced apoptosis involves death receptor 5 and the caspase 8-dependent pathway in human colon and prostate cancer cells.
		Sulindac targets nuclear ß-catenin accumulation and Wnt signalling in adenomas of patients with familial adenomatous polyposis and in human colorectal cancer cell lines.
		Sulindac sulfide, an aspirin-like compound, inhibits proliferation, causes cell cycle quiescence, and induces apoptosis in HT-9 colon adenocarcinoma cells.
	cebp.aacrjournals.org /cgi/content/full/14/7/1608 (3076 words)

	Sulindac - Drugs & Vitamins - Drug Library - DrugDigest
		SULINDAC (Clinoril®) is a nonsteroidal anti-inflammatory drug (NSAID).
		It is especially important not to use sulindac during the last 3 months of pregnancy unless specifically directed to do so by your health care provider.
		Sulindac may cause problems in the unborn child or complications during delivery.
	www.drugdigest.org /DD/DVH/Uses/0,3915,631\|Sulindac,00.html (899 words)

	The Chemopreventive Agent Sulindac Attenuates Expression of the Antiapoptotic Protein Survivin in Colorectal Carcinoma ...
		that sulindac decreases the expression of this antiapoptotic
		J (2000) Sulindac and a cyclooxygenase-2 inhibitor, etodolac, increase APC mRNA in the colon of rats treated with azoxymethane.
		Sulindac sulfide-induced apoptosis is enhanced by a small-molecule Bcl-2 inhibitor and by TRAIL in human colon cancer cells overexpressing Bcl-2
	jpet.aspetjournals.org /cgi/content/full/308/2/434 (2865 words)

	Sulindac - Patient UK
		Sulindac can be used to relieve pain and inflammation in rheumatic disease, sprains, strains, backache and gout.
		Sulindac works by preventing the production of irritant chemicals that cause pain and inflammation in the body.
		Sulindac may cause your skin to become more sensitive to sunlight than it is usually.
	www.patient.co.uk /showdoc/30002269 (754 words)

	Cyclooxygenase-independent Induction of Apoptosis by Sulindac Sulfone Is Mediated by Polyamines in Colon Cancer -- ...
		sulindac sulfone for 24 or 48 h and harvested, and total RNA was extracted as described under "Experimental Procedures." Top, 20 µg of RNA was loaded onto the gel from cells treated with either vehicle (V) or sulindac sulfone (Sulfone) for 24 or 48 h.
		in the induction of SSAT by the sulindac sulfone in the Caco-2
		for the induction of SSAT by sulindac sulfone.
	www.jbc.org /cgi/content/full/278/48/47762 (6792 words)

	Sulindac (Site not responding. Last check: 2007-10-09)
		Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) used to treat minor aches and pains associated with the common cold, headache, muscle aches, backache, and arthritis.
		Sulindac may also be used to reduce fever.
		Sulindac works by blocking the enzyme in your body that makes prostaglandins.
	www.prescriptiondrugchat.com /showthread.php?t=583 (231 words)

	Clinical Trial: A Randomized Study of Sulindac in Oral Premalignant Lesions
		The purpose of this study is to see if a drug called sulindac can prevent the development of changes in the mouth that are related to oral pre-cancer growths (oral epithelial dysplasia) or oral cancer.
		Sulindac is an anti-inflammatory drug that has already been tested in people with arthritis (inflammation of a joint).
		Primary Outcomes: - To evaluate the efficacy of sulindac in subjects with early or advanced oral premalignant lesion (OPL) by both clinical response (reduction in size of all lesions) and histological response (change in histological grade).
	www.clinicaltrials.gov /ct/show/NCT00299195 (1219 words)

	Rectal epithelial apoptosis in familial adenomatous polyposis patients treated with sulindac -- Keller et al. 45 (6): ...
		Sulindac regression of colorectal adenomas is accompanied by alteration of the rectal epithelial apoptotic ratio with relative
		Sulindac sulfide, an aspirin-like compound, inhibits proliferation, causes cell cycle quiesence, and induces apoptosis in HT-29 colon adenocarcinoma cells.
		The anti-proliferative effect of sulindac and sulindac sulfide on HT-29 colon cancer cells: alterations in tumor suppressor and cell cycle-regulatory proteins.
	gut.bmj.com /cgi/content/full/45/6/822 (4126 words)

	Sulindac Sulfide-induced Apoptosis Involves Death Receptor 5 and the Caspase 8-dependent Pathway in Human Colon and ... (Site not responding. Last check: 2007-10-09)
		Sulindac Sulfide-induced Apoptosis Involves Death Receptor 5 and the Caspase 8-dependent Pathway in Human Colon and Prostate Cancer Cells -- Huang et al.
		in the lysates of untreated and sulindac sulfide-treated DU145
		The inhibitor was added 30 min before the addition of sulindac sulfide, and apoptotic cells were analyzed after approximately 24 h of sulindac sulfide treatment.
	cancerres.aacrjournals.org /cgi/content/full/61/18/6918 (6112 words)

	Sulindac enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human lung cancer -- Oida et al. 4 ...
		MDA-7 expression was not observed in PBS or sulindac sulfone–treated cells.
		After a 2-h incubation in medium without sulindac (–) or with 1 mmol/L sulindac (+), cells were incubated for the indicated periods with 10 µg/mL cycloheximide, a known protein synthesis inhibitor.
		C, H1299 cells were grown in medium (control), in Ad-mda7 in combination with sulindac at the indicated concentrations for 48 h, or in 5 µm MG132 for 24 h.
	mct.aacrjournals.org /cgi/content/full/4/2/291 (7765 words)

	sulindac
		Remain upright (sitting or standing) for 15 to 30 minutes after each dose to prevent irritation of your esophagus (throat).
		Other prescription and over-the-counter drugs may interact with sulindac.
		Talk to your doctor before taking sulindac if you are taking any other medicines, especially any of the ones listed above.
	hw.healthdialog.com /kbase/multum/d00033a1.htm (1218 words)

	The Nonsteroidal Anti-inflammatory Drug Sulindac Causes Down-Regulation of Signal Transducer and Activator of ...
		sulindac sulfide or sulindac sulfone dissolved in 100% DMSO
		sulindac sulfide for 45 min, 1.5 h, 3 h, 4.5 h, 9 h, 24 h, 48 h, or 72 h, as indicated.
		sulindac sulfide and cell growth was assessed by counting cells in a Coulter counter at indicated time points.
	cancerres.aacrjournals.org /cgi/content/full/62/4/1004 (2782 words)

	Medical Dictionary: Sulindac - WrongDiagnosis.com
		Sulindac: A sulfinylindene derivative prodrug with potential antineoplastic activity.
		Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cyclic guanosine monophosphate-phosphodiesterase (cGMP-PDE), an enzyme that inhibits the normal apoptosis signal pathway; this inhibition permits the apoptotic signal pathway to proceed unopposed, resulting in apoptotic cell death.
		The following list attempts to classify Sulindac into categories where each line is subset of the next.
	www.wrongdiagnosis.com /medical/sulindac.htm (265 words)

	Sulindac Information
		Sulindac is in a class of medications known as non-steroidal anti-inflammatory drugs (
		Current research is exploring the possibility sulindac and other
		Test tube studies have shown catechins, which are compounds found in green tea, significantly enhance the ability of sulindac to cause the death of and inhibit the growth of
	www.evitamins.com /healthnotes.asp?ContentID=1506001 (796 words)

	Sulindac Enhances Tumor Necrosis Factor-{alpha}-mediated Apoptosis of Lung Cancer Cell Lines by Inhibition of Nuclear ...
		Sulindac Enhances Tumor Necrosis Factor-{alpha}-mediated Apoptosis of Lung Cancer Cell Lines by Inhibition of Nuclear Factor-{kappa}B -- Berman et al.
		combination with sulindac, sulindac sulfide, and sulindac sulfone.
		Shiff S. J., Qiao L., Tsai L. L., Rigas B. Sulindac sulfide, an aspirin-like compound, inhibits proliferation, causes cell cycle quiescence, and induces apoptosis in HT-29 colon adenocarcinoma cells.
	clincancerres.aacrjournals.org /cgi/content/full/8/2/354 (3604 words)

	Double Blind Randomized Study of Sulindac and An Open Pilot Study of Sialor [Lung Cancer: Lung Cancer Chemoprevention : ...
		Double Blind Randomized Study of Sulindac and An Open Pilot Study of Sialor [Lung Cancer: Lung Cancer Chemoprevention : Research Areas : Cancer Imaging : BC Cancer Research Centre]
		Sulindac 150 mg orally BID versus placebo for 6 months or
		The BCCRC is the research arm of the BC Cancer Agency (BCCA),
	www.bccrc.ca /ci/lc01_sulindac.html (372 words)

	NEJM -- Primary Chemoprevention of Familial Adenomatous Polyposis with Sulindac
		(43 percent) in the sulindac group and 11 of 20 subjects in
		Zhang, T., Fields, J. Z., Ehrlich, S. M., Boman, B. The Chemopreventive Agent Sulindac Attenuates Expression of the Antiapoptotic Protein Survivin in Colorectal Carcinoma Cells.
		Sulindac Does Not Prevent Polyp Development in FAP Gene Carriers.
	content.nejm.org /cgi/content/abstract/346/14/1054 (1148 words)

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