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Topic: Sulphonylurea

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	Diabin Is A Natural Diabetes Treatment, Diabetes Diet Supplement.
		Diabetes, Type II is a non-Insulin dependent diabetes (NIDDM), being a disorder of glucose homeostasis characterized by hyperglycemia, peripheral Insulin resistance, impaired hepatic glucose metabolism, and diminished glucose-dependent secretion of Insulin from pancreatic ß-cells.
		This latter defect may lie in the glucose signaling pathway in ß-cells involving metabolically regulated Potassium channels which are the targets of sulphonylurea drugs commonly used in the treatment of NIDDM.
		Type II is characterized by Insulin insensitivity evidenced by typically high levels of circulating Insulin and the reversibility of blood sugar elevation by dietary changes and/or weight loss sufficient to restore Insulin sensitivity.
	www.vaxa.com /669.cfm (2119 words)

	Diabetes and Endocrinology Research Unit
		Groop LC, Ratheiser K, Luzi L, Melander A, Simonson DC, Petrides A, Bonadonna RC, Widén E, DeFronzo RA: Effect of sulphonylurea on glucose-stimulated insulin secretion in healthy and non-insulin dependent diabetic subjects: a dose-response study.
		Taskinen M-R, Groop L: C-peptide and free insulin determinations in type 1 diabetes: relationship with metabolic control and insulin therapy.
		Melander A, Bitzén P-O, Faber O, Groop L: Sulphonylurea antidiabetic drugs: An update on their clinical pharmacology and rational therapeutic use.
	www.endo.mas.lu.se /endo/staff/leif/leif.shtml (8598 words)

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