
	Where results make sense

Topic: Sumatriptan

In the News (Tue 2 Dec 08)

Damian Green

Sumner Redstone

Crimson Tide

Tommy Tuberville

Bill Clinton

Wayne Rooney

Vilasrao Deshmukh

Wake Forest

Grand Slam

Oklahoma State

	Sumatriptan - Wikipedia, the free encyclopedia
		Sumatriptan was the first triptan available (in 1991), and, in the United States and most developed countries, is available only by medical prescription.
		Sumatriptan is administered in several forms; tablets, subcutaneous injection, and nasal spray.
		Sumatriptan is metabolised primarily by monoamine oxidase A into an indole acetic acid analogue, part of which is further conjugated with glucuronic acid.
	en.wikipedia.org /wiki/Sumatriptan (263 words)

	Imitrex Indications, Dosage, Storage, Stability - Sumatriptan Succinate - RxList Monographs (Site not responding. Last check: 2007-10-19)
		Sumatriptan succinate tablets are indicated for the acute treatment of migraine attacks with or without aura in adults.
		Safety and effectiveness of sumatriptan succinate tablets have not been established for cluster headache, which is present in an older, predominantly male population.
		In controlled clinical trials, single doses of 25, 50, or 100 mg of sumatriptan succinate tablets were effective for the acute treatment of migraine in adults.
	www.rxlist.com /cgi/generic/sumitr_ids.htm (401 words)

	Sumatriptan Succinate (Site not responding. Last check: 2007-10-19)
		It appears that sumatriptan activates chemical messengers that cause blood vessels in the brain to constrict, thus lessening the effects of a migraine.
		Sumatriptan should not be used by anyone with any symptoms of active heart disease (chest pain or tightness, shortness of breath).
		Sumatriptan should be used with caution in patients with liver disease or severely impaired kidney function.
	www.wholehealthmd.com /refshelf/drugs_view/1,1524,578,00.html (659 words)

	Hill Health Topics A-Z - Sumatriptan for cluster headaches : Examples (Site not responding. Last check: 2007-10-19)
		Sumatriptan (also sometimes referred to as 5-HT-1 receptor agonists) shrinks the blood vessels in the brain, which may relieve pain by reducing pressure from inflammation that can occur with cluster headaches.
		Another type of sumatriptan called zolmitriptan (Zomig) is used to treat migraine headaches and is now being studied for the treatment of cluster headaches in nasal spray form.
		Sumatriptan cannot be used on a daily basis to treat cluster headaches.
	www.healthwise.net /hillhealth/Content/StdDocument.aspx?DOCHWID=hw185495 (465 words)

	AASH--Headache, October 1998, abstracts (Site not responding. Last check: 2007-10-19)
		Sumatriptan (all doses) was similarly effective at relieving nausea and photophobia or phonophobia or both and at reducing clinical disability.
		Treatment with sumatriptan was effective in 88% of the attacks and 57% of the patients were pain-free within 15 min after injection; 42% of the patients became pain-free within 15 min after at least 90% of their attacks.
		Sumatriptan, 6 mg subcutaneous, was tried in an open fashion in 7 patients (6 women and 1 man) with chronic paroxysmal hemicrania and 7 patients (5 women and 2 men) with hemicrania continua.
	www.ahsnet.org /journal/archive/oct98abs.htm (13982 words)

	Imitrex - Drugs & Vitamins - Drug Library - DrugDigest
		Sumatriptan is not used to prevent migraine attacks.
		Sumatriptan is taken at the first symptoms of a migraine attack; it is not for everyday use.
		Sumatriptan is not for regular use to prevent migraine attacks.
	www.drugdigest.org /DD/DVH/Uses/0,3915,633\|Imitrex,00.html (775 words)

	Cerebrovascular Events with Sumatriptan
		Sumatriptan is contraindicated in patients with a history of transient ischaemic attacks or stroke.
		Sumatriptan is contraindicated in patients with a history of stroke or TIA.
		This patient used sumatriptan within the recommended guidelines, but an IMMP report has also been received of spasm causing occlusion in a peripheral artery after the recommended dose was exceeded.
	www.medsafe.govt.nz /Profs/PUarticles/sumatriptan.htm (664 words)

	sumatriptan - Migraine Headaches and other Neurological Disorders treatment, symptoms and medications
		Sumatriptan causes constriction of the blood vessels, thus relieving migraine headache.
		Sumatriptan should be avoided by patients with coronary artery disease (patients with angina pectoris and a history of heart attacks), and by patients with poorly controlled high blood pressure.
		Sumatriptan should not be administered along with ergot type migraine medications, or with MAO inhibitors.
	www.medicinenet.com /sumatriptan/article.htm (544 words)

	Sumatriptan
		Sumatriptan is a member of the selective serotonin receptor agonist family of drugs used to treat, but not prevent, migraine headaches.
		Sumatriptan is available in injection, nasal spray, and oral tablet forms.
		Sumatriptan tablets may begin to work faster when taken with fluid on an empty stomach at the first sign of migraine.
	www.gianteagle.com /healthnotes/Drug/Sumatriptan.htm (360 words)

	Actions of the 5-hydroxytryptamine 1 receptor agonist sumatriptan on interdigestive gastrointestinal motility in man ...
		In the treatment of migraine, sumatriptan 6 mg is administered subcutaneously, with a bioavailability of 96%.
		The sumatriptan induced premature jejunal activity front is not accompanied by a plasma motilin peak.
		of sumatriptan, 40 mg of erythromycin was administered intravenously.
	gut.bmjjournals.com /cgi/content/full/42/1/36 (3595 words)

	MedlinePlus Drug Information: Sumatriptan (Systemic) (Site not responding. Last check: 2007-10-19)
		Sumatriptan often relieves other symptoms that occur together with a migraine headache, such as nausea, vomiting, sensitivity to light, and sensitivity to sound.
		If you are not much better in 1 or 2 hours after an injection of sumatriptan or after sumatriptan nasal solution, or in 2 to 4 hours after a tablet is taken, do not use any more of this medicine for the same migraine.
		Most side effects of sumatriptan are milder and occur less often with the tablets than with the injection.
	www.nlm.nih.gov /medlineplus/druginfo/uspdi/202665.html (1951 words)

	Healthopedia.com Drugs Information - Sumatriptan : Proper Use (Imitrex)
		If you are not much better in 1 or 2 hours after an injection of sumatriptan, or in 2 to 4 hours after a tablet is taken, do not use any more of this medicine for the same migraine.
		A migraine that is not relieved by the first dose of sumatriptan probably will not be relieved by a second dose, either.
		Sumatriptan tablets are to be swallowed whole with a full glass of water.
	www.healthopedia.com /drugs/detailed/sumatriptan/proper-use.html (1097 words)

	Imitrex Oral Clinical Pharmacology - Sumatriptan - USA Today
		The vascular 5-HT1 receptor subtype that sumatriptan activates is present on cranial arteries in both dog and primate, on the human basilar artery, and in the vasculature of human dura mater and mediates vasoconstriction.
		When given as a single dose, sumatriptan displays dose proportionality in its extent of absorption (area under the curve [AUC]) over the dose range of 25 to 200 mg, but the Cmax after 100 mg is approximately 25% less than expected (based on the 25-mg dose).
		In vitro studies with human microsomes suggest that sumatriptan is metabolized by monoamine oxidase (MAO), predominantly the A isoenzyme, and inhibitors of that enzyme may alter sumatriptan pharmacokinetics to increase systemic exposure.
	www.healthscout.com /rxdetail/68/17/5/main.html (542 words)

	news item - Nasal sumatriptan in children
		Nasal sumatriptan appears to be safe and effective for the treatment of migraine in children older than 8 years of age, according to a new report.
		The dose of sumatriptan was 10 mg and 20 mg for body weights of 20 to 39 kg and 40 kg or higher, respectively.
		At 1 hour, headache relief was also more frequent after sumatriptan than after placebo The difference was even more obvious in patients who received the 20-mg dose as well as in the intention-to-treat analyses.
	www.ukmicentral.nhs.uk /headline/database/story.asp?NewsID=3132 (212 words)

	Sumatriptan - Patient UK
		Sumatriptan is used to treat migraine attacks and cluster headaches.
		Sumatriptan is available in tablet, nasal spray and injection form.
		Sumatriptan should not be used in combination with migraine treatments containing ergotamine.
	www.patient.co.uk /showdoc/30002594 (823 words)

	British Journal of Pharmacology - Contractile responses to sumatriptan and ergotamine in the rabbit saphenous vein: ...
		Although ergotamine and sumatriptan are efficacious in the treatment of migraine headache, the cardiovascular liabilities of these agents limit their more wide spread utility and acceptance (Yasue et al., 1981; Bax and Saxena, 1993; Chester et al., 1993; MacIntyre et al., 1993; Koh et al., 1994).
		With the identification of 5-HT receptor agonists and their utility in migraine, the rabbit saphenous vein, a tissue whose responses to sumatriptan are thought to mimic the responses to sumatriptan in human coronary arteries (Cohen et al., 1997), was used to understand whether 5-HT receptor agonists exhibit vasocontractile properties.
		Because responses to sumatriptan and to a lesser extent to ergotamine could be augmented in the rabbit saphenous vein, we examined the ability of LY334370 and LY344864 to enhance or augment the contractile response to sumatriptan and ergotamine in the rabbit saphenous vein.
	www.nature.com /bjp/journal/v131/n3/full/0703587a.html (4038 words)

	Subcutaneous sumatriptan for acute migraine (Site not responding. Last check: 2007-10-19)
		For subcutaneous sumatriptan 6 mg in eight trials, 379/477 patients (79%) had a headache response at two hours compared with 131/461 (28%) with placebo.
		Results for subcutaneous sumatriptan were consistent between trials, and those for two hour headache response are shown in Figure 1.
		Sumatriptan is clearly effective in the treatment of acute migraine, in several doses and by three routes of administration.
	www.jr2.ox.ac.uk /bandolier/booth/Migraine/SumSCacu.html (361 words)

	Sumatriptan: Economic Evidence for its use in the Treatment of Migraine, the Canadian Comparative Economic Analysis
		The objective of this study was to evaluate economic and health effects of sumatriptan relative to customary therapy in Canada.
		Sumatriptan is expected to reduce the time spent with migraine symptoms and resulting time lost.
		The cost of sumatriptan treatment is significantly offset by a substantial reduction of costs associated with time lost due to migraine symptoms.
	www.headachedrugs.com /archives/sumatriptan_canadian.html (191 words)

	HEADACHE MEETING: Eletriptan Provides Faster, Superior Relief Of Acute Migraine Than Sumatriptan (Site not responding. Last check: 2007-10-19)
		In a randomised placebo-controlled study of 774 patients treated with Pfizer Inc.’s eletriptan 40 or 80 mg, sumatriptan 50 or 100 mg, or given placebo, eletriptan produced relief of pain, nausea and vomiting, as early as one hour after medication was taken.
		Headache response rates were higher with eletriptan 40 mg and 80 mg than sumatriptan 50 mg and 100 mg at one hour (respectively 30-37 percent versus 24-27 percent) and two hours (64-67 percent versus 50-53 percent) after treatment.
		The increases in the proportion of patients relieved of nausea, photophobia and phonophobia by two hours after dosing were greater in the eletriptan groups than in the sumatriptan and placebo groups.
	www.pslgroup.com /dg/10e4c6.htm (730 words)

	Amplification of sumatriptan-induced contraction in rabbit saphenous vein but not in basilar artery -- Bhattacharya et ... (Site not responding. Last check: 2007-10-19)
		6.8) and efficacy (from 52.3% to 88.2%) of sumatriptan.
		efficacy (from 51.8% to 92.1%) of sumatriptan in the saphenous
		Effect of histamine precontraction on the potency and efficacy of sumatriptan in the rabbit saphenous vein and basilar artery.
	ajpheart.physiology.org /cgi/content/full/284/2/H719 (3509 words)

	RemedyFind: patient ratings of Imitrex for Migraine Disease (Site not responding. Last check: 2007-10-19)
		Imitrex (Sumatriptan) is the first of a new group of medications called “triptans” (selective serotonin 5-HT1B/1D agonists), which are used to abort and treat, but not prevent, migraine headaches.
		Studies have shown the triptans to be quite similar in terms of effectiveness, tolerability and safety, though, compared to Sumatriptan, the second-generation triptans have a higher oral bioavailability and longer plasma half-life.
		As Sumatriptan has a powerful constricting effect on the heart and blood vessels it should not be used by anyone with any symptoms of active heart disease.
	remedyfind.com /rm-329-Imitrex.asp (1266 words)

	Arch Fam Med -- Multiple-Attack Efficacy and Tolerability of Sumatriptan Nasal Spray in the Treatment of Migraine, May ...
		Sumatriptan nasal spray (5, 10, or 20 mg) was administered
		The number of patients using study medication to treat a recurrent headache in the 20-mg, 10-mg, and 5-mg drug groups and the placebo group was 55, 49, 51, and 24, respectively, for attack 1; 57, 54, 36, and 25, respectively, for attack 2; and 34, 30, 24, and 15 for attack 3, respectively.
		Sumatriptan: A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the acute treatment of migraine and cluster headache.
	archfami.ama-assn.org /cgi/content/full/7/3/234 (3622 words)

	SUMATRIPTAN (Site not responding. Last check: 2007-10-19)
		The manufacturer does not recommend use of sumatriptan in the elderly, because they may be more sensitive to its side effects.
		Sumatriptan should be used during pregnancy only when clearly needed.
		Do not take MAO inhibitors with sumatriptan or use sumatriptan within 2 weeks of stopping use of MAO inhibitors.
	www.cheap-pharmacy.net /sumatriptan (406 words)

	Influence of sumatriptan on gastric fundus tone and on the perception of gastric distension in man -- Tack et al. 46 ... (Site not responding. Last check: 2007-10-19)
		The effect of sumatriptan on fundic tone was assessed in 11 volunteers, in whom the MDP was 6.5 (0.5) mm Hg.
		Sumatriptan significantly decreased the average perception score at the same distending volumes (fig 4B).
		Sumatriptan induced a significant shift of the volume-perception curve and of the volume-discomfort curve towards higher volumes (p<0.005; logistic regression).
	gut.bmjjournals.com /cgi/content/full/46/4/468 (4075 words)

	MedlinePlus Drug Information: Sumatriptan Oral and Nasal
		Sumatriptan is used to relieve migraine headache symptoms.
		Sumatriptan comes as a tablet to take by mouth and a nasal spray.
		If you are at risk for heart disease and you have never taken sumatriptan before, you may need to take the first dose in your doctor's office.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a601116.html (705 words)

	A Randomized, Double-Blind, Placebo-Controlled Study of Sumatriptan Nasal Spray in the Treatment of Acute Migraine in ... (Site not responding. Last check: 2007-10-19)
		Sumatriptan nasal spray (NS) is effective in adults with rapid-onset migraine and associated symptoms.
		Sumatriptan Auto-Injector Study Group Self-treatment of acute migraine with subcutaneous sumatriptan using and auto-injector device.
		Korsgaard A. The tolerability, safety, and efficacy of oral sumatriptan 50 mg and 100 mg for the acute treatment of migraine in adolescents.
	pediatrics.aappublications.org /cgi/content/full/106/5/989 (4795 words)

	Drug points: Atrial fibrillation associated with sumatriptan -- Morgan et al. 321 (7256): 275 -- BMJ
		Sumatriptan is a 5-hydroxytryptanine agonist active at 5-hyroxytryptanine 1B and 1D receptors.
		Sumatriptan is the drug most frequently reported to cause chest pain.
		In this patient's case there was evidence of rechallenge, implicating sumatriptan as the cause of the atrial fibrillation,
	bmj.bmjjournals.com /cgi/content/full/321/7256/275 (317 words)

Try your search on: Qwika (all wikis)