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Na+/I- Symporter The key player in this process is the sodium-iodide symporter, an integral membrane protein that resides in the basolateral membrane of thyroid epithelial cells. The presence of the symporter in mammary gland leads to secretion of iodine in milk, which is probably important for thyroid function in neonatal animals. The most important stimulator of symporter gene and protein expression is thyroid-stimulating hormone, similar to what is observed with other important thyroid proteins such as thyroglobulin and thyroid peroxidase. arbl.cvmbs.colostate.edu /hbooks/pathphys/endocrine/thyroid/nai_symport.html   (554 words)

Symporter - Wikipedia, the free encyclopedia A symporter, also known as a cotransporter, is an integral membrane protein that is involved in secondary active transport. Symporter is also sometimes misspelled simporter because of the simultaneous transport of molecules (and the phonetic resemblance to symporter). In particular, symporters do not require the splitting of ATP because they derive the necessary energy for the movement of one molecule from the movement of the another. en.wikipedia.org /wiki/Symporter   (179 words)

[No title] It has been shown [1] that integral membrane proteins that mediate the uptake of a wide variety of molecules with the concomitant uptake of sodium ions (sodium symporters) can be grouped, on the basis of sequence and functional similarities into a number of distinct families. Such re-uptake of neurotransmitters from the synapses, is thought to be an important mechanism for terminating their action, by removing these chemicals from the synaptic cleft, and transporting them into presynaptic nerve terminals, and surrounding neuroglia. Tolner B. Poolman B. Konings W.N. Characterization and functional expression in Escherichia coli of the sodium/proton/glutamate symport proteins of Bacillus stearothermophilus and Bacillus caldotenax. www.ebi.ac.uk /interpro/IEntry?ac=IPR001991   (470 words)

Na/I Symporter/Van Dyken/1997   (Site not responding. Last check: 2007-11-03) The Na+/I- symporter sits within the cell membrane of the thyroid cells. The three charged amino acids within the membrane are thought to be central in the symporter activity. These characteristics and functions were able to show that the rat symporter has a 24.6% amino acid homology with that of the human symporter. wwwchem.csustan.edu /chem4400/SJBR/Vandyk.htm   (1737 words)

Symport   (Site not responding. Last check: 2007-11-03) To the right is shown an animation of the process of symport, the simultaneous transport of two different molecules or ions across across a lipid bilayer membrane in the same direction. Note that at the beginning of the animation, the symporter is poised to accept the blue diamond, but not the red circle. When both molecules are bound, there is a conformational change in the symporter such that binding sites are open to the inside of the cell rather than to the outside. bio.winona.edu /berg/ANIMTNS/symport.htm   (244 words)

Sucrose-mediated transcriptional regulation of sucrose symporter activity in the phloem -- Vaughn et al. 99 (16): 10876 ... Sucrose-mediated transcriptional regulation of sucrose symporter activity in the phloem -- Vaughn et al. a reduction in the abundance of symporter protein. transcription of the sucrose symporter gene that, because of www.pnas.org /cgi/content/full/99/16/10876   (2987 words)

Increased Expression of the Sodium/Iodide Symporter in Papillary Thyroid Carcinomas -- Saito et al. 101 (7): 1296 -- ... Increased Expression of the Sodium/Iodide Symporter in Papillary Thyroid Carcinomas Onaya (1997) Increased expression of the Na symporter in cultured human thyroid cells exposed to thyrotropin and in Graves' thyroid tissue. Carrasco (1997) Characterization of the thyroid Na symporter with an anti-COOH terminus antibody. www.jci.org /cgi/content/full/101/7/1296   (4298 words)

v014 : Na+/I- Symporter Expression is inhibited by IL-1 alpha, IL-2, TGF-beta, and TNF-alpha in Primary Human Thyrocytes   (Site not responding. Last check: 2007-11-03) Na+/I- Symporter Expression is inhibited by IL-1 alpha, IL-2, TGF-beta, and TNF-alpha in Primary Human Thyrocytes The human sodium iodide symporter (hNIS) plays a key role in iodination, the first step in the biosynthesis of the thyroid hormones T3 and T4. It is thought to be critically involved in several thyroid diseases associated with altered iodide uptake, especially autoimmune diseases. www.thieme.de /abstracts/eced/abstracts2002/daten/v014.html   (334 words)

WebLSD The sodium/iodide symporter (NIS) stimulates iodide uptake in normal lactating breast, but is not known to be active in nonlactating breast or breast cancer. The electrochemical gradient for HCO3- is used by a Na+-HCO3- symporter in the basolateral membrane to transport NaHCO3 into the interstitial space. The energy in the electrochemical gradient for Na+ is harnessed by a Na+-Cl- symporter in the luminal membrane which moves Cl- into the epithelial cell against its electrochemical gradient. wwwsoc.nii.ac.jp /cgi-bin/lsdproj/ejlookup04.pl?lang=Japanese&dicmode=yourei&query=symporter   (132 words)

Detection of Binding and Blocking Autoantibodies to the Human Sodium-Iodide Symporter in Patients with Autoimmune ... symporter in the sera of patients with autoimmune thyroid disease. 1997 Binding of IgG from patients with autoimmune thyroid disease to rat sodium-iodine symporter peptides: evidence for the iodine transporter as an autoantigen. 1998 Increased expression of the sodium/iodide symporter in papillary thyroid carcinomas. jcem.endojournals.org /cgi/content/full/85/5/2020   (5698 words)

[No title] The solutes transported may be sugars, amino acids, organo cations such as choline, nucleosides, inositols, vitamins, urea or anions, depending on the system. The human placental multivitamin symporter cotransports an anionic vitamin with two Na In the rabbit Na :D-glucose cotransporter, SGLT1, the glucose translocation pathway probably involves TMSs 10-13, and the binding site for the inhibitor, phlorizin, involves loop 13 (residues 604-610). symport mechanism as a dependency on Na could not be demonstrated and uptake was strongly inhibited by 10 μM CCCP. www.tcdb.org /tcdb/tcfamilybrowse.php?tcname=2.A.21   (895 words)

Direct inhibitory effect of CCCP on the Cl--H+ symporter of the guinea pig ileal brush-border membrane -- Alvarado and ... symporter that is strongly inhibited by CCCP (3, 17). symporter, and not indirectly by dissipating an imposed pH gradient, Trans-potassium effects on the chloride/proton symporter activity of guinea pig ileal brush-border membrane vesicles. ajpcell.physiology.org /cgi/content/full/274/2/C481   (5847 words)

The Na++/I- - symporter (NIS): Physiological and pathophysiological implications The Na+/I- symporter (NIS) is a plasma membrane glycoprotein that mediates active I- transport in the thyroid follicular cells (the first step in thyroid hormone biosynthesis), and in other tissues, such as lactating mammary gland. NIS is the basis for the effective use of radioiodide in the diagnostic and treatment of thyroid cancer. Radioiodide may be administered to breast cancer patients whose thyroids are protected by downregulation of thyroid NIS with T3. www.endocrine-abstracts.org /ea/0005/ea0005s4.htm   (326 words)

K+-neutral amino acid symport of Bombyx mori larval midgut: a system operative in extreme conditions -- Giordana et al. ... Relative contribution of symporter and uniporter to total leucine uptake in M- (A and B) and P-BBMV (C and D) within range of symporter's activity in absence (A and C) or presence (B and D) of K symporters for neutral amino acids along the midgut of lepidopteran larvae: functional differentiations. Neutral amino acid symport in larval Manduca sexta midgut brush-border membrane vesicles deduced from cation-dependent uptake of leucine, alanine and phenylalanine. ajpregu.physiology.org /cgi/content/full/274/5/R1361   (5724 words)

Pew Scholars Program in the Biomedical Sciences - Nancy Carrasco A major topic is the characterization of the sodium/iodide symporter, the protein that mediates the accumulation of iodide in the thyroid gland. Biochemical, biophysical and immunological approaches are being used to identify the symporter. Our studies on the regulation of the thyroid sodium/iodide symporter have revealed that the protein is activated by proteolysis, and that stimulation of iodide accumulation by thyroid stimulating hormone (TSH) involves not only increased biosynthesis but also activation of the symporter. futurehealth.ucsf.edu /scholars/89spages/carrasco.html   (278 words)

Molecular Analysis of the Sodium/Iodide Symporter: Impact on Thyroid and Extrathyroid Pathophysiology -- De la Vieja et ... Molecular Analysis of the Sodium/Iodide Symporter: Impact on Thyroid and Extrathyroid Pathophysiology. The Na symporter (NIS) is an intrinsic membrane protein that mediates the active transport of iodide into the thyroid and Expression of sodium-iodide symporter mRNA in the thyroid gland of Xenopus laevis tadpoles: developmental expression, effects of antithyroidal compounds, and regulation by TSH. physrev.physiology.org /cgi/content/abstract/80/3/1083   (1540 words)

PI3K Is Involved in the IGF-I Inhibition of TSH-Induced Sodium/Iodide Symporter Gene Expression -- García and ... PI3K Is Involved in the IGF-I Inhibition of TSH-Induced Sodium/Iodide Symporter Gene Expression -- García and Santisteban 16 (2): 342 -- Molecular Endocrinology PI3K Is Involved in the IGF-I Inhibition of TSH-Induced Sodium/Iodide Symporter Gene Expression A perspective view of sodium iodide symporter research and its clinical implications. mend.endojournals.org /cgi/content/abstract/16/2/342   (584 words)

Does the KdpA Subunit from the High Affinity K+-Translocating P-Type KDP-ATPase have a Structure Similar to That of K+ ... A dash indicates that none of the symporter residues was identical to any of the KdpA residues. symporter sequences, three are the central glycines in the P2 and P2 segments (Durell et al., 1999 In the symporters, the energy to drive the transport cycle comes from movement of the cotransported ion, Na or H www.biophysj.org /cgi/content/full/78/1/188   (7248 words)

IngentaConnect Characterization of Gastric Na+I Symporter of the Rat Characterization of Gastric Na Symporter of the Rat Characterization of gastric Na symporter (NIS) of the rat was carried out. Symporter of the Rat" title="post to CiteUlike">Post to CiteUlike www.ingentaconnect.com /content/ap/ii/1998/00000089/00000003/art04595   (321 words)

Unbound MEDLINE | journal articles related to Analysis of human sodium/iodide symporter, thyroid transcription ... Analysis of human sodium/iodide symporter, thyroid transcription factor-1, and paired-box-protein-8 gene expression in benign thyroid diseases. Analysis of human sodium iodide symporter gene expression in extrathyroidal tissues and cloning of its complementary deoxyribonucleic acids from salivary gland, mammary gland, and gastric mucosa. A thyroid-specific far-upstream enhancer in the human sodium/iodide symporter gene requires Pax-8 binding and cyclic adenosine 3',5'-monophosphate response element-like sequence binding proteins for full activity and is differentially regulated in normal and thyroid cancer cells. www.unboundmedicine.com /medline/ebm/related/10365677/Analysis_of_human_sodium/iodide_symporter_thyroid_transcription_factor_1_and_paired_box_protein_8_gene_expression_in_benign_thyroid_diseases   (311 words)

Rotavirus Infection Stimulates the Cl- Reabsorption Process across the Intestinal Brush-Border Membrane of Young ... Rotavirus activating effects on BBM Cl symporter as a function of time after infection. Direct inhibitory effect of CCCP on the Cl(-)-H+ symporter of the guinea pig ileal brush-border membrane. Mechanisms of trans-chloride activation of a Cl-/H+ symport in brush-border membrane vesicles from guinea-pig ileum. jvi.asm.org /cgi/content/full/77/17/9305   (4739 words)

Major Facilitator Superfamily -- Pao et al. 62 (1): 1 -- Microbiology and Molecular Biology Reviews Family 14, the anion:cation symporter (ACS) family, is a relatively large family with 40 sequenced members. is believed to be a sugar:proton symporter (61). permeases appear to be energized by proton symport (80). mmbr.asm.org /cgi/content/full/62/1/1   (7224 words)

A novel proline, glycine: K+ symporter in midgut brush-border membrane vesicles from larval Manduca sexta -- Bader et ... A novel proline, glycine: K+ symporter in midgut brush-border membrane vesicles from larval Manduca sexta -- Bader et al. A novel proline, glycine: K+ symporter in midgut brush-border membrane vesicles from larval Manduca sexta its symport appears to be exclusively through the pro, gly: K+ symporter. jeb.biologists.org /cgi/content/abstract/198/12/2599   (316 words)

Structural Models of the KtrB, TrkH, and Trk1,2 Symporters Based on the Structure of the KcsA K+ Channel -- Durell and ... The backbones of all primary symporter segments are similar to those of the channels, except for the more cytoplasmic portions of M2 and M2 (see text for details). All linkers between the ion-selective portion of the P2 segment and M2 are longer in the symporters than in most of the channels. of the MPM motif with a symporter sequence. www.biophysj.org /cgi/content/full/77/2/789   (10339 words)

B PERRON et al.: mNIS cloning & expression in the mammary gland (Journal of Endocrinology) De La Vieja A, Dohan O, Levy O and Carrasco N. 2000 Molecular analysis of the sodium/iodide symporter: impact on thyroid and extrathyroid pathophysiology. Pohlenz J and Refetoff S. 1999 Mutations in the sodium/iodide symporter (NIS) gene as a cause for iodide transport defects and congenital hypothyroidism. 1998 Analysis of human sodium iodide symporter gene expression in extrathyroidal tissues and cloning of its complementary deoxyribonucleic acids from salivary gland, mammary gland, and gastric mucosa. journals.endocrinology.org /joe/170/0185/joe1700185.htm   (825 words)

Establishment of a Human Hepatocellular Carcinoma Cell Line Highly Expressing Sodium Iodide Symporter for Radionuclide ... In vivo imaging and tumor therapy with the sodium iodide symporter. Radioiodide treatment after sodium iodide symporter gene transfer is a highly effective therapy in neuroendocrine tumor cells. Ectopic expression of the thyroperoxidase gene augments radioiodide uptake and retention mediated by the sodium iodide symporter in non-small cell lung cancer. jnm.snmjournals.org /cgi/content/full/45/9/1571   (2677 words)

[No title] Sodium/substrate symport (or co-transport) is a widespread mechanism of solute transport across cytoplasmic membranes of pro- and eukaryotic cells. One of these families, known as the sodium:solute symporter family (SSSF), contains over a hundred members of pro- and eukaryotic origin [3]. Reizer J. Reizer A. Saier Jr M.H. The Na+/pantothenate symporter (PanF) of Escherichia coli is homologous to the Na+/proline symporter (PutP) of E. coli and the Na+/glucose symporters of mammals. www.ebi.ac.uk /interpro/IEntry?ac=IPR001734   (352 words)

Sodium Iodide Symporter: Its Role in Nuclear Medicine -- Chung 43 (9): 1188 -- The Journal of Nuclear Medicine Escape from the acute Wolff-Chaikoff effect is associated with a decrease in thyroid sodium/iodide symporter messenger ribonucleic acid and protein. Iodide symporter gene expression in normal and transformed rat thyroid cells. Relationship between differentiation and expression of sodium/iodide symporter or glucose transporter-1 in differentiated thyroid carcinoma [abstract]. jnm.snmjournals.org /cgi/content/full/43/9/1188   (7469 words)

GeneCard for SLC5A5 ALL other users require a Commercial License from XenneX, Inc. Unauthorized usage of this service is in breach of the terms and conditions of this web site, and may cause the user to incur fees for usage. A novel mutation in the sodium/iodide symporter gene in the largest family with iodide transport defect. Dean H.J. Novel, missense and loss-of-function mutations in the sodium/iodide symporter gene causing iodide transport defect in three Japanese patients. www.genecards.org /cgi-bin/carddisp.pl?gene=SLC5A5   (710 words)

Transcription Factor Nkx-2.5 Induces Sodium/Iodide Symporter Gene Expression and Participates in Retinoic Acid- and ... Transcription Factor Nkx-2.5 Induces Sodium/Iodide Symporter Gene Expression and Participates in Retinoic Acid- and Lactation-Induced Transcription in Mammary Cells -- Dentice et al. Transcription Factor Nkx-2.5 Induces Sodium/Iodide Symporter Gene Expression and Participates in Retinoic Acid- and Lactation-Induced Transcription in Mammary Cells The sodium/iodide symporter (NIS) is a plasma membrane protein mcb.asm.org /cgi/content/abstract/24/18/7863   (456 words)

A Monocarboxylate Permease of Rhizobium leguminosarum Is the First Member of a New Subfamily of Transporters -- Hosie ... symporters as it is in accordance with the experimentally determined symporter), the best-characterized member of this family (25). The Na+ pantothenate symporter (panF) of Escherichia coli is homologous to the Na+ proline symporter (putP) of Escherichia coli and the Na+ glucose symporters of mammals. jb.asm.org /cgi/content/full/184/19/5436   (5671 words)

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