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Topic: Synovial sarcoma

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Synovial sarcoma

Osteogenic sarcoma

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Sarcoma, Granulocytic

synovial cell sarcoma

Primary granulocytic sarcoma

Adult Soft Tissue Sarcomas

Endometrial stromal sarcoma

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	Synovial sarcoma - Wikipedia, the free encyclopedia
		It usually occurs adjacent to joints in the limbs and was originally thought to arise from synovium; however, synovial sarcoma is a misnomer and the tissue of origin is unknown.
		SYT-SSX is thus thought to underlie synovial sarcoma pathogenesis through dysregulation of gene expression; accordingly, gene expression studies have identified a pattern of gene expression typical of synovial sarcoma.
		This is the mainstay of synovial sarcoma treatment and is curative in approximately 20-70% of patients, depending on the particular study being quoted.
	en.wikipedia.org /wiki/Synovial_sarcoma (726 words)

	Synovial Sarcoma
		Synovial tissue can be found in tendons (tissues that connect muscle to bone), bursae (fluid-filled, cushioning sacs found in spaces between tendons, ligaments, and bones), and the cavity (hollow enclosed area) that separates the bones of a freely movable joint, such as the knee or elbow.
		Synovial sarcomas occur mainly in the arms and legs, where they tend to arise in the area of large joints, especially the knee region.
		The diagnosis of synovial sarcoma is made by biopsy (removal of tissue for examination under a microscope).
	www.medhelp.org /lib/cancernet/600061.htm (629 words)

	Synovial Sarcoma
		MAGE antigen expression in monophasic and biphasic synovial sarcoma.
		Synovial sarcomas usually occur in the soft tissues of the extremities of adolescents and middle-aged patients, in the vicinity of large joints.
		Synovial sarcoma should be considered in the differential diagnosis of biphasic and monophasic spindle cell neoplasms of the mediastinum.
	www.thedoctorsdoctor.com /diseases/synovial_sarcoma.htm (7075 words)

	Synovial Sarcoma On The Anterior Abdominal Wall
		Synovial sarcoma is a malignant mesenchymal neoplasm which commonly occurs in the extremities of adults.
		Synovial sarcoma is a malignant mesenchymal tumor which occurs in close association with joint capsules, tendon sheaths, bursae and fascial structures.
		Synovial sarcoma should also be included in the differential diagnosis of a malignant neoplasm in the extremities of infants.
	www.ispub.com /ostia/index.php?xmlFilePath=journals/ijs/vol7n1/synovial.xml (1059 words)

	Synovial Sarcoma - My Child Has - Children's Hospital Boston
		Synovial tissue is found around the tendons (bands of fiber that connect muscle to bone), and can form bursa (fluid filled cushioning pouches or sacs found in spaces between tendons, ligaments and bones) found in the area of joints.
		The exact cause of synovial sarcoma is not entirely understood, however, studies have indicated that genetic alterations may play a role in the formation of soft tissue sarcomas.
		A synovial sarcoma may be localized, meaning it has not spread beyond the joint where it arose or beyond nearby tissues, or metastatic, meaning it has spread to lungs, bones other than the bone that the tumor originated in, or to other organs or structures of the body.
	www.childrenshospital.org /az/Site1031/mainpageS1031P0.html (1967 words)

	Cancer
		Synovial sarcoma, a soft tissue cancer that most often occurs around leg or arm joints, has a 50% rate of metastasis.
		Human synovial sarcoma cells SW 982 (ATCC) were grown in DME medium supplemented with 10% FBS, penicillin (100 U/ml) and streptomycin (100 mg/ml) in 24-well tissue culture plates.
		The invasion of human synovial sarcoma cells through Matrigel was significantly reduced at 500 µg/ml (79%) and totally inhibited at 1000 µg/ml concentration of the synergistically acting nutrient mixture (p<0.0001).
	www.drrathresearch.org /lab_research/study_c_synovial_sarcoma.html (507 words)

	Sarcoma Cancer - Sarcoma Definitions (Site not responding. Last check: 2007-10-12)
		A sarcoma is a highly malignant and rare type of cancer that arises in the connective tissues in the body.
		Synovial Sarcoma - This form of sarcoma is comprised of cells that resemble the cells in joints.
		The name of this particular form of sarcoma is probably a misnomer, since the cancer cells in synovial sarcoma are likely to be very different from normal joint cells, Synovial sarcomas can originate in any location in the body, and it often appears in young adults.
	www.sarcomacancer.org /resources/definitions (761 words)

	Cardiac Sarcoma
		Cardiac sarcoma is a type of tumor that occurs in the heart.
		Once a cardiac sarcoma has progressed to the point that symptoms begin to occur, it has often spread to other parts of the body (in 80 percent of cases), making treatment difficult and challenging.
		In some cases, the sarcoma has invaded the heart to such an extent that it is impossible to remove it completely.
	www.healthsystem.virginia.edu /uvahealth/adult_cardiac/sarcoma.cfm (939 words)

	Sarcoma – Cancer of the Connective Tissue
		Sarcomas are cancers that arise from the cells that hold the body together.
		Kaposi sarcoma is one of the rare forms of cancer caused by a virus, KSHV or HHV-8, which escapes control of the immune system as seen in patients with HIV or in elderly patients, typically living in the areas around the Mediterranean Sea.
		Their prognosis may be better than that of other sarcomas, perhaps because they are found to be lower grade (less aggressive) than other sarcomas of comparable size, and tend to occur at a slightly younger age than other sarcomas, with a peak incidence between ages 30 and 40.
	www.curesarcoma.org /subtypes.htm (9190 words)

	Ewing Sarcoma - Lucile Packard Children's Hospital
		Ewing sarcoma is a cancer that occurs primarily in the bone or soft tissue.
		Ewing sarcoma can occur in any bone, but is most often found in the extremities and can involve muscle and the soft tissues around the tumor site.
		Ewing sarcoma cells can also spread (metastasize) to other areas of the body including the bone marrow, lungs, kidneys, heart, adrenal gland, and other soft tissues.
	www.lpch.org /DiseaseHealthInfo/HealthLibrary/oncology/ewing.html (881 words)

	Facts
		Sarcoma is a general class of uncommon cancers in which the cancer cells arise from or resemble normal cells in the body known as "connective tissues".
		("Synovial cells" line the joints.) However, synovial sarcoma does not necessarily arise in any joint, and the name is probably a misnomer, since the cancer cells are probably quite different from normal joint cells.
		Synovial sarcomas can arise in any location in the body, and it often appears in young adults.
	www.sarcoma.net /facts.htm (999 words)

	Poster # 15 - Intraarticular Synovial Sarcoma (Site not responding. Last check: 2007-10-12)
		Synovial sarcoma is a morphologically well delineated neoplasm typically found in extremities of children and young adults, usually in near vicinity of articulations.
		Rare times, synovial sarcomas are found in tissues without near synovial structures, such as head and neck (specially in retrofaringeal area), oral cavity, retroperitoneum, anterior abdominal wall, mediastinum and intravascular.
		Synovial sarcoma is a neoplasm of adolescents and young adults between 15 and 35 years old.
	www.uclm.es /inabis2000/posters/files/015/session.htm (1818 words)

	NW Sarcoma Foundation Sarcoma General (Site not responding. Last check: 2007-10-12)
		Sarcomas are cancers of the body tissues, and of the bone as opposed to specific organs.
		Although soft tissue sarcomas may develop in any part of the body, in both children and adults they are most commonly found in the trunk, arms, and legs.
		Bone sarcomas usually present with symptoms of pain and swelling of a bone or a bone region.
	www.nwsarcoma.org /sarcoma.html (295 words)

	Synovial Sarcoma: National Cancer Institute Information
		Synovial sarcoma is a type of soft tissue sarcoma.
		Synovial tissue lines the cavities of joints, such as the knee or elbow, tendons (tissues that connect muscle to bone), and bursae (fluid-filled, cushioning sacs in the spaces between tendons, ligaments, and bones).
		Although synovial sarcoma does not have a clearly defined cause, genetic factors are believed to influence the development of this disease.
	www.annieappleseedproject.org /synsarnatcan.html (139 words)

	Synovial Sarcoma: Questions and Answers - National Cancer Institute
		Synovial sarcoma is a rare type of soft tissue sarcoma that occurs mostly in young adults (see Questions 1 and 2).
		Synovial sarcoma occurs mostly in young adults, with a median age of 26.5 (1).
		Half of the cases of synovial sarcoma metastasize (spread to other areas of the body) to the lungs, lymph nodes, or bone marrow (1).
	www.cancer.gov /cancertopics/factsheet/Sites-Types/synovial (873 words)

	Synovial Sarcoma - Symptoms, Treatment and Prevention
		Sarcomas are uncommon malignant tumors that begin either in bones or in soft tissues such as muscles, cartilage, fat or connective tissue.
		Some soft tissue sarcomas arise in connective tissue (fibrosarcoma); nerve structures (neurofibrosarcoma); smooth muscles (leiomyosarcoma); fat (liposarcoma) and in membranes lining joints (synovial sarcoma).
		Because of the rarity of soft tissue sarcomas (non-rhabdomyosarcoma) in children and young adults, all patients should have their treatment planned by a multidisciplinary team of cancer specialists with experience treating children with soft tissue sarcomas.
	www.healthscout.com /ency/448/70/main.html (439 words)

	SYNOVIAL-SARCOMA
		Synovial sarcomas occur mainly in the arms and legs, more specifically in the area of large joints, especially the knee region.
		The symptoms of synovial sarcoma are a deep-seated swelling or a mass that may be accompanied by pain or tenderness.
		Synovial sarcoma occurs mostly in adolescents and young adults, and it affects more males than females.
	www.ugr.es /~oncoterm/csdata/SYNOVIAL-SARCOMA.html (246 words)

	Synovial Sarcoma in Pediatric Patients -- McCarville et al. 179 (3): 797 -- American Journal of Roentgenology
		Mixed cystic and solid appearance of tumor is common in synovial sarcoma and may be due to hemorrhage, necrosis, or both.
		Synovial sarcoma metastasizes to bone in 10-20% of cases.
		Synovial sarcoma has also been reported to occur in infratemporal fossa, external temporal fossa, posterior neck, parotid region, tongue, and other parts of neck.
	www.ajronline.org /cgi/content/full/179/3/797 (1776 words)

	Soft Tissue Sarcoma Resource Directory - CancerIndex
		Soft tissue sarcomas are malignant tumours that may arise in any of the mesodermal tissues (muscles, tendons, vessels that carry blood or lymph, joints, and fat).
		Sarcomas are a diverse range of tumours, they are named after the type of soft tissue cell they arise from.
		Kaposi's sarcoma is a type of cancer where malignant cells are found in the tissues under the skin, lining of the mouth, nose, and anus.
	www.cancerindex.org /clinks3u.htm (1349 words)

	SFA-Exclusive Panel Chat Transcript - Synovial Sarcoma, the Team Approach
		Synovial sarcomas occur most often in pararticular regions, arising from the tendon sheaths of muscles (the part of a muscle attached to bone), bursae (fluid filled sacs near joints or between muscles), or joint capsules.
		If a synovial sarcoma is tested for the SYT-SSX gene fusion and found to be negative and no technical reasons can explain the negative result, then it is wise to have the tumor slides re-examined by the pathologist in case it is another type of sarcoma.
		Poorly differentiated synovial sarcoma is perhaps the hardest subtype of synovial sarcoma to diagnose.
	www.curesarcoma.org /chat/transcripts/panelChat.htm (3707 words)

	eMedicine - Synovial Cell Sarcoma : Article by Mark Clayer, MD, MBBS, FRACS, FAOrthA (Site not responding. Last check: 2007-10-12)
		Synovial sarcoma is rare, representing approximately 5-10% of all soft tissue sarcomas.
		Clinical: Synovial sarcoma usually presents within the first 3 decades of life and generally is associated with a history of a small nodule that has increased rapidly in size.
		Plain radiograph may aid in the diagnosis as synovial sarcoma typically produces spotty calcification (snowstorm) within the matrix of the soft tissue tumor that may be visualized on plain radiograph (see Image 1).
	www.emedicine.com /orthoped/topic564.htm (1916 words)

	CytoJournal \| Full text \| Biphasic parapharyngeal synovial sarcoma: a cytologic and immunocytologic report of a case
		Synovial sarcoma is a rare soft tissue sarcoma in the head and neck region and parapharyngeal space.
		Synovial sarcoma(SS) usually occurs in young adults and is found in the paraarticular areas of the tendon sheaths and joints in the lower and upper-extremity.
		A specific translocation between chromosome X and 18, t(x; 18) (p11.2; q11.2) is mandatory for a conclusive diagnosis of synovial sarcoma[6,10,11].
	www.cytojournal.com /content/3/1/20 (2345 words)

	Bonetumor.org - The Web's Most Comprehensive Bone Tumor Resource
		Synovial chondromatosis is the rare and benign metaplasia of the synovial membrane resulting in the formation of multiple intra-articular cartilaginous bodies.
		Synovial chondromatosis is known by several other names including articular chondrosis and synovial chondrosis.
		Synovial chondromatosis presents as the gradual onset of monoarticular pain and stiffness.
	www.bonetumor.org /tumors/pages/page71.html (521 words)

	Soft Tissue Sarcoma Treatment in Adults and Children
		Soft tissue sarcomas are treated with surgery, chemotherapy and radiation.
		At Mayo Clinic soft tissue sarcomas are treated with two goals in mind: to cure the cancer and to save as much function of the affected area as possible.
		Soft tissue (non-bone) sarcomas are rare, but they can occur in many parts of the body such as muscle or fat of the extremities or the trunk.
	www.mayoclinic.org /soft-tissue-sarcoma/index.html (367 words)

	Synovial Sarcoma - Clinical Services- Soft Tissue Sarcomas - Stanford Comprehensive Cancer Center
		Synovial sarcoma is type of soft tissue sarcoma that occurs in the tissue around joints.
		The Cancer Center is a recognized center of cancer excellence and physicians here treat synovial sarcoma patients and actively research the disease and conduct clinical trials including:
		Because synovial sarcoma is rare, diagnosis can be difficult and getting an accurate diagnosis is extremely important to receive the most appropriate treatment.
	cancer.stanford.edu /sarcoma/synovial.html (170 words)

	Primary Pulmonary Synovial Sarcoma Confirmed by Molecular Detection of SYT-SSX1 Fusion Gene Transcripts: a Case Report ...
		it was diagnosed as primary pulmonary synovial sarcoma.
		Primary pulmonary sarcoma with features of monophasic synovial sarcoma: a clinicopathological, immunohistochemical, and ultrastructural study of 25 cases.
		Co-existence of SYT–SSX1 and SYT–SSX2 fusions in synovial sarcomas.
	jjco.oxfordjournals.org /cgi/content/full/35/5/274 (2329 words)

	Prognostic factors in advanced synovial sarcoma: an analysis of 104 patients treated at the Royal Marsden Hospital -- ...
		Synovial sarcoma: a clinicopathologic, staging, and prognostic assessment.
		Synovial sarcoma: prognostic significance of tumor size, margin of resection, and mitotic activity for survival.
		Synovial sarcoma: a multivariate analysis of prognostic factors in 112 patients with primary localized tumors of the extremity.
	annonc.oxfordjournals.org /cgi/content/full/16/3/437 (3308 words)

	ewing's sarcoma vs. synovial sarcoma
		i was diagnosed with ewing's sarcoma back on may 9th.
		Of what i have read, the initial treatment for ewing's is a long bout of chemo, whereas synovial is moreso based in radiation.
		But also, synovial has a much higher recurrence rate and seems like a longer battle over the course of time.
	www.sarcomaalliance.com /anyboard9/forum/posts/4560.html (219 words)

	Primary Synovial Sarcoma of the Lung: a Case Report Confirmed by Molecular Detection of SYT-SSX Fusion Gene Transcripts ... (Site not responding. Last check: 2007-10-12)
		Primary synovial sarcoma arising in the lung is rare.
		we suspected that the tumor was a synovial sarcoma of the monophasic
		Primary pulmonary sarcomas with features of monophasic synovial sarcoma: a clinicopathologic, immunohistochemical and ultrastructural study of 25 cases.
	jjco.oxfordjournals.org /cgi/content/full/31/5/212 (1976 words)

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