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Topic: Synthetase

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	Regulation of glutamine synthetase - Ammonia Assimilation and Recycling - HORT640 - Metabolic Plant Physiology - ...
		Although the nitrogen signal regulating the activity of the GlnR and TnrA proteins is not known, the wild-type glutamine synthetase protein is required for the transduction of this signal to the GlnR and TnrA proteins (Fisher, 1999).
		U.S.A. Foor F, Janssen KA, Magasanik B 1975 Regulation of synthesis of glutamine synthetase by adenylylated glutamine synthetase.
		Rochefort DA, Benson DR 1990 Molecular cloning, sequencing, and expression of the glutamine synthetase II (glnII) gene from the actinomycete root nodule symbiont Frankia sp.
	www.hort.purdue.edu /rhodcv/hort640c/ammonia/am00006.htm (3223 words)

	S-Adenosylmethionine Synthetase Is Overexpressed in Murine Neuroblastoma Cells Resistant to Nucleoside Analogue ...
		Inhibition of AdoMet synthetase gene expression and enzymic
		A significant increase in the expression of the catalytic subunit
		Expression of AdoMet synthetase subunits in wild-type (wMNB) and nucleotide analogue-resistant murine neuroblastoma (rMNB-MDL) cells.
	cancerres.aacrjournals.org /cgi/content/full/59/8/1852 (3211 words)

	InterPro: IPR002314 tRNA synthetase, class II (G, H, P and S)
		The aminoacyl-tRNA synthetases (6.1.1.-) catalyse the attachment of an amino acid to its cognate transfer RNA molecule in a highly specific two-step reaction.
		Class I aminoacyl-tRNA synthetases contain a characteristic Rossman fold and are mostly monomeric [ 2 ], while class II aminoacyl-tRNA synthetases share an anti-parallel beta-sheet formation, flanked by alpha-helices [ 3 ], and are mostly dimeric or multimeric.
		The 10 class I synthetases are considered to have in common the catalytic domain structure based on the Rossmann fold, which is totally different from the class II catalytic domain structure.
	www.ebi.ac.uk /interpro/IEntry?ac=IPR002314 (3169 words)

	Aminoacyl tRNA synthetase - Wikipedia, the free encyclopedia
		aminoacyl tRNA synthetase (abbreviated aaRs) is an enzyme that catalyzes the binding of a specific amino acid to a tRNA to form an aminoacyl-tRNA.
		The synthetase hydrolyzes ATP to bind the appropriate amino acid to the 3' hydroxyl of the tRNA molecule.
		It also mediates a proofreading reaction to ensure high fidelity of tRNA charging; if the tRNA is found to be improperly charged, the amino acid-tRNA bond is hydrolyzed.
	en.wikipedia.org /wiki/Aminoacyl_tRNA_synthetase (157 words)

	Chemicon - Product #MAB302 - Anti-Glutamine Synthetase, clone GS-6
		Glutamine synthetase, an enzyme that catalyzes the amination of glutamic acid to form glutamine, is found in mammals as an octamer of eight identical 45 kDa subunits.
		Glutamine synthetase activity has been shown to be a useful marker of astrocytes and an important differentiation feature in retina.
		Glutamine synthetase is also considered to be a key enzyme in the recycling of the neurotransmitter glutamate.
	www.chemicon.com /Product/ProductDataSheet.asp?ProductItem=MAB302 (499 words)

	Anti-KS: Identification of Autoantibodies to Asparaginyl-Transfer RNA Synthetase Associated with Interstitial Lung ...
		Polymyositis, pulmonary fibrosis and autoantibodies to aminoacyl-tRNA synthetase enzymes.
		Antibodies to glycyl-transfer RNA synthetase in patients with myositis and interstitial lung disease.
		The role of an autoantigen, histidyl-tRNA synthetase, in the induction and maintenance of autoimmunity.
	www.jimmunol.org /cgi/content/full/162/4/2315 (3935 words)

	Holocarboxylase synthetase deficiency - Genetics Home Reference
		Holocarboxylase synthetase deficiency is an inherited disorder in which the body is unable to use the vitamin biotin effectively.
		The signs and symptoms of holocarboxylase synthetase deficiency typically appear within the first few months of life, but the age of onset varies.
		Mutations in the HLCS gene cause holocarboxylase synthetase deficiency.
	ghr.nlm.nih.gov /condition=holocarboxylasesynthetasedeficiency (602 words)

	An Inhibitor of Exported Mycobacterium tuberculosis Glutamine Synthetase Selectively Blocks the Growth of Pathogenic ...
		Interestingly, the release of glutamine synthetase by pathogenic mycobacteria is correlated with the presence of a poly-
		glutamine synthetase by the recombinant strain was 69 mU/10
		Glutamine synthetase of Mycobacterium tuberculosis: extracellular release and characterization of its enzymatic activity.
	www.jem.org /cgi/content/full/189/9/1425 (4626 words)

	InterPro: IPR004529 Phenylalanyl-tRNA synthetase, alpha subunit (Site not responding. Last check: 2007-11-01)
		Phenylalanyl-tRNA synthetase (6.1.1.20) is an alpha2/beta2 tetramer composed of 2 subunits that belongs to class IIc.
		Identification of phenylalanyl-tRNA synthetase as a member of class II aaRSs was based only on sequence alignment of the small alpha-subunit with other synthetases [ 8 ].
		Mitochondrial phenylalanyl-tRNA synthetase is a single polypeptide chain, active as a monomer, and similar to this chain rather than to the beta chain, but excluded from this family.
	www.ebi.ac.uk /interpro/IEntry?ac=IPR004529 (3212 words)

	Use of Genomics To Identify Bacterial Undecaprenyl Pyrophosphate Synthetase: Cloning, Expression, and Characterization ...
		The prenyltransferase undecaprenyl pyrophosphate synthetase (di-trans,poly-cis-decaprenylcistransferase; EC 2.5.1.31) was
		To verify the functionality of the Upp synthetase, the genes from E.
		synthetase is a new class of isoprenoid synthetase because it
	jb.asm.org /cgi/content/full/181/2/483 (6191 words)

	Sulfation in high endothelial venules: cloning and expression of the human PAPS synthetase -- Girard et al. 12 (7): 603 ...
		The amino-terminal part of human PAPS synthetase is homologous to APS kinases from bacteria, yeast, and plants, whereas the carboxy-terminal part is very similar to ATP sulfurylases from yeast, fungi, and plants.
		Hu: human PAPS synthetase (aa 241–624); At1, At2, and At3: Arabidopsis thaliana ATP sulfurylases 1 (aa 65–463; GenBank N°U05218), 2 (aa 79–476; GenBank N°U06276), and 3 (aa 67–465; GenBank N°U06275); St1 and St2: Solanum tuberosum ATP sulfurylases 1 (aa 26–424; GenBank N°X75041) and 2 (aa 65–463; GenBank N°X79053).
		These observations indicate that PAPS synthetase, the target for chlorate inhibition, plays a key role in the control of L-selectin counterreceptor sulfation and functional activity.
	www.fasebj.org /cgi/content/full/12/7/603 (5635 words)

	Nucleolar Localization of Human Methionyl-tRNA Synthetase and Its Role in Ribosomal RNA Synthesis -- Ko et al. 149 (3): ...
		Dang, C.V., Yang, D.C., Pollard, T.D. Association of methionyl–tRNA synthetase with detergent-insoluble components of the rough endoplasmic reticulum.
		Labouesse, M. The yeast mitochondrial leucyl–tRNA synthetase is a splicing factor for the excision of several group I introns.
		Ludmerer, S.W., Schimmel, P. Gene for yeast glutamine tRNA synthetase encodes a large amino-terminal extension and provides a strong confirmation of the signature sequence for a group of the aminoacyl–tRNA synthetases.
	www.jcb.org /cgi/content/full/149/3/567 (4530 words)

	Decreased Accumulation or Increased Isoleucyl-tRNA Synthetase Activity Confers Resistance to the Cyclic beta -Amino ...
		The number of isoleucyl-tRNA synthetase molecules per cell was calculated based on data from a procedure for the purification
		Isoleucyl-tRNA synthetase activity was determined in crude extracts of selected mutants (Table 2).
		We determined the accumulations of BAY 10-8888 and the specific isoleucyl-tRNA synthetase activities for seven C.
	aac.asm.org /cgi/content/full/42/7/1581 (3344 words)

	Mammalian cytidine 5'-monophosphate N-acetylneuraminic acid synthetase: A nuclear protein with evolutionarily conserved ...
		Heterologous expression of the murine CMP-Neu5Ac synthetase in E.
		The signal in LEC29.Lec32 is caused by the presence of Lec32 revertants.
		Structure of a Sialic Acid-activating Synthetase, CMP-acylneuraminate Synthetase in the Presence and Absence of CDP
	www.pnas.org /cgi/content/full/95/16/9140 (4550 words)

	The Reported Human NADsyn2 Is Ammonia-dependent NAD Synthetase from a Pseudomonad -- Bieganowski and Brenner 278 (35): ...
		The Reported Human NADsyn2 Is Ammonia-dependent NAD Synthetase from a Pseudomonad -- Bieganowski and Brenner 278 (35): 33056 -- Journal of Biological Chemistry
		synthetase was cloned and shown to depend on Cys-175 for glutamine-dependent
		Genome organization of pncB (nicotinic acid phosphoribosyltransferase), and nadE (ammonia-dependent NAD synthetase) cistrons in E.
	www.jbc.org /cgi/content/full/278/35/33056 (2019 words)

	N-Acetyl Glutamate Synthetase Deficiency
		It is possible that the main title of the report N-Acetyl Glutamate Synthetase Deficiency is not the name you expected.
		N-acetylglutamate synthetase (NAGS) deficiency is a rare genetic disorder characterized by complete or partial lack of the enzyme N-acetylglutamate synthetase (NAGS).
		NAGS is one of six enzymes that play a role in the break down and removal of nitrogen from the body, a process known as the urea cycle.
	www.webmd.com /hw/raising_a_family/nord313.asp (511 words)

	eMedicine - Carbamoyl Phosphate Synthetase Deficiency : Article by Karl S Roth, MD (Site not responding. Last check: 2007-11-01)
		Background: Carbamoyl phosphate synthetase (CPS) deficiency is a urea cycle defect that results from a deficient enzyme mediating the normal path for incorporation of ammonia.
		In cases of homozygous deficiency of CPS I, the ability to fix waste nitrogen is completely absent, which results in increasing levels of free ammonia with the attendant effects on the central nervous system (CNS).
		Wong LJ, Craigen WJ, O'Brien WE: Postpartum coma and death due to carbamoyl-phosphate synthetase I deficiency.
	www.emedicine.com /PED/topic314.htm (2148 words)

	Human asparaginyl-tRNA synthetase: molecular cloning and the inference of the evolutionary history of Asx-tRNA ...
		Human asparaginyl-tRNA synthetase: molecular cloning and the inference of the evolutionary history of Asx-tRNA synthetase family -- Shiba et al.
		Human asparaginyl-tRNA synthetase: molecular cloning and the inference of the evolutionary history of Asx-tRNA synthetase family
		synthetase, and support the occurrence of AsnRS early in the course of
	nar.oxfordjournals.org /cgi/content/abstract/26/22/5045?vol=26&fp=5045&view=abstract (453 words)

	eMedicine - N-Acetylglutamate Synthetase Deficiency : Article by Karl S Roth, MD
		Ammonul must be administered with arginine for carbamyl phophate synthetase (CPS), ornithine transcarbamylase (OTC), argininosuccinate synthetase (ASS), or argininosuccinate lyase (ASL) deficiencies.
		Compound 3 is aspartic acid, which is combined with citrulline to form argininosuccinic acid (ASA) (4); the reaction is mediated by ASA synthetase.
		Compound 5 is fumaric acid generated in the reaction that converts ASA to arginine (6), which is mediated by ASA lyase.
	www.emedicine.com /ped/topic10.htm (2393 words)

	Glutamine Synthetase
		620 KDa) and the complex regulation patterns of glutamine synthetase (GS) stem from its central role in cellular nitrogen metabolism.
		It brings nitrogen into metabolism by condensing ammonia with glutamate, with the aid of ATP, to yield glutamine.
		The absence of interaction between Glu 327 and Gln permits residues (324-328) to open, allowing Gln to leave the active site.
	www.doe-mbi.ucla.edu /People/Eisenberg/Gallery/GS.html (283 words)

	InterPro: IPR002305 Aminoacyl-tRNA synthetase, class Ib
		O29482 Tyrosyl-tRNA synthetase (EC 6.1.1.1) (Tyrosine--tRNA ligase) (TyrRS)
		P12063 Tyrosyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.1) (Tyrosine--tRNA ligase) (TyrRS)
		Doublie S. Bricogne G. Gilmore C. Carter Jr C.W. Tryptophanyl-tRNA synthetase crystal structure reveals an unexpected homology to tyrosyl-tRNA synthetase.
	www.ebi.ac.uk /interpro/IEntry?ac=IPR002305 (2996 words)

	EC 6.2.1.3 (Site not responding. Last check: 2007-11-01)
		Bakken, A.M. and Farstad, M. Identical subcellular distribution of palmitoyl-CoA and arachidonoyl-CoA synthetase activities in human blood platelets.
		Nagamatsu, K., Soeda, S., Mori, M. and Kishimoto, Y. Lignoceroyl-coenzyme A synthetase from developing rat brain: partial purification, characterization and comparison with palmitoyl-coenzyme A synthetase activity and liver enzyme.
		Tanaka, T., Hosaka, K., Hoshimaru, M. and Numa, S. Purification and properties of long-chain acyl-coenzyme-A synthetase from rat liver.
	www.chem.qmul.ac.uk /iubmb/enzyme/EC6/2/1/3.html (154 words)

	GMPS (guanine monphosphate synthetase)
		Title:The glutamine hydrolysis function of human GMP synthetase.
		The crystal structure of GMP synthetase reveals a novel catalytic triad and is a structural paradigm for two enzyme families.
		t(3;11)(q25;q23) fuses MLL with the GMPS (guanosine 5'-monophosphate synthetase) gene in treatment-related acute myeloid leukemia (AML).
	www.infobiogen.fr /services/chromcancer/Genes/GMPSID229.html (404 words)

	Neuromuscular: Muscle Autoantibodies
		ANTIBODIES and COMPLEMENT IN MYOPATHIES AND NMJ DISORDERS
		t-RNA synthetase antibodies may be stimulated by apoptotic bodies in skin
		Associated with PM and other connective tissue disorders
	www.neuro.wustl.edu /neuromuscular/lab/mantibody.html (501 words)

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