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| | [Clinical Preventive Services] Screening for Syphilis (Site not responding. Last check: 2007-10-22) |
 | | Primary syphilis produces ulcers of the genitalia, pharynx, or rectum, and secondary syphilis is characterized by contagious skin lesions, lymph- adenopathy, and condylomata lata.2 Systemic spread, including invasion of the central nervous system, can occur early in infection and may be symptomatic during early or late stages of syphilis. |
 | | In early primary syphilis, when antibody levels may be too low to detect, results may be nonreactive, and the sensitivity of nontreponemal tests is 62-76%.10 Antibody levels rise as disease progresses; titers usually peak during secondary syphilis, when the sensitivity of nontreponemal tests approaches 100%. |
 | | Co-infection with HIV and syphilis does not generally impair the sensitivity of syphilis testing, although there are sporadic reports of absent or delayed response to nontreponemal tests. |
| cpmcnet.columbia.edu /texts/gcps/gcps0036.html (1474 words) |
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