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Topic: Systemic Lupus Erythematosus

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	Lupus - WrongDiagnosis.com
		Lupus is one of a group of conditions with vague symptoms such as fatigue or malaise, and may need to be distinguished from fibromyalgia, chronic fatigue syndrome, Type 2 diabetes, depression, Lyme disease, multiple sclerosis, or various other conditions.
		Lupus (also called systemic lupus erythematosus or SLE) is a disorder of the immune system which normally functions to protect the body against invading infections and cancers.
		Lupus is a disorder of the immune system known as an autoimmune disease.
	www.wrongdiagnosis.com /l/lupus/intro.htm (1226 words)

	Systemic Lupus Erythematosus (SLE) Causes, Symptoms, Treatment, Diagnosis and Information on MedicineNet.com (Site not responding. Last check: 2007-11-03)
		Lupus nephritis is kidney disease that is caused by lupus.
		Lupus is a condition of chronic inflammation caused by an autoimmune disease.
		Genetic factors increase the tendency of developing autoimmune diseases, and autoimmune diseases such as lupus, rheumatoid arthritis, and immune thyroid disorders are more common among relatives of patients with lupus than the general population.
	www.medicinenet.com /systemic_lupus/article.htm (1160 words)

	MedlinePlus Medical Encyclopedia: Systemic lupus erythematosus
		Systemic lupus erythematosus (SLE) is a chronic, inflammatory autoimmune disorder.
		When this occurs, it is known as drug-induced lupus erythematosus and it is usually reversible when the medication is stopped.
		Women with SLE who become pregnant are often able to carry the pregnancy safely to term and deliver normal infants, provided severe kidney or heart disease is not present and the SLE is being managed.
	www.nlm.nih.gov /medlineplus/ency/article/000435.htm (1182 words)

	Systemic Lupus Erythematosus (SLE) Clinical Overview
		SLE is a complex disorder affecting a predominately young population and shares similarities with HIV infection as regards the propensity for multiple organ involvement, potentially life-threatening episodes, and need for sophisticated monitoring.
		SLE is notable for unpredictable exacerbations and remissions and a predilection for clinical involvement of the joints, skin, kidney, brain, serosa, lung, heart, and gastrointestinal tract.
		SLE is associated with anemia of chronic inflammation, acute hemolytic anemia, leukopenia, lymphopenia, and thrombocytopenia.
	www.cerebel.com /lupus/overview.html (3839 words)

	Patient Education - Systemic Lupus Erythematosus
		Systemic lupus erythematosus (also called SLE or lupus) is a chronic inflammatory disease that can affect the skin, joints, kidneys, lungs, nervous system, and/or other organs of the body.
		SLE is an autoimmune disorder which develops when the body's own immune system, which normally protects against cancers and invading infections, begins to attack the patient's own tissues (known medically as a “loss of self-tolerance”).
		Lupus is a disease that can lead to inflammation in multiple organs including the kidneys, the lining tissue of the heart and lungs (pleuritis and pericarditis), and the brain as well as the joints and skin.
	www.rheumatology.org /public/factsheets/sle_new.asp?aud=pat (1598 words)

	Postgraduate Medicine: Systemic lupus erythematosus
		SLE can occur at any age but is most often a disease of women in their childbearing years.
		SLE is a chronic disease that waxes and wanes.
		SLE is a chronic autoimmune disease with an unpredictable history and course.
	www.postgradmed.com /issues/1999/11_99/greenberg.htm (3364 words)

	Handout on Health: Systemic Lupus Erythematosus (Site not responding. Last check: 2007-11-03)
		Systemic lupus erythematosus (SLE) is the form of the disease that most people are referring to when they say “lupus.” The word “systemic” means the disease can affect many parts of the body.
		Lupus is a complex disease, and its cause is unknown.
		Lupus patients with a history of kidney disease have a higher risk of preeclampsia (hypertension with a buildup of excess watery fluid in cells or tissues of the body).
	www.niams.nih.gov /hi/topics/lupus/slehandout (6488 words)

	THE MERCK MANUAL, Sec. 5, Ch. 50, Diffuse Connective Tissue Disease
		Blistering and ulceration are rare, although recurrent ulcers on mucous membranes (particularly the central portion of the hard palate near the junction of the hard and soft palate, the buccal and gum mucosa, and the anterior nasal septum) are common.
		SLE is obvious when a patient (particularly a young woman) is febrile with an erythematous skin rash, polyarthritis, evidence of renal disease, intermittent pleuritic pain, leukopenia, and hyperglobulinemia with anti-double-stranded DNA antibodies.
		To simplify therapy, SLE should be classified as mild (fever, arthritis, pleurisy, pericarditis, headache, or rash) or severe (life-threatening disease, eg, hemolytic anemia, thrombocytopenic purpura, massive pleural and pericardial involvement, significant renal damage, acute vasculitis of the extremities or GI tract, florid CNS involvement).
	www.merck.com /pubs/mmanual/section5/chapter50/50e.htm (1999 words)

	Postgraduate Medicine: Systemic lupus erythematosus
		SLE affects the mucocutaneous system in 80% to 90% of patients with the disease.
		Because the diagnosis and ramifications of SLE can be confusing and frightening for patients, physicians need to educate patients and their families about the disease and refer them to appropriate resources such as the Lupus and Arthritis foundations (see box at the end of this article).
		Autoantibodies in the diagnosis of systemic rheumatic diseases.
	www.postgradmed.com /issues/2003/11_03/dallera.htm (2428 words)

	Lupus: Overview
		Lupus erythematosus is an autoimmune disease of unknown cause defined by a list of clinical characteristics in association with auto antibody production.
		The disease presents as a spectrum from limited skin disease at one pole to life-threatening systemic disease at the other pole.
		Treating lupus: topical and local treatment like corticsteriod cream or ointment, systemic treatment like vitamin A derivatives (isotretinoin or acitretin)or severe lupus uses more potent immunosuppressive drugs.
	www.skincareguide.ca /conditions/lupus.html (177 words)

	SLE (Site not responding. Last check: 2007-11-03)
		SLE is an autoimmune disease in which the body's own immune system is directed against the body's own tissues.
		SLE must be distinguished from discoid lupus erythematosus (DLE) which affects the skin (but only in sun exposed regions) and is unlikely to be associated with systemic illness, such as renal disease.
		Systemic lupus erythematosus, skin biopsy, H and E stain, microscopic.
	www-medlib.med.utah.edu /WebPath/TUTORIAL/SLE/SLE.html (380 words)

	Systemic Lupus Erythematosus
		Systemic lupus erythematosus (SLE) is a challenging 'autoimmune' whose wide variety of manifestations makes it a necessary part of the differential diagnosis for children and adolescents with many different presenting complaints.
		Many pediatricians dismiss SLE from their differential diagnosis as 'uncommon in childhood', but positive tests for antinuclear antibodies (ANA) and other findings which warrant inclusion of SLE in the differential diagnosis are in fact quite common.
		SLE is an unpredictable disease and may be fatal with or without renal involvement.
	www.goldscout.com /page2.html (2462 words)

	Systemic Lupus Erythematosus
		Lupus flare, miscarriage or stillbirth, pregnancy-induced hypertension, neonatal lupus.
		Twenty years ago, women with lupus were counseled not to become pregnant because of the risk of a flare of the disease and an increased risk of miscarriage.
		SLE affects the immune system, thus reducing the body’s ability to prevent and fight infection.
	www.seniorthinking.com /sampledisk/lupus/linkg4.htm (5139 words)

	► Systemic lupus erythematosus
		A chronic, inflammatory autoimmune disorder that may affect many organ systems including the skin, joints, and internal organs.
		In systemic lupus erythematosus (SLE) and other autoimmune diseases, these defenses are turned against the body when antibodies are produced against its own cells.
		Most people with SLE have some deposits of protein within the cells (glomeruli) of the kidney; however, only 50% have lupus nephritis as defined by persistent inflammation in the kidney.
	www.umm.edu /ency/article/000435.htm (598 words)

	eMedicine - Systemic Lupus Erythematosus : Article by David W Lamont, DO (Site not responding. Last check: 2007-11-03)
		Background: Systemic lupus erythematosus (SLE) is an autoimmune disease involving multiple organ systems that is defined clinically and associated with antibodies directed against cell nuclei.
		Renal system - Specific signs and symptoms of renal disease may not be apparent until advanced nephrotic syndrome or renal failure is present; therefore, obtaining a urine analysis and serum BUN and creatinine levels on a regular basis is important.
		Many of the clinical manifestations of SLE are caused by the effects of circulating immune complexes on various tissues or to the direct effects of antibodies to cell surface components.
	www.emedicine.com /emerg/topic564.htm (3632 words)

	European Lupus Erythematosus Federation
		Lupus is a condition whereby the body's defence mechanism goes into overdrive and starts to attack itself.
		Lupus adversely influences the lives of sufferers, the family and their friends.
		The First International Lupus Patients Conference in 1992 which took place concurrently with the Third International Scientific Conference on SLE was organised by ELEF.
	www.elef.rheumanet.org (577 words)

	Lupus Foundation of America, Inc.
		Lupus Now: State of the Art Approaches from Lupus Experts.
		The official national wristbands for lupus are $1 each and are available in packages of 10, 25, 50 and 100 wristbands in sizes for adults and children.
		Lupus Now®, the first-ever national magazine for people with lupus, their families, and lupus health professionals.
	www.lupus.org (182 words)

	The Genetics of Systemic Lupus Erythematosus Family Study - What is Lupus? (Site not responding. Last check: 2007-11-03)
		A research study at the University of Minnesota, sponsored by the National Institute of Health and the Lupus Foundation of Minnesota.
		We are looking nationwide for individuals with lupus or families with two or more family members with lupus.
		Timothy W. Behrens, M.D. is the Principal Investigator on this project and is a Professor of Medicine and a Rheumatologist at the University of Minnesota.
	www.lupusstudy.org (182 words)

	Disease Category Listing (144): Systemic Lupus Erythematosus
		HSC# 9955, A randomized, double-blind, placebo-controlled, multicenter, Phase II/III study to evaluate the safety and efficacy of a B-cell depleting therapy in the treatment of patients with active moderate to severe systematic lupus erythematosus.
		The effects of an investigational drug on patients with Systemic Lupus Erythematosus (SLE) will be evaluated.
		The pharacoproteomic relationship between anti-DNA antibodies and an investigational drug for systemic lupus erythematosus is being evaluated.
	www.centerwatch.com /patient/studies/cat144.html (498 words)

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